{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:43:34Z","timestamp":1761155014975},"reference-count":24,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Injury"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1016\/j.injury.2006.09.001","type":"journal-article","created":{"date-parts":[[2006,11,8]],"date-time":"2006-11-08T12:29:04Z","timestamp":1162988944000},"page":"1172-1177","source":"Crossref","is-referenced-by-count":8,"title":["The use of factor VIIa in haemorrhagic shock and intracerebral bleeding"],"prefix":"10.1016","volume":"37","author":[{"given":"Richard P.","family":"Dutton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah M.","family":"Stein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.injury.2006.09.001_bib1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/01.TA.0000171453.37949.B7","article-title":"Recombinant factor VIIa as adjunctive therapy for bleeding control in severely injured trauma patients: two parallel randomized, placebo-controlled, double-blind clinical trials","volume":"59","author":"Boffard","year":"2005","journal-title":"J Trauma"},{"key":"10.1016\/j.injury.2006.09.001_bib2","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.0042-9007.2004.00393.x","article-title":"\u201cLast-ditch\u201d use of recombinant factor VIIa in patients with massive haemorrhage is ineffective","volume":"86","author":"Clark","year":"2004","journal-title":"Vox Sang"},{"key":"10.1016\/j.injury.2006.09.001_bib3","doi-asserted-by":"crossref","first-page":"884","DOI":"10.7326\/0003-4819-137-11-200212030-00009","article-title":"Reversal of warfarin-induced excessive anticoagulation with recombinant factor VII concentrate","volume":"137","author":"Deveras","year":"2002","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.injury.2006.09.001_bib4","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/01.TA.0000140646.66852.AB","article-title":"Factor VIIa for correction of traumatic coagulopathy","volume":"57","author":"Dutton","year":"2004","journal-title":"J Trauma"},{"key":"10.1016\/j.injury.2006.09.001_bib5","series-title":"Perioperative transfusion medicine","first-page":"289","article-title":"Initial resuscitation of the hemorrhaging patient","author":"Dutton","year":"2006"},{"key":"10.1016\/j.injury.2006.09.001_bib6","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0002-9610(05)81018-9","article-title":"Hypothermia and acidosis worsen coagulopathy in the patient requiring massive transfusion","volume":"160","author":"Ferrara","year":"1990","journal-title":"Am J Surg"},{"key":"10.1016\/j.injury.2006.09.001_bib7","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0140-6736(03)12268-4","article-title":"Effect of recombinant activated factor VII on perioperative blood loss in patients undergoing retropubic prostatectomy: a double-blind placebo-controlled randomized trial","volume":"361","author":"Friederich","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.injury.2006.09.001_bib8","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.injury.2004.08.001","article-title":"The role of recombinant factor VIIa in the treatment of life-threatening haemorrhage in blunt trauma","volume":"36","author":"Geeraedts","year":"2005","journal-title":"Inj, Int J Care Inj"},{"key":"10.1016\/j.injury.2006.09.001_bib9","first-page":"112","article-title":"Potential role of recombinant factor VIIa as a hemostatic agent","volume":"1","author":"Hedner","year":"2003","journal-title":"Clin Adv Hemat Onc"},{"key":"10.1016\/j.injury.2006.09.001_bib10","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1016\/S0140-6736(99)05155-7","article-title":"Treatment of traumatic bleeding with recombinant factor VIIa","volume":"354","author":"Kenet","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.injury.2006.09.001_bib11","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.amjsurg.2004.11.021","article-title":"Recombinant factor VIIa for the treatment of severe postoperative and traumatic hemorrhage","volume":"189","author":"Khan","year":"2005","journal-title":"Am J Surg"},{"key":"10.1016\/j.injury.2006.09.001_bib12","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1002\/lt.20470","article-title":"Efficacy and safety of repeated perioperative doses of recombinant factor VIIa in liver transplantation","volume":"11","author":"Lodge","year":"2005","journal-title":"Liver Transpl"},{"key":"10.1016\/j.injury.2006.09.001_bib13","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/00000542-200502000-00006","article-title":"Recombinant coagulation factor VIIa in major liver resection","volume":"102","author":"Lodge","year":"2005","journal-title":"Anesthesiology"},{"key":"10.1016\/j.injury.2006.09.001_bib14","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/00005373-200109000-00002","article-title":"Recombinant activated factor VII for adjunctive hemorrhage control in trauma","volume":"51","author":"Martinowitz","year":"2001","journal-title":"J Trauma"},{"key":"10.1016\/j.injury.2006.09.001_bib15","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1056\/NEJMoa042991","article-title":"Recombinant activated factor VII for acute intracerebral hemorrhage","volume":"352","author":"Mayer","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.injury.2006.09.001_bib16","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1097\/01.TA.0000066184.20808.A5","article-title":"The effect of temperature and pH on the activity of factor VIIa: implications for the efficacy of high-dose factor VIIa in hypothermic and acidotic patients","volume":"55","author":"Meng","year":"2003","journal-title":"J Trauma"},{"key":"10.1016\/j.injury.2006.09.001_bib17","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1161\/01.ATV.0000047645.37970.AB","article-title":"Mechanism of action of high-dose factor VIIa. Points of agreement and disagreement","volume":"23","author":"Monroe","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.injury.2006.09.001_bib18","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1001\/jama.295.3.293","article-title":"Thromboembolic adverse events after use of recombinant human coagulation factor VIIa","volume":"295","author":"O\u2019Connell","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.injury.2006.09.001_bib19","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1046\/j.0041-1132.2003.00577.x","article-title":"Recombinant FVIIa in the management of uncontrolled hemorrhage","volume":"43","author":"O\u2019Connell","year":"2003","journal-title":"Transfusion"},{"key":"10.1016\/j.injury.2006.09.001_bib20","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1097\/00005373-200202000-00034","article-title":"Successful use of recombinant activated factor VII for trauma-associated hemorrhage in a patient without preexisting coagulopathy","volume":"52","author":"O\u2019Neill","year":"2002","journal-title":"J Trauma"},{"key":"10.1016\/j.injury.2006.09.001_bib21","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1227\/01.NEU.0000068830.54968.A8","article-title":"Recombinant activated factor VII for the rapid correction of coagulopathy in nonhemophilic neurosurgical patients","volume":"53","author":"Park","year":"2003","journal-title":"Neurosurgery"},{"key":"10.1016\/j.injury.2006.09.001_bib22","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1093\/bja\/aei102","article-title":"Use of activated recombinant coagulation factor VII in patients undergoing reconstruction surgery for traumatic fracture of pelvis or pelvis and acetabulum: a double-blind, randomized, placebo-controlled trial","volume":"94","author":"Raobaikady","year":"2005","journal-title":"Br J Anaeth"},{"key":"10.1016\/j.injury.2006.09.001_bib23","first-page":"609","article-title":"Determinants of futility of administration of recombinant factor VIIa in trauma","volume":"59","author":"Stein","year":"2005","journal-title":"J Trauma"},{"key":"10.1016\/j.injury.2006.09.001_bib24","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1097\/00000542-200306000-00034","article-title":"Treatment of excessive bleeding in Jehovah's Witness patients after cardiac surgery with recombinant factor VIIa (NovoSeven)","volume":"98","author":"Tanaka","year":"2003","journal-title":"Anesthesiology"}],"container-title":["Injury"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020138306005808?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020138306005808?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T16:53:15Z","timestamp":1547225595000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020138306005808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S0020138306005808"],"URL":"https:\/\/doi.org\/10.1016\/j.injury.2006.09.001","relation":{},"ISSN":["0020-1383"],"issn-type":[{"value":"0020-1383","type":"print"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}