{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T02:02:12Z","timestamp":1773712932932,"version":"3.50.1"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T00:00:00Z","timestamp":1597104000000},"content-version":"vor","delay-in-days":223,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Informatics in Medicine Unlocked"],"published-print":{"date-parts":[[2020]]},"DOI":"10.1016\/j.imu.2020.100413","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T12:10:10Z","timestamp":1597320610000},"page":"100413","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["SARS-CoV-2-human protein-protein interaction network"],"prefix":"10.1016","volume":"20","author":[{"given":"Babak","family":"Khorsand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdorreza","family":"Savadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Naghibzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.imu.2020.100413_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.29252\/mlj.12.6.1","article-title":"Survey of coronaviruses infection among patients with flu-like symptoms in the golestan province, Iran TT -","volume":"12","author":"Khani","year":"2018","journal-title":"mljgoums"},{"issue":"8","key":"10.1016\/j.imu.2020.100413_bib2","first-page":"1501","article-title":"SARS, MERS and the sunspot cycle","volume":"113","author":"Qu","year":"2017","journal-title":"Curr Sci"},{"key":"10.1016\/j.imu.2020.100413_bib3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.meegid.2019.03.001","article-title":"Molecular epidemiology, evolution and phylogeny of SARS coronavirus","volume":"71","author":"Luk","year":"2019","journal-title":"Infect Genet Evol"},{"key":"10.1016\/j.imu.2020.100413_bib4","series-title":"Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003","author":"Organization","year":"2003"},{"key":"10.1016\/j.imu.2020.100413_bib5","article-title":"MERS-CoV spillover at the camel-human interface","volume":"7","author":"Dudas","year":"2018","journal-title":"Elife"},{"issue":"10223","key":"10.1016\/j.imu.2020.100413_bib6","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.imu.2020.100413_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(20)30627-9","article-title":"COVID-19 and Italy: what next?","author":"Remuzzi","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.imu.2020.100413_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-020-2951-z","article-title":"A\u00a0pneumonia outbreak associated with a new coronavirus of probable bat origin","author":"Zhou","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.imu.2020.100413_bib9","series-title":"Host and Infectivity Prediction of Wuhan 2019 Novel Coronavirus Using Deep Learning Algorithm","author":"Zhu","year":"2020"},{"issue":"10223","key":"10.1016\/j.imu.2020.100413_bib10","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/S0140-6736(20)30185-9","article-title":"A\u00a0novel coronavirus outbreak of global health concern","volume":"395","author":"Wang","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.imu.2020.100413_bib11","doi-asserted-by":"crossref","first-page":"101575","DOI":"10.1016\/j.tmaid.2020.101575","article-title":"\u201cCoronavirus infections reported by ProMED, february 2000\u2013January 2020","author":"Bonilla-Aldana","year":"2020","journal-title":"Trav Med Infect Dis"},{"key":"10.1016\/j.imu.2020.100413_bib12","series-title":"Therapeutic Options for the 2019 Novel Coronavirus (2019-nCoV)","author":"Li","year":"2020"},{"key":"10.1016\/j.imu.2020.100413_bib13","doi-asserted-by":"crossref","DOI":"10.1007\/s15010-020-01401-y","article-title":"2019 Novel coronavirus: where we are and what we know","author":"Cheng","year":"2020","journal-title":"Infection"},{"key":"10.1016\/j.imu.2020.100413_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.26234","article-title":"Emerging coronaviruses: genome structure, replication, and pathogenesis","author":"Chen","year":"2020","journal-title":"J\u00a0Med Virol"},{"issue":"6","key":"10.1016\/j.imu.2020.100413_bib15","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.tim.2016.03.003","article-title":"Epidemiology, genetic recombination, and pathogenesis of coronaviruses","volume":"24","author":"Su","year":"2016","journal-title":"Trends Microbiol"},{"issue":"4","key":"10.1016\/j.imu.2020.100413_bib16","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S1097-2765(02)00496-3","article-title":"Visualization of interactions among bZIP and Rel family proteins in living cells using bimolecular fluorescence complementation","volume":"9","author":"Hu","year":"2002","journal-title":"Mol Cell"},{"key":"10.1016\/j.imu.2020.100413_bib17","series-title":"Protein-protein interactions: a molecular cloning manual","author":"Golemis","year":"2005"},{"issue":"1","key":"10.1016\/j.imu.2020.100413_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12859-017-1700-2","article-title":"Sequence-based prediction of protein protein interaction using a deep-learning algorithm","volume":"18","author":"Sun","year":"2017","journal-title":"BMC Bioinf"},{"issue":"5","key":"10.1016\/j.imu.2020.100413_bib19","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.meegid.2011.02.022","article-title":"Supervised learning and prediction of physical interactions between human and HIV proteins","volume":"11","author":"Dyer","year":"2011","journal-title":"Infect Genet Evol"},{"issue":"2","key":"10.1016\/j.imu.2020.100413_bib20","doi-asserted-by":"crossref","first-page":"264","DOI":"10.2478\/s11658-011-0008-x","article-title":"PPI_SVM: prediction of protein-protein interactions using machine learning, domain-domain affinities and frequency tables","volume":"16","author":"Chatterjee","year":"2011","journal-title":"Cell Mol Biol Lett"},{"issue":"11","key":"10.1016\/j.imu.2020.100413_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0079606","article-title":"Probability weighted ensemble transfer learning for predicting interactions between HIV-1 and human proteins","volume":"8","author":"Mei","year":"2013","journal-title":"PloS One"},{"issue":"8","key":"10.1016\/j.imu.2020.100413_bib22","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1093\/bioinformatics\/btv737","article-title":"DeNovo: virus-host sequence-based protein\u2013protein interaction prediction","volume":"32","author":"Eid","year":"2016","journal-title":"Bioinformatics"},{"issue":"3","key":"10.1016\/j.imu.2020.100413_bib23","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.bbe.2018.04.006","article-title":"Virus\u2013human protein\u2013protein interaction prediction using Bayesian matrix factorization and projection techniques","volume":"38","author":"Nourani","year":"2018","journal-title":"Biocybern Biomed Eng"},{"issue":"4","key":"10.1016\/j.imu.2020.100413_bib24","doi-asserted-by":"crossref","first-page":"1850014","DOI":"10.1142\/S0219720018500142","article-title":"Training host-pathogen protein\u2013protein interaction predictors","volume":"16","author":"Basit","year":"2018","journal-title":"J\u00a0Bioinf Comput Biol"},{"key":"10.1016\/j.imu.2020.100413_bib25","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.csbj.2019.12.005","article-title":"Prediction of human-virus protein-protein interactions through a sequence embedding-based machine learning method","volume":"18","author":"Yang","year":"2020","journal-title":"Comput Struct Biotechnol J"},{"issue":"11","key":"10.1016\/j.imu.2020.100413_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112034","article-title":"Prediction of interactions between viral and host proteins using supervised machine learning methods","volume":"9","author":"Barman","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.imu.2020.100413_bib27","series-title":"International Conference on Bioinformatics and Biomedical Engineering","first-page":"360","article-title":"Computational prediction of host-pathogen interactions through omics data analysis and machine learning","author":"Leite","year":"2017"},{"issue":"1","key":"10.1016\/j.imu.2020.100413_bib28","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-019-1813-7","article-title":"AntAngioCOOL: Computational detection of anti-angiogenic peptides","volume":"17","author":"Zahiri","year":"2019","journal-title":"J. Transl. Med."},{"issue":"4","key":"10.1016\/j.imu.2020.100413_bib29","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.3934\/mbe.2020176","article-title":"Alpha influenza virus infiltration prediction using virus-human protein-protein interaction network","volume":"17","author":"Khorsand","year":"2020","journal-title":"Math. Biosci. Eng."},{"issue":"1","key":"10.1016\/j.imu.2020.100413_bib30","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1109\/TNB.2018.2797696","article-title":"Computational prediction of HCV-human protein-protein interaction via topological analysis of HCV infected PPI modules","volume":"17","author":"Ray","year":"2018","journal-title":"IEEE Trans Nanobiosci"},{"issue":"9","key":"10.1016\/j.imu.2020.100413_bib31","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1080\/07391102.2018.1479659","article-title":"Structure-based prediction of West Nile virus-human protein\u2013protein interactions","volume":"37","author":"Chen","year":"2019","journal-title":"J\u00a0Biomol Struct Dyn"},{"issue":"6","key":"10.1016\/j.imu.2020.100413_bib32","article-title":"Protein interactions and consensus clustering analysis uncover insights into herpesvirus virion structure and function relationships","volume":"17","author":"Dur\u00e1n","year":"2019","journal-title":"PLoS Biol"},{"key":"10.1016\/j.imu.2020.100413_bib33","article-title":"Predicting interactions between virus and host proteins using repeat patterns and composition of amino acids","volume":"2018","author":"Alguwaizani","year":"2018","journal-title":"J\u00a0Healthc Eng"},{"key":"10.1016\/j.imu.2020.100413_bib34","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.compbiolchem.2018.12.001","article-title":"\u201cA new sequence based encoding for prediction of host\u2013pathogen protein interactions","volume":"78","author":"K\u00f6sesoy","year":"2019","journal-title":"Comput Biol Chem"},{"key":"10.1016\/j.imu.2020.100413_bib35","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.biosystems.2017.08.005","article-title":"INDEX: incremental depth extension approach for protein\u2013protein interaction networks alignment","volume":"162","author":"Mir","year":"2017","journal-title":"Biosystems"},{"key":"10.1016\/j.imu.2020.100413_bib36","series-title":"Computational methods in protein evolution","first-page":"317","article-title":"Interface-based structural prediction of novel host-pathogen interactions","author":"Guven-Maiorov","year":"2019"},{"key":"10.1016\/j.imu.2020.100413_bib37","series-title":"Complete Genome Characterisation of a Novel Coronavirus Associated with Severe Human Respiratory Disease in Wuhan, China","author":"Wu","year":"2020"},{"issue":"D1","key":"10.1016\/j.imu.2020.100413_bib38","doi-asserted-by":"crossref","first-page":"D506","DOI":"10.1093\/nar\/gky1049","article-title":"UniProt: a worldwide hub of protein knowledge","volume":"47","author":"Consortium","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"10.1016\/j.imu.2020.100413_bib39","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1056\/NEJMp2000929","article-title":"A\u00a0novel coronavirus emerging in China\u2014key questions for impact assessment","volume":"382","author":"Munster","year":"2020","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.imu.2020.100413_bib40","first-page":"gkr1088","article-title":"The IntAct molecular interaction database in 2012","author":"Kerrien","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.imu.2020.100413_bib41","doi-asserted-by":"crossref","first-page":"D669","DOI":"10.1093\/nar\/gkn739","article-title":"VirusMINT: a viral protein interaction database","volume":"37","author":"Chatr-aryamontri","year":"2009","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"10.1016\/j.imu.2020.100413_bib42","doi-asserted-by":"crossref","first-page":"D447","DOI":"10.1093\/nar\/gku1003","article-title":"\u201cSTRING v10: protein\u2013protein interaction networks, integrated over the tree of life","volume":"43","author":"Szklarczyk","year":"2014","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.imu.2020.100413_bib43","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/nar\/30.1.303","article-title":"DIP, the Database of Interacting Proteins: a research tool for studying cellular networks of protein interactions","volume":"30","author":"Xenarios","year":"2002","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"10.1016\/j.imu.2020.100413_bib44","doi-asserted-by":"crossref","first-page":"D529","DOI":"10.1093\/nar\/gky1079","article-title":"The BioGRID interaction database: 2019 update","volume":"47","author":"Oughtred","year":"2018","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"10.1016\/j.imu.2020.100413_bib45","doi-asserted-by":"crossref","first-page":"9495","DOI":"10.1007\/s10586-018-2421-7","article-title":"\u201cImproving the performance of smith\u2013waterman sequence algorithm on gpu using shared memory for biological protein sequences","volume":"22","author":"Prasad","year":"2019","journal-title":"Cluster Comput"},{"issue":"11","key":"10.1016\/j.imu.2020.100413_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0080635","article-title":"Maximum allowed solvent accessibilites of residues in proteins","volume":"8","author":"Tien","year":"2013","journal-title":"PloS One"},{"issue":"D1","key":"10.1016\/j.imu.2020.100413_bib47","doi-asserted-by":"crossref","first-page":"D331","DOI":"10.1093\/nar\/gkw1108","article-title":"Expansion of the gene ontology knowledgebase and resources","volume":"45","author":"Consortium","year":"2017","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.imu.2020.100413_bib48","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/1471-2105-7-302","article-title":"A\u00a0new measure for functional similarity of gene products based on Gene Ontology","volume":"7","author":"Schlicker","year":"2006","journal-title":"BMC Bioinf"},{"key":"10.1016\/j.imu.2020.100413_bib49","first-page":"100356","article-title":"Developing an ultra-efficient microsatellite discoverer to find structural differences between SARS-CoV-1 and Covid-19","author":"Naghibzadeh","year":"2020","journal-title":"Inf Med"},{"issue":"D1","key":"10.1016\/j.imu.2020.100413_bib50","doi-asserted-by":"crossref","first-page":"D419","DOI":"10.1093\/nar\/gky1038","article-title":"PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools","volume":"47","author":"Mi","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"7","key":"10.1016\/j.imu.2020.100413_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021800","article-title":"REVIGO summarizes and visualizes long lists of gene ontology terms","volume":"6","author":"Supek","year":"2011","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.imu.2020.100413_bib52","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2172-6-2","article-title":"Expression profile of immune response genes in patients with severe acute respiratory syndrome","volume":"6","author":"Reghunathan","year":"2005","journal-title":"BMC Immunol"}],"container-title":["Informatics in Medicine Unlocked"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352914820305633?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352914820305633?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T05:19:01Z","timestamp":1762492741000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352914820305633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":52,"alternative-id":["S2352914820305633"],"URL":"https:\/\/doi.org\/10.1016\/j.imu.2020.100413","relation":{},"ISSN":["2352-9148"],"issn-type":[{"value":"2352-9148","type":"print"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SARS-CoV-2-human protein-protein interaction network","name":"articletitle","label":"Article Title"},{"value":"Informatics in Medicine Unlocked","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imu.2020.100413","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100413"}}