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Dis."},{"key":"10.1016\/j.immuni.2025.06.014_bib73","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1086\/319283","article-title":"Procalcitonin as a Parameter of Disease Severity and Risk of Mortality in Patients with Plasmodium falciparum Malaria","volume":"183","author":"Chiwakata","year":"2001","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.immuni.2025.06.014_bib74","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/1475-2875-8-206","article-title":"Procalcitonin as a biomarker for severe Plasmodium falciparum disease: A critical appraisal of a semi-quantitative point-of-care test in a cohort of travellers with imported malaria","volume":"8","author":"Hesselink","year":"2009","journal-title":"Malar. 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Immunol."},{"key":"10.1016\/j.immuni.2025.06.014_bib78","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1128\/jcm.27.8.1887-1889.1989","article-title":"Evolution of the Levels of Soluble Interleukin-2 Receptors during Plasmodium falciparum and P. vivax Malaria","volume":"27","author":"Deloron","year":"1989","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.immuni.2025.06.014_bib79","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12916-019-1255-3","article-title":"Antibody responses to merozoite antigens after natural Plasmodium falciparum infection: Kinetics and longevity in absence of re-exposure","volume":"17","author":"Yman","year":"2019","journal-title":"BMC Med."},{"key":"10.1016\/j.immuni.2025.06.014_bib80","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-27863-8","article-title":"Distinct kinetics of antibodies to 111 Plasmodium falciparum proteins identifies markers of recent malaria exposure","volume":"13","author":"Yman","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2025.06.014_bib81","article-title":"B cell profiling in malaria reveals expansion and remodelling of CD11c+ B cell subsets","volume":"5","author":"Sundling","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.immuni.2025.06.014_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.tmaid.2025.102861","article-title":"Fever in travelers returning from tropical and subtropical areas: a hospital-based study of factors affecting investigations and diagnoses in children and adults","volume":"65","author":"Sond\u00e9n","year":"2025","journal-title":"Travel Med. Infect. Dis."},{"key":"10.1016\/j.immuni.2025.06.014_bib83","doi-asserted-by":"crossref","first-page":"e272","DOI":"10.1097\/CCM.0000000000005318","article-title":"Peripheral Oxygen Saturation Facilitates Assessment of Respiratory Dysfunction in the Sequential Organ Failure Assessment Score with Implications for the Sepsis-3 Criteria","volume":"50","author":"Valik","year":"2022","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.immuni.2025.06.014_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2021.100168","article-title":"Proximity Extension Assay in Combination with Next-Generation Sequencing for High-throughput Proteome-wide Analysis","volume":"20","author":"Wik","year":"2021","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.immuni.2025.06.014_bib85","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2025.06.014_bib86","doi-asserted-by":"crossref","DOI":"10.21105\/joss.01686","article-title":"Welcome to the Tidyverse","volume":"4","author":"Wickham","year":"2019","journal-title":"J. Open Source Softw."},{"key":"10.1016\/j.immuni.2025.06.014_bib87","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.immuni.2025.06.014_bib88","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1093\/bioinformatics\/btu393","article-title":"Genome analysis circlize implements and enhances circular visualization in R","volume":"30","author":"Gu","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.immuni.2025.06.014_bib89","unstructured":"Chang, W., Cheng, J., Allaire, J.J., Sievert, C., Schloerke, B., Xie, Y., Allen, J., McPherson, J., Dipert, A., and Borges, B. (2023). shiny: Web Application Framework for R. https:\/\/cran.r-project.org\/web\/packages\/shiny\/index.html."},{"key":"10.1016\/j.immuni.2025.06.014_bib90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v082.i13","article-title":"lmerTest Package: Tests in Linear Mixed Effects Models","volume":"82","author":"Kuznetsova","year":"2017","journal-title":"J. Stat. Softw."},{"key":"10.1016\/j.immuni.2025.06.014_bib91","unstructured":"Lenth, R.V. (2024). emmeans: Estimated Marginal Means, aka Least-Squares Means. https:\/\/cran.r-project.org\/web\/packages\/emmeans\/emmeans.pdf."},{"key":"10.1016\/j.immuni.2025.06.014_bib92","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Series B Stat. Methodol."},{"key":"10.1016\/j.immuni.2025.06.014_bib93","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb)"},{"key":"10.1016\/j.immuni.2025.06.014_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.03.063","article-title":"A Targeted Multi-omic Analysis Approach Measures Protein Expression and Low-Abundance Transcripts on the Single-Cell Level","volume":"31","author":"Mair","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2025.06.014_bib95","doi-asserted-by":"crossref","DOI":"10.1038\/s41596-024-01137-1","article-title":"CellPhoneDB v5: inferring cell-cell communication from single-cell multiomics data","author":"Troul\u00e9","year":"2025","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.immuni.2025.06.014_bib96","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/1471-2105-12-253","article-title":"Sparse PLS discriminant analysis: Biologically relevant feature selection and graphical displays for multiclass problems","volume":"12","author":"L\u00ea Cao","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.immuni.2025.06.014_bib97","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: Gene set variation analysis for microarray and RNA-Seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.immuni.2025.06.014_bib98","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1000217","article-title":"Inferring Pathway Activity toward Precise Disease Classification","volume":"4","author":"Lee","year":"2008","journal-title":"PLoS Comput. 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