{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:46:02Z","timestamp":1792856762816,"version":"4.5.0"},"reference-count":72,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["RS-470329"],"award-info":[{"award-number":["RS-470329"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["RS-342013"],"award-info":[{"award-number":["RS-342013"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.immuni.2025.05.002","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T14:36:21Z","timestamp":1748615781000},"page":"2054-2068.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis"],"prefix":"10.1016","volume":"58","author":[{"given":"Carlos H.","family":"Hiroki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mortaza F.","family":"Hassanabad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon","family":"Defaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Sarden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandria","family":"Bartlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Farias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela P.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idaira M.","family":"Guerrero-Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyungjun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrel","family":"Belke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Fatehi","family":"Hassanabad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"McCoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole L.","family":"Rosin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis J.","family":"Orton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.M.","family":"Fedak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce A.","family":"Vallance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevan","family":"Jacobson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nargis","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Altier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret M.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan G.","family":"Yipp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2025.05.002_bib1","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1056\/NEJMra2005230","article-title":"Spectrum of Fibrotic Lung Diseases","volume":"383","author":"Wijsenbeek","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.immuni.2025.05.002_bib2","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1001\/jama.2024.3669","article-title":"Interstitial Lung Disease: A Review","volume":"331","author":"Maher","year":"2024","journal-title":"JAMA"},{"key":"10.1016\/j.immuni.2025.05.002_bib3","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1146\/annurev-pathol-042320-030240","article-title":"Pathogenic Mechanisms Underlying Idiopathic Pulmonary Fibrosis","volume":"17","author":"Moss","year":"2022","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.immuni.2025.05.002_bib4","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1056\/NEJMoa1113354","article-title":"Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibrosis","volume":"366","author":"Raghu","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.immuni.2025.05.002_bib5","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nri.2017.90","article-title":"Type 2 immunity in tissue repair and fibrosis","volume":"18","author":"Gieseck","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2025.05.002_bib6","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1056\/NEJMoa2303951","article-title":"Dupilumab for COPD with Type 2 Inflammation Indicated by Eosinophil Counts","volume":"389","author":"Bhatt","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.immuni.2025.05.002_bib7","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02442-2019","article-title":"Phase 2 trial to assess lebrikizumab in patients with idiopathic pulmonary fibrosis","volume":"57","author":"Maher","year":"2021","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.immuni.2025.05.002_bib8","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01130-2018","article-title":"SAR156597 in idiopathic pulmonary fibrosis: a phase 2 placebo-controlled study (DRI11772)","volume":"52","author":"Raghu","year":"2018","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.immuni.2025.05.002_bib9","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.cell.2023.11.027","article-title":"Sensory neurons promote immune homeostasis in the lung","volume":"187","author":"Tamari","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2025.05.002_bib10","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nm.4501","article-title":"Nociceptor sensory neurons suppress neutrophil and gammadelta T cell responses in bacterial lung infections and lethal pneumonia","volume":"24","author":"Baral","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2025.05.002_bib11","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.immuni.2019.09.005","article-title":"Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses","volume":"51","author":"Wallrapp","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2025.05.002_bib12","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/s41586-023-05753-x","article-title":"Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion","volume":"615","author":"Pinho-Ribeiro","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2025.05.002_bib13","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.cell.2018.04.006","article-title":"Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection","volume":"173","author":"Pinho-Ribeiro","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2025.05.002_bib14","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.1016\/j.cell.2022.09.024","article-title":"Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection","volume":"185","author":"Yang","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2025.05.002_bib15","doi-asserted-by":"crossref","first-page":"33-49.e22","DOI":"10.1016\/j.cell.2019.11.014","article-title":"Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense","volume":"180","author":"Lai","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2025.05.002_bib16","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1016\/j.cell.2024.03.001","article-title":"Biofilm exopolysaccharides alter sensory-neuron-mediated sickness during lung infection","volume":"187","author":"Granton","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2025.05.002_bib17","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.biocel.2007.08.011","article-title":"The bleomycin animal model: A useful tool to investigate treatment options for idiopathic pulmonary fibrosis?","volume":"40","author":"Moeller","year":"2008","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.immuni.2025.05.002_bib18","article-title":"Bleomycin induces molecular changes directly relevant to idiopathic pulmonary fibrosis: a model for \"active\" disease","volume":"8","author":"Peng","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.immuni.2025.05.002_bib19","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0002-9440(10)64529-4","article-title":"The Development of Bleomycin-Induced Pulmonary Fibrosis in Mice Deficient for Components of the Fibrinolytic System","volume":"157","author":"Swaisgood","year":"2000","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.immuni.2025.05.002_bib20","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1136\/jcp.41.4.467","article-title":"Simple method of estimating severity of pulmonary fibrosis on a numerical scale","volume":"41","author":"Ashcroft","year":"1988","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.immuni.2025.05.002_bib21","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nm1332","article-title":"IL-13 signaling through the IL-13\u03b12 receptor is involved in induction of TGF-\u03b21 production and fibrosis","volume":"12","author":"Fichtner-Feigl","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2025.05.002_bib22","doi-asserted-by":"crossref","first-page":"L585","DOI":"10.1152\/ajplung.00151.2001","article-title":"Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice","volume":"282","author":"Zhao","year":"2002","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.immuni.2025.05.002_bib23","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1165\/rcmb.2020-0542MA","article-title":"Persistent, Progressive Pulmonary Fibrosis and Epithelial Remodeling in Mice","volume":"64","author":"Redente","year":"2021","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.immuni.2025.05.002_bib24","doi-asserted-by":"crossref","first-page":"L442","DOI":"10.1152\/ajplung.00026.2010","article-title":"Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis","volume":"299","author":"Degryse","year":"2010","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.immuni.2025.05.002_bib25","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.neuron.2015.06.007","article-title":"Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation","volume":"87","author":"Talbot","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.immuni.2025.05.002_bib26","doi-asserted-by":"crossref","DOI":"10.1172\/JCI156876","article-title":"Siglec-F-expressing neutrophils are essential for creating a profibrotic microenvironment in renal fibrosis","volume":"132","author":"Ryu","year":"2022","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.immuni.2025.05.002_bib27","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1165\/rcmb.2019-0433OC","article-title":"PAD4 Deficiency Improves Bleomycin-induced Neutrophil Extracellular Traps and Fibrosis in Mouse Lung","volume":"63","author":"Suzuki","year":"2020","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.immuni.2025.05.002_bib28","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1189\/jlb.3HI1014-493R","article-title":"Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis","volume":"98","author":"Gregory","year":"2015","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.immuni.2025.05.002_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108164","article-title":"Tumor-Promoting Ly-6G(+) SiglecF(high) Cells Are Mature and Long-Lived Neutrophils","volume":"32","author":"Pfirschke","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2025.05.002_bib30","doi-asserted-by":"crossref","DOI":"10.1126\/science.aal5081","article-title":"Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF(high) neutrophils","volume":"358","author":"Engblom","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.immuni.2025.05.002_bib31","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/s41590-017-0030-x","article-title":"Aged polymorphonuclear leukocytes cause fibrotic interstitial lung disease in the absence of regulation by B cells","volume":"19","author":"Kim","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2025.05.002_bib32","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1084\/jem.20160530","article-title":"Peptidylarginine deiminase 4 promotes age-related organ fibrosis","volume":"214","author":"Martinod","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2025.05.002_bib33","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.jaci.2021.09.031","article-title":"A unique population of neutrophils generated by air pollutant\u2013induced lung damage exacerbates airway inflammation","volume":"149","author":"Shin","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.immuni.2025.05.002_bib34","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.devcel.2017.10.013","article-title":"Cell-Cycle Proteins Control Production of Neutrophil Extracellular Traps","volume":"43","author":"Amulic","year":"2017","journal-title":"Dev. Cell"},{"key":"10.1016\/j.immuni.2025.05.002_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.103256","article-title":"Zinc-dependent histone deacetylases drive neutrophil extracellular trap formation and potentiate local and systemic inflammation","volume":"24","author":"Poli","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.immuni.2025.05.002_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2023.102372","article-title":"Quantitative cytofluorimetric analysis of mouse neutrophil extracellular traps","volume":"4","author":"Poli","year":"2023","journal-title":"Star Protoc."},{"key":"10.1016\/j.immuni.2025.05.002_bib37","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nchembio.1735","article-title":"Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation","volume":"11","author":"Lewis","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.immuni.2025.05.002_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.107162","article-title":"Inhibition of NETosis via PAD4 alleviated inflammation in giant cell myocarditis","volume":"26","author":"Hu","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.immuni.2025.05.002_bib39","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1164\/rccm.202311-2101OC","article-title":"Epidemiology and Prognostic Significance of Cough in Fibrotic Interstitial Lung Disease","volume":"210","author":"Khor","year":"2024","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.immuni.2025.05.002_bib40","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1164\/rccm.201508-1602OC","article-title":"Neurophenotypes in Airway Diseases. Insights from Translational Cough Studies","volume":"193","author":"Belvisi","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.immuni.2025.05.002_bib41","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1113\/jphysiol.2010.201434","article-title":"Breath-taking complexity of vagal C-fibre nociceptors: implications for inflammatory pulmonary disease, dyspnoea and cough","volume":"589","author":"Adriaensen","year":"2011","journal-title":"J. Physiol."},{"key":"10.1016\/j.immuni.2025.05.002_bib42","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S2213-2600(23)00432-0","article-title":"Morphine for treatment of cough in idiopathic pulmonary fibrosis (PACIFY COUGH): a prospective, multicentre, randomised, double-blind, placebo-controlled, two-way crossover trial","volume":"12","author":"Wu","year":"2024","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.immuni.2025.05.002_bib43","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/S0301-472X(02)00875-5","article-title":"Vasoactive intestinal peptide (VIP) inhibits the proliferation of bone marrow progenitors through the VPAC1 receptor","volume":"30","author":"Rameshwar","year":"2002","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.immuni.2025.05.002_bib44","doi-asserted-by":"crossref","first-page":"9032","DOI":"10.4238\/2014.October.31.18","article-title":"Vasoactive intestinal polypeptide suppresses proliferation of human cord blood-derived hematopoietic progenitor cells by increasing TNF-\u03b1 and TGF-\u03b2 production in the liver","volume":"13","author":"Wang","year":"2014","journal-title":"Genet. Mol. Res."},{"key":"10.1016\/j.immuni.2025.05.002_bib45","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.1182\/blood-2005-11-4497","article-title":"Vasoactive intestinal peptide generates human tolerogenic dendritic cells that induce CD4 and CD8 regulatory T cells","volume":"107","author":"Gonzalez-Rey","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2025.05.002_bib46","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1006\/bbrc.1993.1658","article-title":"Cloning and Functional Expression of a Human Neuroendocrine Vasoactive Intestinal Peptide Receptor","volume":"193","author":"Sreedharan","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.immuni.2025.05.002_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2000.tb06946.x","article-title":"In Vitro Evaluation of VIP\/PACAP Receptors in Healthy and Diseased Human Tissues: Clinical Implications","volume":"921","author":"Reubi","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.immuni.2025.05.002_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108211","article-title":"Vasoactive intestinal peptide attenuates bleomycin-induced murine pulmonary fibrosis by inhibiting epithelial-mesenchymal transition: Restoring autophagy in alveolar epithelial cells","volume":"101","author":"Duan","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.immuni.2025.05.002_bib49","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S2213-2600(23)00147-9","article-title":"Intravenous aviptadil and remdesivir for treatment of COVID-19-associated hypoxaemic respiratory failure in the USA (TESICO): a randomised, placebo-controlled trial","volume":"11","author":"Brown","year":"2023","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.immuni.2025.05.002_bib50","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1097\/CCM.0000000000005660","article-title":"The Use of IV Vasoactive Intestinal Peptide (Aviptadil) in Patients With Critical COVID-19 Respiratory Failure: Results of a 60-Day Randomized Controlled Trial","volume":"50","author":"Youssef","year":"2022","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.immuni.2025.05.002_bib51","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1183\/09031936.00050008","article-title":"Inhalation of vasoactive intestinal peptide in pulmonary hypertension","volume":"32","author":"Leuchte","year":"2008","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.immuni.2025.05.002_bib52","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.019019","article-title":"SiglecF(HI) Marks Late-Stage Neutrophils of the Infarcted Heart: A Single-Cell Transcriptomic Analysis of Neutrophil Diversification","volume":"10","author":"Calcagno","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.immuni.2025.05.002_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101819","article-title":"Machine Learning Analysis of the Bleomycin Mouse Model Reveals the Compartmental and Temporal Inflammatory Pulmonary Fingerprint","volume":"23","author":"Bordag","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.immuni.2025.05.002_bib54","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/BF01920753","article-title":"Priming effect of vasoactive intestinal peptide on the respiratory burst of neutrophils non-mediated by plasma membrane receptors","volume":"50","author":"L\u00f3pez-Gonz\u00e1lez","year":"1994","journal-title":"Experientia"},{"key":"10.1016\/j.immuni.2025.05.002_bib55","doi-asserted-by":"crossref","first-page":"732","DOI":"10.4049\/jimmunol.2100184","article-title":"Siglec-F Promotes IL-33-Induced Cytokine Release from Bone Marrow-Derived Eosinophils Independently of the ITIM and ITIM-like Motif Phosphorylation","volume":"208","author":"Westermann","year":"2022","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2025.05.002_bib56","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.jaci.2014.10.027","article-title":"Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis","volume":"135","author":"Kiwamoto","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.immuni.2025.05.002_bib57","doi-asserted-by":"crossref","first-page":"4280","DOI":"10.1182\/blood-2006-08-039255","article-title":"Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils","volume":"109","author":"Zhang","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2025.05.002_bib58","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1016\/j.neuron.2021.06.015","article-title":"IL-23\/IL-17A\/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice","volume":"109","author":"Luo","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.immuni.2025.05.002_bib59","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nri.2016.90","article-title":"Sex differences in immune responses","volume":"16","author":"Klein","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2025.05.002_bib60","doi-asserted-by":"crossref","DOI":"10.1186\/s12890-019-0994-4","article-title":"Gender differences at presentation of idiopathic pulmonary fibrosis in Sweden","volume":"19","author":"Kalafatis","year":"2019","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.immuni.2025.05.002_bib61","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1183\/09031936.00165207","article-title":"Sex differences in physiological progression of idiopathic pulmonary fibrosis","volume":"31","author":"Han","year":"2008","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.immuni.2025.05.002_bib62","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2106634118","article-title":"Vasoactive intestinal peptide promotes host defense against enteric pathogens by modulating the recruitment of group 3 innate lymphoid cells","volume":"118","author":"Yu","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2025.05.002_bib63","doi-asserted-by":"crossref","first-page":"R939","DOI":"10.1152\/ajpregu.00200.2003","article-title":"Disrupted circadian rhythms in VIP- and PHI-deficient mice","volume":"285","author":"Colwell","year":"2003","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.immuni.2025.05.002_bib64","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.immuni.2020.10.001","article-title":"Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens","volume":"53","author":"Perner","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2025.05.002_bib65","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/j.jaci.2013.01.015","article-title":"Role of IL-17A and neutrophils in fibrosis in experimental hypersensitivity pneumonitis","volume":"131","author":"Hasan","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.immuni.2025.05.002_bib66","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-68377-9","article-title":"Targeted proteomic approach for quantification of collagen type I and type III in formalin-fixed paraffin-embedded tissue","volume":"14","author":"Rosin","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.immuni.2025.05.002_bib67","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/s41586-022-05660-7","article-title":"Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE","volume":"614","author":"Pernet","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2025.05.002_bib68","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.it.2018.09.002","article-title":"The Lung Microvasculature Is a Functional Immune Niche","volume":"39","author":"Granton","year":"2018","journal-title":"Trends Immunol."},{"key":"10.1016\/j.immuni.2025.05.002_bib69","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.cell.2020.09.062","article-title":"M. tuberculosis Reprograms Hematopoietic Stem Cells to Limit Myelopoiesis and Impair Trained Immunity","volume":"183","author":"Khan","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2025.05.002_bib70","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.exphem.2016.12.008","article-title":"Shipping mouse bone marrow: Keep it in the bone","volume":"49","author":"Papazian","year":"2017","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.immuni.2025.05.002_bib71","first-page":"2099","article-title":"An orally active small molecule TGF-beta receptor I antagonist inhibits the growth of metastatic murine breast cancer","volume":"29","author":"Rausch","year":"2009","journal-title":"Anticancer Res."},{"key":"10.1016\/j.immuni.2025.05.002_bib72","article-title":"Neutrophil Extracellular Traps Effectively Control Acute Chikungunya Virus Infection","volume":"10","author":"Hiroki","year":"2019","journal-title":"Front. Immunol."}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761325002213?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761325002213?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:28:02Z","timestamp":1778797682000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761325002213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":72,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S1074761325002213"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2025.05.002","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2025.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}