{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T10:20:07Z","timestamp":1793874007119,"version":"4.6.1"},"reference-count":121,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"am","delay-in-days":374,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme United Kingdom","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007311","name":"Cleveland Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007311","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS112526"],"award-info":[{"award-number":["R01NS112526"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006975","name":"Indiana Clinical and Translational Sciences Institute","doi-asserted-by":"publisher","award":["UL1TR002529"],"award-info":[{"award-number":["UL1TR002529"]}],"id":[{"id":"10.13039\/100006975","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["P50AA024333"],"award-info":[{"award-number":["P50AA024333"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014040","name":"US Department of Defense Peer Reviewed Alzheimers Research Program","doi-asserted-by":"publisher","award":["W81XWH2010665"],"award-info":[{"award-number":["W81XWH2010665"]}],"id":[{"id":"10.13039\/100014040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006377","name":"Purdue University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["RF1MH128866"],"award-info":[{"award-number":["RF1MH128866"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG081840"],"award-info":[{"award-number":["R01AG081840"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013415","name":"Purdue University Institute for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013415","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.immuni.2025.04.029","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T10:38:18Z","timestamp":1747651098000},"page":"1536-1552.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":130,"title":["Amyloid-\u03b2 induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer\u2019s disease"],"prefix":"10.1016","volume":"58","author":[{"given":"Priya","family":"Prakash","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palak","family":"Manchanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evi","family":"Paouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanchan","family":"Bisht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaushik","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitika","family":"Rajpoot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Wendt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahad","family":"Hossain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prageeth R.","family":"Wijewardhane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin E.","family":"Randolph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Stanko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Gasmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anxhela","family":"Gjojdeshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Card","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Fine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krupal P.","family":"Jethava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew G.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seohee","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Crockett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Thayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlo","family":"Nicolas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryann","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhruv","family":"Hardikar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Allende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Prayson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Davalos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0942-7898","authenticated-orcid":false,"given":"Gaurav","family":"Chopra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2025.04.029_bib1","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006189","article-title":"Neuropathological alterations in Alzheimer disease","volume":"1","author":"Serrano-Pozo","year":"2011","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.immuni.2025.04.029_bib2","doi-asserted-by":"crossref","first-page":"7825","DOI":"10.2147\/IJN.S444115","article-title":"Current Anti-Amyloid-\u03b2 Therapy for Alzheimer\u2019s Disease Treatment: From Clinical Research to Nanomedicine","volume":"18","author":"Zhao","year":"2023","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.immuni.2025.04.029_bib3","first-page":"135","article-title":"Inconsistencies and Controversies Surrounding the Amyloid Hypothesis of Alzheimer\u2019s Disease","volume":"2","author":"Morris","year":"2014","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.immuni.2025.04.029_bib4","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.ajhg.2008.10.008","article-title":"Genome-wide Association Analysis Reveals Putative Alzheimer\u2019s Disease Susceptibility Loci in Addition to APOE","volume":"83","author":"Bertram","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.immuni.2025.04.029_bib5","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/ng.803","article-title":"Common variants at ABCA7, MS4A6A\/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer\u2019s disease","volume":"43","author":"Hollingworth","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.immuni.2025.04.029_bib6","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/ng.801","article-title":"Common variants at MS4A4\/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer\u2019s disease","volume":"43","author":"Naj","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.immuni.2025.04.029_bib7","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJMoa1211851","article-title":"TREM2 Variants in Alzheimer\u2019s Disease","volume":"368","author":"Guerreiro","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.immuni.2025.04.029_bib8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa1211103","article-title":"Variant of TREM2 Associated with the Risk of Alzheimer\u2019s Disease","volume":"368","author":"Jonsson","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.immuni.2025.04.029_bib9","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.cell.2017.05.018","article-title":"A Unique Microglia Type Associated with Restricting Development of Alzheimer\u2019s Disease","volume":"169","author":"Keren-Shaul","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2025.04.029_bib10","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.immuni.2017.08.008","article-title":"The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases","volume":"47","author":"Krasemann","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2025.04.029_bib11","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1126\/science.aay0793","article-title":"Brain cell type\u2013specific enhancer\u2013promoter interactome maps and disease-risk association","volume":"366","author":"Nott","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.immuni.2025.04.029_bib12","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006346","article-title":"Inflammation in Alzheimer disease-A brief review of the basic science and clinical literature","volume":"2","author":"Wyss-Coray","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.immuni.2025.04.029_bib13","doi-asserted-by":"crossref","first-page":"6176","DOI":"10.1038\/ncomms7176","article-title":"Microglia constitute a barrier that prevents neurotoxic protofibrillar A\u03b242 hotspots around plaques","volume":"6","author":"Condello","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2025.04.029_bib14","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.neuron.2016.05.003","article-title":"TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy","volume":"90","author":"Yuan","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.immuni.2025.04.029_bib15","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer\u2019s disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.immuni.2025.04.029_bib16","doi-asserted-by":"crossref","first-page":"8354","DOI":"10.1523\/JNEUROSCI.0616-08.2008","article-title":"Microglial dysfunction and defective \u03b2-amyloid clearance pathways in aging alzheimer\u2019s disease mice","volume":"28","author":"Hickman","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.immuni.2025.04.029_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0060921","article-title":"Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology","volume":"8","author":"Krabbe","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.immuni.2025.04.029_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2019.134348","article-title":"Direct and indirect effects of lipids on microglia function","volume":"708","author":"Leyrolle","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.immuni.2025.04.029_bib19","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12974-016-0580-0","article-title":"Remodeling of lipid bodies by docosahexaenoic acid in activated microglial cells","volume":"13","author":"Tremblay","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.immuni.2025.04.029_bib20","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41593-019-0566-1","article-title":"Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain","volume":"23","author":"Marschallinger","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.immuni.2025.04.029_bib21","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.semcdb.2020.08.001","article-title":"Microglia and lipids: how metabolism controls brain innate immunity","volume":"112","author":"Chausse","year":"2021","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.immuni.2025.04.029_bib22","series-title":"Food for the Ageing Population","first-page":"219","article-title":"Brain lipids and ageing","author":"Bourre","year":"2009"},{"key":"10.1016\/j.immuni.2025.04.029_bib23","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1126\/science.aan4183","article-title":"Defective cholesterol clearance limits remyelination in the aged central nervous system","volume":"359","author":"Cantuti-Castelvetri","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.immuni.2025.04.029_bib24","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.jalz.2017.01.008","article-title":"Dysregulation of lipids in Alzheimer\u2019s disease and their role as potential biomarkers","volume":"13","author":"Wong","year":"2017","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.immuni.2025.04.029_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105303","article-title":"INPP5D expression is associated with risk for Alzheimer\u2019s disease and induced by plaque-associated microglia","volume":"153","author":"Tsai","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.immuni.2025.04.029_bib26","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.cell.2015.01.049","article-title":"TREM2 lipid sensing sustains the microglial response in an Alzheimer\u2019s disease model","volume":"160","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2025.04.029_bib27","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1038\/s41467-021-23762-0","article-title":"Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer\u2019s disease","volume":"12","author":"Fitz","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2025.04.029_bib28","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s42255-021-00341-7","article-title":"Diet-dependent regulation of TGF\u03b2 impairs reparative innate immune responses after demyelination","volume":"3","author":"Bosch-Queralt","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.immuni.2025.04.029_bib29","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20210227","article-title":"TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination","volume":"218","author":"Gouna","year":"2021","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2025.04.029_bib30","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/s41593-020-0650-6","article-title":"Alzheimer\u2019s-associated PLC\u03b32 is a signaling node required for both TREM2 function and the inflammatory response in human microglia","volume":"23","author":"Andreone","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.immuni.2025.04.029_bib31","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.neuron.2019.12.007","article-title":"TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge","volume":"105","author":"Nugent","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.immuni.2025.04.029_bib32","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/ca.980080612","article-title":"An english translation of alzheimer\u2019s 1907 paper, \u201cUber eine eigenartige Erkankung der Hirnrinde\u201d","volume":"8","author":"Alzheimer","year":"1995","journal-title":"Clin. Anat."},{"key":"10.1016\/j.immuni.2025.04.029_bib33","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.cell.2009.11.005","article-title":"Lipid Droplets Finally Get a Little R-E-S-P-E-C-T","volume":"139","author":"Farese","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2025.04.029_bib34","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a004838","article-title":"Not Just Fat: The Structure and Function of the Lipid Droplet","volume":"3","author":"Fujimoto","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.immuni.2025.04.029_bib35","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.bbalip.2012.01.007","article-title":"Dynamics and regulation of lipid droplet formation in lipopolysaccharide (LPS)-stimulated microglia","volume":"1821","author":"Khatchadourian","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.immuni.2025.04.029_bib36","doi-asserted-by":"crossref","first-page":"9093","DOI":"10.3390\/ijms22169093","article-title":"Palmitic acid lipotoxicity in microglia cells is ameliorated by unsaturated fatty acids","volume":"22","author":"Urso","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.immuni.2025.04.029_bib37","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13024-021-00473-0","article-title":"Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer\u2019s disease","volume":"16","author":"Claes","year":"2021","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.immuni.2025.04.029_bib38","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal \u03b2-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer\u2019s disease mutations: Potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.immuni.2025.04.029_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.713726","article-title":"Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study","volume":"13","author":"Oblak","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.immuni.2025.04.029_bib40","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.neuron.2019.01.014","article-title":"Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer\u2019s Disease Model","volume":"101","author":"Merlini","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.immuni.2025.04.029_bib41","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41586-021-03960-y","article-title":"Neurotoxic reactive astrocytes induce cell death via saturated lipids","volume":"599","author":"Guttenplan","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2025.04.029_bib42","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.bbalip.2014.02.003","article-title":"Shedding new light on lipid functions with CARS and SRS microscopy","volume":"1841","author":"Yu","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.immuni.2025.04.029_bib43","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13024-019-0333-5","article-title":"The neuropathological diagnosis of Alzheimer\u2019s disease","volume":"14","author":"Deture","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.immuni.2025.04.029_bib44","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0165-5728(89)90115-X","article-title":"Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease","volume":"24","author":"Itagaki","year":"1989","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.immuni.2025.04.029_bib45","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/acel.12210","article-title":"Accelerated microglial pathology is associated with A\u03b2 plaques in mouse models of Alzheimer\u2019s disease","volume":"13","author":"Baron","year":"2014","journal-title":"Aging Cell"},{"key":"10.1016\/j.immuni.2025.04.029_bib46","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1016\/j.neurobiolaging.2014.06.004","article-title":"Isolation of glia from Alzheimer\u2019s mice reveals inflammation and dysfunction","volume":"35","author":"Orre","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.immuni.2025.04.029_bib47","doi-asserted-by":"crossref","first-page":"10901","DOI":"10.1039\/D1SC03486C","article-title":"Monitoring phagocytic uptake of amyloid \u03b2 into glial cell lysosomes in real time","volume":"12","author":"Prakash","year":"2021","journal-title":"Chem. Sci."},{"key":"10.1016\/j.immuni.2025.04.029_bib48","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.cell.2018.05.003","article-title":"Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration","volume":"173","author":"Deczkowska","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2025.04.029_bib49","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1194\/jlr.R800018-JLR200","article-title":"Thematic review series: Glycerolipids. DGAT enzymes and triacylglycerol biosynthesis","volume":"49","author":"Yen","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.immuni.2025.04.029_bib50","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1194\/jlr.M093112","article-title":"The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes","volume":"60","author":"Chitraju","year":"2019","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.immuni.2025.04.029_bib51","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.devcel.2013.01.013","article-title":"Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets","volume":"24","author":"Wilfling","year":"2013","journal-title":"Dev. Cell"},{"key":"10.1016\/j.immuni.2025.04.029_bib52","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1600-0854.2007.00689.x","article-title":"Imaging of lipid biosynthesis: How a neutral lipid enters lipid droplets","volume":"9","author":"Kuerschner","year":"2008","journal-title":"Traffic"},{"key":"10.1016\/j.immuni.2025.04.029_bib53","doi-asserted-by":"crossref","first-page":"5352","DOI":"10.1074\/jbc.M805768200","article-title":"The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria","volume":"284","author":"Stone","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.immuni.2025.04.029_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2023.106150","article-title":"Most dystrophic neurites in the common 5xFAD Alzheimer mouse model originate from axon terminals","volume":"182","author":"Mabrouk","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.immuni.2025.04.029_bib55","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1002\/acn3.50948","article-title":"APP-derived peptides reflect neurodegeneration in frontotemporal dementia","volume":"6","author":"Ill\u00e1n-Gala","year":"2019","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.immuni.2025.04.029_bib56","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1002\/alz.12546","article-title":"APP accumulates with presynaptic proteins around amyloid plaques: A role for presynaptic mechanisms in Alzheimer\u2019s disease?","volume":"18","author":"Jord\u00e0-Siquier","year":"2022","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.immuni.2025.04.029_bib57","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1016\/j.neuron.2022.10.020","article-title":"Microglia states and nomenclature: A field at its crossroads","volume":"110","author":"Paolicelli","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.immuni.2025.04.029_bib58","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1038\/s41467-021-23111-1","article-title":"Transcriptional signature in microglia associated with A\u03b2 plaque phagocytosis","volume":"12","author":"Grubman","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2025.04.029_bib59","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/0014-4800(77)90035-1","article-title":"Saturated free fatty acid toxicity. II. Lipid accumulation, ultrastructural alterations, and toxicity in mammalian cells in culture","volume":"27","author":"Gordon","year":"1977","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.immuni.2025.04.029_bib60","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1073\/pnas.0630588100","article-title":"Triglyceride accumulation protects against fatty acid-induced lipotoxicity","volume":"100","author":"Listenberger","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2025.04.029_bib61","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1038\/jcbfm.2013.128","article-title":"Why does brain metabolism not favor burning of fatty acids to provide energy? Reflections on disadvantages of the use of free fatty acids as fuel for brain","volume":"33","author":"Sch\u00f6nfeld","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.immuni.2025.04.029_bib62","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.freeradbiomed.2012.09.027","article-title":"Lipid peroxidation triggers neurodegeneration: A redox proteomics view into the Alzheimer disease brain","volume":"62","author":"Sultana","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.immuni.2025.04.029_bib63","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.cell.2019.04.001","article-title":"Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity","volume":"177","author":"Ioannou","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2025.04.029_bib64","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41586-024-07185-7","article-title":"APOE4\/4 is linked to damaging lipid droplets in Alzheimer\u2019s disease microglia","volume":"628","author":"Haney","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2025.04.029_bib65","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.dadm.2014.12.001","article-title":"Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer\u2019s disease","volume":"1","author":"Carlesimo","year":"2015","journal-title":"Alzheimers. Dement. (Amst)"},{"key":"10.1016\/j.immuni.2025.04.029_bib66","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12974-021-02124-z","article-title":"Uncovering sex differences of rodent microglia","volume":"18","author":"Han","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.immuni.2025.04.029_bib67","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3389\/fnagi.2019.00299","article-title":"Age and Sex Influence the Neuro-inflammatory Response to a Peripheral Acute LPS Challenge","volume":"11","author":"Murtaj","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.immuni.2025.04.029_bib68","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1523\/JNEUROSCI.2906-16.2017","article-title":"Sex differences in microglia activity within the periaqueductal gray of the rat: A potential mechanism driving the dimorphic effects of morphine","volume":"37","author":"Doyle","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.immuni.2025.04.029_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2024.148772","article-title":"Altered metabolism and DAM-signatures in female brains and microglia with aging","volume":"1829","author":"Cleland","year":"2024","journal-title":"Brain Res."},{"key":"10.1016\/j.immuni.2025.04.029_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0089454","article-title":"Galantamine slows down plaque formation and behavioral decline in the 5XFAD mouse model of Alzheimer\u2019s disease","volume":"9","author":"Bhattacharya","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.immuni.2025.04.029_bib71","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41597-021-01054-y","article-title":"Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer\u2019s disease","volume":"8","author":"Forner","year":"2021","journal-title":"Sci. Data"},{"key":"10.1016\/j.immuni.2025.04.029_bib72","doi-asserted-by":"crossref","DOI":"10.1002\/alz.083212","article-title":"Cellular dynamics across aged human brains uncover a multicellular cascade leading to Alzheimer\u2019s disease","volume":"19","author":"Green","year":"2023","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.immuni.2025.04.029_bib73","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1126\/science.1197623","article-title":"Decreased clearance of CNS \u03b2-amyloid in Alzheimer\u2019s disease","volume":"330","author":"Mawuenyega","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.immuni.2025.04.029_bib74","doi-asserted-by":"crossref","first-page":"17091","DOI":"10.1523\/JNEUROSCI.4403-10.2010","article-title":"CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-\u03b2 phagocytosis","volume":"30","author":"Liu","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.immuni.2025.04.029_bib75","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1523\/JNEUROSCI.5572-08.2009","article-title":"Microglia mediate the clearance of soluble a\u03b2 through fluid phase macropinocytosis","volume":"29","author":"Mandrekar","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.immuni.2025.04.029_bib76","doi-asserted-by":"crossref","first-page":"195.e1","DOI":"10.1016\/j.neurobiolaging.2010.05.008","article-title":"Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function","volume":"33","author":"Njie","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.immuni.2025.04.029_bib77","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.cmet.2019.06.005","article-title":"A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer\u2019s Disease","volume":"30","author":"Baik","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2025.04.029_bib78","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/s41586-019-1088-4","article-title":"CD22 blockade restores homeostatic microglial phagocytosis in ageing brains","volume":"568","author":"Pluvinage","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2025.04.029_bib79","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41590-021-00913-5","article-title":"Microglia use TAM receptors to detect and engulf amyloid \u03b2 plaques","volume":"22","author":"Huang","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2025.04.029_bib80","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1038\/s41467-020-17881-3","article-title":"Triacylglycerol synthesis enhances macrophage inflammatory function","volume":"11","author":"Castoldi","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2025.04.029_bib81","doi-asserted-by":"crossref","first-page":"20192","DOI":"10.1074\/jbc.M110.107854","article-title":"Efficient phagocytosis requires triacylglycerol hydrolysis by adipose triglyceride lipase","volume":"285","author":"Chandak","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.immuni.2025.04.029_bib82","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.cmet.2016.07.016","article-title":"Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils","volume":"24","author":"Kirchgessner","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2025.04.029_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175953","article-title":"Liver X receptors: From pharmacology to nanoparticle-based drug delivery","volume":"956","author":"Hua","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.immuni.2025.04.029_bib84","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.cmet.2024.01.011","article-title":"DGAT2 inhibition blocks SREBP-1 cleavage and improves hepatic steatosis by increasing phosphatidylethanolamine in the ER","volume":"36","author":"Rong","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2025.04.029_bib85","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.clinthera.2022.12.008","article-title":"Inhibition of Diacylglycerol Acyltransferase 2 Versus Diacylglycerol Acyltransferase 1: Potential Therapeutic Implications of Pharmacology","volume":"45","author":"Amin","year":"2023","journal-title":"Clin. Ther."},{"key":"10.1016\/j.immuni.2025.04.029_bib86","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1038\/s41591-021-01489-1","article-title":"ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials","volume":"27","author":"Calle","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2025.04.029_bib87","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.metabol.2014.04.003","article-title":"De novo lipogenesis in health and disease","volume":"63","author":"Ameer","year":"2014","journal-title":"Metabolism"},{"key":"10.1016\/j.immuni.2025.04.029_bib88","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3389\/fimmu.2020.00131","article-title":"Classical Activation of Macrophages Leads to Lipid Droplet Formation Without de novo Fatty Acid Synthesis","volume":"11","author":"Rosas-Ballina","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2025.04.029_bib89","doi-asserted-by":"crossref","first-page":"5697","DOI":"10.1074\/jbc.M806173200","article-title":"Lipid droplet biogenesis induced by stress involves triacylglycerol synthesis that depends on Group VIA phospholipase A2","volume":"284","author":"Gubern","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.immuni.2025.04.029_bib90","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1016\/j.bbalip.2014.10.004","article-title":"Phospholipase A2 regulation of lipid droplet formation","volume":"1841","author":"Guijas","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.immuni.2025.04.029_bib91","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1021\/acschembio.6b00410","article-title":"Specific Triacylglycerols Accumulate via Increased Lipogenesis during 5-FU-Induced Apoptosis","volume":"11","author":"Li","year":"2016","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.immuni.2025.04.029_bib92","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1039\/C6MB00842A","article-title":"Regulation of lipids is central to replicative senescence","volume":"13","author":"Lizardo","year":"2017","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.immuni.2025.04.029_bib93","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.cmet.2018.12.008","article-title":"Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis","volume":"29","author":"Ogrodnik","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2025.04.029_bib94","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1093\/abbs\/gms008","article-title":"Proteomic profiling of lipid droplet-associated proteins in primary adipocytes of normal and obese mouse","volume":"44","author":"Ding","year":"2012","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"},{"key":"10.1016\/j.immuni.2025.04.029_bib95","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.996716","article-title":"Lipid droplet accumulation in \u03b2 cells in patients with type 2 diabetes is associated with insulin resistance, hyperglycemia and \u03b2 cell dysfunction involving decreased insulin granules","volume":"13","author":"Horii","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.immuni.2025.04.029_bib96","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqac007","article-title":"Lipid Droplets\u2019 Role in the Regulation of \u03b2-Cell Function and \u03b2-Cell Demise in Type 2 Diabetes","volume":"163","author":"Tong","year":"2022","journal-title":"Endocrinology"},{"key":"10.1016\/j.immuni.2025.04.029_bib97","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1038\/s41593-022-01199-y","article-title":"TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury","volume":"25","author":"Zambusi","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.immuni.2025.04.029_bib98","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1172\/JCI46069","article-title":"The role of lipid droplets in metabolic disease in rodents and humans","volume":"121","author":"Greenberg","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.immuni.2025.04.029_bib99","article-title":"Isolation and Culture of Microglia","volume":"125","author":"Bohlen","year":"2019","journal-title":"Curr. Protoc. Immunol."},{"key":"10.1016\/j.immuni.2025.04.029_bib100","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3390\/mps2020048","article-title":"Rapid, Refined, and Robust Method for Expression, Purification, and Characterization of Recombinant Human Amyloid beta 1\u201342","volume":"2","author":"Prakash","year":"2019","journal-title":"Methods Protoc."},{"key":"10.1016\/j.immuni.2025.04.029_bib101","doi-asserted-by":"crossref","first-page":"11612","DOI":"10.1074\/jbc.M210207200","article-title":"In vitro characterization of conditions for amyloid-\u03b2 peptide oligomerization and fibrillogenesis","volume":"278","author":"Stine","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.immuni.2025.04.029_bib102","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-1-60761-744-0_2","article-title":"Preparing synthetic A\u03b2 in different aggregation states","volume":"670","author":"Stine","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.immuni.2025.04.029_bib103","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/y59-099","article-title":"A Rapid Method Of Total Lipid Extraction and Purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Can. J. Biochem. Physiol."},{"key":"10.1016\/j.immuni.2025.04.029_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemphyslip.2021.105048","article-title":"Multiple reaction monitoring profiling (MRM profiling): Small molecule exploratory analysis guided by chemical functionality","volume":"235","author":"Xie","year":"2021","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.immuni.2025.04.029_bib105","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1002\/rcm.7927","article-title":"Multiple reaction monitoring (MRM)-profiling for biomarker discovery applied to human polycystic ovarian syndrome","volume":"31","author":"Cordeiro","year":"2017","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.immuni.2025.04.029_bib106","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1002\/jms.4301","article-title":"Comprehensive lipid profiling of early stage oocytes and embryos by MRM profiling","volume":"53","author":"de Lima","year":"2018","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.immuni.2025.04.029_bib107","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1194\/jlr.R800095-JLR200","article-title":"Update of the LIPID MAPS comprehensive classification system for lipids","volume":"50","author":"Fahy","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.immuni.2025.04.029_bib108","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: A Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.immuni.2025.04.029_bib109","doi-asserted-by":"crossref","first-page":"4288","DOI":"10.1093\/nar\/gks042","article-title":"Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation","volume":"40","author":"McCarthy","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.immuni.2025.04.029_bib110","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. B"},{"key":"10.1016\/j.immuni.2025.04.029_bib111","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/glia.22287","article-title":"Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices","volume":"60","author":"Tremblay","year":"2012","journal-title":"Glia"},{"key":"10.1016\/j.immuni.2025.04.029_bib112","doi-asserted-by":"crossref","first-page":"9032","DOI":"10.1021\/acs.analchem.9b01333","article-title":"Generating Fatty Acid Profiles in the Gas Phase: Fatty Acid Identification and Relative Quantitation Using Ion\/Ion Charge Inversion Chemistry","volume":"91","author":"Randolph","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.immuni.2025.04.029_bib113","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.aca.2020.07.005","article-title":"Charge-switch derivatization of fatty acid esters of hydroxy fatty acids via gas-phase ion\/ion reactions","volume":"1129","author":"Randolph","year":"2020","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.immuni.2025.04.029_bib114","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jasms.2004.09.017","article-title":"Mutual storage mode ion\/ion reactions in a hybrid linear ion trap","volume":"16","author":"Xia","year":"2005","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.immuni.2025.04.029_bib115","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/j.jasms.2005.07.013","article-title":"Pulsed dual electrospray ionization for ion\/ion reactions","volume":"16","author":"Xia","year":"2005","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.immuni.2025.04.029_bib116","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/S1044-0305(03)00446-X","article-title":"Mass selective axial ion ejection from a linear quadrupole ion trap","volume":"14","author":"Londry","year":"2003","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.immuni.2025.04.029_bib117","doi-asserted-by":"crossref","first-page":"12861","DOI":"10.1021\/acs.analchem.8b03441","article-title":"Gas-Phase Ion\/Ion Reactions Involving Tris-Phenanthroline Alkaline Earth Metal Complexes as Charge Inversion Reagents for the Identification of Fatty Acids","volume":"90","author":"Randolph","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.immuni.2025.04.029_bib118","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1021\/jasms.0c00348","article-title":"Localization of Carbon-Carbon Double Bond and Cyclopropane Sites in Cardiolipins via Gas-Phase Charge Inversion Reactions","volume":"32","author":"Randolph","year":"2021","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.immuni.2025.04.029_bib119","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1093\/bioinformatics\/btq418","article-title":"MetPA: a web-based metabolomics tool for pathway analysis and visualization","volume":"26","author":"Xia","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.immuni.2025.04.029_bib120","article-title":"Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System","volume":"75","author":"DeVos","year":"2013","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.immuni.2025.04.029_bib121","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1111\/j.1600-0854.2009.00980.x","article-title":"Live cell multicolor imaging of lipid droplets with a new dye, LD540","volume":"10","author":"Spandl","year":"2009","journal-title":"Traffic"}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107476132500192X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107476132500192X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T17:25:52Z","timestamp":1762363552000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S107476132500192X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":121,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S107476132500192X"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2025.04.029","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amyloid-\u03b2 induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2025.04.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}