{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:04:57Z","timestamp":1789736697230,"version":"4.0.1"},"reference-count":81,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004385","name":"UGent","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004385","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.immuni.2026.06.020","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:46:35Z","timestamp":1784299595000},"page":"2429-2446.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Autophagy maintains high endothelial venule identity and function during inflammation"],"prefix":"10.1016","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3632-6400","authenticated-orcid":false,"given":"Kathryn A.","family":"Jacobs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichao","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apostolos Panagiotis","family":"Nikolakopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerlanda","family":"Vella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Filipa Domingues","family":"Laranjeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Bonnereau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Guyot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Livia","family":"Sassano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Mourao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feyza","family":"Cansiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Allies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Van Baren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Kawashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiebke","family":"Sondermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Rambow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alpaslan","family":"Tasdogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colinda","family":"Scheele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Agostinis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Bergers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2026.06.020_bib1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.ccell.2023.02.002","article-title":"High endothelial venules in cancer: Regulation, function, and therapeutic implication","volume":"41","author":"Vella","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.immuni.2026.06.020_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.736670","article-title":"High Endothelial Venules: A Vascular Perspective on Tertiary Lymphoid Structures in Cancer","volume":"12","author":"Vella","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2026.06.020_bib3","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s10456-021-09792-8","article-title":"High endothelial venules (HEVs) in immunity, inflammation and cancer","volume":"24","author":"Blanchard","year":"2021","journal-title":"Angiogenesis"},{"key":"10.1016\/j.immuni.2026.06.020_bib4","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1016\/j.celrep.2019.02.042","article-title":"Single-Cell Analysis Reveals Heterogeneity of High Endothelial Venules and Different Regulation of Genes Controlling Lymphocyte Entry to Lymph Nodes","volume":"26","author":"Veerman","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2026.06.020_bib5","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1084\/jem.20010685","article-title":"Lymphocyte homing to bronchus-associated lymphoid tissue (BALT) is mediated by L-selectin\/PNAd, alpha4beta1 integrin\/VCAM-1, and LFA-1 adhesion pathways","volume":"197","author":"Xu","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2026.06.020_bib6","doi-asserted-by":"crossref","first-page":"717","DOI":"10.4049\/jimmunol.0903589","article-title":"Chronic rejection triggers the development of an aggressive intragraft immune response through recapitulation of lymphoid organogenesis","volume":"185","author":"Thaunat","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2026.06.020_bib7","doi-asserted-by":"crossref","first-page":"17807","DOI":"10.1073\/pnas.0407503101","article-title":"Induction of peripheral lymph node addressin in human gastric mucosa infected by Helicobacter pylori","volume":"101","author":"Kobayashi","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2026.06.020_bib8","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/j.ccell.2022.11.002","article-title":"Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop","volume":"40","author":"Hua","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.immuni.2026.06.020_bib9","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/s41586-019-1922-8","article-title":"B cells and tertiary lymphoid structures promote immunotherapy response","volume":"577","author":"Helmink","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2026.06.020_bib10","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/cei\/uxae003","article-title":"PNAd-expressing vessels characterize the dermis of CD3+ T-cell-mediated cutaneous diseases","volume":"216","author":"Budair","year":"2024","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.immuni.2026.06.020_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.02700","article-title":"The Role of Endothelial Cells and TNF-Receptor Superfamily Members in Lymphoid Organogenesis and Function During Health and Inflammation","volume":"10","author":"Jeucken","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2026.06.020_bib12","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41580-018-0003-4","article-title":"Mechanism and medical implications of mammalian autophagy","volume":"19","author":"Dikic","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.immuni.2026.06.020_bib13","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.immuni.2021.01.018","article-title":"Autophagy in inflammation, infection, and immunometabolism","volume":"54","author":"Deretic","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.06.020_bib14","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.immuni.2021.07.012","article-title":"Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation","volume":"54","author":"Reglero-Real","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.06.020_bib15","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202318028","article-title":"Tumor endothelial cell autophagy is a key vascular-immune checkpoint in melanoma","volume":"15","author":"Verhoeven","year":"2023","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.immuni.2026.06.020_bib16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/19768354.2023.2181217","article-title":"Crosstalk between endoplasmic reticulum stress response and autophagy in human diseases","volume":"27","author":"Kwon","year":"2023","journal-title":"Anim. Cells Syst. (Seoul)"},{"key":"10.1016\/j.immuni.2026.06.020_bib17","doi-asserted-by":"crossref","first-page":"7683","DOI":"10.1093\/nar\/gkt563","article-title":"The eIF2\u03b1\/ATF4 pathway is essential for stress-induced autophagy gene expression","volume":"41","author":"B\u2019chir","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.immuni.2026.06.020_bib18","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1093\/hmg\/dds040","article-title":"Targeting the UPR transcription factor XBP1 protects against Huntington\u2019s disease through the regulation of FoxO1 and autophagy","volume":"21","author":"Vidal","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.immuni.2026.06.020_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/s41421-020-0161-3","article-title":"Emerging roles of ATG proteins and membrane lipids in autophagosome formation","volume":"6","author":"Nishimura","year":"2020","journal-title":"Cell Discov."},{"key":"10.1016\/j.immuni.2026.06.020_bib20","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.4049\/jimmunol.177.5.3369","article-title":"Synchrony of High Endothelial Venules and Lymphatic Vessels Revealed by Immunization","volume":"177","author":"Liao","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2026.06.020_bib21","doi-asserted-by":"crossref","first-page":"691","DOI":"10.4161\/auto.27749","article-title":"Seeing is believing: Dynamic changes in renal epithelial autophagy during injury and repair","volume":"10","author":"Lin","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.immuni.2026.06.020_bib22","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1681\/ASN.2013040374","article-title":"New Autophagy Reporter Mice Reveal Dynamics of Proximal Tubular Autophagy","volume":"25","author":"Li","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.immuni.2026.06.020_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-021-04121-9","article-title":"A gene toolbox for monitoring autophagy transcription","volume":"12","author":"Bordi","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.immuni.2026.06.020_bib24","doi-asserted-by":"crossref","first-page":"11019","DOI":"10.1073\/pnas.93.20.11019","article-title":"A developmental switch in lymphocyte homing receptor and endothelial vascular addressin expression regulates lymphocyte homing and permits CD4+ CD3- cells to colonize lymph nodes","volume":"93","author":"Mebius","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2026.06.020_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-17291-5","article-title":"A molecular map of murine lymph node blood vascular endothelium at single cell resolution","volume":"11","author":"Brulois","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2026.06.020_bib26","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.immuni.2005.10.002","article-title":"Lymphotoxin-beta receptor signaling is required for the homeostatic control of HEV differentiation and function","volume":"23","author":"Browning","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.06.020_bib27","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.tibs.2015.01.002","article-title":"UPR, autophagy, and mitochondria crosstalk underlies the ER stress response","volume":"40","author":"Senft","year":"2015","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.immuni.2026.06.020_bib28","article-title":"Common Gene Networks Orchestrate Organelle Architecture and Inter-Organelle Metabolic Flows for Mucin Production in High Endothelial and Goblet Cells","author":"Bi","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.immuni.2026.06.020_bib29","article-title":"A novel monoclonal antibody against 6-sulfo sialyl Lewis x glycans attenuates murine allergic rhinitis by suppressing Th2 immune responses","volume":"13","author":"Liu","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.immuni.2026.06.020_bib30","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.immuni.2018.09.018","article-title":"Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis","volume":"49","author":"Girbl","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.06.020_bib31","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/eji.202149238","article-title":"ACKR1 favors transcellular over paracellular T-cell diapedesis across the blood-brain barrier in neuroinflammation in vitro","volume":"52","author":"Marchetti","year":"2022","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.immuni.2026.06.020_bib32","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nature10540","article-title":"Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules","volume":"479","author":"Moussion","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2026.06.020_bib33","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/nri2832","article-title":"New insights into the development of lymphoid tissues","volume":"10","author":"van de Pavert","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2026.06.020_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms8114","article-title":"Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity","volume":"6","author":"Peske","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2026.06.020_bib35","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nri.2017.52","article-title":"The non-canonical NF-\u03baB pathway in immunity and inflammation","volume":"17","author":"Sun","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2026.06.020_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-00859-z","article-title":"Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins","volume":"8","author":"Newman","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2026.06.020_bib37","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1080\/15548627.2023.2208931","article-title":"Blocking glycosphingolipid production alters autophagy in osteoclasts and improves myeloma bone disease","volume":"20","author":"Leng","year":"2024","journal-title":"Autophagy"},{"key":"10.1016\/j.immuni.2026.06.020_bib38","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1084\/jem.20121462","article-title":"Endothelial cell-specific lymphotoxin-\u03b2 receptor signaling is critical for lymph node and high endothelial venule formation","volume":"210","author":"Onder","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2026.06.020_bib39","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1002\/pmic.201600064","article-title":"Development and application of a novel recombinant Aleuria aurantia lectin with enhanced core fucose binding for identification of glycoprotein biomarkers of hepatocellular carcinoma","volume":"16","author":"Norton","year":"2016","journal-title":"Proteomics"},{"key":"10.1016\/j.immuni.2026.06.020_bib40","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41580-020-0250-z","article-title":"Mechanisms, regulation and functions of the unfolded protein response","volume":"21","author":"Hetz","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.immuni.2026.06.020_bib41","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-022-04523-3","article-title":"Advances in the pathogenesis of psoriasis: from keratinocyte perspective","volume":"13","author":"Zhou","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.immuni.2026.06.020_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12090789","article-title":"Advanced Characterization of Imiquimod-Induced Psoriasis-Like Mouse Model","volume":"12","author":"Jabeen","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.immuni.2026.06.020_bib43","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aak9679","article-title":"Combined antiangiogenic and anti\u2013PD-L1 therapy stimulates tumor immunity through HEV formation","volume":"9","author":"Allen","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.immuni.2026.06.020_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1186455","article-title":"Revisiting the interleukin 17 family of cytokines in psoriasis: pathogenesis and potential targets for innovative therapies","volume":"14","author":"Brembilla","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2026.06.020_bib45","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1002\/eji.200535503","article-title":"IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis","volume":"36","author":"Wolk","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.immuni.2026.06.020_bib46","doi-asserted-by":"crossref","first-page":"26898","DOI":"10.1074\/jbc.M113.464503","article-title":"Basal Autophagy Is Required for the Efficient Catabolism of Sialyloligosaccharides","volume":"288","author":"Seino","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.immuni.2026.06.020_bib47","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1038\/ncb3066","article-title":"O-GlcNAc-modification of SNAP-29 regulates autophagosome maturation","volume":"16","author":"Guo","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.immuni.2026.06.020_bib48","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1016\/j.celrep.2018.11.042","article-title":"ULK1 O-GlcNAcylation Is Crucial for Activating VPS34 via ATG14L during Autophagy Initiation","volume":"25","author":"Pyo","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2026.06.020_bib49","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1007\/s00018-012-1173-4","article-title":"Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress","volume":"70","author":"Deegan","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.immuni.2026.06.020_bib50","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s00125-011-2350-y","article-title":"Autophagy deficiency in beta cells leads to compromised unfolded protein response and progression from obesity to diabetes in mice","volume":"55","author":"Quan","year":"2012","journal-title":"Diabetologia"},{"key":"10.1016\/j.immuni.2026.06.020_bib51","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.immuni.2004.06.010","article-title":"XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation","volume":"21","author":"Shaffer","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.06.020_bib52","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202401945R","article-title":"Chloroquine-induced proinsulin misfolding in the endoplasmic reticulum underlies the attenuation of mature insulin synthesis","volume":"38","author":"Xu","year":"2024","journal-title":"FASEB J."},{"key":"10.1016\/j.immuni.2026.06.020_bib53","article-title":"ER-Phagy: A New Regulator of ER Homeostasis","volume":"9","author":"Yang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.immuni.2026.06.020_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114020","article-title":"An autophagy program that promotes T cell egress from the lymph node controls responses to immune checkpoint blockade","volume":"43","author":"Houbaert","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2026.06.020_bib55","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1001\/jamadermatol.2021.2007","article-title":"Psoriasis Prevalence in Adults in the United States","volume":"157","author":"Armstrong","year":"2021","journal-title":"JAMA Dermatol."},{"key":"10.1016\/j.immuni.2026.06.020_bib56","article-title":"Challenges and Future Trends in the Treatment of Psoriasis","volume":"24","author":"Lee","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.immuni.2026.06.020_bib57","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1111\/1346-8138.14498","article-title":"Analysis of possible structures of inducible skin-associated lymphoid tissue in lupus erythematosus profundus","volume":"45","author":"Kogame","year":"2018","journal-title":"J. Dermatol."},{"key":"10.1016\/j.immuni.2026.06.020_bib58","first-page":"145","article-title":"Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity","volume":"11","author":"Malhotra","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.immuni.2026.06.020_bib78","doi-asserted-by":"crossref","first-page":"14489","DOI":"10.1073\/pnas.0701311104","article-title":"Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration","volume":"104","author":"Komatsu","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.immuni.2026.06.020_bib59","doi-asserted-by":"crossref","first-page":"5680","DOI":"10.1182\/blood-2008-08-174508","article-title":"DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries","volume":"113","author":"S\u00f6rensen","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2026.06.020_bib61","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/emboj.2011.52","article-title":"The unfolded protein response transducer IRE1\u03b1 prevents ER stress-induced hepatic steatosis","volume":"30","author":"Zhang","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.immuni.2026.06.020_bib62","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.4049\/jimmunol.1103324","article-title":"Lymphotoxin \u03b2 Receptor Activation on Macrophages Induces Cross-Tolerance to TLR4 and TLR9 Ligands","volume":"188","author":"Wimmer","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2026.06.020_bib71","doi-asserted-by":"crossref","unstructured":"Hua, Y., Weng, L., Zhao, F., and Rambow, F. (2024) SeuratExtend: Streamlining Single-Cell RNA-Seq Analysis Through an Integrated and Intuitive Framework. https:\/\/doi.org\/10.1101\/2024.08.01.606144.","DOI":"10.1101\/2024.08.01.606144"},{"key":"10.1016\/j.immuni.2026.06.020_bib67","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nmeth.4463","article-title":"SCENIC: single-cell regulatory network inference and clustering","volume":"14","author":"Aibar","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.immuni.2026.06.020_bib68","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/s41587-019-0068-4","article-title":"Characterization of cell fate probabilities in single-cell data with Palantir","volume":"37","author":"Setty","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.immuni.2026.06.020_bib69","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1038\/s41587-020-0591-3","article-title":"Generalizing RNA velocity to transient cell states through dynamical modeling","volume":"38","author":"Bergen","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.immuni.2026.06.020_bib79","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/s41586-018-0414-6","article-title":"RNA velocity of single cells","volume":"560","author":"La Manno","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2026.06.020_bib80","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.immuni.2026.06.020_bib81","doi-asserted-by":"crossref","first-page":"16878","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: Open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.immuni.2026.06.020_bib60","doi-asserted-by":"crossref","first-page":"4307","DOI":"10.1093\/emboj\/cdf418","article-title":"Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy","volume":"21","author":"Enge","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.immuni.2026.06.020_bib63","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nature21046","article-title":"Identity and dynamics of mammary stem cells during branching morphogenesis","volume":"542","author":"Scheele","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2026.06.020_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2022.101267","article-title":"Analyses of murine lymph node endothelial cell subsets using single-cell RNA sequencing and spectral flow cytometry","volume":"3","author":"Menzel","year":"2022","journal-title":"Star Protoc."},{"key":"10.1016\/j.immuni.2026.06.020_bib65","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2026.06.020_bib66","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.immuni.2026.06.020_bib70","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1126\/science.aax0249","article-title":"Single-cell transcriptional diversity is a hallmark of developmental potential","volume":"367","author":"Gulati","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.immuni.2026.06.020_bib72","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s41596-024-01045-4","article-title":"CellChat for systematic analysis of cell-cell communication from single-cell transcriptomics","volume":"20","author":"Jin","year":"2025","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.immuni.2026.06.020_bib73","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1038\/s41590-023-01502-4","article-title":"PI16+ reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches","volume":"24","author":"De Martin","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2026.06.020_bib74","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.immuni.2026.06.020_bib75","first-page":"D498","article-title":"The reactome pathway knowledgebase","volume":"48","author":"Jassal","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.immuni.2026.06.020_bib76","article-title":"Pooling across cells to normalize single-cell RNA sequencing data with many zero counts","volume":"17","author":"Lun","year":"2016","journal-title":"Genome Biol."},{"key":"10.1016\/j.immuni.2026.06.020_bib77","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc., B (Methodol.)"}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761326002712?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761326002712?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:14:10Z","timestamp":1789733650000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761326002712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":81,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S1074761326002712"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2026.06.020","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autophagy maintains high endothelial venule identity and function during inflammation","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2026.06.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}