{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:14:47Z","timestamp":1793103287108,"version":"4.5.0"},"reference-count":125,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"am","delay-in-days":372,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI169789"],"award-info":[{"award-number":["R21AI169789"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI121840"],"award-info":[{"award-number":["R21AI121840"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI180874"],"award-info":[{"award-number":["R21AI180874"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK007792"],"award-info":[{"award-number":["DK007792"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK130425"],"award-info":[{"award-number":["R01DK130425"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R44AI176894"],"award-info":[{"award-number":["R44AI176894"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI160706"],"award-info":[{"award-number":["R01AI160706"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI052066"],"award-info":[{"award-number":["AI052066"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI142985"],"award-info":[{"award-number":["R01AI142985"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI093637"],"award-info":[{"award-number":["R01AI093637"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI176069"],"award-info":[{"award-number":["R21AI176069"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["R21AI121840"],"award-info":[{"award-number":["R21AI121840"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["R21AI169789"],"award-info":[{"award-number":["R21AI169789"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["R01AI142985"],"award-info":[{"award-number":["R01AI142985"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["R01DK130425"],"award-info":[{"award-number":["R01DK130425"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["R01AI093637"],"award-info":[{"award-number":["R01AI093637"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["DK007792"],"award-info":[{"award-number":["DK007792"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["R44AI176894"],"award-info":[{"award-number":["R44AI176894"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["R21AI180874"],"award-info":[{"award-number":["R21AI180874"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["AI052066"],"award-info":[{"award-number":["AI052066"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["R01AI160706"],"award-info":[{"award-number":["R01AI160706"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["R21AI176069"],"award-info":[{"award-number":["R21AI176069"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007319","name":"Albert Einstein College of Medicine, Yeshiva University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007737","name":"St. Jude Children's Research Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007737","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.immuni.2025.05.025","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T10:31:51Z","timestamp":1750847511000},"page":"1742-1761.e14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prolonged but finite antigen presentation promotes reversible defects of \u201chelpless\u201d memory CD8+ T cells"],"prefix":"10.1016","volume":"58","author":[{"given":"Verena","family":"van der Heide","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Laghlali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bennett","family":"Davenport","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Cubitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Roudko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Choo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Jhun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Humblin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abishek","family":"Vaidya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista","family":"Angeliadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glaucia","family":"Furtado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice O.","family":"Kamphorst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schotsaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafi","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"de la Torre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7622-5754","authenticated-orcid":false,"given":"Dirk","family":"Homann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2025.05.025_bib1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev.immunol.25.022106.141548","article-title":"Effector and memory CTL differentiation","volume":"25","author":"Williams","year":"2007","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib2","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s12026-007-0081-4","article-title":"CD8 T cell memory development: CD4 T cell help is appreciated","volume":"39","author":"Khanolkar","year":"2007","journal-title":"Immunol. Res."},{"key":"10.1016\/j.immuni.2025.05.025_bib3","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1002\/eji.201142205","article-title":"From crucial to negligible: functional CD8(+) T-cell responses and their dependence on CD4(+) T-cell help","volume":"42","author":"Wiesel","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib4","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nri.2015.10","article-title":"The multifaceted role of CD4(+) T cells in CD8(+) T cell memory","volume":"16","author":"Laidlaw","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib5","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/s41577-018-0044-0","article-title":"CD4(+) T cell help in cancer immunology and immunotherapy","volume":"18","author":"Borst","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib6","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20211519","article-title":"DCs at the center of help: Origins and evolution of the three-cell-type hypothesis","volume":"219","author":"Wu","year":"2022","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2025.05.025_bib7","doi-asserted-by":"crossref","first-page":"5791","DOI":"10.4049\/jimmunol.161.11.5791","article-title":"Immune responses in the absence of costimulation: viruses know the trick","volume":"161","author":"Bachmann","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib8","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/ni978","article-title":"Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon","volume":"4","author":"Le Bon","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib9","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nri1413","article-title":"Helping the CD8(+) T-cell response","volume":"4","author":"Bevan","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib10","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/nature01441","article-title":"CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes","volume":"421","author":"Janssen","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2025.05.025_bib11","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1126\/science.1082305","article-title":"Requirement for CD4 T cell help in generating functional CD8 T cell memory","volume":"300","author":"Shedlock","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.immuni.2025.05.025_bib12","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1126\/science.1083317","article-title":"Defective CD8 T cell memory following acute infection without CD4 T cell help","volume":"300","author":"Sun","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.immuni.2025.05.025_bib13","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nri2251","article-title":"Shaping and reshaping CD8+ T-cell memory","volume":"8","author":"Harty","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib14","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/s41590-023-01517-x","article-title":"CD4(+) T cell calibration of antigen-presenting cells optimizes antiviral CD8(+) T cell immunity","volume":"24","author":"Gressier","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib15","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nature03337","article-title":"CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death","volume":"434","author":"Janssen","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2025.05.025_bib16","doi-asserted-by":"crossref","first-page":"999","DOI":"10.4049\/jimmunol.177.2.999","article-title":"TRAIL deficiency delays, but does not prevent, erosion in the quality of \"helpless\" memory CD8 T cells","volume":"177","author":"Badovinac","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib17","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.4049\/jimmunol.0802041","article-title":"Recall responses by helpless memory CD8+ T cells are restricted by the up-regulation of PD-1","volume":"182","author":"Fuse","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib18","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1084\/jem.20070841","article-title":"Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells","volume":"204","author":"Intlekofer","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2025.05.025_bib19","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/159152","article-title":"Shaping successful and unsuccessful CD8 T cell responses following infection","volume":"2010","author":"Cox","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.immuni.2025.05.025_bib20","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.immuni.2014.09.007","article-title":"CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection","volume":"41","author":"Laidlaw","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2025.05.025_bib21","doi-asserted-by":"crossref","first-page":"4481","DOI":"10.1073\/pnas.1808849116","article-title":"CD4(+) T help promotes influenza virus-specific CD8(+) T cell memory by limiting metabolic dysfunction","volume":"116","author":"Cullen","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2025.05.025_bib22","doi-asserted-by":"crossref","first-page":"865","DOI":"10.4049\/jimmunol.181.2.865","article-title":"Cutting edge: chromatin remodeling as a molecular basis for the enhanced functionality of memory CD8 T cells","volume":"181","author":"Northrop","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib23","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.4049\/jimmunol.177.2.1062","article-title":"Epigenetic remodeling of the IL-2 and IFN-gamma loci in memory CD8 T cells is influenced by CD4 T cells","volume":"177","author":"Northrop","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib24","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.4049\/jimmunol.1600591","article-title":"Immediate Dysfunction of Vaccine-Elicited CD8+ T Cells Primed in the Absence of CD4+ T Cells","volume":"197","author":"Provine","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.592569","article-title":"Helpless Priming Sends CD8(+) T Cells on the Road to Exhaustion","volume":"11","author":"Busselaar","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109696","article-title":"CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection","volume":"36","author":"Lu","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2025.05.025_bib27","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1084\/jem.20050137","article-title":"Differential contributions of central and effector memory T cells to recall responses","volume":"202","author":"Roberts","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2025.05.025_bib28","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1084\/jem.20070322","article-title":"Activation phenotype, rather than central- or effector-memory phenotype, predicts the recall efficacy of memory CD8+ T cells","volume":"204","author":"Hikono","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2025.05.025_bib29","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.immuni.2007.08.007","article-title":"Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection","volume":"27","author":"Kaech","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2025.05.025_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005219","article-title":"Phenotypic and Functional Alterations in Circulating Memory CD8 T Cells with Time after Primary Infection","volume":"11","author":"Martin","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.immuni.2025.05.025_bib31","doi-asserted-by":"crossref","first-page":"3942","DOI":"10.1172\/JCI88546","article-title":"Aging promotes acquisition of naive-like CD8+ memory T cell traits and enhanced functionalities","volume":"126","author":"Eberlein","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.immuni.2025.05.025_bib32","doi-asserted-by":"crossref","first-page":"460","DOI":"10.4049\/jimmunol.1801277","article-title":"Aging of Antiviral CD8(+) Memory T Cells Fosters Increased Survival, Metabolic Adaptations, and Lymphoid Tissue Homing","volume":"202","author":"Davenport","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008144","article-title":"Aging boosts antiviral CD8+T cell memory through improved engagement of diversified recall response determinants","volume":"15","author":"Davenport","year":"2019","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.immuni.2025.05.025_bib34","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.4049\/jimmunol.2000254","article-title":"Chemokine Signatures of Pathogen-Specific T Cells II: Memory T Cells in Acute and Chronic Infection","volume":"205","author":"Davenport","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib35","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/j.immuni.2016.10.018","article-title":"The Chemokine Receptor CX3CR1 Defines Three Antigen-Experienced CD8 T Cell Subsets with Distinct Roles in Immune Surveillance and Homeostasis","volume":"45","author":"Gerlach","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2025.05.025_bib36","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1016\/j.immuni.2023.06.025","article-title":"Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation","volume":"56","author":"Zwijnenburg","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2025.05.025_bib37","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01556-22","article-title":"Longitudinal Analysis of the Phenotype, Transcriptional Profile, and Anatomic Location of Memory CD8 T Cell Subsets after Acute Viral Infection","volume":"97","author":"Gill","year":"2023","journal-title":"J. Virol."},{"key":"10.1016\/j.immuni.2025.05.025_bib38","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/imcb.12274","article-title":"The metabolic spectrum of memory T cells","volume":"97","author":"O'Sullivan","year":"2019","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.immuni.2025.05.025_bib39","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/nature25144","article-title":"Effector CD8 T cells dedifferentiate into long-lived memory cells","volume":"552","author":"Youngblood","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2025.05.025_bib40","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.immuni.2008.02.020","article-title":"Human effector and memory CD8+ T cell responses to smallpox and yellow fever vaccines","volume":"28","author":"Miller","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2025.05.025_bib41","doi-asserted-by":"crossref","first-page":"7919","DOI":"10.4049\/jimmunol.0803903","article-title":"The yellow fever virus vaccine induces a broad and polyfunctional human memory CD8+ T cell response","volume":"183","author":"Akondy","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib42","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/nature24633","article-title":"Origin and differentiation of human memory CD8 T cells after vaccination","volume":"552","author":"Akondy","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2025.05.025_bib43","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1128\/jvi.62.6.2102-2106.1988","article-title":"T4+ T helper cell function in vivo: differential requirement for induction of antiviral cytotoxic T-cell and antibody responses","volume":"62","author":"Ahmed","year":"1988","journal-title":"J. Virol."},{"key":"10.1016\/j.immuni.2025.05.025_bib44","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/353180a0","article-title":"Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4","volume":"353","author":"Rahemtulla","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2025.05.025_bib45","doi-asserted-by":"crossref","first-page":"8056","DOI":"10.1128\/jvi.68.12.8056-8063.1994","article-title":"CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection","volume":"68","author":"Matloubian","year":"1994","journal-title":"J. Virol."},{"key":"10.1016\/j.immuni.2025.05.025_bib46","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1006\/viro.1995.1477","article-title":"An essential role for type 1 interferon-gamma in terminating persistent viral infection","volume":"212","author":"Tishon","year":"1995","journal-title":"Virology"},{"key":"10.1016\/j.immuni.2025.05.025_bib47","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1128\/jvi.70.2.1072-1079.1996","article-title":"CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge","volume":"70","author":"von Herrath","year":"1996","journal-title":"J. Virol."},{"key":"10.1016\/j.immuni.2025.05.025_bib48","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.immuni.2007.04.013","article-title":"Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8(+) T cell response to infection","volume":"26","author":"Badovinac","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2025.05.025_bib49","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.immuni.2013.05.009","article-title":"Effector-like CD8(+) T cells in the memory population mediate potent protective immunity","volume":"38","author":"Olson","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2025.05.025_bib50","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.immuni.2018.03.015","article-title":"KLRG1(+) Effector CD8(+) T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity","volume":"48","author":"Herndler-Brandstetter","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2025.05.025_bib51","doi-asserted-by":"crossref","first-page":"25667","DOI":"10.1073\/pnas.2008571117","article-title":"Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population","volume":"117","author":"Milner","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2025.05.025_bib52","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/j.immuni.2023.06.005","article-title":"Single-cell protein expression profiling resolves circulating and resident memory T cell diversity across tissues and infection contexts","volume":"56","author":"Evrard","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2025.05.025_bib53","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1084\/jem.20102110","article-title":"Inflammatory chemokine receptors regulate CD8(+) T cell contraction and memory generation following infection","volume":"208","author":"Kohlmeier","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2025.05.025_bib54","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.immuni.2013.09.013","article-title":"Lung airway-surveilling CXCR3(hi) memory CD8(+) T cells are critical for protection against influenza A virus","volume":"39","author":"Sl\u00fctter","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2025.05.025_bib55","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.4049\/jimmunol.1901512","article-title":"KLRG1(+) Memory CD8 T Cells Combine Properties of Short-Lived Effectors and Long-Lived Memory","volume":"205","author":"Renkema","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib56","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/ni889","article-title":"Lineage relationship and protective immunity of memory CD8 T cell subsets","volume":"4","author":"Wherry","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib57","doi-asserted-by":"crossref","first-page":"4686","DOI":"10.4049\/jimmunol.175.7.4686","article-title":"Functional properties and lineage relationship of CD8+ T cell subsets identified by expression of IL-7 receptor alpha and CD62L","volume":"175","author":"Bachmann","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib58","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.immuni.2007.07.010","article-title":"Inflammation Directs Memory Precursor and Short-Lived Effector CD8(+) T Cell Fates via the Graded Expression of T-bet Transcription Factor","volume":"27","author":"Joshi","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2025.05.025_bib59","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.1016\/j.celrep.2018.03.020","article-title":"Active Maintenance of T Cell Memory in Acute and Chronic Viral Infection Depends on Continuous Expression of FOXO1","volume":"22","author":"Utzschneider","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2025.05.025_bib60","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.immuni.2010.08.002","article-title":"Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1","volume":"33","author":"Zhou","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2025.05.025_bib61","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1146\/annurev-immunol-041015-055318","article-title":"CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer","volume":"37","author":"McLane","year":"2019","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib62","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/ni1227","article-title":"Initial T cell frequency dictates memory CD8+ T cell lineage commitment","volume":"6","author":"Marzo","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib63","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1084\/jem.20001021","article-title":"Estimating the precursor frequency of naive antigen-specific CD8 T cells","volume":"195","author":"Blattman","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2025.05.025_bib64","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/ni1009","article-title":"Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells","volume":"4","author":"Kaech","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib65","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1084\/jem.20071641","article-title":"Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates","volume":"205","author":"Sarkar","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2025.05.025_bib66","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.immuni.2013.07.014","article-title":"Environmental cues dictate the fate of individual CD8+ T cells responding to infection","volume":"39","author":"Plumlee","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2025.05.025_bib67","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.immuni.2017.10.009","article-title":"CD4(+) T Cell Help Confers a Cytotoxic T Cell Effector Program Including Coinhibitory Receptor Downregulation and Increased Tissue Invasiveness","volume":"47","author":"Ahrends","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2025.05.025_bib68","article-title":"Dimensionality reduction for visualizing single-cell data using UMAP","author":"Becht","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.immuni.2025.05.025_bib69","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-41695-z","article-title":"From Louvain to Leiden: guaranteeing well-connected communities","volume":"9","author":"Traag","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.immuni.2025.05.025_bib70","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1038\/s41590-022-01338-4","article-title":"Shared and distinct biological circuits in effector, memory and exhausted CD8(+) T cells revealed by temporal single-cell transcriptomics and epigenetics","volume":"23","author":"Giles","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib71","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-25960-2","article-title":"Confronting false discoveries in single-cell differential expression","volume":"12","author":"Squair","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2025.05.025_bib72","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-35519-4","article-title":"A balanced measure shows superior performance of pseudobulk methods in single-cell RNA-sequencing analysis","volume":"13","author":"Murphy","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2025.05.025_bib73","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1016\/j.celrep.2018.01.072","article-title":"Suppression of Tcf1 by Inflammatory Cytokines Facilitates Effector CD8 T Cell Differentiation","volume":"22","author":"Danilo","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2025.05.025_bib74","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.immuni.2020.09.005","article-title":"Central memory CD8(+) T cells derive from stem-like Tcf7(hi) effector cells in the absence of cytotoxic differentiation","volume":"53","author":"Pais Ferreira","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2025.05.025_bib75","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adh3113","article-title":"Emergence and fate of stem cell-like Tcf7(+) CD8(+) T cells during a primary immune response to viral infection","volume":"8","author":"Silva","year":"2023","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib76","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abe3702","article-title":"Inhibitory signaling sustains a distinct early memory CD8(+) T cell precursor that is resistant to DNA damage","volume":"6","author":"Johnnidis","year":"2021","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib77","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1084\/jem.191.7.1241","article-title":"Differentiating between memory and effector CD8 T cells by altered expression of cell surface O-glycans","volume":"191","author":"Harrington","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2025.05.025_bib78","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1038\/ni.3248","article-title":"TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow","volume":"16","author":"Yang","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib79","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.immuni.2023.12.006","article-title":"Reversible, tunable epigenetic silencing of TCF1 generates flexibility in the T cell memory decision","volume":"57","author":"Abadie","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2025.05.025_bib80","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1002\/eji.201847772","article-title":"Residual LCMV antigen in transiently CD4(+) T cell-depleted mice induces high levels of virus-specific antibodies but only limited B-cell memory","volume":"49","author":"Schweier","year":"2019","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib81","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/eji.200324717","article-title":"Maintenance of memory CTL responses by T helper cells and CD40-CD40 ligand: antibodies provide the key","volume":"34","author":"Bachmann","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib82","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000041","article-title":"Tentative T cells: memory cells are quick to respond, but slow to divide","volume":"4","author":"Whitmire","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.immuni.2025.05.025_bib83","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1084\/jem.20131271","article-title":"Memory CD8+ T cells exhibit increased antigen threshold requirements for recall proliferation","volume":"211","author":"Mehlhop-Williams","year":"2014","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2025.05.025_bib84","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.immuni.2018.08.002","article-title":"CD8(+) T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity","volume":"49","author":"Snell","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2025.05.025_bib85","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1128\/JVI.75.11.5099-5107.2001","article-title":"In vivo selection of a lymphocytic choriomeningitis virus variant that affects recognition of the GP33-43 epitope by H-2Db but not H-2Kb","volume":"75","author":"Puglielli","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.immuni.2025.05.025_bib86","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.virol.2006.01.012","article-title":"Rescue of the prototypic Arenavirus LCMV entirely from plasmid","volume":"350","author":"S\u00e1nchez","year":"2006","journal-title":"Virology"},{"key":"10.1016\/j.immuni.2025.05.025_bib87","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1038\/nature04790","article-title":"Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells","volume":"441","author":"Williams","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2025.05.025_bib88","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/ni1105","article-title":"CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection","volume":"5","author":"Sun","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib89","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adg3868","article-title":"Cellular and molecular waypoints along the path of T cell exhaustion","volume":"8","author":"Lan","year":"2023","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib90","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/imr.12653","article-title":"The (gradual) rise of memory inflation","volume":"283","author":"Klenerman","year":"2018","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.immuni.2025.05.025_bib91","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.it.2011.02.006","article-title":"T cell responses during influenza infection: getting and keeping control","volume":"32","author":"Kim","year":"2011","journal-title":"Trends Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib92","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1038\/s41590-023-01601-2","article-title":"SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC)","volume":"24","author":"Proal","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib93","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s41590-023-01724-6","article-title":"Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2","volume":"25","author":"Yin","year":"2024","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib94","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1038\/s41590-021-00975-5","article-title":"Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation","volume":"22","author":"Abdel-Hakeem","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib95","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-13438-1","article-title":"CD4(+) T cell help creates memory CD8(+) T cells with innate and help-independent recall capacities","volume":"10","author":"Ahrends","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2025.05.025_bib96","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/s41586-024-08562-y","article-title":"An early precursor CD8(+) T cell that adapts to acute or chronic viral infection","volume":"640","author":"McManus","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2025.05.025_bib97","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/s41586-024-08451-4","article-title":"Precursors of exhausted T cells are pre-emptively formed in acute infection","volume":"640","author":"Chu","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2025.05.025_bib98","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adn1945","article-title":"Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression","volume":"10","author":"Gago da Gra\u00e7a","year":"2025","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib99","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-48704-4","article-title":"Memory CD8 T cells are vulnerable to chronic IFN-gamma signals but not to CD4 T cell deficiency in MHCII-deficient mice","volume":"15","author":"Setoguchi","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2025.05.025_bib100","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.4049\/jimmunol.1001421","article-title":"Homeostatic turnover of virus-specific memory CD8 T cells occurs stochastically and is independent of CD4 T cell help","volume":"185","author":"Choo","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib101","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1038\/nm1670","article-title":"Extralymphatic virus sanctuaries as a consequence of potent T-cell activation","volume":"13","author":"Recher","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2025.05.025_bib102","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/ni.3224","article-title":"Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells","volume":"16","author":"Laidlaw","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib103","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.immuni.2015.05.023","article-title":"Quiescence of Memory CD8(+) T Cells Is Mediated by Regulatory T Cells through Inhibitory Receptor CTLA-4","volume":"42","author":"Kalia","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2025.05.025_bib110","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nature07657","article-title":"Complete but curtailed T-cell response to very low-affinity antigen","volume":"458","author":"Zehn","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2025.05.025_bib111","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.celrep.2016.09.072","article-title":"A Minimum Epitope Overlap between Infections Strongly Narrows the Emerging T Cell Repertoire","volume":"17","author":"Oberle","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2025.05.025_bib108","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1084\/jem.20102545","article-title":"Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells","volume":"208","author":"Hickman","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2025.05.025_bib104","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/342559a0","article-title":"Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen","volume":"342","author":"Pircher","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2025.05.025_bib115","doi-asserted-by":"crossref","first-page":"8431","DOI":"10.1128\/JVI.79.13.8431-8439.2005","article-title":"Attenuation of equine influenza viruses through truncations of the NS1 protein","volume":"79","author":"Quinlivan","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.immuni.2025.05.025_bib122","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omics"},{"key":"10.1016\/j.immuni.2025.05.025_bib124","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.immuni.2025.05.025_bib121","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-017-1382-0","article-title":"SCANPY: large-scale single-cell gene expression data analysis","volume":"19","author":"Wolf","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.immuni.2025.05.025_bib123","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41590-018-0276-y","article-title":"Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage","volume":"20","author":"Aran","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib125","doi-asserted-by":"crossref","DOI":"10.1093\/bioadv\/vbac016","article-title":"decoupleR: ensemble of computational methods to infer biological activities from omics data","volume":"2","author":"Badia-I-Mompel","year":"2022","journal-title":"Bioinform. Adv."},{"key":"10.1016\/j.immuni.2025.05.025_bib105","doi-asserted-by":"crossref","first-page":"911","DOI":"10.4049\/jimmunol.1700595","article-title":"Differential Requirements for Tcf1 Long Isoforms in CD8(+) and CD4(+) T Cell Responses to Acute Viral Infection","volume":"199","author":"Gullicksrud","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib106","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1084\/jem.160.2.521","article-title":"Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence","volume":"160","author":"Ahmed","year":"1984","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2025.05.025_bib107","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1084\/jem.167.5.1719","article-title":"Organ-specific selection of viral variants during chronic infection","volume":"167","author":"Ahmed","year":"1988","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2025.05.025_bib109","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.4049\/jimmunol.168.4.1528","article-title":"Cutting edge: CD4 and CD8 T cells are intrinsically different in their proliferative responses","volume":"168","author":"Foulds","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2025.05.025_bib112","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1073\/pnas.0900088106","article-title":"Generation of recombinant lymphocytic choriomeningitis viruses with trisegmented genomes stably expressing two additional genes of interest","volume":"106","author":"Emonet","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2025.05.025_bib113","doi-asserted-by":"crossref","first-page":"12166","DOI":"10.1128\/JVI.02075-15","article-title":"General Molecular Strategy for Development of Arenavirus Live-Attenuated Vaccines","volume":"89","author":"Iwasaki","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.immuni.2025.05.025_bib114","doi-asserted-by":"crossref","first-page":"7235","DOI":"10.1073\/pnas.1232449100","article-title":"Protection and compensation in the influenza virus-specific CD8+ T cell response","volume":"100","author":"Webby","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2025.05.025_bib116","doi-asserted-by":"crossref","DOI":"10.3791\/2057","article-title":"Generation of recombinant influenza virus from plasmid DNA","author":"Mart\u00ednez-Sobrido","year":"2010","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.immuni.2025.05.025_bib117","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/cyto.a.22451","article-title":"Improved method to retain cytosolic reporter protein fluorescence while staining for nuclear proteins","volume":"85","author":"Heinen","year":"2014","journal-title":"Cytometry A"},{"key":"10.1016\/j.immuni.2025.05.025_bib118","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/cyto.a.21010","article-title":"Interpretation of cellular proliferation data: avoid the panglossian","volume":"79","author":"Roederer","year":"2011","journal-title":"Cytometry A"},{"key":"10.1016\/j.immuni.2025.05.025_bib119","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jim.2006.04.005","article-title":"Simultaneous assessment of antigen-stimulated cytokine production and memory subset composition of memory CD8 T cells","volume":"313","author":"Jabbari","year":"2006","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.immuni.2025.05.025_bib120","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14049","article-title":"Massively parallel digital transcriptional profiling of single cells","volume":"8","author":"Zheng","year":"2017","journal-title":"Nat. Commun."}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761325002468?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761325002468?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T09:04:56Z","timestamp":1761642296000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761325002468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":125,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S1074761325002468"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2025.05.025","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.01.22.576725","asserted-by":"object"}]},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prolonged but finite antigen presentation promotes reversible defects of \u201chelpless\u201d memory CD8+ T cells","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2025.05.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}