{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:57:04Z","timestamp":1792616224276,"version":"4.5.0"},"reference-count":10,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100006492","name":"National Institute of Allergy and Infectious Diseases Division of Intramural Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.immuni.2026.09.017","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:20:02Z","timestamp":1791904802000},"page":"2605-2607","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Viral deISGylation holds the key to the metabolic kingdom"],"prefix":"10.1016","volume":"59","author":[{"given":"Byron","family":"Shue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0206-297X","authenticated-orcid":false,"given":"Sonja M.","family":"Best","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2026.09.017_bib1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/s41579-018-0020-5","article-title":"ISG15 in antiviral immunity and beyond","volume":"16","author":"Perng","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.immuni.2026.09.017_bib2","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020106275","article-title":"Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2","volume":"39","author":"Klemm","year":"2020","journal-title":"EMBO J."},{"key":"10.1016\/j.immuni.2026.09.017_bib3","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1016\/j.immuni.2026.07.007","article-title":"Virus-induced deconjugation of ISG15 dysregulates innate immunity and cellular metabolism","volume":"59","author":"Zhu","year":"2026","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2026.09.017_bib4","doi-asserted-by":"crossref","first-page":"9829","DOI":"10.1128\/JVI.01199-08","article-title":"Murine coronavirus mouse hepatitis virus is recognized by MDA5 and induces type I interferon in brain macrophages\/microglia","volume":"82","author":"Roth-Cross","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.immuni.2026.09.017_bib5","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41564-021-00884-1","article-title":"ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity","volume":"6","author":"Liu","year":"2021","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.immuni.2026.09.017_bib6","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1093\/cvr\/cvae026","article-title":"ISG15 blocks cardiac glycolysis and ensures sufficient mitochondrial energy production during Coxsackievirus B3 infection","volume":"120","author":"Bredow","year":"2024","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.immuni.2026.09.017_bib7","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abq1533","article-title":"Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts","volume":"15","author":"Guarnieri","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.immuni.2026.09.017_bib8","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1038\/s41590-021-01035-8","article-title":"Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection","volume":"22","author":"Munnur","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2026.09.017_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1012561","article-title":"Mitochondrial hyperactivity and reactive oxygen species drive innate immunity to the yellow fever virus-17D live-attenuated vaccine","volume":"21","author":"Muccilli","year":"2025","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.immuni.2026.09.017_bib10","doi-asserted-by":"crossref","first-page":"8666","DOI":"10.1073\/pnas.0912613107","article-title":"Adaptive evolution of energy metabolism genes and the origin of flight in bats","volume":"107","author":"Shen","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761326003924?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761326003924?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:31:42Z","timestamp":1792614702000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761326003924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S1074761326003924"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2026.09.017","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Viral deISGylation holds the key to the metabolic kingdom","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2026.09.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}