{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T02:27:54Z","timestamp":1793759274302,"version":"4.6.1"},"reference-count":234,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":378,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01-NS095441"],"award-info":[{"award-number":["R01-NS095441"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01-NS132493"],"award-info":[{"award-number":["R01-NS132493"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["RF1-NS128947"],"award-info":[{"award-number":["RF1-NS128947"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01-NS126467"],"award-info":[{"award-number":["R01-NS126467"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01-NS081179"],"award-info":[{"award-number":["R01-NS081179"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01-NS\/HL37853"],"award-info":[{"award-number":["R01-NS\/HL37853"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001674","name":"Leducq Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.immuni.2024.12.008","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T10:59:04Z","timestamp":1736852344000},"page":"18-39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["The immunology of stroke and dementia"],"prefix":"10.1016","volume":"58","author":[{"given":"Costantino","family":"Iadecola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Anrather","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2024.12.008_bib1","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1016\/S0140-6736(24)00367-2","article-title":"Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021","volume":"403","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.immuni.2024.12.008_bib2","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1016\/S0140-6736(24)00757-8","volume":"403","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.immuni.2024.12.008_bib3","doi-asserted-by":"crossref","first-page":"e347","DOI":"10.1161\/CIR.0000000000001209","article-title":"2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association","volume":"149","author":"Martin","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.immuni.2024.12.008_bib4","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1002\/alz.13809","article-title":"2024 Alzheimer's disease facts and figures","volume":"20","year":"2024","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.immuni.2024.12.008_bib5","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/s43587-024-00611-5","article-title":"The advent of Alzheimer treatments will change the trajectory of human aging","volume":"4","author":"Selkoe","year":"2024","journal-title":"Nat. Aging"},{"key":"10.1016\/j.immuni.2024.12.008_bib6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1161\/HYPERTENSIONAHA.123.19943","article-title":"Cerebral Small Vessel Disease, Hypertension, and Vascular Contributions to Cognitive Impairment and Dementia","volume":"81","author":"Hainsworth","year":"2024","journal-title":"Hypertension"},{"key":"10.1016\/j.immuni.2024.12.008_bib7","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1161\/01.STR.0000217971.88034.e9","article-title":"Increasing rates of dementia at time of declining mortality from stroke","volume":"37","author":"Ukraintseva","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.immuni.2024.12.008_bib8","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1146\/annurev-immunol-101921-035222","article-title":"Immune Activation in Alzheimer Disease","volume":"42","author":"Mary","year":"2024","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.immuni.2024.12.008_bib9","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/s41583-019-0255-9","article-title":"Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration","volume":"21","author":"Pluvinage","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.immuni.2024.12.008_bib10","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/s41582-024-01016-z","article-title":"Systemic determinants of brain health in ageing","volume":"20","author":"Smith","year":"2024","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.immuni.2024.12.008_bib11","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12916-014-0206-2","article-title":"The overlap between vascular disease and Alzheimer's disease--lessons from pathology","volume":"12","author":"Attems","year":"2014","journal-title":"BMC Med."},{"key":"10.1016\/j.immuni.2024.12.008_bib12","doi-asserted-by":"crossref","first-page":"S144","DOI":"10.1161\/STROKEAHA.110.598326","article-title":"Where vascular meets neurodegenerative disease","volume":"41","author":"Schneider","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.immuni.2024.12.008_bib13","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev-neuro-113023-103045","article-title":"Meningeal Lymphatics in Central Nervous System Diseases","volume":"47","author":"Salvador","year":"2024","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.immuni.2024.12.008_bib14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neuron.2017.07.030","article-title":"The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease","volume":"96","author":"Iadecola","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.immuni.2024.12.008_bib15","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1038\/s41593-021-00904-7","article-title":"Revisiting the neurovascular unit","volume":"24","author":"Schaeffer","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.immuni.2024.12.008_bib16","doi-asserted-by":"crossref","first-page":"e251","DOI":"10.1161\/STR.0000000000000431","article-title":"The Neurovasculome: Key Roles in Brain Health and Cognitive Impairment: A Scientific Statement From the American Heart Association\/American Stroke Association","volume":"54","author":"Iadecola","year":"2023","journal-title":"Stroke"},{"key":"10.1016\/j.immuni.2024.12.008_bib17","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/s41593-023-01515-0","article-title":"Synaptic-like transmission between neural axons and arteriolar smooth muscle cells drives cerebral neurovascular coupling","volume":"27","author":"Zhang","year":"2024","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.immuni.2024.12.008_bib18","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/jmri.28759","article-title":"Current Understanding of the Anatomy, Physiology, and Magnetic Resonance Imaging of Neurofluids: Update From the 2022 \"ISMRM Imaging Neurofluids Study group\" Workshop in Rome","volume":"59","author":"Agarwal","year":"2024","journal-title":"J.\u00a0Magn. Reson. Imaging."},{"key":"10.1016\/j.immuni.2024.12.008_bib19","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1152\/physrev.00050.2017","article-title":"Blood-Brain Barrier: From Physiology to Disease and Back","volume":"99","author":"Sweeney","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.immuni.2024.12.008_bib20","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1152\/physrev.00022.2020","article-title":"Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation","volume":"101","author":"Claassen","year":"2021","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.immuni.2024.12.008_bib21","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev-physiol-042022-030946","article-title":"Mechanosensing by Vascular Endothelium","volume":"86","author":"Lim","year":"2024","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.immuni.2024.12.008_bib22","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1161\/STROKEAHA.122.041444","article-title":"Emerging Roles of Endothelial Nitric Oxide in Preservation of Cognitive Health","volume":"54","author":"Katusic","year":"2023","journal-title":"Stroke"},{"key":"10.1016\/j.immuni.2024.12.008_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1096","article-title":"Novel insights into the origin and development of CNS macrophage subsets","volume":"12","author":"Masuda","year":"2022","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.immuni.2024.12.008_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112092","article-title":"CD206+ macrophages transventricularly infiltrate the early embryonic cerebral wall to differentiate into microglia","volume":"42","author":"Hattori","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2024.12.008_bib25","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/s41593-019-0393-4","article-title":"A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment","volume":"22","author":"Van Hove","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.immuni.2024.12.008_bib26","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1016\/j.cell.2021.04.003","article-title":"A cellular and spatial map of the choroid plexus across brain ventricles and ages","volume":"184","author":"Dani","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2024.12.008_bib27","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1097\/NEN.0b013e31818f9ca8","article-title":"Perivascular spaces and the two steps to neuroinflammation","volume":"67","author":"Owens","year":"2008","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.immuni.2024.12.008_bib28","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/s41586-024-07202-9","article-title":"Venous-plexus-associated lymphoid hubs support meningeal humoral immunity","volume":"628","author":"Fitzpatrick","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2024.12.008_bib29","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/s41593-021-00880-y","article-title":"Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges","volume":"24","author":"Schafflick","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.immuni.2024.12.008_bib30","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1084\/jem.20161982","article-title":"Characterization of meningeal type 2 innate lymphocytes and their response to CNS injury","volume":"214","author":"Gadani","year":"2017","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2024.12.008_bib31","doi-asserted-by":"crossref","DOI":"10.1126\/science.abf7844","article-title":"Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma","volume":"373","author":"Cugurra","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.immuni.2024.12.008_bib32","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/s41593-018-0213-2","article-title":"Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration","volume":"21","author":"Herisson","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.immuni.2024.12.008_bib33","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.neuron.2010.07.002","article-title":"The science of stroke: mechanisms in search of treatments","volume":"67","author":"Moskowitz","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.immuni.2024.12.008_bib34","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1016\/j.neuron.2024.01.031","article-title":"Leptomeningeal collaterals regulate reperfusion in ischemic stroke and rescue the brain from futile recanalization","volume":"112","author":"Binder","year":"2024","journal-title":"Neuron"},{"key":"10.1016\/j.immuni.2024.12.008_bib35","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1038\/jcbfm.2012.108","article-title":"Next-generation antithrombotics in ischemic stroke: preclinical perspective on 'bleeding-free antithrombosis","volume":"32","author":"Kraft","year":"2012","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.immuni.2024.12.008_bib36","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1161\/CIRCRESAHA.108.185785","article-title":"Stimulation of Toll-like receptor 2 in human platelets induces a thromboinflammatory response through activation of phosphoinositide 3-kinase","volume":"104","author":"Blair","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.immuni.2024.12.008_bib37","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1160\/th14-02-0167","article-title":"Protease-activated receptor signalling by coagulation proteases in endothelial cells","volume":"112","author":"Rezaie","year":"2014","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.immuni.2024.12.008_bib38","doi-asserted-by":"crossref","first-page":"e2346","DOI":"10.1212\/WNL.0000000000009532","article-title":"Thrombus NET content is associated with clinical outcome in stroke and myocardial infarction","volume":"94","author":"Novotny","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.immuni.2024.12.008_bib39","first-page":"71","article-title":"Interaction between the coagulation and complement system","volume":"632","author":"Amara","year":"2008","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.immuni.2024.12.008_bib40","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.immuni.2019.03.003","article-title":"The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1\u03b1 by Thrombin","volume":"50","author":"Burzynski","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2024.12.008_bib41","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/s41590-020-0671-z","article-title":"The immunology of blood: connecting the dots at the neurovascular interface","volume":"21","author":"Akassoglou","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2024.12.008_bib42","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.atherosclerosis.2008.07.044","article-title":"Strong complement activation after acute ischemic stroke is associated with unfavorable outcomes","volume":"204","author":"Sz\u00e9plaki","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.immuni.2024.12.008_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008433","article-title":"Genetically-defined deficiency of mannose-binding lectin is associated with protection after experimental stroke in mice and outcome in human stroke","volume":"5","author":"Cervera","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.immuni.2024.12.008_bib44","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1161\/01.RES.0000232544.90675.42","article-title":"Complement component C3 mediates inflammatory injury following focal cerebral ischemia","volume":"99","author":"Mocco","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.immuni.2024.12.008_bib45","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/0271678X231208476","article-title":"No-reflow\" phenomenon in acute ischemic stroke","volume":"44","author":"Zhang","year":"2024","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.immuni.2024.12.008_bib46","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/nm.2399","article-title":"The immunology of stroke: from mechanisms to translation","volume":"17","author":"Iadecola","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2024.12.008_bib47","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00401-014-1381-0","article-title":"Neutrophil recruitment to the brain in mouse and human ischemic stroke","volume":"129","author":"Perez-de-Puig","year":"2015","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.immuni.2024.12.008_bib48","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/s41590-023-01505-1","article-title":"Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology","volume":"24","author":"Gullotta","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2024.12.008_bib49","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1161\/STROKEAHA.121.036299","article-title":"Endogenous Deoxyribonuclease Activity and Cell-Free Deoxyribonucleic Acid in Acute Ischemic Stroke: A Cohort Study","volume":"53","author":"Grosse","year":"2022","journal-title":"Stroke"},{"key":"10.1016\/j.immuni.2024.12.008_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108260","article-title":"Neutrophils Obstructing Brain Capillaries Are a Major Cause of No-Reflow in Ischemic Stroke","volume":"33","author":"El Amki","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2024.12.008_bib51","doi-asserted-by":"crossref","DOI":"10.1177\/1756286418774254","article-title":"Danger signals in stroke and their role on microglia activation after ischemia","volume":"11","author":"G\u00fclke","year":"2018","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"10.1016\/j.immuni.2024.12.008_bib52","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s004010050878","article-title":"Time course of microglia activation and apoptosis in various brain regions after permanent focal cerebral ischemia in mice","volume":"96","author":"Rupalla","year":"1998","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.immuni.2024.12.008_bib53","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.neuropharm.2013.05.032","article-title":"P2X7 receptor activation regulates microglial cell death during oxygen-glucose deprivation","volume":"73","author":"Eyo","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.immuni.2024.12.008_bib54","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bbi.2018.09.001","article-title":"Evidence that NLRC4 inflammasome mediates apoptotic and pyroptotic microglial death following ischemic stroke","volume":"75","author":"Poh","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.immuni.2024.12.008_bib55","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s00401-024-02695-0","article-title":"Endothelial cells and macrophages as allies in the healthy and diseased brain","volume":"147","author":"Denes","year":"2024","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.immuni.2024.12.008_bib56","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00401-014-1372-1","article-title":"Perivascular microglia promote blood vessel disintegration in the ischemic penumbra","volume":"129","author":"Jolivel","year":"2015","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.immuni.2024.12.008_bib57","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1038\/sj.jcbfm.9600495","article-title":"Proliferating resident microglia after focal cerebral ischaemia in mice","volume":"27","author":"Denes","year":"2007","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.immuni.2024.12.008_bib58","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00401-018-1954-4","article-title":"Microglial cell loss after ischemic stroke favors brain neutrophil accumulation","volume":"137","author":"Otxoa-de-Amezaga","year":"2019","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.immuni.2024.12.008_bib59","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11499","article-title":"Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke","volume":"7","author":"Szalay","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2024.12.008_bib60","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1177\/0271678X17694185","article-title":"Depletion of microglia exacerbates postischemic inflammation and brain injury","volume":"37","author":"Jin","year":"2017","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.immuni.2024.12.008_bib61","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.immuni.2021.04.022","article-title":"Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke","volume":"54","author":"Shi","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2024.12.008_bib62","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1038\/s41593-024-01684-6","article-title":"Derivation and transcriptional reprogramming of border-forming wound repair astrocytes after spinal cord injury or stroke in mice","volume":"27","author":"O'Shea","year":"2024","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.immuni.2024.12.008_bib63","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1440-1789.2012.01322.x","article-title":"NG2 and NG2-positive cells delineate focal cerebral infarct demarcation in rats","volume":"33","author":"Claus","year":"2013","journal-title":"Neuropathology"},{"key":"10.1016\/j.immuni.2024.12.008_bib64","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1523\/JNEUROSCI.1432-18.2018","article-title":"Claudin-1-Dependent Destabilization of the Blood-Brain Barrier in Chronic Stroke","volume":"39","author":"Sladojevic","year":"2019","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.immuni.2024.12.008_bib65","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.nbd.2018.01.007","article-title":"Glial scars are permeable to the neurotoxic environment of chronic stroke infarcts","volume":"112","author":"Zbesko","year":"2018","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.immuni.2024.12.008_bib66","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1038\/s41593-019-0497-x","article-title":"Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood-brain barrier dysfunction module","volume":"22","author":"Munji","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.immuni.2024.12.008_bib67","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/jcbfm.2012.187","article-title":"Early loss of pericytes and perivascular stromal cell-induced scar formation after stroke","volume":"33","author":"Fern\u00e1ndez-Klett","year":"2013","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.immuni.2024.12.008_bib68","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0474-19.2020","article-title":"Pericyte-Mediated Tissue Repair through PDGFR\u03b2 Promotes Peri-Infarct Astrogliosis, Oligodendrogenesis, and Functional Recovery after Acute Ischemic Stroke","volume":"7","author":"Shibahara","year":"2020","journal-title":"eNeuro"},{"key":"10.1016\/j.immuni.2024.12.008_bib69","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/jnr.25146","article-title":"Vascular perfusion differs in two distinct PDGFR\u03b2-positive zones within the ischemic core of male mice 2\u2009weeks following photothrombotic stroke","volume":"101","author":"Morris","year":"2023","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.immuni.2024.12.008_bib70","doi-asserted-by":"crossref","DOI":"10.1177\/1756286418783708","article-title":"The meningeal and choroidal infiltration routes for leukocytes in stroke","volume":"11","author":"Benakis","year":"2018","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"10.1016\/j.immuni.2024.12.008_bib71","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1007\/s12975-021-00887-4","article-title":"Immune Cell Infiltration into the Brain After Ischemic Stroke in Humans Compared to Mice and Rats: a Systematic Review and Meta-Analysis","volume":"12","author":"Beuker","year":"2021","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.immuni.2024.12.008_bib72","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s00401-017-1758-y","article-title":"The choroid plexus is a key cerebral invasion route for T\u00a0cells after stroke","volume":"134","author":"Llovera","year":"2017","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.immuni.2024.12.008_bib73","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1186\/s12974-023-02980-x","article-title":"Lateralized response of skull bone marrow via osteopontin signaling in mice after ischemia reperfusion","volume":"20","author":"Xu","year":"2023","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.immuni.2024.12.008_bib74","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1161\/CIRCRESAHA.116.305207","article-title":"Ischemic stroke activates hematopoietic bone marrow stem cells","volume":"116","author":"Courties","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.immuni.2024.12.008_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2019.116445","article-title":"Neutrophil to lymphocyte ratio predicts poor outcomes after acute ischemic stroke: A cohort study and systematic review","volume":"406","author":"Wang","year":"2019","journal-title":"J.\u00a0Neurol. Sci."},{"key":"10.1016\/j.immuni.2024.12.008_bib76","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s12975-019-00694-y","article-title":"Functional Dynamics of Neutrophils After Ischemic Stroke","volume":"11","author":"Cai","year":"2020","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.immuni.2024.12.008_bib77","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/sj.jcbfm.9600264","article-title":"Gene expression in blood changes rapidly in neutrophils and monocytes after ischemic stroke in humans: a microarray study","volume":"26","author":"Tang","year":"2006","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.immuni.2024.12.008_bib78","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jneuroim.2014.07.015","article-title":"Prognostic value of blood interleukin-6 in the prediction of functional outcome after stroke: a systematic review and meta-analysis","volume":"274","author":"Bustamante","year":"2014","journal-title":"J.\u00a0Neuroimmunol."},{"key":"10.1016\/j.immuni.2024.12.008_bib79","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1089\/ars.2015.6397","article-title":"HMGB1 as a Key Mediator of Immune Mechanisms in Ischemic Stroke","volume":"24","author":"Singh","year":"2016","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.immuni.2024.12.008_bib80","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/imr.12577","article-title":"Alarmins and immunity","volume":"280","author":"Yang","year":"2017","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.immuni.2024.12.008_bib81","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1523\/JNEUROSCI.2439-14.2015","article-title":"DAMP signaling is a key pathway inducing immune modulation after brain injury","volume":"35","author":"Liesz","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.immuni.2024.12.008_bib82","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1373\/49.4.562","article-title":"Prognostic use of circulating plasma nucleic acid concentrations in patients with acute stroke","volume":"49","author":"Rainer","year":"2003","journal-title":"Clin. Chem."},{"key":"10.1016\/j.immuni.2024.12.008_bib83","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00281-023-00993-5","article-title":"The role of circulating cell-free DNA as an inflammatory mediator after stroke","volume":"45","author":"Roth","year":"2023","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.immuni.2024.12.008_bib84","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1016\/j.cell.2024.06.028","article-title":"Innate immune memory after brain injury drives inflammatory cardiac dysfunction","volume":"187","author":"Simats","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2024.12.008_bib85","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1111\/j.1749-6632.1988.tb27188.x","article-title":"Lymphocyte subsets after stroke","volume":"540","author":"Cz\u0142onkowska","year":"1988","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.immuni.2024.12.008_bib86","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1084\/jem.20021098","article-title":"Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation","volume":"198","author":"Prass","year":"2003","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2024.12.008_bib87","doi-asserted-by":"crossref","first-page":"6523","DOI":"10.4049\/jimmunol.176.11.6523","article-title":"Splenic atrophy in experimental stroke is accompanied by increased regulatory T\u00a0cells and circulating macrophages","volume":"176","author":"Offner","year":"2006","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2024.12.008_bib88","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.neuron.2009.09.039","article-title":"The neurology of the immune system: neural reflexes regulate immunity","volume":"64","author":"Rosas-Ballina","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.immuni.2024.12.008_bib89","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1126\/science.1210301","article-title":"Functional innervation of hepatic iNKT cells is immunosuppressive following stroke","volume":"334","author":"Wong","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.immuni.2024.12.008_bib90","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nrn1765","article-title":"Central nervous system injury-induced immune deficiency syndrome","volume":"6","author":"Meisel","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.immuni.2024.12.008_bib91","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1002\/glia.24377","article-title":"Translatome analysis reveals microglia and astrocytes to be distinct regulators of inflammation in the hyperacute and acute phases after stroke","volume":"71","author":"Hernandez","year":"2023","journal-title":"Glia"},{"key":"10.1016\/j.immuni.2024.12.008_bib92","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/s41590-023-01711-x","article-title":"Analysis of brain and blood single-cell transcriptomics in acute and subacute phases after experimental stroke","volume":"25","author":"Garcia-Bonilla","year":"2024","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2024.12.008_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114250","article-title":"Phenotypic and spatial heterogeneity of brain myeloid cells after stroke is associated with cell ontogeny, tissue damage, and brain connectivity","volume":"43","author":"Patir","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2024.12.008_bib94","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s13073-023-01257-5","article-title":"Acute ischemia induces spatially and transcriptionally distinct microglial subclusters","volume":"15","author":"Li","year":"2023","journal-title":"Genome Med."},{"key":"10.1016\/j.immuni.2024.12.008_bib95","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1161\/STROKEAHA.108.534503","article-title":"Temporal and spatial dynamics of cerebral immune cell accumulation in stroke","volume":"40","author":"Gelderblom","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.immuni.2024.12.008_bib96","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1177\/0271678X211026770","article-title":"Single cell RNA-seq reveals the transcriptional landscape in ischemic stroke","volume":"42","author":"Zheng","year":"2022","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.immuni.2024.12.008_bib97","first-page":"0287","article-title":"Age-Related Alterations in Peripheral Immune Landscape with Magnified Impact on Post-Stroke Brain","volume":"6","author":"Lu","year":"2023","journal-title":"Brain Res."},{"key":"10.1016\/j.immuni.2024.12.008_bib98","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14518","article-title":"Novel subsets of peripheral immune cells associated with promoting stroke recovery in mice","volume":"30","author":"Gu","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.immuni.2024.12.008_bib99","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adg1323","article-title":"Integrating spatial and single-cell transcriptomics to characterize the molecular and cellular architecture of the ischemic mouse brain","volume":"16","author":"Han","year":"2024","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.immuni.2024.12.008_bib100","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1007\/s12975-023-01169-x","article-title":"The Transcriptional Landscape of Pericytes in Acute Ischemic Stroke","volume":"15","author":"Buizza","year":"2023","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.immuni.2024.12.008_bib101","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1093\/brain\/aws075","article-title":"Essential role of interleukin-6 in post-stroke angiogenesis","volume":"135","author":"Gertz","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.immuni.2024.12.008_bib102","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1073\/pnas.1315943111","article-title":"Ischemic neurons recruit natural killer cells that accelerate brain infarction","volume":"111","author":"Gan","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2024.12.008_bib103","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/nm.1999","article-title":"Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury","volume":"15","author":"Shichita","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2024.12.008_bib104","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/nm.4068","article-title":"Commensal microbiota affects ischemic stroke outcome by regulating intestinal \u03b3\u03b4 T\u00a0cells","volume":"22","author":"Benakis","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2024.12.008_bib105","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12974-023-02799-6","article-title":"Novel CH25H+ and OASL+ microglia subclusters play distinct roles in cerebral ischemic stroke","volume":"20","author":"Zhang","year":"2023","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.immuni.2024.12.008_bib106","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2404203121","article-title":"Spatiotemporal transcriptomic map of glial cell response in a mousemodel of acute brain ischemia","volume":"121","author":"Zucha","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2024.12.008_bib107","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.immuni.2015.01.012","article-title":"DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity","volume":"42","author":"H\u00e4rtlova","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2024.12.008_bib108","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1016\/j.cell.2024.02.020","article-title":"Type-I-interferon-responsive microglia shape cortical development and behavior","volume":"187","author":"Escoubas","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2024.12.008_bib109","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3389\/fncel.2017.00201","article-title":"Loss of IRF2BP2 in Microglia Increases Inflammation and Functional Deficits after Focal Ischemic Brain Injury","volume":"11","author":"Cruz","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.immuni.2024.12.008_bib110","article-title":"Interferon-beta Modulates Inflammatory Response in Cerebral Ischemia","volume":"5","author":"Kuo","year":"2016","journal-title":"J.\u00a0Am. Heart Assoc."},{"key":"10.1016\/j.immuni.2024.12.008_bib111","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/s12974-015-0427-0","article-title":"Endogenous IFN-\u03b2 signaling exerts anti-inflammatory actions in experimentally induced focal cerebral ischemia","volume":"12","author":"In\u00e1cio","year":"2015","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.immuni.2024.12.008_bib112","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41586-023-06373-1","article-title":"cGAS-STING drives ageing-related inflammation and neurodegeneration","volume":"620","author":"Gulen","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2024.12.008_bib113","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/s41580-020-0232-1","article-title":"The clearance of dead cells by efferocytosis","volume":"21","author":"Boada-Romero","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.immuni.2024.12.008_bib114","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/s41467-022-28593-1","article-title":"Stroke induces disease-specific myeloid cells in the brain parenchyma and pia","volume":"13","author":"Beuker","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2024.12.008_bib115","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neuron.2018.12.006","article-title":"Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing","volume":"101","author":"Li","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.immuni.2024.12.008_bib116","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.immuni.2018.11.004","article-title":"Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes","volume":"50","author":"Hammond","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2024.12.008_bib117","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.cell.2017.05.018","article-title":"A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease","volume":"169","author":"Keren-Shaul","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2024.12.008_bib118","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1114663","article-title":"Single-cell analyses reveal the dynamic functions of Itgb2+ microglia subclusters at different stages of cerebral ischemia-reperfusion injury in transient middle cerebral occlusion mice model","volume":"14","author":"Zeng","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2024.12.008_bib119","doi-asserted-by":"crossref","first-page":"6943","DOI":"10.1038\/s41467-021-27248-x","article-title":"Stroke subtype-dependent synapse elimination by reactive gliosis in mice","volume":"12","author":"Shi","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2024.12.008_bib120","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1093\/brain\/aww298","article-title":"Myelin phagocytosis by astrocytes after myelin damage promotes lesion pathology","volume":"140","author":"Ponath","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.immuni.2024.12.008_bib121","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.949079","article-title":"Galectin-3 (MAC-2) controls phagocytosis and macropinocytosis through intracellular and extracellular mechanisms","volume":"16","author":"Rotshenker","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.immuni.2024.12.008_bib122","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41467-017-00037-1","article-title":"Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway","volume":"8","author":"Morizawa","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2024.12.008_bib123","doi-asserted-by":"crossref","first-page":"E4098","DOI":"10.1073\/pnas.1308679110","article-title":"Phagocytosis executes delayed neuronal death after focal brain ischemia","volume":"110","author":"Neher","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2024.12.008_bib124","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abe7915","article-title":"CD300a blockade enhances efferocytosis by infiltrating myeloid cells and ameliorates neuronal deficit after ischemic stroke","volume":"6","author":"Nakahashi-Oda","year":"2021","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.immuni.2024.12.008_bib125","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1523\/JNEUROSCI.2620-14.2015","article-title":"Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke","volume":"35","author":"Kawabori","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.immuni.2024.12.008_bib126","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.immuni.2024.01.008","article-title":"Fate mapping of Spp1 expression reveals age-dependent plasticity of disease-associated microglia-like cells after brain injury","volume":"57","author":"Lan","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2024.12.008_bib127","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13073-024-01368-7","article-title":"Microglial heterogeneity in the ischemic stroke mouse brain of both sexes","volume":"16","author":"Del \u00c1guila","year":"2024","journal-title":"Genome Med."},{"key":"10.1016\/j.immuni.2024.12.008_bib128","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41593-019-0566-1","article-title":"Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain","volume":"23","author":"Marschallinger","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.immuni.2024.12.008_bib129","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1523\/JNEUROSCI.0933-21.2021","article-title":"Repeated Administration of 2-Hydroxypropyl-\u03b2-Cyclodextrin (HP\u03b2CD) Attenuates the Chronic Inflammatory Response to Experimental Stroke","volume":"42","author":"Becktel","year":"2022","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.immuni.2024.12.008_bib130","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/nrn3680","article-title":"Wallerian degeneration: an emerging axon death pathway linking injury and disease","volume":"15","author":"Conforti","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.immuni.2024.12.008_bib131","doi-asserted-by":"crossref","first-page":"686","DOI":"10.3389\/fimmu.2019.00686","article-title":"Autoimmunity After Ischemic Stroke and Brain Injury","volume":"10","author":"Javidi","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2024.12.008_bib132","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/jcbfm.2012.128","article-title":"Regulatory T\u00a0cells accumulate and proliferate in the ischemic hemisphere for up to 30\u00a0days after MCAO","volume":"33","author":"Stubbe","year":"2013","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.immuni.2024.12.008_bib133","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1177\/0271678X18792372","article-title":"Experimental ischemic stroke induces long-term T\u00a0cell activation in the brain","volume":"39","author":"Xie","year":"2019","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.immuni.2024.12.008_bib134","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20202411","article-title":"Chronic T\u00a0cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies","volume":"218","author":"Heindl","year":"2021","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2024.12.008_bib135","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1523\/JNEUROSCI.4098-14.2015","article-title":"B-lymphocyte-mediated delayed cognitive impairment following stroke","volume":"35","author":"Doyle","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.immuni.2024.12.008_bib136","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1161\/STR.0b013e3182299496","article-title":"Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association\/american stroke association","volume":"42","author":"Gorelick","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.immuni.2024.12.008_bib137","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1161\/CIRCRESAHA.122.319951","article-title":"Post-Stroke Cognitive Impairment and Dementia","volume":"130","author":"Rost","year":"2022","journal-title":"Circ. Res."},{"key":"10.1016\/j.immuni.2024.12.008_bib138","doi-asserted-by":"crossref","first-page":"e272","DOI":"10.1161\/STR.0000000000000430","article-title":"Cognitive Impairment After Ischemic and Hemorrhagic Stroke: A Scientific Statement From the American Heart Association\/American Stroke Association","volume":"54","author":"El Husseini","year":"2023","journal-title":"Stroke"},{"key":"10.1016\/j.immuni.2024.12.008_bib139","first-page":"2593","article-title":"Biological and imaging predictors of cognitive impairment after stroke: a systematic review","volume":"266","author":"Casolla","year":"2019","journal-title":"J.\u00a0Neurol."},{"key":"10.1016\/j.immuni.2024.12.008_bib140","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1097\/PHM.0000000000002125","article-title":"Baseline Function and Rehabilitation Are as Important as Stroke Severity as Long-term Predictors of Cognitive Performance Post-stroke","volume":"102","author":"Girgenti","year":"2023","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"10.1016\/j.immuni.2024.12.008_bib141","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/S1474-4422(21)00060-0","article-title":"Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts","volume":"20","author":"Weaver","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.immuni.2024.12.008_bib142","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2016.08.009","article-title":"Does B lymphocyte-mediated autoimmunity contribute to post-stroke dementia?","volume":"64","author":"Doyle","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.immuni.2024.12.008_bib143","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1161\/STROKEAHA.123.044290","article-title":"Poststroke Cognitive Decline: Is Functional Connectivity the Key to Tangible Therapeutic Targets?","volume":"55","author":"Dallasta","year":"2024","journal-title":"Stroke"},{"key":"10.1016\/j.immuni.2024.12.008_bib144","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.754204","article-title":"Neurodegeneration Over 3 Years Following Ischaemic Stroke: Findings From the Cognition and Neocortical Volume After Stroke Study","volume":"12","author":"Brodtmann","year":"2021","journal-title":"Front. Neurol."},{"key":"10.1016\/j.immuni.2024.12.008_bib145","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1007\/s00401-004-0918-z","article-title":"Human cerebral infarct: a proposed histopathologic classification based on 137 cases","volume":"108","author":"Mena","year":"2004","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.immuni.2024.12.008_bib146","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.bbi.2020.09.029","article-title":"CD4+ T\u00a0cells promote delayed B cell responses in the ischemic brain after experimental stroke","volume":"91","author":"Weitbrecht","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.immuni.2024.12.008_bib147","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.4049\/jimmunol.1102289","article-title":"Brain-derived antigens in lymphoid tissue of patients with acute stroke","volume":"188","author":"Planas","year":"2012","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2024.12.008_bib148","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jneuroim.2016.04.001","article-title":"Antibodies to myelin basic protein are associated with cognitive decline after stroke","volume":"295\u2013296","author":"Becker","year":"2016","journal-title":"J.\u00a0Neuroimmunol."},{"key":"10.1016\/j.immuni.2024.12.008_bib149","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jns.2010.09.023","article-title":"NR2 antibodies: risk assessment of transient ischemic attack (TIA)\/stroke in patients with history of isolated and multiple cerebrovascular events","volume":"300","author":"Weissman","year":"2011","journal-title":"J.\u00a0Neurol. Sci."},{"key":"10.1016\/j.immuni.2024.12.008_bib150","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/BF00294806","article-title":"Ischemic stress induces deposition of amyloid beta immunoreactivity in human brain","volume":"90","author":"Jendroska","year":"1995","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.immuni.2024.12.008_bib151","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s12883-020-01753-w","article-title":"No evidence for amyloid pathology as a key mediator of neurodegeneration post-stroke - a seven-year follow-up study","volume":"20","author":"Hagberg","year":"2020","journal-title":"BMC Neurol."},{"key":"10.1016\/j.immuni.2024.12.008_bib152","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.nbd.2007.11.012","article-title":"Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degeneration","volume":"30","author":"Palin","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.immuni.2024.12.008_bib153","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1007\/s004010050747","article-title":"Long lasting perivascular accumulation of major histocompatibility complex class II-positive lipophages in the spinal cord of stroke patients: possible relevance for the immune privilege of the brain","volume":"94","author":"K\u00f6sel","year":"1997","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.immuni.2024.12.008_bib154","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1038\/s41380-022-01446-5","article-title":"Peripheral immunity is associated with the risk of incident dementia","volume":"27","author":"Zhang","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.immuni.2024.12.008_bib155","article-title":"Inflammation, Anti-inflammatory Interventions, and Post-stroke Cognitive Impairment: a Systematic Review and Meta-analysis of Human and Animal Studies","author":"Tack","year":"2023","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.immuni.2024.12.008_bib156","article-title":"Potential Biomarkers for Post-Stroke Cognitive Impairment: A Systematic Review and Meta-Analysis","volume":"23","author":"Kim","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.immuni.2024.12.008_bib157","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1093\/brain\/awz022","article-title":"A year-long immune profile of the systemic response in acute stroke survivors","volume":"142","author":"Tsai","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.immuni.2024.12.008_bib158","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1161\/01.STR.0000259890.18354.d2","article-title":"C-reactive protein predicts future cardiovascular events in patients with carotid stenosis","volume":"38","author":"Schlager","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.immuni.2024.12.008_bib159","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41586-024-07803-4","article-title":"DNA-sensing inflammasomes cause recurrent atherosclerotic stroke","volume":"633","author":"Cao","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2024.12.008_bib160","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/S1474-4422(17)30196-5","article-title":"Detection, risk factors, and functional consequences of cerebral microinfarcts","volume":"16","author":"van Veluw","year":"2017","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.immuni.2024.12.008_bib161","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/S1474-4422(23)00131-X","article-title":"Neuroimaging standards for research into small vessel disease-advances since 2013","volume":"22","author":"Duering","year":"2023","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.immuni.2024.12.008_bib162","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1016\/j.cell.2023.07.027","article-title":"Atlas of the aging mouse brain reveals white matter as vulnerable foci","volume":"186","author":"Hahn","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2024.12.008_bib163","first-page":"431","article-title":"Features of the cerebral vascular pattern that predict vulnerability to perfusion or oxygenation deficiency: an anatomic study","volume":"11","author":"Moody","year":"1990","journal-title":"AJNR. Am. J. Neuroradiol."},{"key":"10.1016\/j.immuni.2024.12.008_bib164","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/ana.24712","article-title":"Development of White Matter Hyperintensity Is Preceded by Reduced Cerebrovascular Reactivity","volume":"80","author":"Sam","year":"2016","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.immuni.2024.12.008_bib165","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1161\/01.STR.0000221308.94473.14","article-title":"White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury","volume":"37","author":"Fernando","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.immuni.2024.12.008_bib166","doi-asserted-by":"crossref","first-page":"e1812","DOI":"10.1212\/WNL.0000000000207113","article-title":"Associations Between CSF Markers of Inflammation, White Matter Lesions, and Cognitive Decline in Individuals Without Dementia","volume":"100","author":"Gertje","year":"2023","journal-title":"Neurology"},{"key":"10.1016\/j.immuni.2024.12.008_bib167","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.jalz.2017.12.007","article-title":"Free water determines diffusion alterations and clinical status in cerebral small vessel disease","volume":"14","author":"Duering","year":"2018","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.immuni.2024.12.008_bib168","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1161\/01.STR.0000058480.77236.B3","article-title":"Is breakdown of the blood brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia?","volume":"34","author":"Wardlaw","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.immuni.2024.12.008_bib169","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.nbd.2018.07.023","article-title":"Mechanisms of demyelination and remyelination in the young and aged brain following white matter stroke","volume":"126","author":"Marin","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.immuni.2024.12.008_bib170","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.bbrc.2019.05.055","article-title":"Depletion of microglia ameliorates white matter injury and cognitive impairment in a mouse chronic cerebral hypoperfusion model","volume":"514","author":"Kakae","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.immuni.2024.12.008_bib171","first-page":"2780","article-title":"Heritable and non-heritable uncommon causes of stroke","volume":"268","author":"Bersano","year":"2021","journal-title":"J.\u00a0Neurol."},{"key":"10.1016\/j.immuni.2024.12.008_bib172","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/s41591-023-02268-w","article-title":"Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease","volume":"29","author":"Duperron","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2024.12.008_bib173","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/s41582-021-00592-8","article-title":"Genetics of common cerebral small vessel disease","volume":"18","author":"Bordes","year":"2022","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.immuni.2024.12.008_bib174","doi-asserted-by":"crossref","first-page":"e3331","DOI":"10.1212\/WNL.0000000000010852","article-title":"Association of common genetic variants with brain microbleeds: A genome-wide association study","volume":"95","author":"Knol","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.immuni.2024.12.008_bib175","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1111\/j.1365-2990.2007.00890.x","article-title":"Microglial activation in white matter lesions and nonlesional white matter of ageing brains","volume":"33","author":"Simpson","year":"2007","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.immuni.2024.12.008_bib176","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1111\/jcmm.17315","article-title":"Single-nucleus transcriptome analysis reveals disease- and regeneration-associated endothelial cells in white matter vascular dementia","volume":"26","author":"Mitroi","year":"2022","journal-title":"J.\u00a0Cell Mol. Med."},{"key":"10.1016\/j.immuni.2024.12.008_bib177","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1093\/brain\/awab003","article-title":"Microglial activation and blood-brain barrier permeability in cerebral small vessel disease","volume":"144","author":"Walsh","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.immuni.2024.12.008_bib178","doi-asserted-by":"crossref","DOI":"10.1186\/s40478-022-01497-3","article-title":"Association between hypertension and neurovascular inflammation in both normal-appearing white matter and white matter hyperintensities","volume":"11","author":"Sol\u00e9-Guardia","year":"2023","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.immuni.2024.12.008_bib179","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2020.541377","article-title":"Patterns of Mitochondrial TSPO Binding in Cerebral Small Vessel Disease: An in\u00a0vivo PET Study With Neuropathological Comparison","volume":"11","author":"Wright","year":"2020","journal-title":"Front. Neurol."},{"key":"10.1016\/j.immuni.2024.12.008_bib180","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1161\/STROKEAHA.117.018675","article-title":"Midlife Systemic Inflammation, Late-Life White Matter Integrity, and Cerebral Small Vessel Disease: The Atherosclerosis Risk in Communities Study","volume":"48","author":"Walker","year":"2017","journal-title":"Stroke"},{"key":"10.1016\/j.immuni.2024.12.008_bib181","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.bbi.2020.09.006","article-title":"Relationships of inflammation trajectories with white matter volume and integrity in midlife","volume":"91","author":"O'Donovan","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.immuni.2024.12.008_bib182","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.nbd.2005.05.002","article-title":"Apolipoprotein E4 enhances brain inflammation by modulation of the NF-kappaB signaling cascade","volume":"20","author":"Ophir","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.immuni.2024.12.008_bib183","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1161\/STROKEAHA.118.023192","article-title":"Trained Immunity Characteristics Are Associated With Progressive Cerebral Small Vessel Disease","volume":"49","author":"Noz","year":"2018","journal-title":"Stroke"},{"key":"10.1016\/j.immuni.2024.12.008_bib184","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2019.100916","article-title":"Inflammation and cerebral small vessel disease: A systematic review","volume":"53","author":"Low","year":"2019","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.immuni.2024.12.008_bib185","doi-asserted-by":"crossref","first-page":"3466","DOI":"10.1161\/STROKEAHA.109.559567","article-title":"Inflammatory biomarkers of vascular risk as correlates of leukoariosis","volume":"40","author":"Wright","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.immuni.2024.12.008_bib186","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1177\/0271678X231173444","article-title":"Blood-brain barrier leakage hotspots collocating with brain lesions due to sporadic and monogenic small vessel disease","volume":"43","author":"Rudilosso","year":"2023","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.immuni.2024.12.008_bib187","doi-asserted-by":"crossref","first-page":"4674","DOI":"10.1172\/JCI86950","article-title":"Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension","volume":"126","author":"Faraco","year":"2016","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2024.12.008_bib188","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1161\/HYPERTENSIONAHA.120.15581","article-title":"Endothelium-Macrophage Crosstalk Mediates Blood-Brain Barrier Dysfunction in Hypertension","volume":"76","author":"Santisteban","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.immuni.2024.12.008_bib189","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41593-023-01497-z","article-title":"Meningeal interleukin-17-producing T\u00a0cells mediate cognitive impairment in a mouse model of salt-sensitive hypertension","volume":"27","author":"Santisteban","year":"2024","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.immuni.2024.12.008_bib190","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00401-010-0718-6","article-title":"The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia","volume":"120","author":"Iadecola","year":"2010","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.immuni.2024.12.008_bib191","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/s41586-021-04369-3","article-title":"A human brain vascular atlas reveals diverse mediators of Alzheimer's risk","volume":"603","author":"Yang","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2024.12.008_bib192","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/s41593-020-0635-5","article-title":"Shared proteomic effects of cerebral atherosclerosis and Alzheimer's disease on the human brain","volume":"23","author":"Wingo","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.immuni.2024.12.008_bib193","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1001\/jama.1997.03540340047031","article-title":"Brain infarction and the clinical expression of Alzheimer disease. The Nun Study","volume":"277","author":"Snowdon","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.immuni.2024.12.008_bib194","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/jnen\/nlad026","article-title":"Cerebral white matter rarefaction has both neurodegenerative and vascular causes and may primarily be a distal axonopathy","volume":"82","author":"Beach","year":"2023","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.immuni.2024.12.008_bib195","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0140-6736(24)01296-0","article-title":"Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission","volume":"404","author":"Livingston","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.immuni.2024.12.008_bib196","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1038\/s41380-021-01249-0","article-title":"The Amyloid-beta Pathway in Alzheimer's Disease","volume":"26","author":"Hampel","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.immuni.2024.12.008_bib197","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1126\/science.1197623","article-title":"Decreased clearance of CNS beta-amyloid in Alzheimer's disease","volume":"330","author":"Mawuenyega","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.immuni.2024.12.008_bib198","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1161\/STROKEAHA.124.044293","article-title":"Cerebral Amyloid Angiopathy","volume":"55","author":"Greenberg","year":"2024","journal-title":"Stroke"},{"key":"10.1016\/j.immuni.2024.12.008_bib199","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1038\/s41590-023-01627-6","article-title":"APOE4 impairs the microglial response in Alzheimer's disease by inducing TGF\u03b2-mediated checkpoints","volume":"24","author":"Yin","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2024.12.008_bib200","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13024-023-00660-1","article-title":"Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress","volume":"18","author":"Uekawa","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.immuni.2024.12.008_bib201","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1038\/s41467-024-46630-z","article-title":"A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer's disease","volume":"15","author":"Tsartsalis","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2024.12.008_bib202","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1073\/pnas.0805453106","article-title":"Selective targeting of perivascular macrophages for clearance of beta-amyloid in cerebral amyloid angiopathy","volume":"106","author":"Hawkes","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2024.12.008_bib203","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/s41586-022-05397-3","article-title":"Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid","volume":"611","author":"Drieu","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2024.12.008_bib204","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.bbi.2024.07.002","article-title":"Proteome-wide analysis identifies plasma immune regulators of amyloid-beta progression","volume":"120","author":"Duggan","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.immuni.2024.12.008_bib205","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1073\/pnas.1300021110","article-title":"Innate immunity receptor CD36 promotes cerebral amyloid angiopathy","volume":"110","author":"Park","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2024.12.008_bib206","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s41583-023-00776-9","article-title":"Cell type-specific roles of APOE4 in Alzheimer disease","volume":"25","author":"Blumenfeld","year":"2024","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.immuni.2024.12.008_bib207","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.1038\/s41467-018-06301-2","article-title":"Apo\u03b54 disrupts neurovascular regulation and undermines white matter integrity and cognitive function","volume":"9","author":"Koizumi","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2024.12.008_bib208","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0041636","article-title":"Disruption of arterial perivascular drainage of amyloid-\u03b2 from the brains of mice expressing the human APOE \u03b54 allele","volume":"7","author":"Hawkes","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.immuni.2024.12.008_bib209","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1038\/s41593-024-01757-6","article-title":"A cell-autonomous role for border-associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury","volume":"27","author":"Anfray","year":"2024","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.immuni.2024.12.008_bib210","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.1093\/brain\/awad188","article-title":"Amyloid related imaging abnormalities (ARIA): radiological, biological and clinical characteristics","volume":"146","author":"Hampel","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.immuni.2024.12.008_bib211","doi-asserted-by":"crossref","first-page":"8220","DOI":"10.1038\/s41467-023-43933-5","article-title":"Fatal iatrogenic cerebral beta-amyloid-related arteritis in a woman treated with lecanemab for Alzheimer's disease","volume":"14","author":"Solopova","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2024.12.008_bib212","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1056\/NEJMc2215148","article-title":"Multiple Cerebral Hemorrhages in a Patient Receiving Lecanemab and Treated with t-PA for Stroke","volume":"388","author":"Reish","year":"2023","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2024.12.008_bib213","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1093\/brain\/awn261","article-title":"Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain","volume":"131","author":"Boche","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.immuni.2024.12.008_bib214","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00401-011-0801-7","article-title":"Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy","volume":"121","author":"Hawkes","year":"2011","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.immuni.2024.12.008_bib215","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13024-023-00649-w","article-title":"Amyloid-\u03b2 (A\u03b2) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer's disease mice","volume":"18","author":"Taylor","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.immuni.2024.12.008_bib216","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-61691-2","article-title":"Amyloid-beta antibody binding to cerebral amyloid angiopathy fibrils and risk for amyloid-related imaging abnormalities","volume":"14","author":"S\u00f6derberg","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.immuni.2024.12.008_bib217","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1161\/STROKEAHA.124.045755","article-title":"Emerging Adjuvant Thrombolytic Therapies for Acute Ischemic Stroke Reperfusion","volume":"55","author":"Yogendrakumar","year":"2024","journal-title":"Stroke"},{"key":"10.1016\/j.immuni.2024.12.008_bib218","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature12808","article-title":"Transcranial amelioration of inflammation and cell death after brain injury","volume":"505","author":"Roth","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2024.12.008_bib229","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2023.106063","article-title":"Regulatory T\u00a0cell expansion promotes white matter repair after stroke","volume":"179","author":"Yuan","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.immuni.2024.12.008_bib230","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202451067","article-title":"IL-17A-producing \u03b3\u03b4 T\u00a0cells: A novel target in stroke immunotherapy","volume":"54","author":"Piepke","year":"2024","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.immuni.2024.12.008_bib231","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neuroscience.2014.12.037","article-title":"Recombinant T-cell receptor ligand RTL1000 limits inflammation and decreases infarct size after experimental ischemic stroke in middle-aged mice","volume":"288","author":"Zhu","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.immuni.2024.12.008_bib232","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1177\/0271678X20914179","article-title":"Dynamic capillary stalls in reperfused ischemic penumbra contribute to\u00a0injury: A hyperacute role for neutrophils in persistent traffic jams","volume":"41","author":"Erdener","year":"2021","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.immuni.2024.12.008_bib233","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1161\/STROKEAHA.123.043424","article-title":"Role of the Meningeal Lymphatics in Stroke","volume":"54","author":"Perla","year":"2023","journal-title":"Stroke"},{"key":"10.1016\/j.immuni.2024.12.008_bib234","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/s43587-024-00691-3","article-title":"Restoration of cervical lymphatic vessel function in aging rescues cerebrospinal fluid drainage","volume":"4","author":"Du","year":"2024","journal-title":"Nat. Aging"},{"key":"10.1016\/j.immuni.2024.12.008_bib219","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.rcl.2023.01.003","article-title":"Advanced Imaging for Acute Stroke Treatment Selection: CT, CTA, CT Perfusion, and MR Imaging","volume":"61","author":"Regenhardt","year":"2023","journal-title":"Radiol. Clin. North Am."},{"key":"10.1016\/j.immuni.2024.12.008_bib220","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1038\/s41593-024-01695-3","article-title":"Central nervous system-associated macrophages modulate the immune response following stroke in aged mice","volume":"27","author":"Levard","year":"2024","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.immuni.2024.12.008_bib221","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abm3596","article-title":"Tracking the immune response by MRI using biodegradable and ultrasensitive microprobes","volume":"8","author":"Martinez de Lizarrondo","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.immuni.2024.12.008_bib222","article-title":"Risk Factors of Futile Recanalization Following Endovascular Treatment in Patients With Large-Vessel Occlusion: Systematic Review and Meta-Analysis","volume":"2","author":"Shahid","year":"2022","journal-title":"Stroke Vasc. Interv. Neurol."},{"key":"10.1016\/j.immuni.2024.12.008_bib223","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.jalz.2019.06.001","article-title":"Preventing dementia by preventing stroke: The Berlin Manifesto","volume":"15","author":"Hachinski","year":"2019","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.immuni.2024.12.008_bib224","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1016\/j.immuni.2024.07.001","article-title":"Innate immune training restores pro-reparative myeloid functions to promote remyelination in the aged central nervous system","volume":"57","author":"Tiwari","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2024.12.008_bib225","article-title":"A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia","volume":"5","author":"Sri","year":"2023","journal-title":"Cereb. Circ. Cogn. Behav."},{"key":"10.1016\/j.immuni.2024.12.008_bib226","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/B978-0-12-394596-9.00002-0","article-title":"Genetic animal models of cerebral vasculopathies","volume":"105","author":"Lee","year":"2012","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.immuni.2024.12.008_bib227","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1038\/s41591-024-02869-z","article-title":"Highly accurate blood test for Alzheimer\u2019s disease is similar or superior to clinical cerebrospinal fluid tests","volume":"30","author":"Barth\u00e9lemy","year":"2024","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2024.12.008_bib228","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1002\/alz.12215","article-title":"MarkVCID cerebral small vessel consortium: I. Enrollment, clinical, fluid protocols","volume":"17","author":"Wilcock","year":"2021","journal-title":"Alzheimers Dement."}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761324005727?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761324005727?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T21:26:50Z","timestamp":1783027610000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761324005727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":234,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S1074761324005727"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2024.12.008","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The immunology of stroke and dementia","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2024.12.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}