{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:50:05Z","timestamp":1793407805895,"version":"4.5.0"},"reference-count":77,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":377,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFA0507400"],"award-info":[{"award-number":["2018YFA0507400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003345","name":"Chinese Academy of Meteorological Sciences","doi-asserted-by":"publisher","award":["2021-I2M-1-017"],"award-info":[{"award-number":["2021-I2M-1-017"]}],"id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003345","name":"Chinese Academy of Meteorological Sciences","doi-asserted-by":"publisher","award":["PCT\/CN2022\/141364"],"award-info":[{"award-number":["PCT\/CN2022\/141364"]}],"id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003345","name":"Chinese Academy of Meteorological Sciences","doi-asserted-by":"publisher","award":["PCT\/CN2022\/141371"],"award-info":[{"award-number":["PCT\/CN2022\/141371"]}],"id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82388201"],"award-info":[{"award-number":["82388201"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32370927"],"award-info":[{"award-number":["32370927"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.immuni.2024.05.025","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T11:04:47Z","timestamp":1718967887000},"page":"1796-1811.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"title":["Cellular spermine targets JAK signaling to restrain cytokine-mediated autoimmunity"],"prefix":"10.1016","volume":"57","author":[{"given":"Henan","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyue","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianjin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu-Yi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9677-7647","authenticated-orcid":false,"given":"Xuetao","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2024.05.025_bib1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1146\/annurev-immunol-051116-052225","article-title":"Understanding human autoimmunity and autoinflammation through transcriptomics","volume":"35","author":"Banchereau","year":"2017","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.immuni.2024.05.025_bib2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev-med-050715-104506","article-title":"The type I interferonopathies","volume":"68","author":"Lee-Kirsch","year":"2017","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.immuni.2024.05.025_bib3","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/s41423-022-00874-1","article-title":"The deacetylase SIRT2 contributes to autoimmune disease pathogenesis by modulating IL-17A and IL-2 transcription","volume":"19","author":"Hisada","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.immuni.2024.05.025_bib4","doi-asserted-by":"crossref","DOI":"10.1172\/JCI141008","article-title":"IL-1beta-driven osteoclastogenic Tregs accelerate bone erosion in arthritis","volume":"131","author":"Levescot","year":"2021","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2024.05.025_bib5","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/art.41666","article-title":"Characterization and function of tumor necrosis factor and interleukin-6-induced osteoclasts in rheumatoid arthritis","volume":"73","author":"Yokota","year":"2021","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.immuni.2024.05.025_bib6","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1056\/NEJMoa2109927","article-title":"Cardiovascular and cancer risk with tofacitinib in rheumatoid arthritis","volume":"386","author":"Ytterberg","year":"2022","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2024.05.025_bib7","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1136\/annrheumdis-2020-219214","article-title":"Filgotinib versus placebo or adalimumab in patients with rheumatoid arthritis and inadequate response to methotrexate: a phase III randomised clinical trial","volume":"80","author":"Combe","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.immuni.2024.05.025_bib8","article-title":"Biologics or tofacitinib for rheumatoid arthritis in incomplete responders to methotrexate or other traditional disease-modifying anti-rheumatic drugs: a systematic review and network meta-analysis","volume":"2016","author":"Singh","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.immuni.2024.05.025_bib9","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nri3581","article-title":"Regulation of type I interferon responses","volume":"14","author":"Ivashkiv","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2024.05.025_bib10","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1091\/mbc.e06-01-0076","article-title":"Stat-mediated signaling induced by type I and type II interferons (IFNs) is differentially controlled through lipid microdomain association and clathrin-dependent endocytosis of IFN receptors","volume":"17","author":"Marchetti","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.immuni.2024.05.025_bib11","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nsmb.2519","article-title":"SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition","volume":"20","author":"Kershaw","year":"2013","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.immuni.2024.05.025_bib12","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nsmb.3378","article-title":"STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling","volume":"24","author":"Arimoto","year":"2017","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.immuni.2024.05.025_bib13","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1038\/sj.emboj.7601149","article-title":"UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity","volume":"25","author":"Malakhova","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.immuni.2024.05.025_bib14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41590-017-0003-0","article-title":"Nuclear RNF2 inhibits interferon function by promoting K33-linked STAT1 disassociation from DNA","volume":"19","author":"Liu","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2024.05.025_bib15","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/s41422-020-0291-z","article-title":"Targeting immunometabolism as an anti-inflammatory strategy","volume":"30","author":"P\u00e5lsson-McDermott","year":"2020","journal-title":"Cell Res."},{"key":"10.1016\/j.immuni.2024.05.025_bib16","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/ni.2833","article-title":"TLR-driven early glycolytic reprogramming via the kinases TBK1-IKK\u03f5 supports the anabolic demands of dendritic cell activation","volume":"15","author":"Everts","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2024.05.025_bib17","doi-asserted-by":"crossref","first-page":"4168","DOI":"10.1016\/j.cell.2021.05.045","article-title":"Metabolic modeling of single Th17 cells reveals regulators of autoimmunity","volume":"184","author":"Wagner","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2024.05.025_bib18","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.molcel.2018.06.023","article-title":"Macrophage-associated PGK1 phosphorylation promotes aerobic glycolysis and tumorigenesis","volume":"71","author":"Zhang","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.immuni.2024.05.025_bib19","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.immuni.2017.07.015","article-title":"CCCTC-binding factor translates interleukin 2- and alpha-Ketoglutarate-sensitive metabolic changes in T\u00a0cells into context-dependent gene programs","volume":"47","author":"Chisolm","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2024.05.025_bib20","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature25986","article-title":"Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1","volume":"556","author":"Mills","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2024.05.025_bib21","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.cell.2019.05.003","article-title":"Lactate is a natural suppressor of RLR signaling by targeting MAVS","volume":"178","author":"Zhang","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2024.05.025_bib22","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2024.05.025_bib23","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/j.cell.2015.10.048","article-title":"Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling","volume":"163","author":"Levy","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2024.05.025_bib24","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/BF03402072","article-title":"Spermine inhibition of monocyte activation and inflammation","volume":"5","author":"Zhang","year":"1999","journal-title":"Mol. Med."},{"key":"10.1016\/j.immuni.2024.05.025_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/science.aan2788","article-title":"Spermidine in health and disease","volume":"359","author":"Madeo","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.immuni.2024.05.025_bib26","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev-med-051113-024537","article-title":"The JAK-STAT pathway: impact on human disease and therapeutic intervention","volume":"66","author":"O\u2019Shea","year":"2015","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.immuni.2024.05.025_bib27","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1016\/j.cell.2022.09.023","article-title":"The JAK-STAT pathway at 30: much learned, much more to do","volume":"185","author":"Philips","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2024.05.025_bib28","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1126\/science.abn8933","article-title":"Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation","volume":"376","author":"Glassman","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.immuni.2024.05.025_bib29","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3389\/fendo.2017.00071","article-title":"The Janus kinase (JAK) FERM and SH2 domains: bringing specificity to JAK-receptor interactions","volume":"8","author":"Ferrao","year":"2017","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.immuni.2024.05.025_bib30","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1126\/science.abo7788","article-title":"Unlocking the secrets to Janus kinase activation","volume":"376","author":"Levine","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.immuni.2024.05.025_bib31","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nrd.2017.201","article-title":"JAK inhibition as a therapeutic strategy for immune and inflammatory diseases","volume":"16","author":"Schwartz","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.immuni.2024.05.025_bib32","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.str.2016.03.023","article-title":"The structural basis for class II cytokine receptor recognition by JAK1","volume":"24","author":"Ferrao","year":"2016","journal-title":"Structure"},{"key":"10.1016\/j.immuni.2024.05.025_bib33","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.1016\/j.jmb.2016.10.005","article-title":"Crystal structure of a complex of the intracellular domain of interferon lambda receptor 1 (IFNLR1) and the FERM\/SH2 domains of human JAK1","volume":"428","author":"Zhang","year":"2016","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.immuni.2024.05.025_bib34","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0021-9258(18)48472-4","article-title":"Mechanism of the irreversible inactivation of mouse ornithine decarboxylase by alpha-difluoromethylornithine. Characterization of sequences at the inhibitor and coenzyme binding sites","volume":"267","author":"Poulin","year":"1992","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.immuni.2024.05.025_bib35","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1096\/fasebj.7.8.8500690","article-title":"Spermidine\/spermine N1-acetyltransferase--the turning point in polyamine metabolism","volume":"7","author":"Casero","year":"1993","journal-title":"FASEB J."},{"key":"10.1016\/j.immuni.2024.05.025_bib36","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41568-022-00473-2","article-title":"Polyamines in cancer: integrating organismal metabolism and antitumour immunity","volume":"22","author":"Holbert","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.immuni.2024.05.025_bib37","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abc4275","article-title":"De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and determine T\u00a0cell proliferation and function","volume":"6","author":"Wu","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.immuni.2024.05.025_bib38","doi-asserted-by":"crossref","first-page":"4650","DOI":"10.1016\/j.molcel.2021.10.002","article-title":"Structural mechanisms for gating and ion selectivity of the human polyamine transporter ATP13A2","volume":"81","author":"Tillinghast","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.immuni.2024.05.025_bib39","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/s41586-020-1968-7","article-title":"ATP13A2 deficiency disrupts lysosomal polyamine export","volume":"578","author":"van Veen","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2024.05.025_bib40","doi-asserted-by":"crossref","first-page":"100182","DOI":"10.1074\/jbc.RA120.013908","article-title":"ATP13A3 is a major component of the enigmatic mammalian polyamine transport system","volume":"296","author":"Hamouda","year":"2021","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.immuni.2024.05.025_bib41","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1053\/jhep.2000.8525","article-title":"High dose and long-term therapy with interferon-alfa inhibits tumor growth and recurrence in nude mice bearing human hepatocellular carcinoma xenografts with high metastatic potential","volume":"32","author":"Wang","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.immuni.2024.05.025_bib42","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.2353\/ajpath.2006.050125","article-title":"Type I interferon production by tertiary lymphoid tissue developing in response to 2,6,10,14-tetramethyl-pentadecane (pristane)","volume":"168","author":"Nacionales","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.immuni.2024.05.025_bib43","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.it.2009.06.003","article-title":"Induction of autoimmunity by pristane and other naturally occurring hydrocarbons","volume":"30","author":"Reeves","year":"2009","journal-title":"Trends Immunol."},{"key":"10.1016\/j.immuni.2024.05.025_bib44","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev.iy.09.040191.001331","article-title":"Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease","volume":"9","author":"Cohen","year":"1991","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.immuni.2024.05.025_bib45","doi-asserted-by":"crossref","first-page":"16082","DOI":"10.1038\/nrdp.2016.82","article-title":"Psoriasis","volume":"2","author":"Greb","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.immuni.2024.05.025_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2019.108251","article-title":"Targeting cytokines to treat autoimmunity","volume":"206","author":"Kyttaris","year":"2019","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.immuni.2024.05.025_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2017.03.008","article-title":"Regulation of type I interferon signaling in immunity and inflammation: A comprehensive review","volume":"83","author":"Chen","year":"2017","journal-title":"J.\u00a0Autoimmun."},{"key":"10.1016\/j.immuni.2024.05.025_bib48","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.jaci.2020.10.022","article-title":"The emerging role of Janus kinase inhibitors in the treatment of autoimmune and inflammatory diseases","volume":"147","author":"Damsky","year":"2021","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.immuni.2024.05.025_bib49","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1056\/NEJMoa1602773","article-title":"Ustekinumab as induction and maintenance therapy for Crohn's disease","volume":"375","author":"Feagan","year":"2016","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2024.05.025_bib50","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/nrrheum.2015.167","article-title":"Type I\/II cytokines, JAKs, and new strategies for treating autoimmune diseases","volume":"12","author":"Schwartz","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.immuni.2024.05.025_bib51","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.chom.2016.01.007","article-title":"Dysregulated type I interferon and inflammatory monocyte-macrophage responses cause lethal pneumonia in SARS-CoV-infected mice","volume":"19","author":"Channappanavar","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.immuni.2024.05.025_bib52","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abd1554","article-title":"Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19","volume":"5","author":"Lee","year":"2020","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.immuni.2024.05.025_bib53","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1038\/s41591-020-0944-y","article-title":"A single-cell atlas of the peripheral immune response in patients with severe COVID-19","volume":"26","author":"Wilk","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2024.05.025_bib54","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1056\/NEJMra1609337","article-title":"Acute graft-versus-host disease - biologic process, prevention, and therapy","volume":"377","author":"Zeiser","year":"2017","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2024.05.025_bib55","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1126\/science.aar6711","article-title":"CAR T\u00a0cell immunotherapy for human cancer","volume":"359","author":"June","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.immuni.2024.05.025_bib56","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature23475","article-title":"Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism","volume":"548","author":"Xu","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2024.05.025_bib57","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","article-title":"Metabolic regulation of gene expression by histone lactylation","volume":"574","author":"Zhang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2024.05.025_bib58","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.cmet.2022.02.002","article-title":"Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages","volume":"34","author":"Runtsch","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2024.05.025_bib59","doi-asserted-by":"crossref","first-page":"4790","DOI":"10.3390\/ijms20194790","article-title":"Polyamine catabolism in acute kidney injury","volume":"20","author":"Zahedi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.immuni.2024.05.025_bib60","doi-asserted-by":"crossref","DOI":"10.1126\/science.abj3510","article-title":"Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice","volume":"378","author":"Al-Habsi","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.immuni.2024.05.025_bib61","doi-asserted-by":"crossref","first-page":"E751","DOI":"10.1073\/pnas.1614958114","article-title":"Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications","volume":"114","author":"Hardbower","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2024.05.025_bib62","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1084\/jem.185.10.1759","article-title":"Spermine inhibits proinflammatory cytokine synthesis in human mononuclear cells: a counterregulatory mechanism that restrains the immune response","volume":"185","author":"Zhang","year":"1997","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2024.05.025_bib63","doi-asserted-by":"crossref","first-page":"4186","DOI":"10.1016\/j.cell.2021.06.007","article-title":"Polyamine metabolism is a central determinant of helper T\u00a0cell lineage fidelity","volume":"184","author":"Puleston","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2024.05.025_bib64","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1007\/s10067-017-3811-6","article-title":"Pristane-induced lupus: considerations on this experimental model","volume":"36","author":"Freitas","year":"2017","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.immuni.2024.05.025_bib65","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0306-9877(03)00340-2","article-title":"Calculating the etiology of systemic lupus erythematosus","volume":"62","author":"Adhami","year":"2004","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.immuni.2024.05.025_bib66","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1177\/0961203317751860","article-title":"Polyamine patterns in plasma of patients with systemic lupus erythematosus and fever","volume":"27","author":"Kim","year":"2018","journal-title":"Lupus"},{"key":"10.1016\/j.immuni.2024.05.025_bib67","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/00054725-200409000-00006","article-title":"Intracellular polyamine levels of intestinal epithelial cells in inflammatory bowel disease","volume":"10","author":"Weiss","year":"2004","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.immuni.2024.05.025_bib68","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2353\/jmoldx.2006.050079","article-title":"Molecular classification of Crohn\u2019s disease and ulcerative colitis patients using transcriptional profiles in peripheral blood mononuclear cells","volume":"8","author":"Burczynski","year":"2006","journal-title":"J.\u00a0Mol. Diagn."},{"key":"10.1016\/j.immuni.2024.05.025_bib69","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1136\/annrheumdis-2016-210104","article-title":"Filgotinib (GLPG0634\/GS-6034), an oral JAK1 selective inhibitor, is effective in combination with methotrexate (MTX) in patients with active rheumatoid arthritis and insufficient response to MTX: results from a randomised, dose-finding study (DARWIN 1)","volume":"76","author":"Westhovens","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.immuni.2024.05.025_bib70","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1002\/art.38745","article-title":"Herpes zoster and tofacitinib therapy in patients with rheumatoid arthritis","volume":"66","author":"Winthrop","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.immuni.2024.05.025_bib71","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","article-title":"Natural products in drug discovery: advances and opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.immuni.2024.05.025_bib72","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1056\/NEJMoa052643","article-title":"Oral fingolimod (FTY720) for relapsing multiple sclerosis","volume":"355","author":"Kappos","year":"2006","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2024.05.025_bib73","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/s41590-021-00993-3","article-title":"Glutathione peroxidase 4-regulated neutrophil ferroptosis induces systemic autoimmunity","volume":"22","author":"Li","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2024.05.025_bib74","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1016\/j.semarthrit.2019.09.009","article-title":"EULAR\/ACR classification criteria for SLE","volume":"49","author":"Aringer","year":"2019","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.immuni.2024.05.025_bib75","article-title":"Spermidine suppresses inflammatory DC function by activating the FOXO3 pathway and counteracts autoimmunity","volume":"23","author":"Li","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.immuni.2024.05.025_bib76","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.immuni.2020.06.004","article-title":"Excessive polyamine generation in keratinocytes promotes self-RNA sensing by dendritic cells in psoriasis","volume":"53","author":"Lou","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2024.05.025_bib77","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.4049\/jimmunol.0802999","article-title":"Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23\/IL-17 axis","volume":"182","author":"van der Fits","year":"2009","journal-title":"J.\u00a0Immunol."}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761324002796?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761324002796?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T01:54:42Z","timestamp":1755050082000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761324002796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":77,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S1074761324002796"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2024.05.025","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cellular spermine targets JAK signaling to restrain cytokine-mediated autoimmunity","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2024.05.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}