{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:45:13Z","timestamp":1792550713072,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100013769","name":"Orthopaedic Trauma Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100013769","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","injuryjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Injury"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.injury.2017.11.006","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T10:30:26Z","timestamp":1511260226000},"page":"177-183","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":94,"title":["Diabetes and Healing Outcomes in Lower Extremity Fractures: A Systematic Review"],"prefix":"10.1016","volume":"49","author":[{"given":"Hilary","family":"Gortler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessyca","family":"Rusyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Godbout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jas","family":"Chahal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil H.","family":"Schemitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Nauth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.injury.2017.11.006_bib0005","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2337\/diacare.27.5.1047","article-title":"Global prevalence of diabetes: estimates for the year 2000 and projections for 2030","volume":"27","author":"Wild","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.injury.2017.11.006_bib0010","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.yexcr.2014.12.011","article-title":"Factors circulating in the blood of type 2 diabetes mellitus patients affect osteoblast maturation \u2013 description of a novel in vitro model","volume":"332","author":"Ehnert","year":"2015","journal-title":"Exp Cell Res"},{"issue":"1","key":"10.1016\/j.injury.2017.11.006_bib0015","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1210\/en.2006-1006","article-title":"Bone loss and increased bone adiposity in spontaneous and pharmacologically induced diabetic mice","volume":"148","author":"Botolin","year":"2007","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.injury.2017.11.006_bib0020","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1185\/03007990902801147","article-title":"Bone health in diabetes: considerations for clinical management","volume":"25","author":"Adami","year":"2009","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.injury.2017.11.006_bib0025","first-page":"1","article-title":"Bone damage in type 2 diabetes mellitus","volume":"115","author":"Carnevale","year":"2014","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"1","key":"10.1016\/j.injury.2017.11.006_bib0030","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jecm.2010.12.006","article-title":"Impact of Diabetes on Fracture Healing","volume":"3","author":"Graves","year":"2011","journal-title":"J Exp Clin Med"},{"issue":"7","key":"10.1016\/j.injury.2017.11.006_bib0035","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.2337\/diacare.24.7.1198","article-title":"Diabetes and Risk of Fracture","volume":"24","author":"Ivers","year":"2001","journal-title":"Diabetes Care"},{"key":"10.1016\/j.injury.2017.11.006_bib0040","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1007\/s00125-005-1786-3","article-title":"Relative fracture risk in patients with diabetes mellitus, and the impact of insulin and oral antidiabetic medication on relative fracture risk","volume":"48","author":"Vestergaard","year":"2005","journal-title":"Diabetologia"},{"issue":"1","key":"10.1016\/j.injury.2017.11.006_bib0045","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0030-5898(05)70198-X","article-title":"Complications of ankle fractures in diabetic patients","volume":"32","author":"Bibbo","year":"2001","journal-title":"Orthop Clin North Am"},{"key":"10.1016\/j.injury.2017.11.006_bib0050","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/S0140-6736(05)67700-8","article-title":"Wound healing and its impairment in the diabetic foot","volume":"366","author":"Falanga","year":"2005","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.injury.2017.11.006_bib0055","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1097\/RLI.0b013e31819a60d3","article-title":"Systemic cardiovascular complications in patients with long-standing diabetes mellitus: comprehensive assessment with whole-body magnetic resonance imaging\/magnetic resonance angiography","volume":"44","author":"Weckbach","year":"2009","journal-title":"Invest Radiol"},{"issue":"2","key":"10.1016\/j.injury.2017.11.006_bib0060","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1677\/joe.0.1590297","article-title":"Serum levels of insulin-like growth factor system components and relationship to bone metabolism in Type 1 and Type 2 diabetes mellitus patients","volume":"159","author":"Jehle","year":"1998","journal-title":"J Endocrinol"},{"issue":"Suppl. 3","key":"10.1016\/j.injury.2017.11.006_bib0065","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s11739-012-0804-y","article-title":"From pathophysiology to personalized medicine","volume":"7","author":"Abbate","year":"2012","journal-title":"Intern Emerg Med"},{"issue":"7","key":"10.1016\/j.injury.2017.11.006_bib0070","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.2106\/JBJS.H.00116","article-title":"The impact of glycemic control and diabetes mellitus on perioperative outcomes after total joint arthroplasty","volume":"91","author":"Marchant","year":"2009","journal-title":"J Bone Joint Surg"},{"issue":"9","key":"10.1016\/j.injury.2017.11.006_bib0075","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1046\/j.1445-2197.2003.02748.x","article-title":"Methodological index for non-randomized studies (Minors): development and validation of a new instrument","volume":"73","author":"Slim","year":"2003","journal-title":"ANZ J Surg"},{"issue":"15","key":"10.1016\/j.injury.2017.11.006_bib0080","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","article-title":"for the Meta-analysis Of Observational Studies in Epidemiology (MOOSE) Group. Meta-analysis of Observational Studies in Epidemiology. A Proposal for Reporting","volume":"283","author":"Stroup","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.injury.2017.11.006_bib0085","unstructured":"Review Manager (RevMan) [Computer program]. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration; 2011."},{"issue":"5","key":"10.1016\/j.injury.2017.11.006_bib0090","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1302\/0301-620X.90B5.19854","article-title":"Intramedullary nailing of fractures of the tibia in diabetics","volume":"90","author":"Aderinto","year":"2008","journal-title":"J Bone Joint Surg Br"},{"issue":"11","key":"10.1016\/j.injury.2017.11.006_bib0095","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1177\/107110079902001103","article-title":"Acute complications in the operative treatment of isolated ankle fractures in patients with diabetes mellitus","volume":"20","author":"Blotter","year":"1999","journal-title":"Foot Ankle"},{"issue":"4","key":"10.1016\/j.injury.2017.11.006_bib0100","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1177\/107110070002100407","article-title":"Closed ankle fractures in the diabetic patient","volume":"21","author":"Flynn","year":"2000","journal-title":"Foot Ankle Int"},{"issue":"8","key":"10.1016\/j.injury.2017.11.006_bib0105","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.injury.2009.01.124","article-title":"Results after immediate operations of closed ankle fractures in patients with preoperatively neglected type 2 diabetes","volume":"40","author":"Guo","year":"2009","journal-title":"Injury"},{"issue":"4","key":"10.1016\/j.injury.2017.11.006_bib0110","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1302\/0301-620X.87B4.15724","article-title":"Ankle fractures in patients with diabetes mellitus","volume":"87","author":"Jones","year":"2005","journal-title":"J Bone Joint Surg Br"},{"issue":"11","key":"10.1016\/j.injury.2017.11.006_bib0115","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.3113\/FAI.2009.1042","article-title":"Early complications following the operative treatment of pilon fractures with and without diabetes","volume":"30","author":"Kline","year":"2009","journal-title":"Foot Ankle Int"},{"issue":"4","key":"10.1016\/j.injury.2017.11.006_bib0120","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1302\/0301-620X.80B4.8648","article-title":"Ankle fractures in diabetics","volume":"80","author":"Mccormack","year":"1998","journal-title":"J Bone Joint Surg"},{"issue":"11","key":"10.1016\/j.injury.2017.11.006_bib0125","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.injury.2011.03.021","article-title":"Diabetes mellitus and hip fracture: a study of 5966 cases","volume":"42","author":"Norris","year":"2011","journal-title":"Injury"},{"issue":"4","key":"10.1016\/j.injury.2017.11.006_bib0130","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1210\/jc.2007-1817","article-title":"Clinical review: the role of advanced glycation end products in progression and complications of diabetes","volume":"93","author":"Goh","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"10.1016\/j.injury.2017.11.006_bib0135","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.numecd.2010.07.008","article-title":"Mechanisms of impaired bone strength in type 1 and 2 diabetes","volume":"20","author":"Merlotti","year":"2010","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"August","key":"10.1016\/j.injury.2017.11.006_bib0140","first-page":"1","article-title":"Increased Risk of Fracture and Postfracture Adverse Events in Patients With Diabetes: two Nationwide Population-Based Retrospective Cohort Studies","volume":"37","author":"Liao","year":"2014","journal-title":"Diabetes Care"},{"issue":"5","key":"10.1016\/j.injury.2017.11.006_bib0145","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3928\/01477447-20110317-19","article-title":"Treatment of ankle fractures in patients with diabetes","volume":"34","author":"Dellenbaugh","year":"2011","journal-title":"Orthopedics"},{"issue":"5","key":"10.1016\/j.injury.2017.11.006_bib0150","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.jhsa.2014.02.008","article-title":"Factors influencing infection rates after open fractures of the radius and\/or ulna","volume":"39","author":"Zumsteg","year":"2014","journal-title":"J Hand Surg"},{"key":"10.1016\/j.injury.2017.11.006_bib0155","first-page":"1","article-title":"Clinical Study Medial Calcar Support and Radiographic Outcomes of Plate Fixation for Proximal Humeral Fractures","volume":"2015","author":"Lin","year":"2015","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.injury.2017.11.006_bib0160","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s00590-013-1252-8","article-title":"Surgical site infection after open reduction and internal fixation of tibial plateau fractures","volume":"24","author":"Lin","year":"2013","journal-title":"Eur J Orthop Surg Traumatol"},{"issue":"3","key":"10.1016\/j.injury.2017.11.006_bib0165","doi-asserted-by":"crossref","first-page":"348","DOI":"10.2106\/JBJS.K.01672","article-title":"Risk Factors for Deep Surgical Site Infection","volume":"95","author":"Ovaska","year":"2013","journal-title":"J Bone Joint Surg"},{"issue":"3","key":"10.1016\/j.injury.2017.11.006_bib0170","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.injury.2013.10.042","article-title":"Predictive factors of distal femoral fracture nonunion after lateral locked plating: a retrospective multicenter case-control study of 283 fractures","volume":"45","author":"Rodriguez","year":"2014","journal-title":"Injury"},{"issue":"3","key":"10.1016\/j.injury.2017.11.006_bib0175","doi-asserted-by":"crossref","first-page":"331","DOI":"10.5312\/wjo.v6.i3.331","article-title":"Diabetes and its negative impact on outcomes in orthopaedic surgery","volume":"6","author":"Wukich","year":"2015","journal-title":"World J Orthop"}],"container-title":["Injury"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020138317307830?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020138317307830?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,7]],"date-time":"2022-08-07T19:30:46Z","timestamp":1659900646000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020138317307830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["S0020138317307830"],"URL":"https:\/\/doi.org\/10.1016\/j.injury.2017.11.006","relation":{},"ISSN":["0020-1383"],"issn-type":[{"value":"0020-1383","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diabetes and Healing Outcomes in Lower Extremity Fractures: A Systematic Review","name":"articletitle","label":"Article Title"},{"value":"Injury","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.injury.2017.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}