{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:28:30Z","timestamp":1790256510156,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","injuryjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Injury"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.injury.2018.07.015","type":"journal-article","created":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T14:25:34Z","timestamp":1532442334000},"page":"1732-1738","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Evaluation of matrix metalloproteases as early biomarkers for bone regeneration during the applied Masquelet therapy for non-unions"],"prefix":"10.1016","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7045-0387","authenticated-orcid":false,"given":"P.","family":"Haubruck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8006-9742","authenticated-orcid":false,"given":"R.","family":"Heller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Apitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kammerer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Alamouti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Schmidmaier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Moghaddam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.injury.2018.07.015_bib0005","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1097\/00003086-199810001-00003","article-title":"The cell and molecular biology of fracture healing","author":"Einhorn","year":"1998","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.injury.2018.07.015_bib0010","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/01.blo.0000163836.66906.74","article-title":"Path analysis of factors for delayed healing and nonunion in 416 operatively treated tibial shaft fractures","volume":"438","author":"Audige","year":"2005","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.injury.2018.07.015_bib0015","first-page":"659","article-title":"Long bone nonunion","volume":"153","author":"Schmidmaier","year":"2015","journal-title":"Zeitschrift fur Orthopadie und Unfallchirurgie"},{"issue":"December (12)","key":"10.1016\/j.injury.2018.07.015_bib0020","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.injury.2011.05.011","article-title":"Cigarette smoking influences the clinical and occupational outcome of patients with tibial shaft fractures","volume":"42","author":"Moghaddam","year":"2011","journal-title":"Injury"},{"key":"10.1016\/j.injury.2018.07.015_bib0025","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/jor.22815","article-title":"The masquelet induced membrane technique with BMP and a synthetic scaffold can heal a rat femoral critical size defect","volume":"33","author":"Bosemark","year":"2015","journal-title":"J Orthop Res"},{"key":"10.1016\/j.injury.2018.07.015_bib0030","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.otsr.2011.11.001","article-title":"Treatment of posttraumatic bone defects by the induced membrane technique","volume":"98","author":"Karger","year":"2012","journal-title":"Orthop Traumatol Surg Res: OTSR"},{"key":"10.1016\/j.injury.2018.07.015_bib0035","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ocl.2009.07.011","article-title":"The concept of induced membrane for reconstruction of long bone defects","volume":"41","author":"Masquelet","year":"2010","journal-title":"Orthop Clin N Am"},{"key":"10.1016\/j.injury.2018.07.015_bib0040","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.injury.2010.09.024","article-title":"Matrix metalloproteases MMP-2 and MMP-9: are they early biomarkers of bone remodelling and healing after arthroscopic acromioplasty?","volume":"41","author":"Galliera","year":"2010","journal-title":"Injury"},{"key":"10.1016\/j.injury.2018.07.015_bib0045","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.biocel.2007.12.006","article-title":"The regulation of matrix metalloproteinases and their inhibitors","volume":"40","author":"Clark","year":"2008","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.injury.2018.07.015_bib0050","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1359\/jbmr.2002.17.1.77","article-title":"The bone lining cell: its role in cleaning Howship\u2019s lacunae and initiating bone formation","volume":"17","author":"Everts","year":"2002","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.injury.2018.07.015_bib0055","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/ar2304","article-title":"Proteinases in the joint: clinical relevance of proteinases in joint destruction","volume":"9","author":"Rengel","year":"2007","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.injury.2018.07.015_bib0060","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1096\/fj.06-7860com","article-title":"Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8)","volume":"21","author":"Gutierrez-Fernandez","year":"2007","journal-title":"FASEB J"},{"key":"10.1016\/j.injury.2018.07.015_bib0065","doi-asserted-by":"crossref","first-page":"7900","DOI":"10.3390\/ijms16047900","article-title":"Posttraumatic inflammation as a key to neuroregeneration after traumatic spinal cord injury","volume":"16","author":"Moghaddam","year":"2015","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.injury.2018.07.015_bib0070","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1007\/s00402-015-2253-3","article-title":"Reaming in treatment of non-unions in long bones: cytokine expression course as a tool for evaluation of non-union therapy","volume":"135","author":"Westhauser","year":"2015","journal-title":"Arch Orthop Trauma Surg"},{"key":"10.1016\/j.injury.2018.07.015_bib0075","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.bone.2005.02.011","article-title":"TGF-beta1 as a marker of delayed fracture healing","volume":"36","author":"Zimmermann","year":"2005","journal-title":"Bone"},{"key":"10.1016\/j.injury.2018.07.015_bib0080","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0736-0266(03)00165-7","article-title":"Induced membranes secrete growth factors including vascular and osteoinductive factors and could stimulate bone regeneration","volume":"22","author":"Pelissier","year":"2004","journal-title":"J Orthop Res"},{"key":"10.1016\/j.injury.2018.07.015_bib0085","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/s00113-011-2100-0","article-title":"Results of nonunion treatment with bone morphogenetic protein 7 (BMP-7)","volume":"115","author":"Moghaddam-Alvandi","year":"2012","journal-title":"Der Unfallchirurg"},{"key":"10.1016\/j.injury.2018.07.015_bib0090","first-page":"1297","article-title":"Validity of subjective smoking status in orthopedic patients","volume":"11","author":"Bender","year":"2015","journal-title":"Ther Clin Risk Manag"},{"key":"10.1016\/j.injury.2018.07.015_bib0095","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.injury.2010.11.017","article-title":"TRACP 5b and CTX as osteological markers of delayed fracture healing","volume":"42","author":"Moghaddam","year":"2011","journal-title":"Injury"},{"key":"10.1016\/j.injury.2018.07.015_bib0100","series-title":"R: a language and environment for statistical computing","author":"Development","year":"2015"},{"key":"10.1016\/j.injury.2018.07.015_bib0105","series-title":"ggplot2: elegant graphics for data analysis","author":"Wickham","year":"2009"},{"key":"10.1016\/j.injury.2018.07.015_bib0110","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/clr.12622","article-title":"Bone repair of critical size defects treated with autogenic, allogenic, or xenogenic bone grafts alone or in combination with rhBMP-2","volume":"27","author":"Issa","year":"2016","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.injury.2018.07.015_bib0115","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1242\/dmm.006304","article-title":"Impaired remodeling phase of fracture repair in the absence of matrix metalloproteinase-2","volume":"4","author":"Lieu","year":"2011","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.injury.2018.07.015_bib0120","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.injury.2005.07.019","article-title":"Current concepts of molecular aspects of bone healing","volume":"36","author":"Dimitriou","year":"2005","journal-title":"Injury"},{"key":"10.1016\/j.injury.2018.07.015_bib0125","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2147\/JIR.S110621","article-title":"The treatment of nonunions with application of BMP-7 increases the expression pattern for angiogenic and inflammable cytokines: a matched pair analysis","volume":"9","author":"Haubruck","year":"2016","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.injury.2018.07.015_bib0130","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nri1418","article-title":"Matrix metalloproteinases as modulators of inflammation and innate immunity","volume":"4","author":"Parks","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.injury.2018.07.015_bib0135","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1189\/jlb.0810446","article-title":"Systemic inflammation and fracture healing","volume":"89","author":"Bastian","year":"2011","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.injury.2018.07.015_bib0140","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1749-799X-7-20","article-title":"Is non-union of tibial shaft fractures due to nonculturable bacterial pathogens? A clinical investigation using PCR and culture techniques","volume":"7","author":"Gille","year":"2012","journal-title":"J Orthop Surg Res"},{"key":"10.1016\/j.injury.2018.07.015_bib0145","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.exger.2006.11.013","article-title":"Aging and estrogen: modulation of inflammatory responses after injury","volume":"42","author":"Gomez","year":"2007","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.injury.2018.07.015_bib0150","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1002\/ar.20717","article-title":"Quantitative analysis and localization of mRNA transcripts of type I collagen, osteocalcin, MMP 2, MMP 8, and MMP 13 during bone healing in a rat calvarial experimental defect model","volume":"291","author":"Itagaki","year":"2008","journal-title":"Anat Rec (Hoboken)"},{"key":"10.1016\/j.injury.2018.07.015_bib0155","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.bone.2005.06.015","article-title":"Matrix metalloproteinases and failed fracture healing","volume":"37","author":"Henle","year":"2005","journal-title":"Bone"},{"key":"10.1016\/j.injury.2018.07.015_bib0160","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1242\/dev.00559","article-title":"Altered fracture repair in the absence of MMP9","volume":"130","author":"Colnot","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.injury.2018.07.015_bib0165","first-page":"598","article-title":"Matrix metalloproteinase-9 regulates graft bone resorption","volume":"76","author":"Lu","year":"2006","journal-title":"Angle Orthod"},{"key":"10.1016\/j.injury.2018.07.015_bib0170","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jor.2016.10.003","article-title":"Treatment of atrophic femoral non-unions according to the diamond concept: results of one- and two-step surgical procedure","volume":"14","author":"Moghaddam","year":"2017","journal-title":"J Orthop"},{"issue":"Suppl. 4","key":"10.1016\/j.injury.2018.07.015_bib0175","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1016\/S0020-1383(15)30017-6","article-title":"Treatment of atrophic tibia non-unions according to\u2019 diamond concept\u2019: results of one- and two-step treatment","volume":"46","author":"Moghaddam","year":"2015","journal-title":"Injury"},{"key":"10.1016\/j.injury.2018.07.015_bib0180","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00132-016-3305-2","article-title":"Tibial defects and infected non-unions: treatment results after Masquelet technique","volume":"46","author":"Moghaddam","year":"2017","journal-title":"Orthopade"},{"key":"10.1016\/j.injury.2018.07.015_bib0185","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.injury.2010.03.014","article-title":"Cigarette smoking decreases TGF-b1 serum concentrations after long bone fracture","volume":"41","author":"Moghaddam","year":"2010","journal-title":"Injury"}],"container-title":["Injury"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020138318303723?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020138318303723?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T07:59:05Z","timestamp":1558166345000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020138318303723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S0020138318303723"],"URL":"https:\/\/doi.org\/10.1016\/j.injury.2018.07.015","relation":{},"ISSN":["0020-1383"],"issn-type":[{"value":"0020-1383","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of matrix metalloproteases as early biomarkers for bone regeneration during the applied Masquelet therapy for non-unions","name":"articletitle","label":"Article Title"},{"value":"Injury","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.injury.2018.07.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}