{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:48:26Z","timestamp":1782521306197,"version":"3.54.5"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","injuryjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Injury"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.injury.2017.04.015","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T09:47:01Z","timestamp":1493027221000},"page":"S3-S6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"S1","title":["Timing of definitive fixation of major long bone fractures: Can fat embolism syndrome be prevented?"],"prefix":"10.1016","volume":"48","author":[{"given":"Taco J.","family":"Blokhuis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Christoph","family":"Pape","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Paul","family":"Fr\u00f6lke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 7","key":"10.1016\/j.injury.2017.04.015_bib0005","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1016\/S0020-1383(15)30041-3","article-title":"Bilateral femoral shaft fractures complicated by fat and pulmonary embolism: a case report","volume":"46","author":"Randelli","year":"2015","journal-title":"Injury"},{"issue":"6","key":"10.1016\/j.injury.2017.04.015_bib0010","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1097\/MAJ.0b013e318172f5d2","article-title":"Fat embolism syndrome","volume":"336","author":"Stein","year":"2008","journal-title":"Am J Med Sci"},{"issue":"Suppl. 4","key":"10.1016\/j.injury.2017.04.015_bib0015","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1016\/j.injury.2006.08.036","article-title":"Bone marrow fat in the circulation: clinical entities and pathophysiological mechanisms","volume":"37","author":"Husebye","year":"2006","journal-title":"Injury"},{"issue":"Suppl. 4","key":"10.1016\/j.injury.2017.04.015_bib0020","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1016\/j.injury.2006.08.040","article-title":"Fat embolism: the reaming controversy","volume":"37","author":"Giannoudis","year":"2006","journal-title":"Injury"},{"issue":"7","key":"10.1016\/j.injury.2017.04.015_bib0025","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1007\/s11999-013-2869-y","article-title":"Role of interleukin-6 as an early marker of fat embolism syndrome: a clinical study","volume":"471","author":"Prakash","year":"2013","journal-title":"Clin Orthop Relat Res"},{"issue":"3","key":"10.1016\/j.injury.2017.04.015_bib0030","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1161\/CIRCULATIONAHA.114.010835","article-title":"Fat embolism syndrome","volume":"131","author":"Kosova","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.injury.2017.04.015_bib0035","series-title":"Practice of intramedullary nailing","author":"K\u00fcntscher","year":"1967"},{"issue":"3","key":"10.1016\/j.injury.2017.04.015_bib0040","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/00000658-198509000-00003","article-title":"Blunt multiple trauma (ISS 36), femur traction, and the pulmonary failure-septic state","volume":"202","author":"Seibel","year":"1985","journal-title":"Ann Surg"},{"issue":"3","key":"10.1016\/j.injury.2017.04.015_bib0045","doi-asserted-by":"crossref","first-page":"336","DOI":"10.2106\/00004623-198971030-00004","article-title":"Early versus delayed stabilization of femoral fractures: a prospective randomized study","volume":"71","author":"Bone","year":"1989","journal-title":"J Bone Joint Surg Am"},{"issue":"5","key":"10.1016\/j.injury.2017.04.015_bib0050","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1097\/TA.0b013e3182701ded","article-title":"Timing of definitive treatment of femoral shaft fractures in patients with multiple injuries: a systematic review of randomized and nonrandomized trials","volume":"73","author":"Nahm","year":"2012","journal-title":"J Trauma Acute Care Surg"},{"issue":"6","key":"10.1016\/j.injury.2017.04.015_bib0055","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s001340050631","article-title":"Fatal systemic inflammatory response syndrome following early bilateral femoral nailing","volume":"24","author":"Giannoudis","year":"1998","journal-title":"Intensive Care Med"},{"issue":"4","key":"10.1016\/j.injury.2017.04.015_bib0060","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1097\/00005373-200004000-00006","article-title":"External fixation as a bridge to intramedullary nailing for patients with multiple injuries and with femur fractures: damage control orthopedics","volume":"48","author":"Scalea","year":"2000","journal-title":"J Trauma"},{"issue":"5","key":"10.1016\/j.injury.2017.04.015_bib0065","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1097\/TA.0b013e3181b890be","article-title":"Resuscitation before stabilization of femoral fractures limits acute respiratory distress syndrome in patients with multiple traumatic injuries despite low use of damage control orthopedics","volume":"67","author":"O\u2019Toole","year":"2009","journal-title":"J Trauma"},{"issue":"1","key":"10.1016\/j.injury.2017.04.015_bib0070","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/01.TA.0000075787.69695.4E","article-title":"Impact of intramedullary instrumentation versus damage control for femoral fractures on immunoinflammatory parameters: prospective randomized analysis by the EPOFF Study Group","volume":"55","author":"Pape","year":"2003","journal-title":"J Trauma"},{"issue":"9","key":"10.1016\/j.injury.2017.04.015_bib0075","doi-asserted-by":"crossref","first-page":"541","DOI":"10.5435\/00124635-200909000-00001","article-title":"Timing of fracture fixation in multitrauma patients: the role of early total care and damage control surgery","volume":"17","author":"Pape","year":"2009","journal-title":"J Am Acad Orthop Surg"},{"issue":"3","key":"10.1016\/j.injury.2017.04.015_bib0080","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1097\/TA.0b013e3181aa21c0","article-title":"Safety and efficacy of damage control external fixation versus early definitive stabilization for femoral shaft fractures in the multiple-injured patient","volume":"67","author":"Tuttle","year":"2009","journal-title":"J Trauma"},{"issue":"5","key":"10.1016\/j.injury.2017.04.015_bib0085","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1097\/TA.0000000000000434","article-title":"Optimal timing of femur fracture stabilization in polytrauma patients: a practice management guideline from the Eastern Association for the Surgery of Trauma","volume":"77","author":"Gandhi","year":"2014","journal-title":"J Trauma Acute Care Surg"},{"issue":"11","key":"10.1016\/j.injury.2017.04.015_bib0090","doi-asserted-by":"crossref","first-page":"687","DOI":"10.4103\/0972-5229.169358","article-title":"Massive cerebral fat embolism leading to brain death: a rare presentation","volume":"19","author":"Aggarwal","year":"2015","journal-title":"Indian J Crit Care Med"},{"issue":"2","key":"10.1016\/j.injury.2017.04.015_bib0095","doi-asserted-by":"crossref","first-page":"309","DOI":"10.4103\/0974-2700.82233","article-title":"Cerebral fat embolism without intracardiac shunt: a novel presentation","volume":"4","author":"Eriksson","year":"2011","journal-title":"J Emerg Trauma Shock"},{"issue":"Suppl. 4","key":"10.1016\/j.injury.2017.04.015_bib0100","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.injury.2006.08.035","article-title":"Fat embolism syndrome: history, definition, epidemiology","volume":"37","author":"Talbot","year":"2006","journal-title":"Injury"},{"issue":"Suppl. 4","key":"10.1016\/j.injury.2017.04.015_bib0105","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1016\/j.injury.2006.08.042","article-title":"Therapeutic aspects of fat embolism syndrome","volume":"37","author":"Habashi","year":"2006","journal-title":"Injury"},{"issue":"1","key":"10.1016\/j.injury.2017.04.015_bib0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.injury.2014.12.001","article-title":"Safe definitive orthopaedic surgery (SDS): repeated assessment for tapered application of Early Definitive Care and Damage Control?: an inclusive view of recent advances in polytrauma management","volume":"46","author":"Pape","year":"2015","journal-title":"Injury"},{"issue":"3","key":"10.1016\/j.injury.2017.04.015_bib0115","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0002-9610(02)00783-3","article-title":"When should we operate on major fractures in patients with severe head injuries?","volume":"183","author":"Giannoudis","year":"2002","journal-title":"Am J Surg"},{"issue":"10","key":"10.1016\/j.injury.2017.04.015_bib0120","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/BOT.0b013e31829efda1","article-title":"Timing of orthopaedic surgery in multiple trauma patients: development of a protocol for early appropriate care","volume":"27","author":"Vallier","year":"2013","journal-title":"J Orthop Trauma"}],"container-title":["Injury"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020138317302437?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020138317302437?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,2]],"date-time":"2018-09-02T07:26:23Z","timestamp":1535873183000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020138317302437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":24,"alternative-id":["S0020138317302437"],"URL":"https:\/\/doi.org\/10.1016\/j.injury.2017.04.015","relation":{},"ISSN":["0020-1383"],"issn-type":[{"value":"0020-1383","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Timing of definitive fixation of major long bone fractures: Can fat embolism syndrome be prevented?","name":"articletitle","label":"Article Title"},{"value":"Injury","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.injury.2017.04.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}