{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:44:41Z","timestamp":1793108681540,"version":"4.5.0"},"reference-count":81,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.immuni.2026.05.019","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:37:22Z","timestamp":1782398242000},"page":"2041-2052.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Antibody binding geometry and affinity control inhibitory hFc\u03b3RIIB receptor signaling"],"prefix":"10.1016","volume":"59","author":[{"given":"Hayden","family":"Fisher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma J.","family":"Sutton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Oldham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard T.","family":"Bradshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Duriez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Frend\u00e9us","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunilla","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giusi","family":"Manfredi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa L.","family":"Martin-Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Mockridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah R.","family":"Needham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Rolfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian M.","family":"Orr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kallum","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Roghanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Tully","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Teige","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla-Carin","family":"Tornberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Tynan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Pendower","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinny","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Tennenhouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarel J.","family":"Fleishman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan W.","family":"Essex","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Tews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2077-089X","authenticated-orcid":false,"given":"Mark S.","family":"Cragg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2026.05.019_bib1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri2206","article-title":"Fcgamma receptors as regulators of immune responses","volume":"8","author":"Nimmerjahn","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2026.05.019_bib2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/imr.12342","article-title":"Fc\u03b3R requirements leading to successful immunotherapy","volume":"268","author":"Dahal","year":"2015","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.immuni.2026.05.019_bib3","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1038\/s41590-023-01544-8","article-title":"Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy","volume":"24","author":"Nimmerjahn","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2026.05.019_bib4","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1182\/blood-2015-09-625343","article-title":"Influence of immunoglobulin isotype on therapeutic antibody function","volume":"127","author":"Beers","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2026.05.019_bib5","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1158\/1078-0432.CCR-23-1014","article-title":"Agonist Antibodies for Cancer Immunotherapy: History, Hopes, and Challenges","volume":"30","author":"Lim","year":"2024","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.immuni.2026.05.019_bib6","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1182\/blood-2014-08-593061","article-title":"Upregulation of Fc\u03b3RIIb on monocytes is necessary to promote the superagonist activity of TGN1412","volume":"125","author":"Hussain","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2026.05.019_bib7","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1056\/NEJMoa063842","article-title":"Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412","volume":"355","author":"Suntharalingam","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.immuni.2026.05.019_bib8","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1158\/1078-0432.CCR-17-1847","article-title":"Activation of 4\u20131BB on Liver Myeloid Cells Triggers Hepatitis via an Interleukin-27-Dependent Pathway","volume":"24","author":"Bartkowiak","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.immuni.2026.05.019_bib9","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aav5989","article-title":"Tumor-targeted 4\u20131BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy","volume":"11","author":"Claus","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.immuni.2026.05.019_bib10","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s00251-007-0208-8","article-title":"Species-specific evolution of the FcR family in endothermic vertebrates","volume":"59","author":"Fayngerts","year":"2007","journal-title":"Immunogenetics"},{"key":"10.1016\/j.immuni.2026.05.019_bib11","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/imr.12341","article-title":"Fcgamma receptors: genetic variation, function, and disease","volume":"268","author":"Hargreaves","year":"2015","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.immuni.2026.05.019_bib12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.immuni.2016.07.006","article-title":"Clarifying the Confusion between Cytokine and Fc Receptor \u201cCommon Gamma Chain\u201d","volume":"45","author":"Brandsma","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.05.019_bib13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0165-2478(96)02653-3","article-title":"The SHIP phosphatase becomes associated with Fc gammaRIIB1 and is tyrosine phosphorylated during 'negative' signaling","volume":"54","author":"D'Ambrosio","year":"1996","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.immuni.2026.05.019_bib14","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S1074-7613(00)80509-9","article-title":"Fc gammaRIIB1 inhibition of BCR-mediated phosphoinositide hydrolysis and Ca2+ mobilization is integrated by CD19 dephosphorylation","volume":"7","author":"Hippen","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.05.019_bib15","doi-asserted-by":"crossref","first-page":"684","DOI":"10.4049\/jimmunol.161.2.684","article-title":"B cell antigen receptor (BCR)-mediated formation of a SHP-2-pp120 complex and its inhibition by Fc gamma RIIB1-BCR coligation","volume":"161","author":"Nakamura","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2026.05.019_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/JLB.2MIR0917-354R","article-title":"New revelations from an old receptor: Immunoregulatory functions of the inhibitory Fc gamma receptor, Fc\u03b3RIIB (CD32B)","author":"Roghanian","year":"2018","journal-title":"J. Leukoc. Biol"},{"key":"10.1016\/j.immuni.2026.05.019_bib17","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.ccell.2015.03.005","article-title":"Antagonistic human Fc\u03b3RIIB (CD32B) antibodies have anti-tumor activity and overcome resistance to antibody therapy in vivo","volume":"27","author":"Roghanian","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1016\/j.immuni.2026.05.019_bib18","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1182\/blood-2013-04-490821","article-title":"Inhibitory Fc\u03b3RIIb (CD32b) becomes activated by therapeutic mAb in both cis and trans and drives internalization according to antibody specificity","volume":"123","author":"Vaughan","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2026.05.019_bib19","doi-asserted-by":"crossref","first-page":"16478","DOI":"10.1074\/jbc.M100351200","article-title":"Recognition of IgG by Fcgamma receptor. The role of Fc glycosylation and the binding of peptide inhibitors","volume":"276","author":"Radaev","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.immuni.2026.05.019_bib20","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.290.5489.84","article-title":"Immune inhibitory receptors","volume":"290","author":"Ravetch","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.immuni.2026.05.019_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-021-02309-5","article-title":"TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity","volume":"4","author":"Yu","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.immuni.2026.05.019_bib22","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.bpj.2018.03.040","article-title":"Evaluating Anti-CD32b F(ab) Conformation Using Molecular Dynamics and Small-Angle X-Ray Scattering","volume":"115","author":"Sutton","year":"2018","journal-title":"Biophys. J."},{"key":"10.1016\/j.immuni.2026.05.019_bib23","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.jmb.2007.05.022","article-title":"Inference of macromolecular assemblies from crystalline state","volume":"372","author":"Krissinel","year":"2007","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.immuni.2026.05.019_bib24","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.ccell.2020.04.013","article-title":"Isotype Switching Converts Anti-CD40 Antagonism to Agonism to Elicit Potent Antitumor Activity","volume":"37","author":"Yu","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.immuni.2026.05.019_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abm3723","article-title":"Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility","volume":"7","author":"Orr","year":"2022","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.immuni.2026.05.019_bib26","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/cdd.2011.208","article-title":"A series of Fas receptor agonist antibodies that demonstrate an inverse correlation between affinity and potency","volume":"19","author":"Chodorge","year":"2012","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.immuni.2026.05.019_bib27","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/s41586-022-05673-2","article-title":"Reducing affinity as a strategy to boost immunomodulatory antibody agonism","volume":"614","author":"Yu","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2026.05.019_bib28","article-title":"Energy-guided combinatorial co-optimization of antibody affinity and stability","author":"Tennenhouse","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.immuni.2026.05.019_bib29","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1093\/hmg\/ddi320","article-title":"FcgammaRIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling","volume":"14","author":"Kono","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.immuni.2026.05.019_bib30","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1042\/bj3350433","article-title":"Effects of cholesterol depletion by cyclodextrin on the sphingolipid microdomains of the plasma membrane","volume":"335","author":"Ilangumaran","year":"1998","journal-title":"Biochem. J."},{"key":"10.1016\/j.immuni.2026.05.019_bib31","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/imr.12336","article-title":"Of ITIMs, ITAMs, and ITAMis: revisiting immunoglobulin Fc receptor signaling","volume":"268","author":"Getahun","year":"2015","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.immuni.2026.05.019_bib32","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1084\/jem.20160528","article-title":"Impairment on the lateral mobility induced by structural changes underlies the functional deficiency of the lupus-associated polymorphism Fc\u03b3RIIB-T232","volume":"213","author":"Xu","year":"2016","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2026.05.019_bib33","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.70169","article-title":"Recovering mixtures of fast-diffusing states from short single-particle trajectories","volume":"11","author":"Heckert","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.immuni.2026.05.019_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111099","article-title":"Fc\u03b3RIIB controls antibody-mediated target cell depletion by ITIM-independent mechanisms","volume":"40","author":"Simpson","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2026.05.019_bib35","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001557","article-title":"Domain binding and isotype dictate the activity of anti-human OX40 antibodies","volume":"8","author":"Griffiths","year":"2020","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.immuni.2026.05.019_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.add4947","article-title":"Anti-PD-1 antibodies recognizing the membrane-proximal region are PD-1 agonists that can down-regulate inflammatory diseases","volume":"8","author":"Suzuki","year":"2023","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.immuni.2026.05.019_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-10088-1","article-title":"Optimization of 4\u20131BB antibody for cancer immunotherapy by balancing agonistic strength with Fc\u03b3R affinity","volume":"10","author":"Qi","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2026.05.019_bib38","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ccell.2014.11.001","article-title":"Conformation of the human immunoglobulin G2 hinge imparts superagonistic properties to immunostimulatory anticancer antibodies","volume":"27","author":"White","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1016\/j.immuni.2026.05.019_bib39","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.ccell.2018.02.009","article-title":"Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies","volume":"33","author":"Yu","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.immuni.2026.05.019_bib40","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.4049\/jimmunol.1101194","article-title":"The inhibiting Fc receptor for IgG, Fc\u03b3RIIB, is a modifier of autoimmune susceptibility","volume":"187","author":"Boross","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2026.05.019_bib41","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1006\/immu.1994.1004","article-title":"Heterogeneity of human IgG Fc receptors","volume":"4","author":"Capel","year":"1994","journal-title":"ImmunoMethods"},{"key":"10.1016\/j.immuni.2026.05.019_bib42","doi-asserted-by":"crossref","first-page":"5279","DOI":"10.4049\/jimmunol.174.9.5279","article-title":"Fc gamma RIIB regulates nasal and oral tolerance: a role for dendritic cells","volume":"174","author":"Samsom","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2026.05.019_bib43","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1084\/jem.170.4.1369","article-title":"Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes","volume":"170","author":"Brooks","year":"1989","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2026.05.019_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/369340a0","article-title":"A 13-amino-acid motif in the cytoplasmic domain of Fc gamma RIIB modulates B-cell receptor signalling","volume":"369","author":"Muta","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2026.05.019_bib45","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/379346a0","article-title":"Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice","volume":"379","author":"Takai","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2026.05.019_bib46","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.immuni.2017.03.013","article-title":"Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors","volume":"46","author":"Arce Vargas","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.05.019_bib47","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/74704","article-title":"Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets","volume":"6","author":"Clynes","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2026.05.019_bib48","doi-asserted-by":"crossref","first-page":"19501","DOI":"10.1073\/pnas.1319502110","article-title":"Antitumor activities of agonistic anti-TNFR antibodies require differential Fc\u03b3RIIB coengagement in vivo","volume":"110","author":"Li","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2026.05.019_bib49","doi-asserted-by":"crossref","first-page":"10966","DOI":"10.1073\/pnas.1208698109","article-title":"Apoptotic and antitumor activity of death receptor antibodies require inhibitory Fcgamma receptor engagement","volume":"109","author":"Li","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2026.05.019_bib50","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1126\/science.1206954","article-title":"Inhibitory Fcgamma receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies","volume":"333","author":"Li","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.immuni.2026.05.019_bib51","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.4049\/jimmunol.1303204","article-title":"Fcgamma receptor dependency of agonistic CD40 antibody in lymphoma therapy can be overcome through antibody multimerization","volume":"193","author":"White","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2026.05.019_bib52","first-page":"355","article-title":"Fc\u03b3RIIB as a key determinant of agonistic antibody efficacy","volume":"382","author":"White","year":"2014","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.immuni.2026.05.019_bib53","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.4049\/jimmunol.1101135","article-title":"Interaction with Fc\u03b3RIIB is critical for the agonistic activity of anti-CD40 monoclonal antibody","volume":"187","author":"White","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2026.05.019_bib54","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1365-2567.2007.02588.x","article-title":"Monoclonal antibodies capable of discriminating the human inhibitory Fcgamma-receptor IIB (CD32B) from the activating Fcgamma-receptor IIA (CD32A): biochemical, biological and functional characterization","volume":"121","author":"Veri","year":"2007","journal-title":"Immunology"},{"key":"10.1016\/j.immuni.2026.05.019_bib55","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.4049\/jimmunol.1301430","article-title":"Immunotherapy Targeting Inhibitory Fcgamma Receptor IIB (CD32b) in the Mouse Is Limited by Monoclonal Antibody Consumption and Receptor Internalization","volume":"191","author":"Williams","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2026.05.019_bib56","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1158\/1535-7163.MCT-19-0003","article-title":"Development of Anti-CD32b Antibodies with Enhanced Fc Function for the Treatment of B and Plasma Cell Malignancies","volume":"19","author":"Lu","year":"2020","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.immuni.2026.05.019_bib57","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/toxsci\/kfab124","article-title":"An Afucosylated Anti-CD32b Monoclonal Antibody Induced Platelet-Mediated Adverse Events in a Human Fcgamma Receptor Transgenic Mouse Model and Its Potential Human Translatability","volume":"185","author":"Wolf","year":"2021","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.immuni.2026.05.019_bib58","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-58773-8","article-title":"Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism","volume":"16","author":"Elliott","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2026.05.019_bib59","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1182\/blood-2011-01-330357","article-title":"Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy","volume":"118","author":"Lim","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2026.05.019_bib60","doi-asserted-by":"crossref","first-page":"5424","DOI":"10.1074\/jbc.M114.593806","article-title":"Activatory and inhibitory Fcgamma receptors augment rituximab-mediated internalization of CD20 independent of signaling via the cytoplasmic domain","volume":"290","author":"Vaughan","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.immuni.2026.05.019_bib61","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1002\/eji.201142302","article-title":"Development and characterisation of monoclonal antibodies specific for the murine inhibitory Fc\u03b3RIIB (CD32B)","volume":"42","author":"Williams","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.immuni.2026.05.019_bib62","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1042\/bj2590347","article-title":"Aglycosylation of human IgG1 and IgG3 monoclonal antibodies can eliminate recognition by human cells expressing Fc gamma RI and\/or Fc gamma RII receptors","volume":"259","author":"Walker","year":"1989","journal-title":"Biochem. J."},{"key":"10.1016\/j.immuni.2026.05.019_bib63","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1126\/science.1248943","article-title":"Complement is activated by IgG hexamers assembled at the cell surface","volume":"343","author":"Diebolder","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.immuni.2026.05.019_bib64","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.immuni.2023.02.019","article-title":"Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1","volume":"56","author":"Seeling","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.05.019_bib68","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1107\/S0021889803012779","article-title":"PRIMUS: a Windows PC-based system for small-angle scattering data analysis","volume":"36","author":"Konarev","year":"2003","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.immuni.2026.05.019_bib71","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1107\/S0907444913000061","article-title":"How good are my data and what is the resolution?","volume":"69","author":"Evans","year":"2013","journal-title":"Acta Crystallogr., D"},{"key":"10.1016\/j.immuni.2026.05.019_bib72","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1107\/S0907444909042589","article-title":"Molecular replacement with MOLREP","volume":"66","author":"Vagin","year":"2010","journal-title":"Acta Crystallogr., D"},{"key":"10.1016\/j.immuni.2026.05.019_bib73","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1107\/S0907444911001314","article-title":"REFMAC5 for the refinement of macromolecular crystal structures","volume":"67","author":"Murshudov","year":"2011","journal-title":"Acta Crystallogr., D"},{"key":"10.1016\/j.immuni.2026.05.019_bib74","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","article-title":"Features and development of Coot","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr., D"},{"key":"10.1016\/j.immuni.2026.05.019_bib75","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1002\/jcc.20290","article-title":"The Amber biomolecular simulation programs","volume":"26","author":"Case","year":"2005","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.immuni.2026.05.019_bib76","doi-asserted-by":"crossref","first-page":"W537","DOI":"10.1093\/nar\/gks375","article-title":"H++ 3.0: automating pK prediction and the preparation of biomolecular structures for atomistic molecular modeling and simulations","volume":"40","author":"Anandakrishnan","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.immuni.2026.05.019_bib80","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1107\/S0021889895007047","article-title":"CRYSOL - A program to evaluate x-ray solution scattering of biological macromolecules from atomic coordinates","volume":"28","author":"Svergun","year":"1995","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.immuni.2026.05.019_bib81","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/B978-0-12-381270-4.00019-6","article-title":"ROSETTA3: an object-oriented software suite for the simulation and design of macromolecules","volume":"487","author":"Leaver-Fay","year":"2011","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.immuni.2026.05.019_bib65","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0171-9335(99)80074-0","article-title":"Rapid reduction of MDCK cell cholesterol by methyl-beta-cyclodextrin alters steady state transepithelial electrical resistance","volume":"78","author":"Francis","year":"1999","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.immuni.2026.05.019_bib66","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1007\/s00249-011-0747-7","article-title":"Automated multidimensional single molecule fluorescence microscopy feature detection and tracking","volume":"40","author":"Rolfe","year":"2011","journal-title":"Eur. Biophys. J."},{"key":"10.1016\/j.immuni.2026.05.019_bib67","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1107\/S1399004714026959","article-title":"BioSAXS Sample Changer: a robotic sample changer for rapid and reliable high-throughput X-ray solution scattering experiments","volume":"71","author":"Round","year":"2015","journal-title":"Acta Crystallogr., D"},{"key":"10.1016\/j.immuni.2026.05.019_bib69","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1107\/S0021889809042022","article-title":"The MORPHEUS protein crystallization screen","volume":"42","author":"Gorrec","year":"2009","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.immuni.2026.05.019_bib70","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1107\/S0907444910045749","article-title":"Overview of the CCP4 suite and current developments","volume":"67","author":"Winn","year":"2011","journal-title":"Acta Crystallogr., D"},{"key":"10.1016\/j.immuni.2026.05.019_bib77","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1021\/acs.jctc.5b00255","article-title":"ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB","volume":"11","author":"Maier","year":"2015","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.immuni.2026.05.019_bib78","doi-asserted-by":"crossref","first-page":"9020","DOI":"10.1021\/jp8001614","article-title":"Determination of alkali and halide monovalent ion parameters for use in explicitly solvated biomolecular simulations","volume":"112","author":"Joung","year":"2008","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.immuni.2026.05.019_bib79","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1021\/ct400341p","article-title":"PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data","volume":"9","author":"Roe","year":"2013","journal-title":"J. Chem. Theory Comput."}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107476132600230X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107476132600230X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:31:47Z","timestamp":1793107907000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S107476132600230X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":81,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S107476132600230X"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2026.05.019","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antibody binding geometry and affinity control inhibitory hFc\u03b3RIIB receptor signaling","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2026.05.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}