{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:37:40Z","timestamp":1785771460659,"version":"3.56.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NanoImpact"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.impact.2022.100392","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T12:09:16Z","timestamp":1645013356000},"page":"100392","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Intracellular reactive oxygen species trigger mitochondrial dysfunction and apoptosis in cadmium telluride quantum dots-induced liver damage"],"prefix":"10.1016","volume":"25","author":[{"given":"Qing","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuna","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuepu","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.impact.2022.100392_bb0005","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1126\/science.271.5251.933","article-title":"Semiconductor clusters, nanocrystals, and quantum dots","volume":"271","author":"Alivisatos","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.impact.2022.100392_bb0010","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1002\/adfm.200801081","article-title":"Enhanced antibacterial activity of nanocrystalline ZnO due to increased ROS-mediated cell injury","volume":"19","author":"Applerot","year":"2009","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.impact.2022.100392_bb0015","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1042\/BST0391520","article-title":"Mitochondrial dynamics in yeast cell death and aging","volume":"39","author":"Braun","year":"2011","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.impact.2022.100392_bb0020","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1146\/annurev.cellbio.22.010305.104638","article-title":"Mitochondrial fusion and fission in mammals","volume":"22","author":"Chan","year":"2006","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.impact.2022.100392_bb0025","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1002\/smll.200600218","article-title":"Evaluation of quantum dot cytotoxicity based on intracellular uptake","volume":"2","author":"Chang","year":"2006","journal-title":"Small"},{"key":"10.1016\/j.impact.2022.100392_bb0030","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev.cb.04.110188.001103","article-title":"Mitochondrial-membrane potential in living cells","volume":"4","author":"Chen","year":"1988","journal-title":"Annu. Rev. Cell Biol."},{"key":"10.1016\/j.impact.2022.100392_bb0035","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.biomaterials.2011.10.070","article-title":"The cytotoxicity of cadmium-based quantum dots","volume":"33","author":"Chen","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.impact.2022.100392_bb0040","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3389\/fnins.2018.00163","article-title":"The association of tau with mitochondrial dysfunction in Alzheimer\u2019s disease","volume":"12","author":"Cheng","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.impact.2022.100392_bb0045","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.tibs.2016.01.001","article-title":"Mitochondrial cristae: where beauty meets functionality","volume":"41","author":"Cogliati","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.impact.2022.100392_bb0050","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1021\/acsbiomaterials.7b00824","article-title":"Quantum dots elicit hepatotoxicity through lysosome-dependent autophagy activation and reactive oxygen species production","volume":"4","author":"Fan","year":"2018","journal-title":"Acs Biomater. Sci. Eng."},{"key":"10.1016\/j.impact.2022.100392_bb0055","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/1750-3841.15599","article-title":"Garlic flavonoids alleviate H2O2 induced oxidative damage in L02 cells and induced apoptosis in HepG2 cells by Bcl-2\/caspase pathway","volume":"86","author":"Gao","year":"2021","journal-title":"J. Food Sci."},{"key":"10.1016\/j.impact.2022.100392_bb0060","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1039\/c0em00547a","article-title":"The release of engineered nanomaterials to the environment","volume":"13","author":"Gottschalk","year":"2011","journal-title":"J. Environ. Monit."},{"key":"10.1016\/j.impact.2022.100392_bb0065","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1289\/ehp.8284","article-title":"A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors","volume":"114","author":"Hardman","year":"2006","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.impact.2022.100392_bb0070","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/smll.200900626","article-title":"In vivo quantum-dot toxicity assessment","volume":"6","author":"Hauck","year":"2010","journal-title":"Small"},{"key":"10.1016\/j.impact.2022.100392_bb0075","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.bbrc.2012.03.118","article-title":"Depletion of mitochondrial fission factor DRP1 causes increased apoptosis in human colon cancer cells","volume":"421","author":"Inoue-Yamauchi","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.impact.2022.100392_bb0080","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1039\/C9EN00322C","article-title":"Engineered nanomaterials in the context of global element cycles","volume":"6","author":"Jankovic","year":"2019","journal-title":"Environmental Science-Nano"},{"key":"10.1016\/j.impact.2022.100392_bb0085","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1177\/0960327119843578","article-title":"Dose- and duration-dependent cytotoxicity and genotoxicity in human hepato carcinoma cells due to CdTe QDs exposure","volume":"38","author":"Katubi","year":"2019","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.impact.2022.100392_bb0090","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.2147\/IJN.S129274","article-title":"Gold nanoparticles enhance TRAIL sensitivity through Drpl-mediated apoptotic and autophagic mitochondrial fission in NSCLC cells","volume":"12","author":"Ke","year":"2017","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.impact.2022.100392_bb0095","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.chemosphere.2015.04.044","article-title":"Necrotic cell death induced by the protein-mediated intercellular uptake of CdTe quantum dots","volume":"135","author":"Lai","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.impact.2022.100392_bb0100","doi-asserted-by":"crossref","first-page":"12356","DOI":"10.1039\/D1NR02153B","article-title":"The crosstalk between DRP1-dependent mitochondrial fission and oxidative stress triggers hepatocyte apoptosis induced by silver nanoparticles","volume":"13","author":"Li","year":"2021","journal-title":"Nanoscale"},{"key":"10.1016\/j.impact.2022.100392_bb0105","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.chembiol.2005.09.008","article-title":"Unmodified cadmium telluride quantum dots induce reactive oxygen species formation leading to multiple organelle damage and cell death","volume":"12","author":"Lovric","year":"2005","journal-title":"Chem. Biol."},{"key":"10.1016\/j.impact.2022.100392_bb0110","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nmat1390","article-title":"Quantum dot bioconjugates for imaging, labelling and sensing","volume":"4","author":"Medintz","year":"2005","journal-title":"Nat. Mater."},{"key":"10.1016\/j.impact.2022.100392_bb0115","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1126\/science.1104274","article-title":"Quantum dots for live cells, in vivo imaging, and diagnostics","volume":"307","author":"Michalet","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.impact.2022.100392_bb0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0134541","article-title":"Titanium dioxide nanoparticles trigger loss of function and perturbation of mitochondrial dynamics in primary hepatocytes","volume":"10","author":"Natarajan","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.impact.2022.100392_bb0125","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.tox.2013.02.010","article-title":"Cadmium telluride quantum dots cause oxidative stress leading to extrinsic and intrinsic apoptosis in hepatocellular carcinoma HepG2 cells","volume":"306","author":"Nguyen","year":"2013","journal-title":"Toxicology"},{"key":"10.1016\/j.impact.2022.100392_bb0130","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1021\/acs.chemrestox.9b00526","article-title":"Hepatotoxicity of cadmium telluride quantum dots induced by mitochondrial dysfunction","volume":"33","author":"Nguyen","year":"2020","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.impact.2022.100392_bb0135","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1080\/07357900802438585","article-title":"Modulation of effector caspase cleavage determines response of breast and lung tumor cell lines to chemotherapy","volume":"27","author":"Odonkor","year":"2009","journal-title":"Cancer Investig."},{"key":"10.1016\/j.impact.2022.100392_bb0140","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nnano.2015.338","article-title":"Meta-analysis of cellular toxicity for cadmium-containing quantum dots","volume":"11","author":"Oh","year":"2016","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.impact.2022.100392_bb0145","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.bbamcr.2013.02.002","article-title":"New insights into the function and regulation of mitochondrial fission","volume":"1833","author":"Otera","year":"2013","journal-title":"Biochim. Biophys. Acta-Mol. Cell Res."},{"key":"10.1016\/j.impact.2022.100392_bb0150","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.tox.2007.11.021","article-title":"The current state of serum biomarkers of hepatotoxicity","volume":"245","author":"Ozer","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.impact.2022.100392_bb0155","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.tox.2016.11.012","article-title":"Markers for toxicity to HepG2 exposed to cadmium sulphide quantum dots; damage to mitochondria","volume":"374","author":"Paesano","year":"2016","journal-title":"Toxicology"},{"key":"10.1016\/j.impact.2022.100392_bb0160","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1002\/smll.200900466","article-title":"Gold nanoparticles of diameter 1.4 nm trigger necrosis by oxidative stress and mitochondrial damage","volume":"5","author":"Pan","year":"2009","journal-title":"Small"},{"key":"10.1016\/j.impact.2022.100392_bb0165","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/toxsci\/kfp188","article-title":"State of academic knowledge on toxicity and biological fate of quantum dots","volume":"112","author":"Pelley","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.impact.2022.100392_bb0170","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1083\/jcb.130.1.157","article-title":"Alterations in mitochondrial structure and function are early events of dexamethasone induced thymocyte apoptosis","volume":"130","author":"Petit","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.impact.2022.100392_bb0175","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1007\/s11051-012-1109-9","article-title":"Industrial production quantities and uses of ten engineered nanomaterials in Europe and the world","volume":"14","author":"Piccinno","year":"2012","journal-title":"J. Nanopart. Res."},{"key":"10.1016\/j.impact.2022.100392_bb0180","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.tibs.2020.03.009","article-title":"Reciprocal regulation of mitochondrial fission and fusion","volume":"45","author":"Sabouny","year":"2020","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.impact.2022.100392_bb0185","doi-asserted-by":"crossref","DOI":"10.1088\/0957-4484\/24\/16\/165101","article-title":"In vivo monitoring of distributional transport kinetics and extravasation of quantum dots in living rat liver","volume":"24","author":"Su","year":"2013","journal-title":"Nanotechnology"},{"key":"10.1016\/j.impact.2022.100392_bb0190","doi-asserted-by":"crossref","first-page":"19265","DOI":"10.18632\/oncotarget.8086","article-title":"Reduced serpinB9-mediated caspase-1 inhibition can contribute to autoinflammatory disease","volume":"7","author":"van der Burgh","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.impact.2022.100392_bb0195","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.envpol.2018.01.004","article-title":"Dynamic probabilistic material flow analysis of nano-SiO2, nano iron oxides, nano-CeO2, nano-Al2O3, and quantum dots in seven European regions","volume":"235","author":"Wang","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.impact.2022.100392_bb0200","first-page":"2319","article-title":"Time-dependent toxicity of cadmium telluride quantum dots on liver and kidneys in mice: histopathological changes with elevated free cadmium ions and hydroxyl radicals","volume":"11","author":"Wang","year":"2016","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.impact.2022.100392_bb0205","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1021\/ar3000585","article-title":"Quantum dot cytotoxicity and ways to reduce it","volume":"46","author":"Winnik","year":"2013","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.impact.2022.100392_bb0210","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.envpol.2020.115681","article-title":"Mitochondrial dynamics and mitophagy involved in MPA-capped CdTe quantum dots-induced toxicity in the human liver carcinoma (HepG2) cell line","volume":"274","author":"Wu","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.impact.2022.100392_bb0215","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1021\/nl061025k","article-title":"Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm","volume":"6","author":"Xia","year":"2006","journal-title":"Nano Lett."},{"key":"10.1016\/j.impact.2022.100392_bb0220","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1016\/j.nano.2018.07.009","article-title":"In vivo biodistribution and toxicology studies of cadmium-free indium-based quantum dot nanoparticles in a rat model","volume":"14","author":"Yaghini","year":"2018","journal-title":"Nanomed.-Nanotechnol. Biol. Med."},{"key":"10.1016\/j.impact.2022.100392_bb0225","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1080\/17435390.2018.1481238","article-title":"Silver nanoparticles inhibit neural induction in human induced pluripotent stem cells","volume":"12","author":"Yamada","year":"2018","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.impact.2022.100392_bb0230","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1126\/science.1219855","article-title":"Mitochondrial fission, fusion, and stress","volume":"337","author":"Youle","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.impact.2022.100392_bb0235","doi-asserted-by":"crossref","first-page":"23279","DOI":"10.3390\/ijms161023279","article-title":"Liver toxicity of cadmium telluride quantum dots (CdTe QDs) due to oxidative stress in vitro and in vivo","volume":"16","author":"Zhang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.impact.2022.100392_bb0240","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1016\/S1001-0742(09)60350-8","article-title":"Quantum dots enhance Cu2+-induced hepatic L02 cells toxicity","volume":"22","author":"Zhao","year":"2010","journal-title":"J. Environ. Sci."}],"container-title":["NanoImpact"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452074822000143?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452074822000143?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T15:32:56Z","timestamp":1762529576000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452074822000143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":48,"alternative-id":["S2452074822000143"],"URL":"https:\/\/doi.org\/10.1016\/j.impact.2022.100392","relation":{},"ISSN":["2452-0748"],"issn-type":[{"value":"2452-0748","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intracellular reactive oxygen species trigger mitochondrial dysfunction and apoptosis in cadmium telluride quantum dots-induced liver damage","name":"articletitle","label":"Article Title"},{"value":"NanoImpact","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.impact.2022.100392","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100392"}}