{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:08:09Z","timestamp":1792710489153,"version":"4.5.0"},"reference-count":88,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Foundation for Medical Research","doi-asserted-by":"publisher","award":["ECO202206015529"],"award-info":[{"award-number":["ECO202206015529"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","award":["ANR-22-CE14-0033"],"award-info":[{"award-number":["ANR-22-CE14-0033"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","award":["ANR-18-CE15-0002"],"award-info":[{"award-number":["ANR-18-CE15-0002"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004100","name":"Labex","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004100","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016842","name":"Institut Fran\u00e7ais de Bioinformatique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016842","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.immuni.2026.01.015","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T15:34:01Z","timestamp":1769787241000},"page":"354-371.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["B cell-intrinsic IL-2 signaling regulates inflammation by promoting IL-10 expression in CD25+ age-associated B cells"],"prefix":"10.1016","volume":"59","author":[{"given":"Juliette","family":"Gauthier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Maugendre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"L\u00e9onard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoni","family":"Desvois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00efwenn","family":"Pineau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Pinon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Hipp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Tarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Am\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Hillion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Michel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Delaloy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2026.01.015_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2014.00065","article-title":"Cytokine-Mediated Regulation of Plasma Cell Generation: IL-21 Takes Center Stage","volume":"5","author":"Moens","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2026.01.015_bib2","doi-asserted-by":"crossref","first-page":"3940","DOI":"10.1182\/blood-2013-06-506865","article-title":"IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts","volume":"122","author":"Berglund","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2026.01.015_bib3","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1084\/jem.20090313","article-title":"IL-4 producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells","volume":"206","author":"King","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2026.01.015_bib4","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/ni.1715","article-title":"Cytokine-secreting follicular T cells shape the antibody repertoire","volume":"10","author":"Reinhardt","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2026.01.015_bib5","doi-asserted-by":"crossref","first-page":"7867","DOI":"10.4049\/jimmunol.175.12.7867","article-title":"IL-21 Induces Differentiation of Human Naive and Memory B Cells into Antibody-Secreting Plasma Cells","volume":"175","author":"Ettinger","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2026.01.015_bib6","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.immuni.2009.10.008","article-title":"Analysis of Interleukin-21-Induced Prdm1 Gene Regulation Reveals Functional Cooperation of STAT3 and IRF4 Transcription Factors","volume":"31","author":"Kwon","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.01.015_bib7","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/ni.3348","article-title":"Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response","volume":"17","author":"Tellier","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2026.01.015_bib8","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.immuni.2024.02.018","article-title":"Interleukin-4 downregulates transcription factor BCL6 to promote memory B cell selection in germinal centers","volume":"57","author":"Shehata","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.01.015_bib9","doi-asserted-by":"crossref","DOI":"10.1126\/science.aao2933","article-title":"Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells","volume":"361","author":"DiToro","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.immuni.2026.01.015_bib10","doi-asserted-by":"crossref","first-page":"11234","DOI":"10.1074\/jbc.M111.324046","article-title":"STAT5 Protein Negatively Regulates T Follicular Helper (Tfh) Cell Generation and Function","volume":"287","author":"Nurieva","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.immuni.2026.01.015_bib11","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.jaci.2006.10.007","article-title":"CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked\u2013like syndrome, and defective IL-10 expression from CD4 lymphocytes","volume":"119","author":"Caudy","year":"2007","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.immuni.2026.01.015_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-01475-7","article-title":"IL-2 imprints human naive B cell fate towards plasma cell through ERK\/ELK1-mediated BACH2 repression","volume":"8","author":"Hipp","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2026.01.015_bib13","first-page":"373","article-title":"The acquisition of cytokine responsiveness by murine B cells: a role for antigen and IL-5 in the induction of IL-2 receptors","volume":"81","author":"Poudrier","year":"1994","journal-title":"Immunology"},{"key":"10.1016\/j.immuni.2026.01.015_bib14","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1182\/blood-2011-01-331462","article-title":"Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c+ B-cell population is important for the development of autoimmunity","volume":"118","author":"Rubtsov","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2026.01.015_bib15","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1182\/blood-2011-01-330530","article-title":"A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice","volume":"118","author":"Hao","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2026.01.015_bib16","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1126\/science.adf8531","article-title":"The transcription factor ZEB2 drives the formation of age-associated B cells","volume":"383","author":"Dai","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.immuni.2026.01.015_bib17","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.4049\/jimmunol.1600522","article-title":"Cutting Edge: IL-4, IL-21, and IFN-\u03b3 Interact to Govern T-Bet and CD11c Expression in TLR-Activated B Cells","volume":"197","author":"Naradikian","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2026.01.015_bib18","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s12026-012-8365-8","article-title":"TLR7 drives accumulation of ABCs and autoantibody production in autoimmune-prone mice","volume":"55","author":"Rubtsov","year":"2013","journal-title":"Immunol. Res."},{"key":"10.1016\/j.immuni.2026.01.015_bib19","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.41641","article-title":"IFN\u03b3 induces epigenetic programming of human T-bethi B cells and promotes TLR7\/8 and IL-21 induced differentiation","volume":"8","author":"Zumaquero","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.immuni.2026.01.015_bib20","doi-asserted-by":"crossref","first-page":"E3216","DOI":"10.1073\/pnas.1312348110","article-title":"T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance","volume":"110","author":"Rubtsova","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2026.01.015_bib21","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.immuni.2018.08.015","article-title":"Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus","volume":"49","author":"Jenks","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.01.015_bib22","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20221346","article-title":"Age-associated B cells are heterogeneous and dynamic drivers of autoimmunity in mice","volume":"220","author":"Nickerson","year":"2023","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2026.01.015_bib23","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ade6844","article-title":"Gammaherpesvirus infection drives age-associated B cells toward pathogenicity in EAE and MS","volume":"8","author":"Mouat","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.immuni.2026.01.015_bib24","doi-asserted-by":"crossref","first-page":"161","DOI":"10.4049\/jimmunol.1200301","article-title":"IL-2 requirement for human plasma cell generation: coupling differentiation and proliferation by enhancing MAPK-ERK signaling","volume":"189","author":"Le Gallou","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2026.01.015_bib25","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-021-02375-w","article-title":"Dysregulated B cell differentiation towards antibody-secreting cells in neuromyelitis optica spectrum disorder","volume":"19","author":"Hoshino","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.immuni.2026.01.015_bib26","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1016\/j.immuni.2024.11.006","article-title":"Interleukin-2-secreting T helper cells promote extra-follicular B cell maturation via intrinsic regulation of a B cell mTOR-AKT-Blimp-1 axis","volume":"57","author":"Faliti","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.01.015_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109096","article-title":"Bach2 attenuates IL-2R signaling to control Treg homeostasis and Tfr development","volume":"35","author":"Zhang","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2026.01.015_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-37424-w","article-title":"Low-dose IL-2 enhances the generation of IL-10-producing immunoregulatory B cells","volume":"14","author":"Inaba","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2026.01.015_bib29","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.celrep.2015.09.070","article-title":"Transcriptomics identify CD9 as a marker of murine IL-10-competent regulatory B cells","volume":"13","author":"Sun","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2026.01.015_bib30","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1681\/ASN.2014040404","article-title":"Tolerant Kidney Transplant Patients Produce B Cells with Regulatory Properties","volume":"26","author":"Chesneau","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.immuni.2026.01.015_bib31","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1172\/JCI46274","article-title":"Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice","volume":"121","author":"Ding","year":"2011","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.immuni.2026.01.015_bib32","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.4049\/jimmunol.1402632","article-title":"Tim-1 is essential for induction and maintenance of IL-10 in regulatory B cells and their regulation of tissue inflammation","volume":"194","author":"Xiao","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2026.01.015_bib33","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.immuni.2015.04.005","article-title":"Regulatory B Cells: Origin, Phenotype, and Function","volume":"42","author":"Rosser","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.01.015_bib34","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.autrev.2011.11.018","article-title":"Human CD19(+)CD25(high) B regulatory cells suppress proliferation of CD4(+) T cells and enhance Foxp3 and CTLA-4 expression in T-regulatory cells","volume":"11","author":"Kessel","year":"2012","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.immuni.2026.01.015_bib35","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jneuroim.2014.02.003","article-title":"New regulatory CD19(+)CD25(+) B-cell subset in clinically isolated syndrome and multiple sclerosis relapse. Changes after glucocorticoids","volume":"270","author":"de Andr\u00e9s","year":"2014","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.immuni.2026.01.015_bib36","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1093\/nar\/25.6.1317","article-title":"B Lymphocyte-Specific, Cre-mediated Mutagenesis in Mice","volume":"25","author":"Rickert","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.immuni.2026.01.015_bib37","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1083\/jcb.129.1.55","article-title":"Endocytosis of interleukin 2 receptors in human T lymphocytes: distinct intracellular localization and fate of the receptor alpha, beta, and gamma chains","volume":"129","author":"H\u00e9mar","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.immuni.2026.01.015_bib38","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1093\/intimm\/6.8.1257","article-title":"IL-2 receptor \u03b1 chain (CD25JAC) expression defines a crucial stage in pre-B cell development","volume":"6","author":"Rolink","year":"1994","journal-title":"Int. Immunol."},{"key":"10.1016\/j.immuni.2026.01.015_bib39","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/ni1008-1091","article-title":"The Immunological Genome Project: networks of gene expression in immune cells","volume":"9","author":"Heng","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2026.01.015_bib40","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.celrep.2017.10.044","article-title":"Cytosolic Recognition of RNA Drives the Immune Response to Heterologous Erythrocytes","volume":"21","author":"Loetsch","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2026.01.015_bib41","doi-asserted-by":"crossref","first-page":"86","DOI":"10.4049\/jimmunol.134.1.86","article-title":"Monoclonal helper T cells induce B cell responses to T-independent antigens: antigen-specific T cells are directly stimulated by activated B cells in the absence of antigen","volume":"134","author":"DeKruyff","year":"1985","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2026.01.015_bib42","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1084\/jem.178.5.1555","article-title":"In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. I. In vivo expression of CD40 ligand, cytokines, and antibody production delineates sites of cognate T-B cell interactions","volume":"178","author":"Van den Eertwegh","year":"1993","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2026.01.015_bib43","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1084\/jem.175.5.1367","article-title":"Induction of IgG3 secretion by interferon gamma: a model for T cell-independent class switching in response to T cell-independent type 2 antigens","volume":"175","author":"Snapper","year":"1992","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2026.01.015_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-21409-7","article-title":"Lack of galectin-3 modifies differentially Notch ligands in bone marrow and spleen stromal cells interfering with B cell differentiation","volume":"8","author":"de Oliveira","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.immuni.2026.01.015_bib45","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-04063-5","article-title":"Galectin-3 deficiency drives lupus-like disease by promoting spontaneous germinal centers formation via IFN-\u03b3","volume":"9","author":"Beccaria","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2026.01.015_bib46","doi-asserted-by":"crossref","first-page":"e02038-20","DOI":"10.1128\/JVI.02038-20","article-title":"Inducible Guanylate-Binding Protein 7 Facilitates Influenza A Virus Replication by Suppressing Innate Immunity via NF-\u03baB and JAK-STAT Signaling Pathways","volume":"95","author":"Feng","year":"2021","journal-title":"J. Virol."},{"key":"10.1016\/j.immuni.2026.01.015_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.110259","article-title":"Uncontrolled CD21low age-associated and B1 B cell accumulation caused by failure of an EGR2\/3 tolerance checkpoint","volume":"38","author":"Masle-Farquhar","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2026.01.015_bib48","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/s41590-018-0056-8","article-title":"Regulation of age-associated B cells by IRF5 in systemic autoimmunity","volume":"19","author":"Manni","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2026.01.015_bib49","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abg8384","article-title":"Shared transcriptional profiles of atypical B cells suggest common drivers of expansion and function in malaria, HIV, and autoimmunity","volume":"7","author":"Holla","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.immuni.2026.01.015_bib50","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.4049\/jimmunol.1601106","article-title":"Age-Associated B Cells Express a Diverse Repertoire of VH and V\u03ba Genes with Somatic Hypermutation","volume":"198","author":"Russell Knode","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2026.01.015_bib51","doi-asserted-by":"crossref","first-page":"D1040","DOI":"10.1093\/nar\/gks1215","article-title":"INTERFEROME v2.0: an updated database of annotated interferon-regulated genes","volume":"41","author":"Rusinova","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.immuni.2026.01.015_bib52","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.3389\/fimmu.2019.01909","article-title":"Blimp-1 Contributes to the Development and Function of Regulatory B Cells","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2026.01.015_bib54","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-52224-6","article-title":"Maf expression in B cells restricts reactive plasmablast and germinal center B cell expansion","volume":"15","author":"Hillion","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2026.01.015_bib55","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/ni833","article-title":"B cells regulate autoimmunity by provision of IL-10","volume":"3","author":"Fillatreau","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2026.01.015_bib56","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.4049\/jimmunol.0900185","article-title":"Nonredundant Roles for B Cell-Derived IL-10 in Immune Counter-Regulation","volume":"183","author":"Madan","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2026.01.015_bib57","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.immuni.2024.02.001","article-title":"Interleukin-2 signaling in the regulation of T cell biology in autoimmunity and cancer","volume":"57","author":"Shouse","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.01.015_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/cells12212556","article-title":"Regulatory ILC2\u2014Role of IL-10 Producing ILC2 in Asthma","volume":"12","author":"Emami Fard","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.immuni.2026.01.015_bib59","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.1182\/blood-2014-07-587493","article-title":"Interleukin-5\u2013producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy","volume":"124","author":"Van Gool","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2026.01.015_bib60","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/352621a0","article-title":"Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting","volume":"352","author":"Schorle","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2026.01.015_bib61","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/1074-7613(95)90180-9","article-title":"Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment","volume":"3","author":"Willerford","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.01.015_bib62","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1093\/jimmun\/vkae045","article-title":"IL-2R\u03b1 is dispensable for murine B cell development and humoral response","volume":"214","author":"Chowdhury","year":"2025","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2026.01.015_bib63","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1038\/ni1536","article-title":"CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation\u2013mediated apoptosis of effector CD4+ T cells","volume":"8","author":"Pandiyan","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2026.01.015_bib64","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature17947","article-title":"EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells","volume":"533","author":"Li","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2026.01.015_bib65","article-title":"B cell-intrinsic IFN-\u03b3 promotes excessive CD11c+ age-associated B cell differentiation and compromised germinal center selection in lupus mice","volume":"405\u2013406","author":"Liu","year":"2024","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.immuni.2026.01.015_bib66","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.immuni.2024.03.016","article-title":"Type I interferons induce an epigenetically distinct memory B cell subset in chronic viral infection","volume":"57","author":"Cooper","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.01.015_bib67","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.tim.2010.06.010","article-title":"BST-2\/tetherin: a new component of the innate immune response to enveloped viruses","volume":"18","author":"Evans","year":"2010","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.immuni.2026.01.015_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.112399","article-title":"BST-2\/Tetherin is involved in BAFF-enhanced proliferation and survival via canonical NF-\u03baB signaling in neoplastic B-lymphoid cells","volume":"398","author":"Fu","year":"2021","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.immuni.2026.01.015_bib69","doi-asserted-by":"crossref","first-page":"807","DOI":"10.4049\/jimmunol.0902528","article-title":"PDCA Expression by B Lymphocytes Reveals Important Functional Attributes","volume":"184","author":"Vinay","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2026.01.015_bib70","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.immuni.2019.04.004","article-title":"T-bet Transcription Factor Promotes Antibody-Secreting Cell Differentiation by Limiting the Inflammatory Effects of IFN-\u03b3 on B Cells","volume":"50","author":"Stone","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.01.015_bib71","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.00206","article-title":"c-MAF, a Swiss Army Knife for Tolerance in Lymphocytes","volume":"11","author":"Imbratta","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2026.01.015_bib53","doi-asserted-by":"crossref","DOI":"10.1111\/sji.12701","article-title":"Transcription factor c-Maf is essential for IL-10 gene expression in B cells","volume":"88","author":"Liu","year":"2018","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.immuni.2026.01.015_bib72","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-22230-z","article-title":"The survival and function of IL-10-producing regulatory B cells are negatively controlled by SLAMF5","volume":"12","author":"Radomir","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2026.01.015_bib73","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.818814","article-title":"Molecular Mechanisms Driving IL-10- Producing B Cells Functions: STAT3 and c-MAF as Underestimated Central Key Regulators?","volume":"13","author":"Mich\u00e9e-Cospolite","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2026.01.015_bib74","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.bj.2019.05.008","article-title":"Regulatory functions of B cells and regulatory plasma cells","volume":"42","author":"Fillatreau","year":"2019","journal-title":"Biomed J."},{"key":"10.1016\/j.immuni.2026.01.015_bib75","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/s41590-023-01712-w","article-title":"Unraveling the diversity and functions of tissue-resident plasma cells","volume":"25","author":"Tellier","year":"2024","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2026.01.015_bib76","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.cell.2018.11.035","article-title":"Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10","volume":"176","author":"Rojas","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2026.01.015_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107892","article-title":"Checkpoint Receptor TIGIT Expressed on Tim-1+ B Cells Regulates Tissue Inflammation","volume":"32","author":"Xiao","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2026.01.015_bib78","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nri3823","article-title":"The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases","volume":"15","author":"Klatzmann","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2026.01.015_bib79","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature10163","article-title":"A conditional knockout resource for the genome-wide study of mouse gene function","volume":"474","author":"Skarnes","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2026.01.015_bib80","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/75973","article-title":"High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP","volume":"25","author":"Rodr\u00edguez","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.immuni.2026.01.015_bib81","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.immuni.2026.01.015_bib82","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.immuni.2026.01.015_bib83","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie enables improved reconstruction of a transcriptome from RNA-seq reads","volume":"33","author":"Pertea","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.immuni.2026.01.015_bib85","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.immuni.2026.01.015_bib86","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nmeth.4197","article-title":"Salmon provides fast and bias-aware quantification of transcript expression","volume":"14","author":"Patro","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.immuni.2026.01.015_bib87","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.immuni.2026.01.015_bib88","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.immuni.2026.01.015_bib84","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet J."}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761326000373?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761326000373?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:21:24Z","timestamp":1782188484000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761326000373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":88,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S1074761326000373"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2026.01.015","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"B cell-intrinsic IL-2 signaling regulates inflammation by promoting IL-10 expression in CD25+ age-associated B cells","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2026.01.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}