{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T21:01:41Z","timestamp":1774818101449,"version":"3.50.1"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T00:00:00Z","timestamp":1666396800000},"content-version":"vor","delay-in-days":294,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Informatics in Medicine Unlocked"],"published-print":{"date-parts":[[2022]]},"DOI":"10.1016\/j.imu.2022.101116","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T19:20:40Z","timestamp":1666984840000},"page":"101116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Severity of COVID-19 patients with coexistence of asthma and vitamin D deficiency"],"prefix":"10.1016","volume":"34","author":[{"given":"M. Babul","family":"Islam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Utpala Nanda","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Asif","family":"Nashiry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Ali","family":"Moni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7798","key":"10.1016\/j.imu.2022.101116_b1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41586-020-2008-3","article-title":"A new coronavirus associated with human respiratory disease in China","volume":"579","author":"Wu","year":"2020","journal-title":"Nature"},{"issue":"7798","key":"10.1016\/j.imu.2022.101116_b2","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","article-title":"A pneumonia outbreak associated with a new coronavirus of probable bat origin","volume":"579","author":"Zhou","year":"2020","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.imu.2022.101116_b3","first-page":"119","article-title":"Optimizing clinical approaches to COVID-19 patients in primary care.","volume":"160","author":"Seifert","year":"2021","journal-title":"Casopis Lekaru Ceskych"},{"key":"10.1016\/j.imu.2022.101116_b4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ijsu.2020.02.034","article-title":"World health organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19)","volume":"76","author":"Sohrabi","year":"2020","journal-title":"Int J Surg"},{"key":"10.1016\/j.imu.2022.101116_b5","series-title":"WHO coronavirus (COVID-19) dashboard","year":"2022"},{"issue":"181","key":"10.1016\/j.imu.2022.101116_b6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor","volume":"2","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.imu.2022.101116_b7","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/s41591-020-0868-6","article-title":"SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes","volume":"26","author":"Sungnak","year":"2020","journal-title":"Nat Med"},{"issue":"8","key":"10.1016\/j.imu.2022.101116_b8","doi-asserted-by":"crossref","first-page":"938","DOI":"10.3390\/vaccines9080938","article-title":"Risk factors associated with the clinical outcomes of COVID-19 and its variants in the context of cytokine storm and therapeutics\/vaccine development challenges","volume":"9","author":"Hanna","year":"2021","journal-title":"Vaccines"},{"key":"10.1016\/j.imu.2022.101116_b9","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3389\/fmolb.2020.00157","article-title":"Immune phenotyping based on the neutrophil-to-lymphocyte ratio and IgG level predicts disease severity and outcome for patients with COVID-19","volume":"7","author":"Zhang","year":"2020","journal-title":"Front Mole Biosci"},{"key":"10.1016\/j.imu.2022.101116_b10","series-title":"Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected: interim guidance, 13 March 2020 (No. WHO\/2019-nCoV\/clinical\/2020.4)","author":"Organization","year":"2020"},{"issue":"10223","key":"10.1016\/j.imu.2022.101116_b11","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"issue":"10223","key":"10.1016\/j.imu.2022.101116_b12","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0140-6736(20)30211-7","article-title":"Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study","volume":"395","author":"Chen","year":"2020","journal-title":"Lancet"},{"issue":"18","key":"10.1016\/j.imu.2022.101116_b13","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of coronavirus disease 2019 in China","volume":"382","author":"Guan","year":"2020","journal-title":"N Engl J Med"},{"issue":"323","key":"10.1016\/j.imu.2022.101116_b14","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1001\/jama.2020.6775","article-title":"Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New york city area","volume":"20","author":"Richardson","year":"2020","journal-title":"JAMA"},{"issue":"8","key":"10.1016\/j.imu.2022.101116_b15","doi-asserted-by":"crossref","first-page":"e1003","DOI":"10.1016\/S2214-109X(20)30264-3","article-title":"Global, regional, and national estimates of the population at increased risk of severe COVID-19 due to underlying health conditions in 2020: a modelling study","volume":"8","author":"Clark","year":"2020","journal-title":"Lancet Glob Health"},{"issue":"5","key":"10.1016\/j.imu.2022.101116_b16","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/s41440-022-00893-5","article-title":"The impact of pre-existing hypertension and its treatment on outcomes in patients admitted to hospital with COVID-19","volume":"45","author":"McFarlane","year":"2022","journal-title":"Hypertension Res"},{"issue":"2","key":"10.1016\/j.imu.2022.101116_b17","doi-asserted-by":"crossref","first-page":"402","DOI":"10.7150\/ijms.67815","article-title":"Potential genes associated with COVID-19 and comorbidity","volume":"19","author":"Feng","year":"2022","journal-title":"Int J Med Sci"},{"issue":"5","key":"10.1016\/j.imu.2022.101116_b18","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00547-2020","article-title":"Comorbidity and its impact on 1590 patients with Covid-19 in China: A nationwide analysis","volume":"55","author":"Guan","year":"2020","journal-title":"Eur Respir J"},{"issue":"10229","key":"10.1016\/j.imu.2022.101116_b19","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study","volume":"395","author":"Zhou","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.imu.2022.101116_b20","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2021.104668","article-title":"Identifying molecular insight of synergistic complexities for SARS-CoV-2 infection with pre-existing type 2 diabetes","author":"Islam","year":"2021","journal-title":"Comput Biol Med"},{"issue":"180","key":"10.1016\/j.imu.2022.101116_b21","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1001\/jamainternmed.2020.0994","article-title":"Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China","volume":"7","author":"Wu","year":"2020","journal-title":"JAMA Int Med"},{"issue":"2","key":"10.1016\/j.imu.2022.101116_b22","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.jaci.2020.06.010","article-title":"Prevalence and characterization of asthma in hospitalized and nonhospitalized patients with COVID-19","volume":"146","author":"Chhiba","year":"2020","journal-title":"J Allergy Clin Immunol"},{"issue":"9","key":"10.1016\/j.imu.2022.101116_b23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0239799","article-title":"Vitamin D sufficiency, a serum 25-hydroxyvitamin d at least 30 ng\/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection","volume":"15","author":"Maghbooli","year":"2020","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.imu.2022.101116_b24","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.3390\/nu12092757","article-title":"Vitamin D deficiency and outcome of COVID-19 patients","volume":"12","author":"Radujkovic","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.imu.2022.101116_b25","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.clnesp.2022.07.011","article-title":"Machine learning approach for automated predicting of COVID-19 severity based on clinical and paraclinical characteristics: Serum levels of zinc, calcium, and vitamin D","volume":"51","author":"Jahangirimehr","year":"2022","journal-title":"Clin Nutrit ESPEN"},{"issue":"5","key":"10.1016\/j.imu.2022.101116_b26","article-title":"Frequency of vitamin D deficiency in patients of Asthma","volume":"13","author":"Alvi","year":"2021","journal-title":"Cureus"},{"issue":"1","key":"10.1016\/j.imu.2022.101116_b27","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/joim.13149","article-title":"Perspective: Vitamin D deficiency and COVID-19 severity\u2013plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2 and thrombosis","volume":"289","author":"Rhodes","year":"2020","journal-title":"J Intern Med"},{"issue":"4","key":"10.1016\/j.imu.2022.101116_b28","first-page":"378","article-title":"Vitamin D in critical care: where are we now and what is next?","volume":"27","author":"Amrein","year":"2021","journal-title":"Curr Opin Crit Care"},{"issue":"1","key":"10.1016\/j.imu.2022.101116_b29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-77093-z","article-title":"Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers","volume":"10","author":"Jain","year":"2020","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.imu.2022.101116_b30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-022-15664-y","article-title":"A correlational analysis of COVID-19 incidence and mortality and urban determinants of vitamin D status across the London boroughs","volume":"12","author":"Borna","year":"2022","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.imu.2022.101116_b31","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1093\/ajcn\/nqaa381","article-title":"Habitual use of vitamin D supplements and risk of coronavirus disease 2019 (COVID-19) infection: a prospective study in UK biobank","volume":"113","author":"Ma","year":"2021","journal-title":"Am J Clin Nutrit"},{"key":"10.1016\/j.imu.2022.101116_b32","series-title":"Vitamin D levels, lung function, and steroid response in adult asthma, Vol. 181","first-page":"699","author":"Sutherland","year":"2010"},{"issue":"2","key":"10.1016\/j.imu.2022.101116_b33","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1080\/14787210.2021.1941871","article-title":"Vitamin d attenuates COVID-19 complications via modulation of proinflammatory cytokines, antiviral proteins, and autophagy","volume":"20","author":"Gilani","year":"2022","journal-title":"Expert Rev Anti-Infect Ther"},{"issue":"5","key":"10.1016\/j.imu.2022.101116_b34","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.cell.2020.04.026","article-title":"Imbalanced host response to SARS-CoV-2 drives development of COVID-19","volume":"181","author":"Blanco-Melo","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.imu.2022.101116_b35","doi-asserted-by":"crossref","first-page":"974","DOI":"10.3389\/fimmu.2020.00974","article-title":"Airway epithelial cell immunity is delayed during Rhinovirus infection in Asthma and COPD","volume":"11","author":"Veerati","year":"2020","journal-title":"Front Immunol"},{"issue":"7","key":"10.1016\/j.imu.2022.101116_b36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0134057","article-title":"Vitamin D modulates expression of the airway smooth muscle transcriptome in fatal asthma","volume":"10","author":"Himes","year":"2015","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.imu.2022.101116_b37","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"issue":"W1","key":"10.1016\/j.imu.2022.101116_b38","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"10.1016\/j.imu.2022.101116_b39","doi-asserted-by":"crossref","first-page":"D833","DOI":"10.1093\/nar\/gkw943","article-title":"DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants","volume":"45","author":"Pi\u00f1ero","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"11","key":"10.1016\/j.imu.2022.101116_b40","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"issue":"D1","key":"10.1016\/j.imu.2022.101116_b41","doi-asserted-by":"crossref","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","article-title":"KEGG: new perspectives on genomes, pathways, diseases and drugs","volume":"45","author":"Kanehisa","year":"2017","journal-title":"Nucleic Acids Res"},{"issue":"7","key":"10.1016\/j.imu.2022.101116_b42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0060184","article-title":"WikiPathways: pathway editing for the people","volume":"6","author":"Pico","year":"2008","journal-title":"PLoS Biol"},{"issue":"D1","key":"10.1016\/j.imu.2022.101116_b43","doi-asserted-by":"crossref","first-page":"D649","DOI":"10.1093\/nar\/gkx1132","article-title":"The reactome pathway knowledgebase","volume":"46","author":"Fabregat","year":"2018","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"10.1016\/j.imu.2022.101116_b44","article-title":"Protein\u2013protein interactions essentials: key concepts to building and analyzing interactome networks","volume":"6","author":"De\u00a0Las\u00a0Rivas","year":"2010","journal-title":"PLoS Comput Biol"},{"issue":"D1","key":"10.1016\/j.imu.2022.101116_b45","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein\u2013protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.imu.2022.101116_b46","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2105-4-2","article-title":"An automated method for finding molecular complexes in large protein interaction networks","volume":"4","author":"Bader","year":"2003","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.imu.2022.101116_b47","unstructured":"Chen\u00a0S-H, Chin\u00a0C-H, Wu\u00a0H-H, Ho\u00a0C-W, Ko\u00a0M-T, Lin\u00a0C-Y. cyto-Hubba: A Cytoscape plug-in for hub object analysis in network biology. In: 20th international conference on genome informatics. 2009."},{"issue":"5871","key":"10.1016\/j.imu.2022.101116_b48","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1126\/science.1151651","article-title":"Gene regulation by transcription factors and microRNAs","volume":"319","author":"Hobert","year":"2008","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.imu.2022.101116_b49","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nprot.2015.052","article-title":"NetworkAnalyst for statistical, visual and network-based meta-analysis of gene expression data","volume":"10","author":"Xia","year":"2015","journal-title":"Nat Protoc"},{"issue":"7414","key":"10.1016\/j.imu.2022.101116_b50","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/489046a","article-title":"ENCODE: The human encyclopaedia","volume":"489","author":"Maher","year":"2012","journal-title":"Nat News"},{"issue":"D1","key":"10.1016\/j.imu.2022.101116_b51","doi-asserted-by":"crossref","first-page":"D239","DOI":"10.1093\/nar\/gkx1141","article-title":"DIANA-TarBase v8: a decade-long collection of experimentally supported miRNA\u2013gene interactions","volume":"46","author":"Karagkouni","year":"2018","journal-title":"Nucleic Acids Res"},{"issue":"18","key":"10.1016\/j.imu.2022.101116_b52","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1093\/bioinformatics\/btv313","article-title":"DSigDB: drug signatures database for gene set analysis","volume":"31","author":"Yoo","year":"2015","journal-title":"Bioinformatics"},{"issue":"10","key":"10.1016\/j.imu.2022.101116_b53","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.jiph.2020.06.021","article-title":"Role of vitamin D in preventing of COVID-19 infection, progression and severity","volume":"13","author":"Ali","year":"2020","journal-title":"J Infect Public Health"},{"issue":"10229","key":"10.1016\/j.imu.2022.101116_b54","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(20)30628-0","article-title":"COVID-19: consider cytokine storm syndromes and immunosuppression","volume":"395","author":"Mehta","year":"2020","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.imu.2022.101116_b55","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.ajem.2007.10.031","article-title":"The cytokine storm and factors determining the sequence and severity of organ dysfunction in multiple organ dysfunction syndrome","volume":"26","author":"Wang","year":"2008","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.imu.2022.101116_b56","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2021.104891","article-title":"Effects of Bacille Calmette Guerin (BCG) vaccination during COVID-19 infection","volume":"138","author":"Chowdhury","year":"2021","journal-title":"Comput Biol Med"},{"key":"10.1016\/j.imu.2022.101116_b57","article-title":"The interplay between inflammatory pathways and COVID-19: A critical review on pathogenesis and therapeutic options","author":"Choudhary","year":"2020","journal-title":"Microbial Pathogenesis"},{"issue":"1","key":"10.1016\/j.imu.2022.101116_b58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41392-020-0191-1","article-title":"Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2","volume":"5","author":"Catanzaro","year":"2020","journal-title":"Signal Transduct Targeted Ther"},{"issue":"1","key":"10.1016\/j.imu.2022.101116_b59","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0091-6749(99)70147-8","article-title":"A variant in the gene for GM-CSF, I117t, is associated with atopic asthma in a Swiss population of asthmatic children","volume":"104","author":"Rohrbach","year":"1999","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"10.1016\/j.imu.2022.101116_b60","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0091-6749(03)01797-4","article-title":"Association between novel GM-CSF gene polymorphisms and the frequency and severity of atopic dermatitis","volume":"112","author":"Rafatpanah","year":"2003","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.imu.2022.101116_b61","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.112204","article-title":"Network perturbation analysis in human bronchial epithelial cells following SARS-CoV2 infection","volume":"395","author":"Nunnari","year":"2020","journal-title":"Exper Cell Res"},{"issue":"5","key":"10.1016\/j.imu.2022.101116_b62","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1034\/j.1399-3003.2000.15e14.x","article-title":"G-CSF and IL-8 but not GM-CSF correlate with severity of pulmonary neutrophilia in acute respiratory distress syndrome","volume":"15","author":"Aggarwal","year":"2000","journal-title":"Eur Respir J"},{"issue":"11","key":"10.1016\/j.imu.2022.101116_b63","doi-asserted-by":"crossref","DOI":"10.1038\/cti.2016.59","article-title":"Guanylate-binding protein 5 is a marker of interferon-\u03b3-induced classically activated macrophages","volume":"5","author":"Fujiwara","year":"2016","journal-title":"Clin Transl Immunol"},{"issue":"4","key":"10.1016\/j.imu.2022.101116_b64","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.chom.2016.02.019","article-title":"Guanylate binding protein (GBP) 5 is an interferon-inducible inhibitor of HIV-1 infectivity","volume":"19","author":"Krapp","year":"2016","journal-title":"Cell Host Microbe"},{"issue":"21","key":"10.1016\/j.imu.2022.101116_b65","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01407-20","article-title":"GBP5 is an interferon-induced inhibitor of respiratory syncytial virus","volume":"94","author":"Li","year":"2020","journal-title":"J Virol"},{"issue":"19","key":"10.1016\/j.imu.2022.101116_b66","doi-asserted-by":"crossref","first-page":"9672","DOI":"10.1128\/JVI.00597-09","article-title":"Molecular mechanism of BST2\/tetherin downregulation by K5\/MIR2 of Kaposi\u2019s sarcoma-associated herpesvirus","volume":"83","author":"Mansouri","year":"2009","journal-title":"J Virol"},{"issue":"6","key":"10.1016\/j.imu.2022.101116_b67","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.23812\/20-1-E","article-title":"Coronavirus-19 (SARS-CoV-2) induces acute severe lung inflammation via IL-1 causing cytokine storm in COVID-19: A promising inhibitory strategy","volume":"34","author":"Conti","year":"2020","journal-title":"J Biol Regul Homeost Agents"},{"issue":"1","key":"10.1016\/j.imu.2022.101116_b68","first-page":"527","article-title":"High expression of ACE2 in the human lung leads to the release of IL6 by suppressing cellular immunity: IL6 plays a key role in COVID-19","volume":"25","author":"Bao","year":"2021","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"4","key":"10.1016\/j.imu.2022.101116_b69","first-page":"388","article-title":"Significant changes of CD4, FOXP3, CD25, and IL6 expression level in Iranian COVID-19 patients","volume":"13","author":"Mohebbi","year":"2020","journal-title":"Gastroenterol Hepatol Bed Bench"},{"issue":"1","key":"10.1016\/j.imu.2022.101116_b70","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000023582","article-title":"Anti-IL6 treatment of serious COVID-19 disease: a monocentric retrospective experience","volume":"100","author":"Castelnovo","year":"2021","journal-title":"Medicine"},{"issue":"1","key":"10.1016\/j.imu.2022.101116_b71","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/jmv.26232","article-title":"The cytokine storm and COVID-19","volume":"93","author":"Hu","year":"2021","journal-title":"J Med Virol"},{"issue":"1","key":"10.1016\/j.imu.2022.101116_b72","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1080\/22221751.2020.1747363","article-title":"Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients","volume":"9","author":"Xiong","year":"2020","journal-title":"Emerg Microbes Infect"},{"key":"10.1016\/j.imu.2022.101116_b73","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.9357","article-title":"Host transcriptome-guided drug repurposing for COVID-19 treatment: a meta-analysis based approach","volume":"8","author":"Loganathan","year":"2020","journal-title":"PeerJ"},{"issue":"6","key":"10.1016\/j.imu.2022.101116_b74","doi-asserted-by":"crossref","first-page":"621","DOI":"10.24272\/j.issn.2095-8137.2020.118","article-title":"Role of neutrophil chemoattractant CXCL5 in SARS-CoV-2 infection-induced lung inflammatory innate immune response in an in vivo hACE2 transfection mouse model","volume":"41","author":"Liang","year":"2020","journal-title":"Zool Res"},{"key":"10.1016\/j.imu.2022.101116_b75","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1146\/annurev-immunol-032713-120231","article-title":"Interferon-stimulated genes: a complex web of host defenses","volume":"32","author":"Schneider","year":"2014","journal-title":"Annu Rev Immunol"},{"issue":"10","key":"10.1016\/j.imu.2022.101116_b76","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101585","article-title":"SARS-CoV-2 infection boosts MX1 antiviral effector in COVID-19 patients","volume":"23","author":"Bizzotto","year":"2020","journal-title":"Iscience"},{"issue":"5167","key":"10.1016\/j.imu.2022.101116_b77","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1126\/science.8009222","article-title":"Involvement of the IRF-1 transcription factor in antiviral responses to interferons","volume":"264","author":"Kimura","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.imu.2022.101116_b78","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.9994","article-title":"Potential role of cellular miRNAs in coronavirus-host interplay","volume":"8","author":"Nersisyan","year":"2020","journal-title":"PeerJ"},{"issue":"9","key":"10.1016\/j.imu.2022.101116_b79","doi-asserted-by":"crossref","first-page":"bqaa127","DOI":"10.1210\/endocr\/bqaa127","article-title":"Estradiol, progesterone, immunomodulation, and COVID-19 outcomes","volume":"161","author":"Mauvais-Jarvis","year":"2020","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.imu.2022.101116_b80","first-page":"38","article-title":"Possible protective role of 17\u03b2-estradiol against COVID-19","volume":"1","author":"Khan","year":"2020","journal-title":"J Allergy Infect Dis"},{"issue":"1","key":"10.1016\/j.imu.2022.101116_b81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-022-04778-y","article-title":"The impact of calcitriol and estradiol on the SARS-CoV-2 biological activity: a molecular modeling approach","volume":"12","author":"Mansouri","year":"2022","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.imu.2022.101116_b82","first-page":"17","article-title":"Zinc and respiratory tract infections: Perspectives for COVID-19","volume":"46","author":"Skalny","year":"2020","journal-title":"Int J Mol Med"},{"issue":"8","key":"10.1016\/j.imu.2022.101116_b83","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1017\/S0007114521002099","article-title":"Antiviral and immunological activity of zinc and possible role in COVID-19","volume":"127","author":"do\u00a0Nascimento\u00a0Marreiro","year":"2022","journal-title":"Br J Nutr"},{"issue":"7","key":"10.1016\/j.imu.2022.101116_b84","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.3390\/nu14071407","article-title":"Free zinc as a predictive marker for COVID-19 mortality risk","volume":"14","author":"Maares","year":"2022","journal-title":"Nutrients"}],"container-title":["Informatics in Medicine Unlocked"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352914822002532?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352914822002532?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T05:24:36Z","timestamp":1762493076000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352914822002532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":84,"alternative-id":["S2352914822002532"],"URL":"https:\/\/doi.org\/10.1016\/j.imu.2022.101116","relation":{},"ISSN":["2352-9148"],"issn-type":[{"value":"2352-9148","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Severity of COVID-19 patients with coexistence of asthma and vitamin D deficiency","name":"articletitle","label":"Article Title"},{"value":"Informatics in Medicine Unlocked","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imu.2022.101116","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101116"}}