{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T04:32:55Z","timestamp":1782621175224,"version":"3.54.5"},"reference-count":35,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","injuryjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Injury"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.injury.2015.08.035","type":"journal-article","created":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T08:00:36Z","timestamp":1441094436000},"page":"2156-2163","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Repair and regeneration of lumbosacral nerve defects in rats with chitosan conduits containing bone marrow mesenchymal stem cells"],"prefix":"10.1016","volume":"46","author":[{"given":"Lei","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai-min","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.injury.2015.08.035_bib0180","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/3-211-27458-8_12","article-title":"Microsurgical treatment of lumbosacral plexus injuries","volume":"92","author":"Alexandre","year":"2005","journal-title":"Acta Neurochir Suppl"},{"key":"10.1016\/j.injury.2015.08.035_bib0185","doi-asserted-by":"crossref","DOI":"10.1007\/s00701-014-2114-9","article-title":"Anterior cornual motoneuron regression pattern after sacral plexus avulsion in rats","author":"Jiang","year":"2014","journal-title":"Acta Neurochir (Wien)"},{"key":"10.1016\/j.injury.2015.08.035_bib0190","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.expneurol.2004.10.019","article-title":"Survival, regeneration and functional recovery of motoneurons after delayed reimplantation of avulsed spinal root in adult rat","volume":"192","author":"Gu","year":"2005","journal-title":"Exp Neurol"},{"key":"10.1016\/j.injury.2015.08.035_bib0195","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3171\/spi.2004.1.1.0064","article-title":"Surgical treatment of lumbosacral plexus injuries","volume":"1","author":"Lang","year":"2004","journal-title":"J Neurosurg Spine"},{"key":"10.1016\/j.injury.2015.08.035_bib0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.injury.2014.01.014","article-title":"Unaffected contralateral S1 transfer for the treatment of lumbosacral plexus avulsion","author":"Li","year":"2014","journal-title":"Injury"},{"key":"10.1016\/j.injury.2015.08.035_bib0205","doi-asserted-by":"crossref","first-page":"714","DOI":"10.3171\/2013.5.JNS121218","article-title":"Contralateral L-6 nerve root transfer to repair lumbosacral plexus root avulsion: experimental study in rhesus monkeys","volume":"119","author":"Lin","year":"2013","journal-title":"J Neurosurg"},{"key":"10.1016\/j.injury.2015.08.035_bib0210","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.fcl.2011.01.009","article-title":"Nerve problems in the lower extremity","volume":"16","author":"Ray","year":"2011","journal-title":"Foot Ankle Clin"},{"key":"10.1016\/j.injury.2015.08.035_bib0215","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1529-8027.2010.00257.x","article-title":"Schwann cell delivery of neurotrophic factors for peripheral nerve regeneration","volume":"15","author":"Madduri","year":"2010","journal-title":"J Peripher Nerv Syst"},{"key":"10.1016\/j.injury.2015.08.035_bib0220","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/ar.1120","article-title":"Peripheral nerve injury: a review and approach to tissue engineered constructs","volume":"263","author":"Evans","year":"2001","journal-title":"Anat Rec"},{"key":"10.1016\/j.injury.2015.08.035_bib0225","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.pneurobio.2010.11.002","article-title":"Construction of tissue engineered nerve grafts and their application in peripheral nerve regeneration","volume":"93","author":"Gu","year":"2011","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.injury.2015.08.035_bib0230","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1016\/j.biomaterials.2003.11.029","article-title":"The interaction of Schwann cells with chitosan membranes and fibers in vitro","volume":"25","author":"Yuan","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.injury.2015.08.035_bib0235","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.carbpol.2012.08.114","article-title":"Chitosan-based nanofibrous membranes for antibacterial filter applications","volume":"92","author":"Cooper","year":"2013","journal-title":"Carbohydr Polym"},{"key":"10.1016\/j.injury.2015.08.035_bib0240","doi-asserted-by":"crossref","first-page":"4409","DOI":"10.1016\/j.biomaterials.2008.07.043","article-title":"Use of hybrid chitosan membranes and N1E-115 cells for promoting nerve regeneration in an axonotmesis rat model","volume":"29","author":"Amado","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.injury.2015.08.035_bib0245","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1007\/s10856-013-4917-2","article-title":"Schwann cell-seeded scaffold with longitudinally oriented micro-channels for reconstruction of sciatic nerve in rats","volume":"24","author":"Zhang","year":"2013","journal-title":"J Mater Sci Mater Med"},{"key":"10.1016\/j.injury.2015.08.035_bib0250","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.expneurol.2011.01.013","article-title":"Differentiation of mesenchymal stem cells to support peripheral nerve regeneration in a rat model","volume":"228","author":"Ladak","year":"2011","journal-title":"Exp Neurol"},{"key":"10.1016\/j.injury.2015.08.035_bib0255","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.brainres.2011.01.098","article-title":"Schwann-like mesenchymal stem cells within vein graft facilitate facial nerve regeneration and remyelination","volume":"1383","author":"Wang","year":"2011","journal-title":"Brain Res"},{"key":"10.1016\/j.injury.2015.08.035_bib0260","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/0014-4886(82)90234-5","article-title":"An index of the functional condition of rat sciatic nerve based on measurements made from walking tracks","volume":"77","author":"de Medinaceli","year":"1982","journal-title":"Exp Neurol"},{"key":"10.1016\/j.injury.2015.08.035_bib0265","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/00006534-199202000-00009","article-title":"Walking track analysis: a long-term assessment of peripheral nerve recovery","volume":"89","author":"Hare","year":"1992","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.injury.2015.08.035_bib0270","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.biomaterials.2012.09.020","article-title":"Long-term outcome of the repair of 50mm long median nerve defects in rhesus monkeys with mesenchymal stem cells-containing, chitosan-based tissue engineered nerve grafts","volume":"34","author":"Hu","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.injury.2015.08.035_bib0275","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1089\/ten.tea.2011.0496","article-title":"Mesenchymal stem cells in a polycaprolactone conduit promote sciatic nerve regeneration and sensory neuron survival after nerve injury","volume":"18","author":"Frattini","year":"2012","journal-title":"Tissue Eng, A"},{"key":"10.1016\/j.injury.2015.08.035_bib0280","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1001\/archneur.1978.00500350061013","article-title":"Traumatic and postoperative lesions of the lumbosacral plexus","volume":"35","author":"Stoehr","year":"1978","journal-title":"Arch Neurol"},{"key":"10.1016\/j.injury.2015.08.035_bib0285","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.biocel.2003.11.001","article-title":"Mesenchymal stem cells: clinical applications and biological characterization","volume":"36","author":"Barry","year":"2004","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.injury.2015.08.035_bib0290","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.micron.2010.05.010","article-title":"Transplantation of bone-marrow-derived cells into a nerve guide resulted in transdifferentiation into Schwann cells and effective regeneration of transected mouse sciatic nerve","volume":"41","author":"Pereira Lopes","year":"2010","journal-title":"Micron"},{"key":"10.1016\/j.injury.2015.08.035_bib0295","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.brainres.2009.01.056","article-title":"Bone marrow mesenchymal stem cells promote cell proliferation and neurotrophic function of Schwann cells in vitro and in vivo","volume":"1262","author":"Wang","year":"2009","journal-title":"Brain Res"},{"key":"10.1016\/j.injury.2015.08.035_bib0300","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.biomaterials.2010.09.046","article-title":"The regeneration of transected sciatic nerves of adult rats using chitosan nerve conduits seeded with bone marrow stromal cell-derived Schwann cells","volume":"32","author":"Ao","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.injury.2015.08.035_bib0305","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.expneurol.2010.01.022","article-title":"Long-term observation of auto-cell transplantation in non-human primate reveals safety and efficiency of bone marrow stromal cell-derived Schwann cells in peripheral nerve regeneration","volume":"223","author":"Wakao","year":"2010","journal-title":"Exp Neurol"},{"key":"10.1016\/j.injury.2015.08.035_bib0310","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1089\/ten.2006.12.1451","article-title":"Peripheral nerve tissue engineering: autologous Schwann cells vs. transdifferentiated mesenchymal stem cells","volume":"12","author":"Keilhoff","year":"2006","journal-title":"Tissue Eng"},{"key":"10.1016\/j.injury.2015.08.035_bib0315","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/micr.20184","article-title":"Study of in vivo differentiation of rat bone marrow stromal cells into Schwann cell-like cells","volume":"26","author":"Chen","year":"2006","journal-title":"Microsurgery"},{"key":"10.1016\/j.injury.2015.08.035_bib0320","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.expneurol.2006.11.018","article-title":"Repair of extended peripheral nerve lesions in rhesus monkeys using acellular allogenic nerve grafts implanted with autologous mesenchymal stem cells","volume":"204","author":"Hu","year":"2007","journal-title":"Exp Neurol"},{"key":"10.1016\/j.injury.2015.08.035_bib0325","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1007\/s11064-011-0567-2","article-title":"Comparison of transdifferentiated and untransdifferentiated human umbilical mesenchymal stem cells in rats after traumatic brain injury","volume":"36","author":"Hong","year":"2011","journal-title":"Neurochem Res"},{"key":"10.1016\/j.injury.2015.08.035_bib0330","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0006-8993(00)02207-1","article-title":"Peripheral nerve regeneration across an 80-mm gap bridged by a polyglycolic acid (PGA)-collagen tube filled with laminin-coated collagen fibers: a histological and electrophysiological evaluation of regenerated nerves","volume":"868","author":"Matsumoto","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.injury.2015.08.035_bib0335","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-0270(01)00378-8","article-title":"Functional evaluation of peripheral nerve regeneration in the rat: walking track analysis","volume":"108","author":"Varejao","year":"2001","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.injury.2015.08.035_bib0340","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1146\/annurev.neuro.30.051606.094337","article-title":"Peripheral regeneration","volume":"30","author":"Chen","year":"2007","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.injury.2015.08.035_bib0345","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1089\/0897715041651006","article-title":"Delayed implantation of a peripheral nerve graft reduces motoneuron survival but does not affect regeneration following spinal root avulsion in adult rats","volume":"21","author":"Wu","year":"2004","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.injury.2015.08.035_bib0350","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1007\/s00701-014-2114-9","article-title":"Anterior cornual motoneuron regression pattern after sacral plexus avulsion in rats","volume":"156","author":"Jiang","year":"2014","journal-title":"Acta Neurochir (Wien)"}],"container-title":["Injury"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020138315005100?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020138315005100?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T01:51:41Z","timestamp":1567129901000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020138315005100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S0020138315005100"],"URL":"https:\/\/doi.org\/10.1016\/j.injury.2015.08.035","relation":{},"ISSN":["0020-1383"],"issn-type":[{"value":"0020-1383","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Repair and regeneration of lumbosacral nerve defects in rats with chitosan conduits containing bone marrow mesenchymal stem cells","name":"articletitle","label":"Article Title"},{"value":"Injury","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.injury.2015.08.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}