{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:00:44Z","timestamp":1792814444667,"version":"4.5.0"},"reference-count":89,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["25828"],"award-info":[{"award-number":["25828"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C5759\/A27412"],"award-info":[{"award-number":["C5759\/A27412"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003043","name":"EMBO","doi-asserted-by":"publisher","award":["aALT-638-2108"],"award-info":[{"award-number":["aALT-638-2108"]}],"id":[{"id":"10.13039\/501100003043","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.immuni.2026.07.002","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:37:01Z","timestamp":1785854221000},"page":"2282-2298.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["CCR7+ activated dendritic cells are essential for spontaneous and immunotherapy-driven anti-tumor immunity"],"prefix":"10.1016","volume":"59","author":[{"given":"Maria A.","family":"Koufaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Bonavita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Reeves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agrin","family":"Moeini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Chieh","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Banyard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles H.","family":"Earnshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte R.","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eimear","family":"Flanagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria S.","family":"Pelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laetitia","family":"Nebot-Bral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Pidoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poppy","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhakar","family":"Sahoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Henri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Malissen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"MacDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Moncaut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6865-3978","authenticated-orcid":false,"given":"Santiago","family":"Zelenay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2026.07.002_bib1","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1084\/jem.20092454","article-title":"Tumor masses support naive T cell infiltration, activation, and differentiation into effectors","volume":"207","author":"Thompson","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2026.07.002_bib2","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.ccell.2016.06.003","article-title":"Critical Role for CD103(+)\/CD141(+) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma","volume":"30","author":"Roberts","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.immuni.2026.07.002_bib3","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.immuni.2016.03.012","article-title":"Expansion and activation of CD103+ dendritic cell progenitors at the tumor site enhances tumor responses to therapeutic PD-L1 and BRAF inhibition","volume":"44","author":"Salmon","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.07.002_bib4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41577-019-0210-z","article-title":"Dendritic cells in cancer immunology and immunotherapy","volume":"20","author":"Wculek","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2026.07.002_bib5","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.ccell.2014.09.007","article-title":"Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity","volume":"26","author":"Broz","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.immuni.2026.07.002_bib6","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.immuni.2018.09.024","article-title":"Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-\u03b3 and IL-12","volume":"49","author":"Garris","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.07.002_bib7","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1016\/j.immuni.2023.09.011","article-title":"The cancer-immunity cycle: Indication, genotype, and immunotype","volume":"56","author":"Mellman","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.07.002_bib8","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1016\/j.immuni.2023.08.014","article-title":"Dendritic cells as shepherds of T cell immunity in cancer","volume":"56","author":"Pittet","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.07.002_bib9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.immuni.2022.12.002","article-title":"CD8+ T cell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor","volume":"56","author":"Prokhnevska","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.07.002_bib10","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.ccell.2017.04.003","article-title":"Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy","volume":"31","author":"Spranger","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.immuni.2026.07.002_bib11","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adf4726","article-title":"Architects of immunity: How dendritic cells shape CD8+ T cell fate in cancer","volume":"10","author":"Bhandarkar","year":"2025","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.immuni.2026.07.002_bib12","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1126\/science.1164206","article-title":"Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity","volume":"322","author":"Hildner","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.immuni.2026.07.002_bib13","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1084\/jem.20100348","article-title":"Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells","volume":"207","author":"Bachem","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2026.07.002_bib14","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1084\/jem.20100223","article-title":"The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8alpha+ dendritic cells","volume":"207","author":"Crozat","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2026.07.002_bib15","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.immuni.2012.04.012","article-title":"Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells","volume":"37","author":"Haniffa","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.07.002_bib16","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1084\/jem.20092140","article-title":"Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens","volume":"207","author":"Jongbloed","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2026.07.002_bib17","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1126\/science.aat5030","article-title":"WDFY4 is required for cross-presentation in response to viral and tumor antigens","volume":"362","author":"Theisen","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.immuni.2026.07.002_bib18","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/s41591-018-0085-8","article-title":"A natural killer\u2013dendritic cell axis defines checkpoint therapy\u2013responsive tumor microenvironments","volume":"24","author":"Barry","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2026.07.002_bib19","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.cell.2018.01.004","article-title":"NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control","volume":"172","author":"B\u00f6ttcher","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2026.07.002_bib20","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abg3570","article-title":"NF-\u03baB-dependent IRF1 activation programs cDC1 dendritic cells to drive antitumor immunity","volume":"6","author":"Ghislat","year":"2021","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.immuni.2026.07.002_bib21","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aav3942","article-title":"IFN-III is selectively produced by cDC1 and predicts good clinical outcome in breast cancer","volume":"5","author":"Hubert","year":"2020","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.immuni.2026.07.002_bib22","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/s41590-018-0145-8","article-title":"Adjustment of dendritic cells to the breast-cancer microenvironment is subset specific","volume":"19","author":"Michea","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2026.07.002_bib23","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1158\/2159-8290.CD-15-0510","article-title":"Cancer Immunotherapy with Immunomodulatory Anti-CD137 and Anti-PD-1 Monoclonal Antibodies Requires BATF3-Dependent Dendritic Cells","volume":"6","author":"S\u00e1nchez-Paulete","year":"2016","journal-title":"Cancer Discov."},{"key":"10.1016\/j.immuni.2026.07.002_bib24","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.immuni.2021.10.020","article-title":"Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity","volume":"55","author":"Duong","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.07.002_bib25","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.immuni.2022.04.016","article-title":"Dendritic cells can prime anti-tumor CD8+ T cell responses through major histocompatibility complex cross-dressing","volume":"55","author":"MacNabb","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.07.002_bib26","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202216523","article-title":"Dendritic cell cross-dressing and tumor immunity","volume":"14","author":"Martinez-Usatorre","year":"2022","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.immuni.2026.07.002_bib27","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.cell.2021.01.010","article-title":"A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells","volume":"184","author":"Cheng","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2026.07.002_bib28","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20200264","article-title":"Tumor-infiltrating dendritic cell states are conserved across solid human cancers","volume":"218","author":"Gerhard","year":"2021","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2026.07.002_bib29","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41422-020-0355-0","article-title":"A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling","volume":"30","author":"Qian","year":"2020","journal-title":"Cell Res."},{"key":"10.1016\/j.immuni.2026.07.002_bib30","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.cell.2019.10.003","article-title":"Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma","volume":"179","author":"Zhang","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2026.07.002_bib31","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.immuni.2019.03.009","article-title":"Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species","volume":"50","author":"Zilionis","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.07.002_bib32","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41577-022-00675-7","article-title":"Expanding dendritic cell nomenclature in the single-cell era","volume":"22","author":"Ginhoux","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2026.07.002_bib33","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s41586-020-2134-y","article-title":"A conserved dendritic-cell regulatory program limits antitumour immunity","volume":"580","author":"Maier","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2026.07.002_bib34","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41568-024-00787-3","article-title":"Dendritic cell maturation in cancer","volume":"25","author":"Moon","year":"2025","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.immuni.2026.07.002_bib35","article-title":"Tumour-retained activated CCR7+ dendritic cells are heterogeneous and regulate local anti-tumour cytolytic activity","volume":"15","author":"Lee","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2026.07.002_bib36","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/978-1-0716-2938-3_22","article-title":"Harnessing Single-Cell RNA Sequencing to Identify Dendritic Cell Types, Characterize Their Biological States, and Infer Their Activation Trajectory","volume":"2618","author":"Cheema","year":"2023","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.immuni.2026.07.002_bib37","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/s41590-024-01792-2","article-title":"Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy","volume":"25","author":"Chen","year":"2024","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2026.07.002_bib38","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/s43018-022-00338-5","article-title":"The interaction of CD4+ helper T cells with dendritic cells shapes the tumor microenvironment and immune checkpoint blockade response","volume":"3","author":"Cohen","year":"2022","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.immuni.2026.07.002_bib39","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1016\/j.cell.2021.07.015","article-title":"CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment","volume":"184","author":"Di Pilato","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2026.07.002_bib40","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1038\/s41591-023-02345-0","article-title":"Intratumoral dendritic cell\u2013CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma","volume":"29","author":"Magen","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2026.07.002_bib41","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.ccell.2024.06.014","article-title":"Lymphatic-localized Treg-mregDC crosstalk limits antigen trafficking and restrains anti-tumor immunity","volume":"42","author":"You","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.immuni.2026.07.002_bib42","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1189\/jlb.0506319","article-title":"NF-\u03baB is required for STAT-4 expression during dendritic cell maturation","volume":"81","author":"Remoli","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.immuni.2026.07.002_bib43","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-020-2632-8","article-title":"TonEBP in dendritic cells mediates pro-inflammatory maturation and Th1\/Th17 responses","volume":"11","author":"Ye","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.immuni.2026.07.002_bib44","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.immuni.2016.07.019","article-title":"Broad and Largely Concordant Molecular Changes Characterize Tolerogenic and Immunogenic Dendritic Cell Maturation in Thymus and Periphery","volume":"45","author":"Ardouin","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.07.002_bib45","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1084\/jem.20062648","article-title":"Notch\u2013RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen","volume":"204","author":"Caton","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2026.07.002_bib46","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.4049\/jimmunol.1101717","article-title":"Cutting edge: expression of XCR1 defines mouse lymphoid-tissue resident and migratory dendritic cells of the CD8\u03b1+ type","volume":"187","author":"Crozat","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2026.07.002_bib47","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1002\/eji.201243106","article-title":"Plasmacytoid, conventional, and monocyte-derived dendritic cells undergo a profound and convergent genetic reprogramming during their maturation","volume":"43","author":"Manh","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.immuni.2026.07.002_bib48","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20222129","article-title":"CCL5-producing migratory dendritic cells guide CCR5+ monocytes into the draining lymph nodes","volume":"220","author":"Rawat","year":"2023","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2026.07.002_bib49","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jim.2014.05.009","article-title":"Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice","volume":"408","author":"Abram","year":"2014","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.immuni.2026.07.002_bib50","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1002\/eji.202149513","article-title":"Dendritic cell functions in vivo: A user\u2019s guide to current and next- generation mutant mouse models","volume":"52","author":"Dalod","year":"2022","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.immuni.2026.07.002_bib51","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aba1896","article-title":"Absence of MHC class II on cDC1 dendritic cells triggers fatal autoimmunity to a cross-presented self-antigen","volume":"5","author":"Wohn","year":"2020","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.immuni.2026.07.002_bib52","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/s41586-020-2611-3","article-title":"cDC1 prime and are licensed by CD4+ T cells to induce anti-tumour immunity","volume":"584","author":"Ferris","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2026.07.002_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.02805","article-title":"Novel Cre-Expressing Mouse Strains Permitting to Selectively Track and Edit Type 1 Conventional Dendritic Cells Facilitate Disentangling Their Complexity in vivo","volume":"9","author":"Mattiuz","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2026.07.002_bib54","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1016\/j.celrep.2016.07.076","article-title":"Differential Intrasplenic Migration of Dendritic Cell Subsets Tailors Adaptive Immunity","volume":"16","author":"Calabro","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2026.07.002_bib55","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41577-018-0088-1","article-title":"Dendritic cell subsets in T cell programming: location dictates function","volume":"19","author":"Eisenbarth","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2026.07.002_bib56","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.immuni.2025.11.020","article-title":"Positioning and reversible suppression of CCR7+ dendritic cells in perivascular tumor niches shape cancer immunity","volume":"59","author":"Zitti","year":"2026","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.07.002_bib57","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-29606-9","article-title":"Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations","volume":"13","author":"Bell","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2026.07.002_bib58","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.cell.2015.08.015","article-title":"Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity","volume":"162","author":"Zelenay","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2026.07.002_bib59","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/s41590-024-02065-8","article-title":"Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer","volume":"26","author":"Belabed","year":"2025","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2026.07.002_bib60","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.add3955","article-title":"LXR signaling controls homeostatic dendritic cell maturation","volume":"8","author":"Bosteels","year":"2023","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.immuni.2026.07.002_bib61","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1146\/annurev-immunol-061020-053707","article-title":"Dendritic Cells Revisited","volume":"39","author":"Cabeza-Cabrerizo","year":"2021","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.immuni.2026.07.002_bib62","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1038\/s41590-019-0450-x","article-title":"Cryptic activation of an Irf8 enhancer governs cDC1 fate specification","volume":"20","author":"Durai","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2026.07.002_bib63","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/s41586-024-08257-4","article-title":"Cancer cells impair monocyte-mediated T cell stimulation to evade immunity","volume":"637","author":"Elewaut","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2026.07.002_bib64","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.1158\/0008-5472.CAN-22-1046","article-title":"Depletion of Conventional Type-1 Dendritic Cells in Established Tumors Suppresses Immunotherapy Efficacy","volume":"82","author":"Teijeira","year":"2022","journal-title":"Cancer Res."},{"key":"10.1016\/j.immuni.2026.07.002_bib65","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.1016\/j.cell.2023.07.034","article-title":"A pan-cancer single-cell panorama of human natural killer cells","volume":"186","author":"Tang","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2026.07.002_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110914","article-title":"PGE2-EP2\/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment","volume":"39","author":"Thumkeo","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2026.07.002_bib67","article-title":"Mature and migratory dendritic cells promote immune infiltration and response to anti-PD-1 checkpoint blockade in metastatic melanoma","volume":"16","author":"Yang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2026.07.002_bib68","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/s41590-024-01856-3","article-title":"Cell shape sensing licenses dendritic cells for homeostatic migration to lymph nodes","volume":"25","author":"Alraies","year":"2024","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2026.07.002_bib69","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.trecan.2024.07.009","article-title":"CD4+ T cells in antitumor immunity","volume":"10","author":"Montauti","year":"2024","journal-title":"Trends Cancer"},{"key":"10.1016\/j.immuni.2026.07.002_bib70","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.ccell.2024.05.025","article-title":"Intratumoral immune triads are required for immunotherapy-mediated elimination of solid tumors","volume":"42","author":"Espinosa-Carrasco","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.immuni.2026.07.002_bib71","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adq8843","article-title":"Proximity-dependent labeling identifies dendritic cells that drive the tumor-specific CD4+ T cell response","volume":"9","author":"Chudnovskiy","year":"2024","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.immuni.2026.07.002_bib72","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-35615-5","article-title":"CD4+ helper T cells endow cDC1 with cancer-impeding functions in the human tumor micro-environment","volume":"14","author":"Lei","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2026.07.002_bib73","doi-asserted-by":"crossref","DOI":"10.1002\/eji.70011","article-title":"Spatial Organisation of Tumour cDC1 States Correlates with Effector and Stem-Like CD8+ T Cells Location","volume":"55","author":"Piot","year":"2025","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.immuni.2026.07.002_bib82","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.immuni.2020.10.020","article-title":"Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade","volume":"53","author":"Bonavita","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.07.002_bib77","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ccr.2009.02.022","article-title":"Oncogenic Braf Induces Melanocyte Senescence and Melanoma in Mice","volume":"15","author":"Dhomen","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.immuni.2026.07.002_bib81","doi-asserted-by":"crossref","first-page":"4016","DOI":"10.1016\/j.cell.2021.05.021","article-title":"Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity","volume":"184","author":"Giampazolias","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2026.07.002_bib89","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.immuni.2026.07.002_bib86","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1038\/s41592-024-02303-9","article-title":"CellRank 2: unified fate mapping in multiview single-cell data","volume":"21","author":"Weiler","year":"2024","journal-title":"Nat. Methods"},{"key":"10.1016\/j.immuni.2026.07.002_bib88","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1038\/s41596-020-0336-2","article-title":"A scalable SCENIC workflow for single-cell gene regulatory network analysis","volume":"15","author":"Van de Sande","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.immuni.2026.07.002_bib84","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-017-1382-0","article-title":"SCANPY: large-scale single-cell gene expression data analysis","volume":"19","author":"Wolf","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.immuni.2026.07.002_bib83","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/s41586-018-0414-6","article-title":"RNA velocity of single cells","volume":"560","author":"La Manno","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2026.07.002_bib85","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1038\/s41587-020-0591-3","article-title":"Generalizing RNA velocity to transient cell states through dynamical modeling","volume":"38","author":"Bergen","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.immuni.2026.07.002_bib74","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1101\/gad.8.9.1030","article-title":"Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice","volume":"8","author":"Spanopoulou","year":"1994","journal-title":"Genes Dev."},{"key":"10.1016\/j.immuni.2026.07.002_bib75","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0092-8674(94)90169-4","article-title":"T cell receptor antagonist peptides induce positive selection","volume":"76","author":"Hogquist","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2026.07.002_bib76","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1038\/sj.bjc.6605642","article-title":"Guidelines for the welfare and use of animals in cancer research","volume":"102","author":"Workman","year":"2010","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.immuni.2026.07.002_bib78","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.1093\/bioinformatics\/btv308","article-title":"WGE: a CRISPR database for genome engineering","volume":"31","author":"Hodgkins","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.immuni.2026.07.002_bib79","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.tig.2017.12.008","article-title":"Detecting and Avoiding Problems When Using the Cre\u2013lox System","volume":"34","author":"Song","year":"2018","journal-title":"Trends Genet."},{"key":"10.1016\/j.immuni.2026.07.002_bib80","doi-asserted-by":"crossref","first-page":"307","DOI":"10.4049\/jimmunol.1401999","article-title":"Altered lymph node composition in diphtheria toxin receptor-based mouse models to ablate dendritic cells","volume":"194","author":"van Blijswijk","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2026.07.002_bib87","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nmeth.4463","article-title":"SCENIC: Single-cell regulatory network inference and clustering","volume":"14","author":"Aibar","year":"2017","journal-title":"Nat. Methods"}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761326002785?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761326002785?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T15:47:41Z","timestamp":1786463261000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761326002785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":89,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S1074761326002785"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2026.07.002","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CCR7+ activated dendritic cells are essential for spontaneous and immunotherapy-driven anti-tumor immunity","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2026.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}