{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:42:34Z","timestamp":1789011754258,"version":"build-2803163510"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","injuryjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Injury"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.injury.2016.07.047","type":"journal-article","created":{"date-parts":[[2016,8,7]],"date-time":"2016-08-07T15:07:06Z","timestamp":1470582426000},"page":"S49-S53","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"S4","title":["Surgical management of spinal fractures and neurological involvement in patients with myeloma"],"prefix":"10.1016","volume":"47","author":[{"given":"Vincenzo","family":"Denaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Denaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Albo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Papapietro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Piccioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Di Martino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.injury.2016.07.047_bib0005","first-page":"291","article-title":"Bone destruction and hypercalcemia in plasma cell myeloma","volume":"13","author":"Mundy","year":"1986","journal-title":"Semin Oncol"},{"issue":"6","key":"10.1016\/j.injury.2016.07.047_bib0010","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.3171\/foc.2001.11.6.3","article-title":"Management of metastatic tumors of the spine: strategies and operative indications","volume":"11","author":"Steinmetz","year":"2001","journal-title":"Neurosurg Focus"},{"issue":"11","key":"10.1016\/j.injury.2016.07.047_bib0015","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1002\/cncr.20652","article-title":"Incidence of multiple myeloma in Olmsted County, Minnesota: trend over 6 decades","volume":"101","author":"Kyle","year":"2004","journal-title":"Cancer"},{"issue":"2","key":"10.1016\/j.injury.2016.07.047_bib0020","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3340\/jkns.2013.54.2.151","article-title":"Multiple myeloma and epidural spinal cord compression: case presentation and a spine surgeon's perspective","volume":"54","author":"Ha","year":"2013","journal-title":"J Korean Neurosurg Soc"},{"issue":"3","key":"10.1016\/j.injury.2016.07.047_bib0025","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1227\/NEU.0b013e318207780c","article-title":"Predictors of survival after surgical treatment of spinal metastasis","volume":"68","author":"Arrigo","year":"2011","journal-title":"Neurosurgery"},{"issue":"1","key":"10.1016\/j.injury.2016.07.047_bib0030","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3171\/2010.3.SPINE09202","article-title":"Diagnosis and management of metastatic spine disease","volume":"13","author":"Sciubba","year":"2010","journal-title":"J Neurosurg Spine"},{"key":"10.1016\/j.injury.2016.07.047_bib0035","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1365-2141.2011.08573.x","article-title":"Haemato-oncology task force of british committee for standards in haematology (BCSH) and UK myeloma forum. guidelines for the diagnosis and management of multiple myeloma","volume":"154","author":"Bird","year":"2011","journal-title":"B J Haematol"},{"key":"10.1016\/j.injury.2016.07.047_bib0040","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s00520-014-2358-1","article-title":"Side effects of analgesia may significantly reduce quality of life in symptomatic multiple myeloma: a cross-sectional prevalence study","volume":"23","author":"Sloot","year":"2015","journal-title":"Support CareCancer"},{"key":"10.1016\/j.injury.2016.07.047_bib0045","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0360-3016(93)90308-I","article-title":"Radiation therapy for the palliation of multiple myeloma","volume":"25","author":"Leigh","year":"1993","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.injury.2016.07.047_bib0050","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s00066-010-2155-9","article-title":"Impact of radiotherapy on pain relief and recalcification in plasma cell neoplasms: long-term experience","volume":"187","author":"Balducci","year":"2011","journal-title":"Strahlenther Onkol"},{"issue":"1","key":"10.1016\/j.injury.2016.07.047_bib0055","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1755-7682-6-6","article-title":"Pain and quality of life in patients undergoing radiotherapy for spinal metastatic disease treatment","volume":"6","author":"Valesin Filho","year":"2013","journal-title":"Int Arch Med"},{"key":"10.1016\/j.injury.2016.07.047_bib0060","first-page":"151","article-title":"Indirizzi diagnostici e terapeutici nel trattamento del plasmocitoma","volume":"37","author":"Ruju","year":"1969","journal-title":"Ortopedia e traumatologia dell\u2019apparato locomotore"},{"key":"10.1016\/j.injury.2016.07.047_bib0065","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3109\/17453679209154821","article-title":"Surgery for multiple myeloma of the spine: a retrospective analysis of 12 patients","volume":"63","author":"Jonsson","year":"1992","journal-title":"Acta Orthop Scand"},{"issue":"6","key":"10.1016\/j.injury.2016.07.047_bib0070","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.jpain.2012.03.003","article-title":"Changes in pain and other symptoms in patients with painful multiple myeloma-related vertebral fracture treated with kyphoplasty or vertebroplasty","volume":"13","author":"Mendoza","year":"2012","journal-title":"J Pain"},{"issue":"8","key":"10.1016\/j.injury.2016.07.047_bib0075","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1038\/leu.2008.127","article-title":"The role of vertebral augmentation in multiple myeloma: international myeloma working group consensus statement","volume":"22","author":"Hussein","year":"2008","journal-title":"Leukemia"},{"issue":"5","key":"10.1016\/j.injury.2016.07.047_bib0080","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1227\/00006123-199111000-00001","article-title":"Treatment of neoplastic spinal cord compression: results of a prospective study","volume":"29","author":"Sundaresan","year":"1991","journal-title":"Neurosurgery"},{"key":"10.1016\/j.injury.2016.07.047_bib0085","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/bjh.13577","article-title":"Optimizing the management of patients with spinal myeloma disease","volume":"171","author":"Molloy","year":"2015","journal-title":"Br J Haematol"},{"key":"10.1016\/j.injury.2016.07.047_bib0090","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3171\/jns.1996.85.2.0211","article-title":"Single-stage posterior vertebrectomy and replacement combined with posterior instrumentation for spinal metastasis","volume":"85","author":"Akeyson","year":"1996","journal-title":"J Neurosurg"},{"key":"10.1016\/j.injury.2016.07.047_bib0095","doi-asserted-by":"crossref","first-page":"514","DOI":"10.2106\/00004623-199704000-00006","article-title":"Posterior decompression and stabilization for spinal metastases: analysis of sixty-seven consecutive patients","volume":"79","author":"Bauer","year":"1997","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.injury.2016.07.047_bib0100","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1097\/00007632-199909150-00014","article-title":"Complication, survival rates, and risk factors of surgery for metastatic disease of the spine","volume":"24","author":"Wise","year":"1999","journal-title":"Spine (PhilaPa 1976)"},{"issue":"2","key":"10.1016\/j.injury.2016.07.047_bib0105","first-page":"431","article-title":"Internal bracing surgery in the management of solid tumor metastases of the thoracic and lumbar spine","volume":"21","author":"Di Martino","year":"2009","journal-title":"Oncol Rep"},{"issue":"3","key":"10.1016\/j.injury.2016.07.047_bib0110","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3171\/2014.9.SPINE14554","article-title":"Outcomes following surgical intervention for impending and gross instability caused by multiple myeloma in the spinal column","volume":"22","author":"Zadnik","year":"2015","journal-title":"J Neurosurg Spine"},{"issue":"12","key":"10.1016\/j.injury.2016.07.047_bib0115","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.spinee.2012.10.015","article-title":"Single-stage posterior decompression and stabilization for metastasis of the thoracic spine: prognostic factors for functional outcome and patients' survival","volume":"12","author":"Chong","year":"2012","journal-title":"Spine J"},{"issue":"2","key":"10.1016\/j.injury.2016.07.047_bib0120","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1586\/14737140.2014.856532","article-title":"Management of patients with metastasis to the vertebrae: recommendations from the Italian Orthopaedic Society (SIOT) Bone Metastasis Study Group","volume":"14","author":"Gasbarrini","year":"2014","journal-title":"Expert Rev Anticancer Ther"},{"issue":"3","key":"10.1016\/j.injury.2016.07.047_bib0125","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1007\/s11999-010-1617-9","article-title":"Patients with cervical metastasis and neoplastic pachymeningitis are less likely to improve neurologically after surgery","volume":"469","author":"Denaro","year":"2011","journal-title":"Clin Orthop Relat Res"},{"issue":"1\u20132","key":"10.1016\/j.injury.2016.07.047_bib0130","first-page":"127","article-title":"Treatment of metastases of the cervical spine","volume":"83","author":"Denaro","year":"1998","journal-title":"Chir Organi Mov"},{"issue":"2","key":"10.1016\/j.injury.2016.07.047_bib0135","doi-asserted-by":"crossref","first-page":"S169","DOI":"10.1007\/s12306-013-0277-9","article-title":"Atraumatic vertebral compression fractures: differential diagnosis between benign osteoporotic and malignant fractures by MRI","volume":"97","author":"Cicala","year":"2013","journal-title":"Musculoskelet Surg"},{"issue":"2","key":"10.1016\/j.injury.2016.07.047_bib0140","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s12306-015-0355-2","article-title":"Lumbar subcutaneous edema and degenerative spinal disease in patients with low back pain: a retrospective MRI study","volume":"99","author":"Quattrocchi","year":"2015","journal-title":"Musculoskelet Surg"},{"issue":"3","key":"10.1016\/j.injury.2016.07.047_bib0145","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1007\/s00586-012-2562-y","article-title":"Treatment of spinal epidural compression due to hematological malignancies: a single institution's retrospective experience","volume":"22","author":"Flouzat-Lachaniette","year":"2013","journal-title":"Eur Spine J"},{"key":"10.1016\/j.injury.2016.07.047_bib0150","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1136\/bmj.317.7150.18","article-title":"Malignant spinal cord compression: prospective study of delays in referral and treatment","volume":"317","author":"Husband","year":"1998","journal-title":"BMJ"},{"key":"10.1016\/j.injury.2016.07.047_bib0155","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0277-5379(89)90008-4","article-title":"Spinal cord compression in myelomatosis: response to chemotherapy alone","volume":"25","author":"Sinoff","year":"1989","journal-title":"Eur J Cancer Clin Oncol"},{"issue":"8","key":"10.1016\/j.injury.2016.07.047_bib0160","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/s00264-010-1127-0","article-title":"Surgical therapy of skeletal complications in multiple myeloma","volume":"35","author":"Utzschneider","year":"2011","journal-title":"Int Orthop"},{"issue":"3","key":"10.1016\/j.injury.2016.07.047_bib0165","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3340\/jkns.2012.51.3.127","article-title":"Analysis of prognostic factors relating to postoperative survival in spinal metastases","volume":"51","author":"Yang","year":"2012","journal-title":"J Korean Neurosurg Soc"},{"issue":"2","key":"10.1016\/j.injury.2016.07.047_bib0170","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/cncr.11039","article-title":"Clinical outcome and survival after palliative surgery for spinal metastases: palliative surgery in spinal metastases","volume":"97","author":"Hirabayashi","year":"2003","journal-title":"Cancer"},{"issue":"5","key":"10.1016\/j.injury.2016.07.047_bib0175","doi-asserted-by":"crossref","first-page":"564","DOI":"10.3171\/spi.2005.2.5.0564","article-title":"Surgical management of spinal metastases: analysis of prognostic factors during a 10-year experience","volume":"2","author":"North","year":"2005","journal-title":"J Neurosurg Spine"},{"key":"10.1016\/j.injury.2016.07.047_bib0180","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1002\/cncr.22991","article-title":"Pathologic fractures correlate with reduced survival in patients with malignant bone disease","volume":"110","author":"Saad","year":"2007","journal-title":"Cancer"}],"container-title":["Injury"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020138316303448?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020138316303448?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,9]],"date-time":"2018-09-09T10:54:19Z","timestamp":1536490459000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020138316303448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":36,"alternative-id":["S0020138316303448"],"URL":"https:\/\/doi.org\/10.1016\/j.injury.2016.07.047","relation":{},"ISSN":["0020-1383"],"issn-type":[{"value":"0020-1383","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Surgical management of spinal fractures and neurological involvement in patients with myeloma","name":"articletitle","label":"Article Title"},{"value":"Injury","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.injury.2016.07.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}