{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:55:35Z","timestamp":1793314535075,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000889","name":"Multiple Sclerosis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000889","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG081038"],"award-info":[{"award-number":["AG081038"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG064823"],"award-info":[{"award-number":["AG064823"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG077816"],"award-info":[{"award-number":["AG077816"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG086042"],"award-info":[{"award-number":["AG086042"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008069","name":"University of California, San Francisco","doi-asserted-by":"publisher","award":["SCR_018206"],"award-info":[{"award-number":["SCR_018206"]}],"id":[{"id":"10.13039\/100008069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000965","name":"American Federation for Aging Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000965","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000893","name":"Simons Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000893","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020188","name":"Barbara and Gerson Bakar Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001167","name":"Larry L Hillblom Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001167","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032645","name":"Hevolution Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100032645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 DK063720"],"award-info":[{"award-number":["P30 DK063720"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.immuni.2026.04.014","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:23:47Z","timestamp":1778797427000},"page":"1651-1666.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Aged circulating CD8+ T cells and their secreted factors drive cognitive decline"],"prefix":"10.1016","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0979-3903","authenticated-orcid":false,"given":"Juliana","family":"Sucharov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Bieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karishma J.B.","family":"Pratt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber R.","family":"Philp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Turan","family":"Aghayev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanan","family":"Sahota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Remesal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam B.","family":"Schroer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedric E.","family":"Snethlage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary J.","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Couthouis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2726-9582","authenticated-orcid":false,"given":"Saul A.","family":"Villeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2026.04.014_bib1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41582-019-0244-7","article-title":"Ageing as a risk factor for neurodegenerative disease","volume":"15","author":"Hou","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.immuni.2026.04.014_bib2","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nature10357","article-title":"The ageing systemic milieu negatively regulates neurogenesis and cognitive function","volume":"477","author":"Villeda","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2026.04.014_bib3","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/s41591-019-0440-4","article-title":"Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1","volume":"25","author":"Yousef","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2026.04.014_bib4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cytogfr.2021.01.006","article-title":"Hallmarks of aging and immunosenescence: Connecting the dots","volume":"59","author":"Rodrigues","year":"2021","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.immuni.2026.04.014_bib5","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/s41574-018-0059-4","article-title":"Inflammaging: a new immune\u2013metabolic viewpoint for age-related diseases","volume":"14","author":"Franceschi","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.immuni.2026.04.014_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.01960","article-title":"Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?","volume":"8","author":"Fulop","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2026.04.014_bib7","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1073\/pnas.1211270110","article-title":"CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging","volume":"110","author":"Baruch","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.immuni.2026.04.014_bib8","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nm.3898","article-title":"\u03b22-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis","volume":"21","author":"Smith","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2026.04.014_bib9","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/s41586-019-1362-5","article-title":"Single-cell analysis reveals T cell infiltration in old neurogenic niches","volume":"571","author":"Dulken","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2026.04.014_bib10","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s41593-020-00745-w","article-title":"Neuroblast senescence in the aged brain augments natural killer cell cytotoxicity leading to impaired neurogenesis and cognition","volume":"24","author":"Jin","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.immuni.2026.04.014_bib11","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/s41586-020-03160-0","article-title":"Restoring metabolism of myeloid cells reverses cognitive decline in ageing","volume":"590","author":"Minhas","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2026.04.014_bib12","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/s43587-021-00049-z","article-title":"Accumulation of cytotoxic T cells in the aged CNS leads to axon degeneration and contributes to cognitive and motor decline","volume":"1","author":"Groh","year":"2021","journal-title":"Nat. Aging"},{"key":"10.1016\/j.immuni.2026.04.014_bib13","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1038\/s41593-022-01183-6","article-title":"CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging","volume":"25","author":"Kaya","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.immuni.2026.04.014_bib14","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/s41586-023-06436-3","article-title":"Platelet factors attenuate inflammation and rescue cognition in ageing","volume":"620","author":"Schroer","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2026.04.014_bib15","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13192","article-title":"The aged hematopoietic system promotes hippocampal-dependent cognitive decline","volume":"19","author":"Smith","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.immuni.2026.04.014_bib16","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.immuni.2020.11.005","article-title":"Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging","volume":"54","author":"Mogilenko","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.04.014_bib17","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cmet.2022.11.005","article-title":"Age-associated remodeling of T cell immunity and metabolism","volume":"35","author":"Han","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2026.04.014_bib18","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.bbi.2020.05.070","article-title":"CD8+ T-cells infiltrate Alzheimer\u2019s disease brains and regulate neuronal- and synapse-related gene expression in APP-PS1 transgenic mice","volume":"89","author":"Unger","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.immuni.2026.04.014_bib19","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.4049\/jimmunol.2100737","article-title":"Transcriptomic Profiling Identifies CD8+ T Cells in the Brain of Aged and Alzheimer\u2019s Disease Transgenic Mice as Tissue-Resident Memory T Cells","volume":"209","author":"Altendorfer","year":"2022","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2026.04.014_bib20","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13198","article-title":"CD8+ T cells are increased in the subventricular zone with physiological and pathological aging","volume":"19","author":"Moreno-Valladares","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.immuni.2026.04.014_bib21","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1126\/science.1251141","article-title":"Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors","volume":"344","author":"Katsimpardi","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.immuni.2026.04.014_bib22","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20210223","article-title":"Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions","volume":"218","author":"Ho","year":"2021","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2026.04.014_bib23","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1084\/jem.182.2.581","article-title":"Pertussis toxin inhibits migration of B and T lymphocytes into splenic white pulp cords","volume":"182","author":"Cyster","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2026.04.014_bib24","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S1074-7613(04)00103-7","article-title":"Dynamics of Blood-Borne CD8 Memory T Cell Migration In Vivo","volume":"20","author":"Klonowski","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.04.014_bib62","unstructured":"Allen Institute for Brain Science. (2011).Allen Mouse Brain. Atlas [dataset]. Allen Institute for Brain Science. mouse.brain-map.org."},{"key":"10.1016\/j.immuni.2026.04.014_bib25","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/S0092-8674(05)80068-6","article-title":"TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4\u22128+ T cells","volume":"71","author":"Van Kaer","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2026.04.014_bib26","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/s41586-024-08395-9","article-title":"GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases","volume":"638","author":"Lan","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2026.04.014_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1620670","article-title":"Pro-inflammatory granzyme K contributes extracellularly to disease","volume":"16","author":"Turner","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2026.04.014_bib28","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1021\/acschembio.7b00549","article-title":"CRISPR-Mediated Tagging of Endogenous Proteins with a Luminescent Peptide","volume":"13","author":"Schwinn","year":"2018","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.immuni.2026.04.014_bib29","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1126\/science.aaw2622","article-title":"Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain","volume":"369","author":"Horowitz","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.immuni.2026.04.014_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1398120","article-title":"Granzyme K mediates IL-23-dependent inflammation and keratinocyte proliferation in psoriasis","volume":"15","author":"Richardson","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2026.04.014_bib31","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.jid.2018.09.031","article-title":"Granzyme K Expressed by Classically Activated Macrophages Contributes to Inflammation and Impaired Remodeling","volume":"139","author":"Turner","year":"2019","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.immuni.2026.04.014_bib32","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41593-022-01238-8","article-title":"Blood-to-brain communication in aging and rejuvenation","volume":"26","author":"Bieri","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.immuni.2026.04.014_bib33","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/bph.16214","article-title":"Update on the role of T cells in cognitive impairment","volume":"181","author":"Ruiz-Fern\u00e1ndez","year":"2024","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.immuni.2026.04.014_bib34","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/s43587-021-00053-3","article-title":"Unwanted help from T cells in the aging central nervous system","volume":"1","author":"Negredo","year":"2021","journal-title":"Nat. Aging"},{"key":"10.1016\/j.immuni.2026.04.014_bib35","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41590-022-01390-0","article-title":"T cells drive aging of the brain","volume":"24","author":"Liston","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2026.04.014_bib36","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-024-00706-y","article-title":"Unraveling the dual nature of brain CD8+ T cells in Alzheimer\u2019s disease","volume":"19","author":"Hu","year":"2024","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.immuni.2026.04.014_bib37","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1038\/s41590-023-01604-z","article-title":"CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer\u2019s disease pathology","volume":"24","author":"Su","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2026.04.014_bib38","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/s41586-023-05788-0","article-title":"Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy","volume":"615","author":"Chen","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2026.04.014_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-62405-6","article-title":"CD103\u2013CD8+ T cells promote neurotoxic inflammation in Alzheimer\u2019s disease via granzyme K\u2013PAR-1 signaling","volume":"16","author":"Terrabuio","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2026.04.014_bib40","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/s41590-025-02198-4","article-title":"Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia","volume":"26","author":"Mason","year":"2025","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2026.04.014_bib41","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.cell.2020.12.040","article-title":"Functional characterization of the dural sinuses as a neuroimmune interface","volume":"184","author":"Rustenhoven","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2026.04.014_bib42","doi-asserted-by":"crossref","first-page":"5028","DOI":"10.1016\/j.cell.2022.11.019","article-title":"Cerebrospinal fluid immune dysregulation during healthy brain aging and cognitive impairment","volume":"185","author":"Piehl","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2026.04.014_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41577-020-00486-8","article-title":"GZMK+ T cells a hallmark of immune ageing","volume":"21","author":"Flemming","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2026.04.014_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105535","article-title":"Clonal GZMK+CD8+ T cells are identified as a hallmark of the pathogenesis of cGVHD-induced bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation","volume":"112","author":"Gao","year":"2025","journal-title":"EBiomedicine"},{"key":"10.1016\/j.immuni.2026.04.014_bib45","first-page":"117","article-title":"Mouse T-cell associated serine proteinase 1 degrades collagen type IV: a structural basis for the migration of lymphocytes through vascular basement membranes","volume":"73","author":"Simon","year":"1991","journal-title":"Immunology"},{"key":"10.1016\/j.immuni.2026.04.014_bib46","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-54685-1","article-title":"Granzyme K+CD8+ T cells interact with fibroblasts to promote neutrophilic inflammation in nasal polyps","volume":"15","author":"Guo","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2026.04.014_bib47","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/bjd\/ljac017","article-title":"Granzyme K contributes to endothelial microvascular damage and leakage during skin inflammation","volume":"189","author":"Turner","year":"2023","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.immuni.2026.04.014_bib48","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/j.cell.2026.01.024","article-title":"Liver exerkine reverses aging- and Alzheimer\u2019s-related memory loss via vasculature","volume":"189","author":"Bieri","year":"2026","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2026.04.014_bib49","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/s41586-025-08589-9","article-title":"Glycocalyx dysregulation impairs blood\u2013brain barrier in ageing and disease","volume":"639","author":"Shi","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2026.04.014_bib50","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neuron.2018.09.010","article-title":"Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM","volume":"100","author":"Park","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.immuni.2026.04.014_bib51","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1126\/science.aax0860","article-title":"T cells with dysfunctional mitochondria induce multimorbidity and premature senescence","volume":"368","author":"Desd\u00edn-Mic\u00f3","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.immuni.2026.04.014_bib52","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1007\/s13258-024-01555-1","article-title":"Distinct granzyme k expression in immune cells: a single-cell rna-seq meta-analysis","volume":"46","author":"Kim","year":"2024","journal-title":"Genes Genomics"},{"key":"10.1016\/j.immuni.2026.04.014_bib53","doi-asserted-by":"crossref","first-page":"633","DOI":"10.4049\/jimmunol.2300083","article-title":"Human Granzyme K Is a Feature of Innate T Cells in Blood, Tissues, and Tumors, Responding to Cytokines Rather than TCR Stimulation","volume":"211","author":"Duquette","year":"2023","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2026.04.014_bib54","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/nm.3569","article-title":"Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice","volume":"20","author":"Villeda","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2026.04.014_bib55","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1016\/j.celrep.2018.02.001","article-title":"Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain","volume":"22","author":"Gontier","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2026.04.014_bib56","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/nmeth.4380","article-title":"Simultaneous epitope and transcriptome measurement in single cells","volume":"14","author":"Stoeckius","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.immuni.2026.04.014_bib57","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nature05453","article-title":"Genome-wide atlas of gene expression in the adult mouse brain","volume":"445","author":"Lein","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2026.04.014_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2020.100029","article-title":"Analysis of Myeloid Cells in Mouse Tissues with Flow Cytometry","volume":"1","author":"Liu","year":"2020","journal-title":"Star Protoc."},{"key":"10.1016\/j.immuni.2026.04.014_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113151","article-title":"Neuronal activation of G\u03b1q EGL-30\/GNAQ late in life rejuvenates cognition across species","volume":"42","author":"Stevenson","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2026.04.014_bib60","article-title":"Transient Expression of Proteins by Hydrodynamic Gene Delivery in Mice","volume":"87","author":"Kovacsics","year":"2014","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.immuni.2026.04.014_bib61","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1038\/nprot.2006.275","article-title":"Two-day radial-arm water maze learning and memory task; robust resolution of amyloid-related memory deficits in transgenic mice","volume":"1","author":"Alamed","year":"2006","journal-title":"Nat. Protoc."}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761326001767?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761326001767?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:22:39Z","timestamp":1783099359000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761326001767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":62,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S1074761326001767"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2026.04.014","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aged circulating CD8+ T cells and their secreted factors drive cognitive decline","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2026.04.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}