{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:01:00Z","timestamp":1791860460327,"version":"4.3.4"},"reference-count":95,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.827426\/2023-00"],"award-info":[{"award-number":["88887.827426\/2023-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["402532\/2023-6"],"award-info":[{"award-number":["402532\/2023-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["442574\/2023-1"],"award-info":[{"award-number":["442574\/2023-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NanoImpact"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.impact.2026.100626","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T06:29:55Z","timestamp":1776234595000},"page":"100626","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Systems toxicology of naturally aged polypropylene microplastics in zebrafish"],"prefix":"10.1016","volume":"42","author":[{"given":"Ra\u00edssa de Oliveira","family":"Ferreira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abra\u00e3o Tiago Batista","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Sueli de Lima","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiarlen Marinho","family":"da Luz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Malafaia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.impact.2026.100626_bib572","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1749-6632.2011.06422.x","article-title":"The use of information theory in evolutionary biology","volume":"1256","author":"Adami","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"7388","key":"10.1016\/j.impact.2026.100626_bb0005","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nature10832","article-title":"Stability criteria for complex ecosystems","volume":"483","author":"Allesina","year":"2012","journal-title":"Nature"},{"issue":"30","key":"10.1016\/j.impact.2026.100626_bb0010","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202303259","article-title":"Nitric oxide: physiological functions, delivery, and biomedical applications","volume":"10","author":"Andrabi","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.impact.2026.100626_bb0015","article-title":"Regular care and maintenance of a zebrafish (Danio rerio) laboratory: an introduction","volume":"69","author":"Avdesh","year":"2012","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.impact.2026.100626_bb0020","series-title":"How Nature Works: The Science of Self-Organized Criticality","author":"Bak","year":"2013"},{"key":"10.1016\/j.impact.2026.100626_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2024.110042","article-title":"Environmental toxicology of microplastic particles on fish: a review","volume":"287","author":"Banaee","year":"2025","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.impact.2026.100626_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.134625","article-title":"Microplastics in wild fish from north East Atlantic Ocean and its potential for causing neurotoxic effects, lipid oxidative damage, and human health risks associated with ingestion exposure","volume":"717","author":"Barboza","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"7","key":"10.1016\/j.impact.2026.100626_bb0035","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3109\/10715761003758114","article-title":"Non-enzymatic antioxidant capacity assays: limitations of use in biomedicine","volume":"44","author":"Bartosz","year":"2010","journal-title":"Free Radic. Res."},{"issue":"6","key":"10.1016\/j.impact.2026.100626_bb0040","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.baae.2007.06.003","article-title":"Networks in ecology","volume":"8","author":"Bascompte","year":"2007","journal-title":"Basic Appl. Ecol."},{"key":"10.1016\/j.impact.2026.100626_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115692","article-title":"Bisphenol a impairs reproductive fitness in zebrafish ovary: potential involvement of oxidative\/nitrosative stress, inflammatory and apoptotic mediators","volume":"267","author":"Biswas","year":"2020","journal-title":"Environ. Pollut."},{"issue":"22","key":"10.1016\/j.impact.2026.100626_bb0055","doi-asserted-by":"crossref","first-page":"13878","DOI":"10.3390\/ijms232213878","article-title":"Dose-dependent cytotoxicity of polypropylene microplastics (PP-MPs) in two freshwater fishes","volume":"23","author":"Bobori","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.impact.2026.100626_bb0060","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0023-6438(95)80008-5","article-title":"Use of a free radical method to evaluate antioxidant activity","volume":"28","author":"Brand-Williams","year":"1995","journal-title":"LWT\u2013Food Sci. Technol."},{"issue":"2","key":"10.1016\/j.impact.2026.100626_bb0065","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s11270-025-07758-w","article-title":"Persistent effects of naturally aged polyethylene terephthalate microplastics on Physalaemus cuvieri Tadpoles: the toxic legacy beyond exposure","volume":"236","author":"Brito","year":"2025","journal-title":"Water Air Soil Pollut."},{"key":"10.1016\/j.impact.2026.100626_bb0070","first-page":"1","article-title":"Embedding information flows within ecological networks","author":"Brose","year":"2025","journal-title":"Nat. Ecol. Evol."},{"key":"10.1016\/j.impact.2026.100626_bb0075","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1046\/j.1523-1755.63.s84.6.x","article-title":"Nitric oxide, oxidative stress, and apoptosis","volume":"63","author":"Br\u00fcne","year":"2003","journal-title":"Kidney Int."},{"issue":"24","key":"10.1016\/j.impact.2026.100626_bb0080","doi-asserted-by":"crossref","first-page":"13195","DOI":"10.1021\/acs.est.6b03220","article-title":"Bayesian networks improve causal environmental assessments for evidence-based policy","volume":"50","author":"Carriger","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.impact.2026.100626_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117485","article-title":"Used disposable face masks are significant sources of microplastics to environment","volume":"285","author":"Chen","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.impact.2026.100626_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.144013","article-title":"Toxicokinetic\/toxicodynamic-based risk assessment of freshwater fish health posed by microplastics at environmentally relevant concentrations","volume":"756","author":"Chen","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"4","key":"10.1016\/j.impact.2026.100626_bb0100","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1137\/070710111","article-title":"Power-law distributions in empirical data","volume":"51","author":"Clauset","year":"2009","journal-title":"SIAM Rev."},{"issue":"1","key":"10.1016\/j.impact.2026.100626_bb0105","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s10646-008-0267-0","article-title":"Genetic variation in strains of zebrafish (Danio rerio) and the implications for ecotoxicology studies","volume":"18","author":"Coe","year":"2009","journal-title":"Ecotoxicology"},{"issue":"1","key":"10.1016\/j.impact.2026.100626_bb0115","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/etc.2406","article-title":"Zebrafish as a model system to study toxicology","volume":"33","author":"Dai","year":"2014","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.impact.2026.100626_bb0120","first-page":"201","article-title":"A modified spectrophotometric assay of superoxide dismutase using nitrite formation by superoxide radicals","volume":"37","author":"Das","year":"2000","journal-title":"Indian J. Biochem. Biophys."},{"key":"10.1016\/j.impact.2026.100626_bb0125","article-title":"Microplastic contamination in wild freshwater fish: global trends, challenges and perspectives","volume":"377","author":"de Ara\u00fajo","year":"2025","journal-title":"Environ. Pollut."},{"issue":"4","key":"10.1016\/j.impact.2026.100626_bb0130","doi-asserted-by":"crossref","first-page":"606","DOI":"10.3390\/ani13040606","article-title":"Subchronic exposure to polystyrene microplastic differently affects redox balance in the anterior and posterior intestine of sparus aurata","volume":"13","author":"Del-Piano","year":"2023","journal-title":"Animals"},{"issue":"8","key":"10.1016\/j.impact.2026.100626_bb0135","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nchembio.607","article-title":"Chemistry and biology of reactive oxygen species in signaling or stress responses","volume":"7","author":"Dickinson","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.impact.2026.100626_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.163480","article-title":"Photoaged microplastics induce neurotoxicity via oxidative stress and abnormal neurotransmission in zebrafish larvae (Danio rerio)","volume":"881","author":"Ding","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"10","key":"10.1016\/j.impact.2026.100626_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026071","article-title":"The energy landscape analysis of cancer mutations in protein kinases","volume":"6","author":"Dixit","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.impact.2026.100626_bb0150","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00128-023-03772-y","article-title":"Deleterious effects of polypropylene microplastic ingestion in nile Tilapia (Oreochromis niloticus)","volume":"111","author":"Do-Nascimento","year":"2023","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.impact.2026.100626_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2025.118238","article-title":"A comprehensive risk analysis for cargo leakage pollution at tanker ship manifold under cloud modelling and Bayesian belief network approach","volume":"219","author":"Elidolu","year":"2025","journal-title":"Mar. Pollut. Bull."},{"issue":"2","key":"10.1016\/j.impact.2026.100626_bb0160","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"issue":"2096","key":"10.1016\/j.impact.2026.100626_bb0165","article-title":"Energy landscape analysis of neuroimaging data","volume":"375","author":"Ezaki","year":"2017","journal-title":"Philos. Trans. R. Soc. A Math. Phys. Eng. Sci."},{"issue":"1","key":"10.1016\/j.impact.2026.100626_bb0170","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13717-016-0063-3","article-title":"Applications of structural equation modeling (SEM) in ecological studies: an updated review","volume":"5","author":"Fan","year":"2016","journal-title":"Ecol. Process."},{"key":"10.1016\/j.impact.2026.100626_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.163617","article-title":"First report on the toxicity of SARS-CoV-2, alone and in combination with polyethylene microplastics in neotropical fish","volume":"882","author":"Ferreira","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"13","key":"10.1016\/j.impact.2026.100626_bb0180","doi-asserted-by":"crossref","first-page":"10998","DOI":"10.3390\/ijms241310998","article-title":"Effect of microplastics on the activity of digestive and oxidative-stress-related enzymes in peled whitefish (Coregonus peled Gmelin) larvae","volume":"24","author":"Frank","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.impact.2026.100626_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2025.107242","article-title":"From plankton to fish: the multifaceted threat of microplastics in freshwater environments","volume":"279","author":"Gao","year":"2025","journal-title":"Aquat. Toxicol."},{"issue":"8\u20139","key":"10.1016\/j.impact.2026.100626_bb0195","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/S0531-5565(02)00088-8","article-title":"Life spans and senescent phenotypes in two strains of zebrafish (Danio rerio)","volume":"37","author":"Gerhard","year":"2002","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.impact.2026.100626_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconhyd.2025.104514","article-title":"Exploring the ecotoxicological impacts of microplastics on freshwater fish: a critical review","volume":"269","author":"Ghosh","year":"2025","journal-title":"J. Contam. Hydrol."},{"key":"10.1016\/j.impact.2026.100626_bb0205","series-title":"Methods in Enzymology","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0076-6879(96)68026-4","article-title":"Quantitation of nitrate and nitrite in extracellular fluids","volume":"Vol. 268","author":"Grisham","year":"1996"},{"key":"10.1016\/j.impact.2026.100626_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124833","article-title":"Toxic effects of naturally-aged microplastics on zebrafish juveniles: a more realistic approach to plastic pollution in freshwater ecosystems","volume":"407","author":"Guimar\u00e3es","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.impact.2026.100626_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.130004","article-title":"Exposure to polystyrene nanoplastics induces an anxiolytic-like effect, changes in antipredator defensive response, and DNA damage in swiss mice","volume":"442","author":"Guimar\u00e3es","year":"2023","journal-title":"J. Hazard. Mater."},{"issue":"2","key":"10.1016\/j.impact.2026.100626_bb0220","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s00244-025-01120-1","article-title":"Necroecological trophic transfer of microplastics: insights into the ecotoxicity of petroleum-derived and biodegradable polymers","volume":"88","author":"Guimar\u00e3es","year":"2025","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.impact.2026.100626_bb0225","doi-asserted-by":"crossref","first-page":"100570","DOI":"10.1016\/j.impact.2025.100570","article-title":"Death-driven exposure: Necrotrophic transfer of polylactic acid and polystyrene microplastics alters biochemical architecture in the saprophagous insect Chrysomya megacephala","volume":"38","author":"Guimar\u00e3es","year":"2025","journal-title":"NanoImpact"},{"key":"10.1016\/j.impact.2026.100626_bb0230","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.dib.2015.12.012","article-title":"Data supporting the spectrophotometric method for the estimation of catalase activity","volume":"6","author":"Hadwan","year":"2016","journal-title":"Data Brief"},{"issue":"12","key":"10.1016\/j.impact.2026.100626_bb0235","doi-asserted-by":"crossref","first-page":"762","DOI":"10.3390\/toxics10120762","article-title":"Microplastics in widely used polypropylene-made food containers","volume":"10","author":"Hu","year":"2022","journal-title":"Toxics"},{"issue":"11","key":"10.1016\/j.impact.2026.100626_bb0245","doi-asserted-by":"crossref","DOI":"10.1002\/slct.202103627","article-title":"Comparison of colorimetric methods to detect malondialdehyde, a biomarker of reactive oxygen species","volume":"7","author":"Islayem","year":"2022","journal-title":"ChemistrySelect"},{"issue":"16","key":"10.1016\/j.impact.2026.100626_bb0250","doi-asserted-by":"crossref","first-page":"8849","DOI":"10.1021\/acs.est.6b01441","article-title":"Microplastic size-dependent toxicity, oxidative stress induction, and p-JNK and p-p38 activation in the monogonont rotifer (Brachionus koreanus)","volume":"50","author":"Jeong","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.impact.2026.100626_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.129616","article-title":"Size-dependent seizurogenic effect of polystyrene microplastics in zebrafish embryos","volume":"439","author":"Jeong","year":"2022","journal-title":"J. Hazard. Mater."},{"issue":"3","key":"10.1016\/j.impact.2026.100626_bb0260","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3390\/toxics11030282","article-title":"Biochemical, genotoxic and histological implications of polypropylene microplastics on freshwater fish Oreochromis mossambicus: an aquatic eco-toxicological assessment","volume":"11","author":"Jeyavani","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.impact.2026.100626_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2023.106690","article-title":"Polyester microplastic fibers induce mitochondrial damage, apoptosis and oxidative stress in Daphnia carinata, accompanied by changes in apoptotic and ferroptosis pathway","volume":"263","author":"Jiang","year":"2023","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.impact.2026.100626_bb0270","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.envpol.2019.05.027","article-title":"Microplastics in municipal mixed-waste organic outputs induce minimal short to long-term toxicity in key terrestrial biota","volume":"252","author":"Judy","year":"2019","journal-title":"Environ. Pollut."},{"issue":"1","key":"10.1016\/j.impact.2026.100626_bb0275","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/ieam.4332","article-title":"Bayesian networks in environmental risk assessment: a review","volume":"17","author":"Kaikkonen","year":"2020","journal-title":"Integr. Environ. Assess. Manag."},{"issue":"11","key":"10.1016\/j.impact.2026.100626_bb0280","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3390\/toxics9110289","article-title":"Toxicity and functional tissue responses of two freshwater fish after exposure to polystyrene microplastics","volume":"9","author":"Kaloyianni","year":"2021","journal-title":"Toxics"},{"issue":"8","key":"10.1016\/j.impact.2026.100626_bb0285","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.3390\/su17083537","article-title":"A data-driven Bayesian belief network influence diagram approach for socio-environmental risk assessment and mitigation in major ecosystem-and landscape-modifier projects","volume":"17","author":"Khan","year":"2025","journal-title":"Sustainability"},{"issue":"3","key":"10.1016\/j.impact.2026.100626_bb0290","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1109\/JBHI.2021.3105397","article-title":"Characterising alzheimers disease with EEG-based energy landscape analysis","volume":"26","author":"Klepl","year":"2021","journal-title":"IEEE J. Biomed. Health Inform."},{"issue":"15","key":"10.1016\/j.impact.2026.100626_bb0295","doi-asserted-by":"crossref","first-page":"6780","DOI":"10.1039\/D1NJ00162K","article-title":"Rapid and sensitive colorimetric detection of dopamine based on the enhanced-oxidase mimicking activity of cerium (IV)","volume":"45","author":"Liang","year":"2021","journal-title":"New J. Chem."},{"issue":"3","key":"10.1016\/j.impact.2026.100626_bb0305","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/j.0030-1299.2004.12685.x","article-title":"Does functional redundancy exist?","volume":"104","author":"Loreau","year":"2004","journal-title":"Oikos"},{"issue":"7","key":"10.1016\/j.impact.2026.100626_bb0310","doi-asserted-by":"crossref","first-page":"4054","DOI":"10.1021\/acs.est.6b00183","article-title":"Uptake and accumulation of polystyrene microplastics in zebrafish (Danio rerio) and toxic effects in liver","volume":"50","author":"Lu","year":"2016","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.impact.2026.100626_bb0315","doi-asserted-by":"crossref","first-page":"12","DOI":"10.19040\/ecocycles.v4i2.108","article-title":"Recent advances and future trends in zebrafish bioassays for aquatic ecotoxicology","volume":"4","author":"Magyary","year":"2018","journal-title":"Ecocycles"},{"key":"10.1016\/j.impact.2026.100626_bb0320","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.aquatox.2018.01.010","article-title":"Toxicity assessment of pyriproxyfen in vertebrate model zebrafish embryos (Danio rerio): a multi biomarker study","volume":"196","author":"Maharajan","year":"2018","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.impact.2026.100626_bb0325","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.marpolbul.2018.10.027","article-title":"Levels of trace metals on microplastic particles in beach sediments of the island of Vis, Adriatic sea, Croatia","volume":"137","author":"Mar\u0161i\u0107-Lu\u010di\u0107","year":"2018","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.impact.2026.100626_bib571","unstructured":"Masura, J., Baker, J., Foster, G., & Arthur, C. (2015). Laboratory methods for the analysis of microplastics in the marine environment: Recommendations for quantifying synthetic particles in waters and sediments (NOAA Technical Memorandum NOS-OR&R-48). National Oceanic and Atmospheric Administration (NOAA). https:\/\/repository.library.noaa.gov\/view\/noaa\/10296. Accessed April 14, 2026."},{"key":"10.1016\/j.impact.2026.100626_bb0330","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3354\/dao03721","article-title":"Microplastic exposure and consumption increases susceptibility to gyrodactylosis and host mortality for a freshwater fish","volume":"153","author":"Masud","year":"2023","journal-title":"Dis. Aquat. Org."},{"issue":"2","key":"10.1016\/j.impact.2026.100626_bb0350","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1007\/s10955-011-0229-4","article-title":"Are biological systems poised at criticality?","volume":"144","author":"Mora","year":"2011","journal-title":"J. Stat. Phys."},{"issue":"3","key":"10.1016\/j.impact.2026.100626_bb0360","doi-asserted-by":"crossref","DOI":"10.1103\/RevModPhys.90.031001","article-title":"Colloquium: criticality and dynamical scaling in living systems","volume":"90","author":"Munoz","year":"2018","journal-title":"Rev. Mod. Phys."},{"issue":"1","key":"10.1016\/j.impact.2026.100626_bb0370","doi-asserted-by":"crossref","DOI":"10.1002\/tqem.22179","article-title":"Growth performance, hematological and oxidative stress responses in nile Tilapia (Oreochromis niloticus) exposed to polypropylene microplastics","volume":"34","author":"Nair","year":"2024","journal-title":"Environ. Qual. Manag."},{"issue":"1","key":"10.1016\/j.impact.2026.100626_bb0375","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1152\/physrev.00029.2006","article-title":"Nitric oxide and peroxynitrite in health and disease","volume":"87","author":"Pacher","year":"2007","journal-title":"Physiol. Rev."},{"issue":"2","key":"10.1016\/j.impact.2026.100626_bb0380","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/0003-2697(86)90026-6","article-title":"A sensitive spectrophotometric method for the determination of superoxide dismutase activity in tissue extracts","volume":"154","author":"Paoletti","year":"1986","journal-title":"Anal. Biochem."},{"issue":"3","key":"10.1016\/j.impact.2026.100626_bb0385","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/bip.10286","article-title":"The physics and bioinformatics of binding and folding\u2014an energy landscape perspective","volume":"68","author":"Papoian","year":"2003","journal-title":"Biopolymers"},{"key":"10.1016\/j.impact.2026.100626_bb0390","first-page":"276","article-title":"A new colorimetric method for determination of serotonine creatinine sulphate","volume":"8A","author":"Pathak","year":"1979","journal-title":"Indian J. Chem."},{"key":"10.1016\/j.impact.2026.100626_bb0395","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.envpol.2016.06.039","article-title":"Exposure of marine mussels Mytilus spp. to polystyrene microplastics: toxicity and influence on fluoranthene bioaccumulation","volume":"216","author":"Paul-Pont","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.impact.2026.100626_bb0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.112059","article-title":"Using Bayesian networks for environmental health risk assessment","volume":"204","author":"P\u00e9rez","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.impact.2026.100626_bb0410","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconhyd.2024.104415","article-title":"Eco-toxicity assessment of polypropylene microplastics in juvenile zebrafish (Danio rerio)","volume":"266","author":"Priyadharshini","year":"2024","journal-title":"J. Contam. Hydrol."},{"issue":"37","key":"10.1016\/j.impact.2026.100626_bb0415","doi-asserted-by":"crossref","first-page":"26464","DOI":"10.1074\/jbc.R113.472936","article-title":"Peroxynitrite, a stealthy biological oxidant","volume":"288","author":"Radi","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"04","key":"10.1016\/j.impact.2026.100626_bb0425","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.rbe.2016.07.002","article-title":"Factors that alter the biochemical biomarkers of environmental contamination in Chironomus sancticaroli (Diptera, Chironomidae)","volume":"60","author":"Rebechi-Baggio","year":"2016","journal-title":"Rev. Bras. Entomol."},{"issue":"25","key":"10.1016\/j.impact.2026.100626_bb0430","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abq4207","article-title":"Toward a cohesive understanding of ecological complexity","volume":"9","author":"Riva","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.impact.2026.100626_bb0440","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120417","article-title":"An ecotoxicological risk model for the microplastics in arctic waters","volume":"315","author":"Saeed","year":"2022","journal-title":"Environ. Pollut."},{"issue":"7260","key":"10.1016\/j.impact.2026.100626_bb0445","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nature08227","article-title":"Early-warning signals for critical transitions","volume":"461","author":"Scheffer","year":"2009","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.impact.2026.100626_bb0460","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.tree.2017.09.012","article-title":"Information theory broadens the spectrum of molecular ecology and evolution","volume":"32","author":"Sherwin","year":"2017","journal-title":"Trends Ecol. Evol."},{"issue":"7","key":"10.1016\/j.impact.2026.100626_bb0465","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","article-title":"Reactive oxygen species (ROS) as pleiotropic physiological signalling agents","volume":"21","author":"Sies","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.impact.2026.100626_bb0470","first-page":"678","article-title":"Spectrophotometric determination of corticosteroids and its application in pharmaceutical formulation","volume":"32","author":"Singh","year":"2009","journal-title":"Oxid. Commun."},{"issue":"6075","key":"10.1016\/j.impact.2026.100626_bb0480","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1126\/science.1216556","article-title":"Evolutionary conservation of species\u2019 roles in food webs","volume":"335","author":"Stouffer","year":"2012","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.impact.2026.100626_bb0485","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1002\/etc.5295","article-title":"Illustrating a species sensitivity distribution for nano-and microplastic particles using Bayesian hierarchical modeling","volume":"41","author":"Takeshita","year":"2022","journal-title":"Environ. Toxicol. Chem."},{"issue":"5","key":"10.1016\/j.impact.2026.100626_bb0490","doi-asserted-by":"crossref","first-page":"957","DOI":"10.18016\/ksutarimdoga.vi.821176","article-title":"Effect of mercury chloride on both nitrosative and oxidative stress in the gill tissue of rainbow trout (Oncorhynchus mykiss)","volume":"24","author":"Tays\u0131","year":"2021","journal-title":"KSU J. Agric. Nat."},{"key":"10.1016\/j.impact.2026.100626_bb0505","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ab.2016.10.021","article-title":"Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: analytical and biological challenges","volume":"524","author":"Tsikas","year":"2017","journal-title":"Anal. Biochem."},{"issue":"14","key":"10.1016\/j.impact.2026.100626_bb0510","doi-asserted-by":"crossref","first-page":"8211","DOI":"10.1021\/acsomega.0c00498","article-title":"Comparison of colorimetric analyses to determine cortisol in human sweat","volume":"5","author":"Tu","year":"2020","journal-title":"ACS Omega"},{"issue":"1","key":"10.1016\/j.impact.2026.100626_bb0515","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/0003-2697(84)90553-0","article-title":"Fluorescein isothiocyanate-labeled casein assay for proteolytic enzymes","volume":"143","author":"Twining","year":"1984","journal-title":"Anal. Biochem."},{"issue":"4","key":"10.1016\/j.impact.2026.100626_bb0520","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0097-8485(01)00073-0","article-title":"Information theory in ecology","volume":"25","author":"Ulanowicz","year":"2001","journal-title":"Comput. Chem."},{"issue":"23","key":"10.1016\/j.impact.2026.100626_bb0525","doi-asserted-by":"crossref","first-page":"14364","DOI":"10.1039\/C7NJ02710A","article-title":"A convenient and label-free colorimetric assay for dopamine detection based on the inhibition of the cu (ii)-catalyzed oxidation of a 3, 3\u2032, 5, 5\u2032-tetramethylbenzidine\u2013H2O2 system","volume":"41","author":"Wang","year":"2017","journal-title":"New J. Chem."},{"issue":"1","key":"10.1016\/j.impact.2026.100626_bb0535","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12302-023-00771-y","article-title":"Biochemical effects of polypropylene microplastics on red tilapia (Oreochromis niloticus) after individual and combined exposure with boron","volume":"35","author":"Yang","year":"2023","journal-title":"Environ. Sci. Eur."},{"key":"10.1016\/j.impact.2026.100626_bb0540","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2023.106540","article-title":"Exposure to polypropylene microplastics via diet and water induces oxidative stress in Cyprinus carpio","volume":"259","author":"Yedier","year":"2023","journal-title":"Aquat. Toxicol."},{"issue":"2","key":"10.1016\/j.impact.2026.100626_bb0545","first-page":"292","article-title":"Investigation of the activity of lipase variants on different 4-nitrophenyl esters by spectrophotometric assay","volume":"8","author":"Yel","year":"2021","journal-title":"Cauc. J. Sci."},{"key":"10.1016\/j.impact.2026.100626_bb0550","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2022.118582","article-title":"Concurrent water-and foodborne exposure to microplastics leads to differential microplastic ingestion and neurotoxic effects in zebrafish","volume":"219","author":"Yu","year":"2022","journal-title":"Water Res."},{"key":"10.1016\/j.impact.2026.100626_bb0555","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.138801","article-title":"Toxic effects of microplastic (polyethylene) exposure: bioaccumulation, hematological parameters and antioxidant responses in crucian carp, Carassius carassius","volume":"332","author":"Yu","year":"2023","journal-title":"Chemosphere"},{"issue":"7","key":"10.1016\/j.impact.2026.100626_bb0560","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3390\/fishes10070307","article-title":"Stress in fish: neuroendocrine and neurotransmitter responses","volume":"10","author":"Yuan","year":"2025","journal-title":"Fishes"},{"key":"10.1016\/j.impact.2026.100626_bb0565","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.aquatox.2013.03.019","article-title":"Acute ZnO nanoparticles exposure induces developmental toxicity, oxidative stress and DNA damage in embryo-larval zebrafish","volume":"136","author":"Zhao","year":"2013","journal-title":"Aquat. Toxicol."}],"container-title":["NanoImpact"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452074826000169?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452074826000169?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T11:33:02Z","timestamp":1781868782000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452074826000169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":95,"alternative-id":["S2452074826000169"],"URL":"https:\/\/doi.org\/10.1016\/j.impact.2026.100626","relation":{},"ISSN":["2452-0748"],"issn-type":[{"value":"2452-0748","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systems toxicology of naturally aged polypropylene microplastics in zebrafish","name":"articletitle","label":"Article Title"},{"value":"NanoImpact","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.impact.2026.100626","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100626"}}