{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:19:00Z","timestamp":1778858340374,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T00:00:00Z","timestamp":1683676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003718","name":"Korea Institute of Oriental Medicine","doi-asserted-by":"publisher","award":["K18182"],"award-info":[{"award-number":["K18182"]}],"id":[{"id":"10.13039\/501100003718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2022M3A9B6017813"],"award-info":[{"award-number":["2022M3A9B6017813"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2021R1A2C2006818"],"award-info":[{"award-number":["NRF-2021R1A2C2006818"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Integrative Medicine Research"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.imr.2023.100954","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T22:28:24Z","timestamp":1683757704000},"page":"100954","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Potential role of acupuncture in the treatment of Parkinson's disease: A narrative review"],"prefix":"10.1016","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3011-8400","authenticated-orcid":false,"given":"Jaeyoung","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9141-0133","authenticated-orcid":false,"given":"Ju-Young","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0538-2664","authenticated-orcid":false,"given":"Hi-Joon","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.imr.2023.100954_bib0004","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1001\/jama.2019.22360","article-title":"Diagnosis and treatment of Parkinson disease: a review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"issue":"11","key":"10.1016\/j.imr.2023.100954_bib45","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S1474-4422(18)30295-3","article-title":"Global, regional, and national burden of Parkinson\u2019s disease, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"17","year":"2018","journal-title":"Lancet Neurol"},{"issue":"1","key":"10.1016\/j.imr.2023.100954_bib50","first-page":"1","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat. Rev. Disease Primers"},{"issue":"3","key":"10.1016\/j.imr.2023.100954_bib0005","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1474-4422(06)70373-8","article-title":"National Institute for Clinical E. Non-motor symptoms of Parkinson's disease: diagnosis and management","volume":"5","author":"Chaudhuri","year":"2006","journal-title":"Lancet Neurol"},{"issue":"11","key":"10.1016\/j.imr.2023.100954_bib0006","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1056\/NEJMcibr1707165","article-title":"Waving hello to noninvasive deep-brain stimulation","volume":"377","author":"Lozano","year":"2017","journal-title":"New England J Med"},{"issue":"24","key":"10.1016\/j.imr.2023.100954_bib0007","doi-asserted-by":"crossref","first-page":"13427","DOI":"10.3390\/ijms222413427","article-title":"Role of the cholinergic anti-inflammatory reflex in central nervous system diseases","volume":"22","author":"Ramos-Martinez","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10.1016\/j.imr.2023.100954_bib0008","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/cns.12507","article-title":"Effect of acupuncture on the motor and nonmotor symptoms in Parkinson's disease-a review of clinical studies","volume":"22","author":"Zeng","year":"2016","journal-title":"CNS Neurosci Ther"},{"issue":"12","key":"10.1016\/j.imr.2023.100954_bib0009","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.molmed.2017.10.006","article-title":"Nerve stimulation: immunomodulation and control of inflammation","volume":"23","author":"Ulloa","year":"2017","journal-title":"Trends Mol Med"},{"issue":"2","key":"10.1016\/j.imr.2023.100954_bib0010","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1089\/acm.2015.0184","article-title":"Unanticipated insights into biomedicine from the study of acupuncture","volume":"22","author":"MacPherson","year":"2016","journal-title":"J Alternat Complement Med"},{"issue":"7","key":"10.1016\/j.imr.2023.100954_bib0011","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1089\/acm.2018.29047.vtn","article-title":"When a white horse is a horse: embracing the (obvious?) overlap between acupuncture and neuromodulation","volume":"24","author":"Napadow","year":"2018","journal-title":"J Alternat Complement Med"},{"issue":"3","key":"10.1016\/j.imr.2023.100954_bib0014","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jpain.2012.11.011","article-title":"Inserting needles into the body: a meta-analysis of brain activity associated with acupuncture needle stimulation","volume":"14","author":"Chae","year":"2013","journal-title":"J Pain"},{"issue":"45","key":"10.1016\/j.imr.2023.100954_bib0012","doi-asserted-by":"crossref","first-page":"E10720","DOI":"10.1073\/pnas.1807991115","article-title":"Median nerve stimulation induces analgesia via orexin-initiated endocannabinoid disinhibition in the periaqueductal gray","volume":"115","author":"Chen","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"10.1016\/j.imr.2023.100954_bib0013","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/joa.13122","article-title":"The anatomical basis for transcutaneous auricular vagus nerve stimulation","volume":"236","author":"Butt","year":"2020","journal-title":"J Anat"},{"issue":"11","key":"10.1016\/j.imr.2023.100954_bib0015","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1001\/jamaoncol.2016.1867","article-title":"Investigation of 2 types of self-administered acupressure for persistent cancer-related fatigue in breast cancer survivors: a randomized clinical trial","volume":"2","author":"Zick","year":"2016","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.imr.2023.100954_bib0016","article-title":"Paradoxes in acupuncture research: strategies for moving forward. Evidence-based complementary and alternative medicine","volume":"2011","author":"Langevin","year":"2011","journal-title":"eCAM"},{"issue":"3","key":"10.1016\/j.imr.2023.100954_bib49","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/hbm.20081","article-title":"Effects of electroacupuncture versus manual acupuncture on the human brain as measured by fMRI","volume":"24","author":"Napadow","year":"2005","journal-title":"Hum. Brain Mapp"},{"issue":"3","key":"10.1016\/j.imr.2023.100954_bib0019","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nm.3479","article-title":"Dopamine mediates vagal modulation of the immune system by electroacupuncture","volume":"20","author":"Torres-Rosas","year":"2014","journal-title":"Nat Med"},{"issue":"5","key":"10.1016\/j.imr.2023.100954_bib0020","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/mds.27360","article-title":"Disease modification in Parkinson's disease: current approaches, challenges, and future considerations","volume":"33","author":"Lang","year":"2018","journal-title":"Mov Disord"},{"key":"10.1016\/j.imr.2023.100954_bib0021","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41531-016-0002-0","article-title":"The gut-brain axis: is intestinal inflammation a silent driver of Parkinson's disease pathogenesis?","volume":"3","author":"Houser","year":"2017","journal-title":"NPJ Parkinson's Dis"},{"issue":"6","key":"10.1016\/j.imr.2023.100954_bib0022","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.brs.2017.08.008","article-title":"Vagus nerve stimulation improves locomotion and neuronal populations in a model of Parkinson's disease","volume":"10","author":"Farrand","year":"2017","journal-title":"Brain Stimul"},{"issue":"10","key":"10.1016\/j.imr.2023.100954_bib0024","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1080\/17434440.2021.1969913","article-title":"Noninvasive vagus nerve stimulation in Parkinson's disease: current status and future prospects","volume":"18","author":"Sigurdsson","year":"2021","journal-title":"Expert Rev Med Devices"},{"issue":"6","key":"10.1016\/j.imr.2023.100954_bib0025","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0254-6272(15)30164-3","article-title":"Acupuncture for Parkinson's Disease: a review of clinical, animal, and functional magnetic resonance imaging studies","volume":"35","author":"Xiao","year":"2015","journal-title":"J Tradit Chin Med"},{"issue":"1","key":"10.1016\/j.imr.2023.100954_bib0026","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.brainres.2006.10.089","article-title":"Acupuncture inhibits microglial activation and inflammatory events in the MPTP-induced mouse model","volume":"1131","author":"Kang","year":"2007","journal-title":"Brain Res"},{"key":"10.1016\/j.imr.2023.100954_bib0027","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.bbi.2020.08.015","article-title":"Acupuncture inhibits neuroinflammation and gut microbial dysbiosis in a mouse model of Parkinson's disease","volume":"89","author":"Jang","year":"2020","journal-title":"Brain Behav Immun"},{"issue":"7882","key":"10.1016\/j.imr.2023.100954_bib0028","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/s41586-021-04001-4","article-title":"A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis","volume":"598","author":"Liu","year":"2021","journal-title":"Nature"},{"issue":"20","key":"10.1016\/j.imr.2023.100954_bib0029","doi-asserted-by":"crossref","first-page":"5781","DOI":"10.1113\/JP271539","article-title":"Anti-inflammatory properties of the vagus nerve: potential therapeutic implications of vagus nerve stimulation","volume":"594","author":"Bonaz","year":"2016","journal-title":"J Physiol"},{"issue":"2","key":"10.1016\/j.imr.2023.100954_bib43","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nn.4477","article-title":"Neural regulation of immunity: molecular mechanisms and clinical translation","volume":"20","author":"Pavlov","year":"2017","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.imr.2023.100954_bib0031","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.685872","article-title":"Selective neuromodulation of the vagus nerve","volume":"15","author":"Fitchett","year":"2021","journal-title":"Front Neurosci"},{"issue":"3","key":"10.1016\/j.imr.2023.100954_bib0032","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.neuron.2020.07.015","article-title":"Somatotopic organization and intensity dependence in driving distinct npy-expressing sympathetic pathways by electroacupuncture","volume":"108","author":"Liu","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.imr.2023.100954_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.117180","article-title":"Opportunities of connectomic neuromodulation","volume":"221","author":"Horn","year":"2020","journal-title":"Neuroimage"},{"issue":"3","key":"10.1016\/j.imr.2023.100954_bib0034","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.neuron.2013.01.020","article-title":"Probing and regulating dysfunctional circuits using deep brain stimulation","volume":"77","author":"Lozano","year":"2013","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.imr.2023.100954_bib47","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/s41582-018-0128-2","article-title":"Deep brain stimulation: current challenges and future directions","volume":"15","author":"Lozano","year":"2019","journal-title":"Nat. Rev. Neurol. Mar"},{"issue":"7","key":"10.1016\/j.imr.2023.100954_bib0035","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1474-4422(18)30169-8","article-title":"Network imaging biomarkers: insights and clinical applications in Parkinson's disease","volume":"17","author":"Schindlbeck","year":"2018","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.imr.2023.100954_bib0036","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.885396","article-title":"Acupuncture regulates symptoms of Parkinson's disease via brain neural activity and functional connectivity in mice","volume":"14","author":"Oh","year":"2022","journal-title":"Front Aging Neurosci"},{"issue":"1","key":"10.1016\/j.imr.2023.100954_bib0037","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/(SICI)1097-0193(2000)9:1<13::AID-HBM2>3.0.CO;2-F","article-title":"Acupuncture modulates the limbic system and subcortical gray structures of the human brain: evidence from fMRI studies in normal subjects","volume":"9","author":"Hui","year":"2000","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.imr.2023.100954_bib0042","series-title":"Medical acupuncture: a Western scientific approach","author":"Filshie","year":"2016"},{"key":"10.1016\/j.imr.2023.100954_bib42","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.brainres.2009.06.061","article-title":"Acupuncture mobilizes the brain\u2019s default mode and its anti-correlated network in healthy subjects","volume":"1287","author":"Hui","year":"2009","journal-title":"Brain Res"},{"issue":"23","key":"10.1016\/j.imr.2023.100954_bib48","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1212\/WNL.0b013e31827689d6","article-title":"Default-mode network connectivity in cognitively unimpaired patients with Parkinson disease","volume":"79","author":"Hou","year":"2012","journal-title":"Neurology"},{"issue":"12","key":"10.1016\/j.imr.2023.100954_bib0039","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1002\/mds.22673","article-title":"Parsing brain activity associated with acupuncture treatment in Parkinson's diseases","volume":"24","author":"Chae","year":"2009","journal-title":"Mov Disord"},{"key":"10.1016\/j.imr.2023.100954_bib0040","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.3389\/fneur.2019.01114","article-title":"Acupuncture effect and mechanism for treating pain in patients with Parkinson's disease","volume":"10","author":"Yu","year":"2019","journal-title":"Front Neurol"},{"key":"10.1016\/j.imr.2023.100954_bib0041","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41746-019-0169-y","article-title":"Feasibility and utility of a clinician dashboard from wearable and mobile application Parkinson's disease data","volume":"2","author":"Elm","year":"2019","journal-title":"NPJ Digit Med"}],"container-title":["Integrative Medicine Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213422023000331?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213422023000331?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:01:05Z","timestamp":1778857265000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213422023000331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S2213422023000331"],"URL":"https:\/\/doi.org\/10.1016\/j.imr.2023.100954","relation":{},"ISSN":["2213-4220"],"issn-type":[{"value":"2213-4220","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potential role of acupuncture in the treatment of Parkinson's disease: A narrative review","name":"articletitle","label":"Article Title"},{"value":"Integrative Medicine Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imr.2023.100954","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Korea Institute of Oriental Medicine. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100954"}}