{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T23:58:23Z","timestamp":1793059103054,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Injury"],"published-print":{"date-parts":[[2005,11]]},"DOI":"10.1016\/j.injury.2005.10.010","type":"journal-article","created":{"date-parts":[[2005,11,13]],"date-time":"2005-11-13T12:12:02Z","timestamp":1131883922000},"page":"S51-S59","source":"Crossref","is-referenced-by-count":124,"special_numbering":"S","title":["Application of recombinant BMP-7 on persistent upper and lower limb non-unions"],"prefix":"10.1016","volume":"36","author":[{"given":"R.","family":"Dimitriou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Dahabreh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Katsoulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.J.","family":"Matthews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Branfoot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.V.","family":"Giannoudis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.injury.2005.10.010_bib1","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/00003086-199608000-00037","article-title":"Complications of iliac crest bone graft harvesting","volume":"329","author":"Arrington","year":"1996","journal-title":"Clin Orthop"},{"key":"10.1016\/j.injury.2005.10.010_bib2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/00003086-200002000-00003","article-title":"Bone graft materials. An overview of the basic science","volume":"371","author":"Bauer","year":"2000","journal-title":"Clin Orthop"},{"issue":"23","key":"10.1016\/j.injury.2005.10.010_bib3","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1097\/00007632-200212010-00005","article-title":"Use of recombinant human bone morphogenetic protein-2 to achieve posterolateral lumbar spine fusion in humans: a prospective, randomized clinical pilot trial: 2002 Volvo Award in clinical studies","volume":"27","author":"Boden","year":"2002","journal-title":"Spine"},{"key":"10.1016\/j.injury.2005.10.010_bib4","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/01.blo.0000096811.78689.2b","article-title":"The efficacy of BMP-2 to induce bone ingrowth in a total hip replacement model","volume":"417","author":"Bragdon","year":"2003","journal-title":"Clin Orthop"},{"issue":"5","key":"10.1016\/j.injury.2005.10.010_bib5","doi-asserted-by":"crossref","first-page":"847","DOI":"10.2106\/00004623-198163050-00030","article-title":"The treatment of non-unions with electricity","volume":"63","author":"Brighton","year":"1981","journal-title":"J Bone Joint Surg [Am]"},{"issue":"3","key":"10.1016\/j.injury.2005.10.010_bib6","doi-asserted-by":"crossref","first-page":"368","DOI":"10.2106\/00004623-197557030-00015","article-title":"Direct-current stimulation of non-union and congenital pseudarthrosis. Exploration of its clinical application","volume":"57","author":"Brighton","year":"1975","journal-title":"J Bone Joint Surg [Am]"},{"key":"10.1016\/j.injury.2005.10.010_bib7","first-page":"507","article-title":"Nonunions: evaluation and treatment","volume":"vol. 1","author":"Brinker","year":"2003"},{"issue":"7","key":"10.1016\/j.injury.2005.10.010_bib8","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1097\/00005131-200408000-00008","article-title":"Osteogenic protein-1 induces bone formation in the presence of bacterial infection in a rat intramuscular osteoinduction model","volume":"18","author":"Chen","year":"2004","journal-title":"J Orthop Trauma"},{"key":"10.1016\/j.injury.2005.10.010_bib9","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/00003086-199404000-00046","article-title":"Recombinant human bone morphogenetic protein-7 induces healing in a canine long-bone segmental defect model","volume":"301","author":"Cook","year":"1994","journal-title":"Clin Orthop"},{"key":"10.1016\/j.injury.2005.10.010_bib10","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/01.blo.0000148573.02745.40","article-title":"Osteogenic protein-1 in knee arthritis and arthroplasty","volume":"428","author":"Cook","year":"2004","journal-title":"Clin Orthop"},{"issue":"8 Suppl 1","key":"10.1016\/j.injury.2005.10.010_bib11","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1054\/arth.2001.28363","article-title":"The use of osteogenic protein-1 in reconstructive surgery of the hip","volume":"16","author":"Cook","year":"2001","journal-title":"J Arthroplasty"},{"issue":"15","key":"10.1016\/j.injury.2005.10.010_bib12","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1097\/00007632-199408000-00002","article-title":"In vivo evaluation of recombinant human osteogenic protein (rhOP-1) implants as a bone graft substitute for spinal fusions","volume":"19","author":"Cook","year":"1994","journal-title":"Spine"},{"issue":"5","key":"10.1016\/j.injury.2005.10.010_bib13","doi-asserted-by":"crossref","first-page":"734","DOI":"10.2106\/00004623-199505000-00010","article-title":"Effect of recombinant human osteogenic protein-1 on healing of segmental defects in non-human primates","volume":"77","author":"Cook","year":"1995","journal-title":"J Bone Joint Surg [Am]"},{"issue":"12","key":"10.1016\/j.injury.2005.10.010_bib14","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1097\/00007632-199212000-00006","article-title":"Chronic donor site pain complicating bone graft harvesting from the posterior iliac crest for spinal fusion","volume":"17","author":"Fernyhough","year":"1992","journal-title":"Spine"},{"key":"10.1016\/j.injury.2005.10.010_bib15","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2106\/00004623-200100002-00010","article-title":"Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions: a prospective, randomized clinical trial comparing rhOP-1 with fresh bone autograft","volume":"83","author":"Friedlaender","year":"2001","journal-title":"J Bone Joint Surg [Am]"},{"key":"10.1016\/j.injury.2005.10.010_bib16","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1302\/0301-620X.81B4.9311","article-title":"Osteogenic activity of OP-1 bone morphogenetic protein (BMP-7) in a human fibular defect","volume":"81B","author":"Geesink","year":"1999","journal-title":"J Bone Joint Surg [Br]"},{"issue":"5","key":"10.1016\/j.injury.2005.10.010_bib17","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1302\/0301-620X.82B5.9899","article-title":"Nonunion of the femoral diaphysis. The influence of reaming and non-steroidal anti-inflammatory drugs","volume":"82","author":"Giannoudis","year":"2000","journal-title":"J Bone Joint Surg [Br]"},{"key":"10.1016\/j.injury.2005.10.010_bib18","doi-asserted-by":"crossref","unstructured":"Govender S, Csimma C, Genant HK, et al. BMP-2 Evaluation in Surgery for Tibial Trauma (BESTT) Study Group. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg [Am] 2002;84-A(12):2123\u201334.","DOI":"10.2106\/00004623-200212000-00001"},{"issue":"2","key":"10.1016\/j.injury.2005.10.010_bib19","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/00007632-200101150-00004","article-title":"2000 Young Investigator Research Award winner. Evaluation of OP-1 as a graft substitute for intertransverse process lumbar fusion","volume":"26","author":"Grauer","year":"2001","journal-title":"Spine"},{"issue":"13","key":"10.1016\/j.injury.2005.10.010_bib20","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1097\/01.BRS.0000129028.25671.96","article-title":"Development of a New Zealand white rabbit model of spinal pseudarthrosis repair and evaluation of the potential role of OP-1 to overcome pseudarthrosis","volume":"29","author":"Grauer","year":"2004","journal-title":"Spine"},{"issue":"8","key":"10.1016\/j.injury.2005.10.010_bib21","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1097\/00005373-198408000-00009","article-title":"Problems in the management of type III (severe) open fractures: a new classification of type III open fractures. Problems in the management of type III (severe) open fractures: a new classification of type II open fractures","volume":"24","author":"Gustilo","year":"1984","journal-title":"J Trauma"},{"key":"10.1016\/j.injury.2005.10.010_bib22","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/00003086-199007000-00039","article-title":"Percutaneous bone marrow grafting of delayed union and nonunion in cancer patients","volume":"256","author":"Healey","year":"1990","journal-title":"Clin Orthop"},{"key":"10.1016\/j.injury.2005.10.010_bib23","unstructured":"Jimenez ML, Anderson TL. The use of allograft, platelet-derived growth factors, and internal bone stimulation for treatment of recalcitrant nonunions. OTA 19th Annual Meeting; 2003 [abstract]."},{"key":"10.1016\/j.injury.2005.10.010_bib24","doi-asserted-by":"crossref","unstructured":"Johnson EE, Urist MR, Finerman GA. Bone morphogenetic protein augmentation grafting of resistant femoral nonunions. A preliminary report. Clin Orthop 1988;230:257\u201365.","DOI":"10.1097\/00003086-198805000-00031"},{"key":"10.1016\/j.injury.2005.10.010_bib25","doi-asserted-by":"crossref","unstructured":"Johnson EE, Urist MR, Finerman GA. Repair of segmental defects of the tibia with cancellous bone grafts augmented with human bone morphogenetic protein. A preliminary report. Clin Orthop 1988;236:249\u201357.","DOI":"10.1097\/00003086-198811000-00034"},{"key":"10.1016\/j.injury.2005.10.010_bib26","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/00003086-199204000-00028","article-title":"Resistant nonunions and partial or complete segmental defects of long bones. Treatment with implants of a composite of human bone morphogenetic protein (BMP) and autolyzed, antigen-extracted, allogeneic (AAA) bone","volume":"277","author":"Johnson","year":"1992","journal-title":"Clin Orthop"},{"issue":"1","key":"10.1016\/j.injury.2005.10.010_bib27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.5435\/00124635-200501000-00010","article-title":"The biology of bone grafting","volume":"13","author":"Khan","year":"2005","journal-title":"J Am Acad Orthop Surg"},{"key":"10.1016\/j.injury.2005.10.010_bib28","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/01.blo.0000150312.53937.6f","article-title":"Treatment of osteonecrosis of the femoral head with core decompression and human bone morphogenetic protein","volume":"429","author":"Lieberman","year":"2004","journal-title":"Clin Orthop"},{"issue":"1\u20132","key":"10.1016\/j.injury.2005.10.010_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/PL00021234","article-title":"Ultrasound\u2014an alternative healing method for nonunions?","volume":"120","author":"Mayr","year":"2000","journal-title":"Arch Orthop Trauma Surg"},{"key":"10.1016\/j.injury.2005.10.010_bib30","unstructured":"McKee MD, Schemitsh EH, Wild L, et al. The treatment of complex, recalcitrant long-bone non-union with a human recombinant bone morphogenic protein: results of a prospective pilot study. OTA 18th Annual Meeting; 2002 [abstract]."},{"issue":"7","key":"10.1016\/j.injury.2005.10.010_bib31","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.2106\/00004623-200107000-00006","article-title":"Strut-autografting with and without osteogenic protein-1: a preliminary study of a canine femoral head defect model","volume":"83-A","author":"Mont","year":"2001","journal-title":"J Bone Joint Surg [Am]"},{"key":"10.1016\/j.injury.2005.10.010_bib32","first-page":"639","article-title":"Enhancement of skeletal repair","volume":"vol. 1","author":"Moucha","year":"2003"},{"key":"10.1016\/j.injury.2005.10.010_bib33","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1302\/0301-620X.84B1.11708","article-title":"Human skeletal muscle cells in ex vivo gene therapy to deliver bone morphogenetic protein-2","volume":"84","author":"Musgrave","year":"2002","journal-title":"J Bone Joint Surg [Br]"},{"issue":"4","key":"10.1016\/j.injury.2005.10.010_bib34","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1097\/00005373-200110000-00012","article-title":"Low-intensity pulsed ultrasound in the treatment of nonunions","volume":"51","author":"Nolte","year":"2001","journal-title":"J Trauma"},{"issue":"7","key":"10.1016\/j.injury.2005.10.010_bib35","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1002\/j.1460-2075.1990.tb07376.x","article-title":"OP-1 cDNA encodes an osteogenic protein in the TGF-beta family","volume":"9","author":"Ozkaynak","year":"1990","journal-title":"EMBO J"},{"key":"10.1016\/j.injury.2005.10.010_bib36","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/00003086-198005000-00017","article-title":"Treatment of delayed union and nonunion with an implanted direct current stimulator","volume":"148","author":"Paterson","year":"1980","journal-title":"Clin Orthop"},{"key":"10.1016\/j.injury.2005.10.010_bib37","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1172\/JCI15153","article-title":"Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4","volume":"110","author":"Peng","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.injury.2005.10.010_bib38","series-title":"Musculoskeletal conditions in the United States","article-title":"Musculoskeletal injuries","author":"Praemer","year":"1992"},{"issue":"Suppl. 1","key":"10.1016\/j.injury.2005.10.010_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2106\/00004623-200100001-00001","article-title":"Bone morphogenetic proteins: from basic science to clinical applications","volume":"83-A","author":"Reddi","year":"2001","journal-title":"J Bone Joint Surg [Am]"},{"key":"10.1016\/j.injury.2005.10.010_bib40","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S8756-3282(98)00053-2","article-title":"Bone morphogenetic proteins: from basic studies to clinical approaches","volume":"22","author":"Sakou","year":"1998","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.injury.2005.10.010_bib41","doi-asserted-by":"crossref","first-page":"803","DOI":"10.2106\/00004623-200106000-00001","article-title":"The effect of osteogenic protein-1 on the healing of segmental bone defects treated with autograft or allograft bone","volume":"83-A","author":"Salkeld","year":"2001","journal-title":"J Bone Joint Surg [Am]"},{"key":"10.1016\/j.injury.2005.10.010_bib42","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/00003086-200106000-00012","article-title":"Extracorporeal shock wave therapy of nonunion or delayed osseous union","volume":"387","author":"Schaden","year":"2001","journal-title":"Clin Orthop"},{"issue":"9","key":"10.1016\/j.injury.2005.10.010_bib43","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1002\/jgm.588","article-title":"Structural and functional healing of critical-size segmental bone defects by transduced muscle-derived cells expressing BMP4","volume":"6","author":"Shen","year":"2004","journal-title":"J Gene Med"},{"issue":"1","key":"10.1016\/j.injury.2005.10.010_bib44","first-page":"24","article-title":"Autogenous bone marrow graft for the management of nonunion of tibia]","volume":"15","author":"Wang","year":"2001","journal-title":"Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi"},{"issue":"3","key":"10.1016\/j.injury.2005.10.010_bib45","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/00005131-198909000-00002","article-title":"Morbidity at bone graft donor sites","volume":"3","author":"Younger","year":"1989","journal-title":"J Orthop Trauma"},{"issue":"2","key":"10.1016\/j.injury.2005.10.010_bib46","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/jbm.b.30110","article-title":"Osteogenic protein-1 enhances osseointegration of titanium implants coated with peri-apatite in rabbit femoral defect","volume":"71B","author":"Zhang","year":"2004","journal-title":"J Biomed Mater Res"}],"container-title":["Injury"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020138305004249?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020138305004249?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T11:06:23Z","timestamp":1683284783000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020138305004249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["S0020138305004249"],"URL":"https:\/\/doi.org\/10.1016\/j.injury.2005.10.010","relation":{},"ISSN":["0020-1383"],"issn-type":[{"value":"0020-1383","type":"print"}],"subject":[],"published":{"date-parts":[[2005,11]]}}}