{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:20:03Z","timestamp":1790486403684,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T00:00:00Z","timestamp":1562630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001702","name":"AO Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001702","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","injuryjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Injury"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.injury.2019.07.016","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T17:15:12Z","timestamp":1568222112000},"page":"1868-1875","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["The impact of the AO Foundation on fracture care: An evaluation of 60 years AO Foundation"],"prefix":"10.1016","volume":"50","author":[{"given":"Alexander","family":"Joeris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"H\u00f6glinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flurina","family":"Meier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Kn\u00f6fler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Scholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs","family":"Br\u00fcgger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eberhard","family":"Denk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Gutzwiller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Prein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus","family":"Renner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Eichler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.injury.2019.07.016_bib0005","series-title":"Leading a Surgical Revolution the AO Foundation \u2013 Social Entrepreneurs in the Treatment of Bone Trauma","first-page":"15","article-title":"A brief overview of the AO organization (chapter 3)","author":"Jeannet","year":"2019"},{"key":"10.1016\/j.injury.2019.07.016_bib0010","series-title":"Leading a Surgical Revolution The AO Foundation Social Entrepreneurs in the Treatment of Bone Trauma","first-page":"21","article-title":"Treatment of bone fractures prior to 1960 (chapter 4)","author":"Jeannet","year":"2019"},{"key":"10.1016\/j.injury.2019.07.016_bib0015","series-title":"Leading a Surgical Revolution The AO Foundation \u2013 Social Entrepreneurs in the Treatment of Bone Trauma","first-page":"61","article-title":"AO Formulates Its Credo (Chapter 8)","author":"Jeannet","year":"2019"},{"key":"10.1016\/j.injury.2019.07.016_bib0020","unstructured":"Winterthurer Institut f\u00fcr Gesundheits\u00f6konomie (WIG), Z\u00fcrcher Hochschule f\u00fcr Angewandte Wissenschaften (ZHAW). https:\/\/wwwzhawch\/de\/sml\/institute-zentren\/wig\/."},{"key":"10.1016\/j.injury.2019.07.016_bib0025","unstructured":"Clarivate analytics. InCites."},{"key":"10.1016\/j.injury.2019.07.016_bib0030","unstructured":"Clarivate analytics. Web of Science."},{"key":"10.1016\/j.injury.2019.07.016_bib0035","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1056\/NEJMra1201534","article-title":"Measuring the global burden of disease","volume":"369","author":"Murray","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.injury.2019.07.016_bib0040","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00068-017-0826-2","article-title":"Complications after hip fracture surgery: are they preventable?","volume":"44","author":"Flikweert","year":"2018","journal-title":"Eur J Trauma Emergency Surg"},{"key":"10.1016\/j.injury.2019.07.016_bib0045","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1056\/NEJMoa074941","article-title":"Zoledronic acid and clinical fractures and mortality after hip fracture","volume":"357","author":"Lyles","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.injury.2019.07.016_bib0050","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1007\/s00402-014-2057-x","article-title":"Orthogeriatric care pathway: a prospective survey of impact on length of stay, mortality and institutionalisation","volume":"134","author":"Suhm","year":"2014","journal-title":"Arch Orthop Trauma Surg"},{"key":"10.1016\/j.injury.2019.07.016_bib0055","series-title":"Technik der operativen Frakturenbehandlung","author":"M\u00fcller","year":"1963"},{"key":"10.1016\/j.injury.2019.07.016_bib0060","series-title":"The comprehensive classification of fractures of long bones","author":"M\u00fcller","year":"1990"},{"key":"10.1016\/j.injury.2019.07.016_bib0065","series-title":"Manual der Osteosynthese. AO-Technik","author":"M\u00fcller","year":"1969"},{"key":"10.1016\/j.injury.2019.07.016_bib0070","series-title":"Manual of internal fixation. Technique recommended by the AO-group Swiss Association for the study of internal fixation: ASIF","author":"M\u00fcller","year":"1970"},{"key":"10.1016\/j.injury.2019.07.016_bib0075","series-title":"Manual of internal fixation. Techniques recommended by the AO Group","author":"M\u00fcller","year":"1979"},{"key":"10.1016\/j.injury.2019.07.016_bib0080","series-title":"Manual of internal fixation. Techniques recommended by the AO-ASIF Group","author":"M\u00fcller","year":"1991"},{"key":"10.1016\/j.injury.2019.07.016_bib0085","series-title":"AO principles of fracture management","author":"R\u00fcedi","year":"2000"},{"key":"10.1016\/j.injury.2019.07.016_bib0090","series-title":"AO principles of fracture management","author":"R\u00fcedi","year":"2007"},{"key":"10.1016\/j.injury.2019.07.016_bib0095","series-title":"AO principles of fracture management","author":"Buckley","year":"2018"},{"key":"10.1016\/j.injury.2019.07.016_bib0100","series-title":"Manual der Osteosynthese. AO-Technik","author":"M\u00fcller","year":"1977"},{"key":"10.1016\/j.injury.2019.07.016_bib0105","series-title":"Classification AO des fractures - les os longs","author":"M\u00fcller","year":"1987"},{"key":"10.1016\/j.injury.2019.07.016_bib0110","series-title":"Manual der Osteosynthese. AO Technik","author":"M\u00fcller","year":"1992"},{"key":"10.1016\/j.injury.2019.07.016_bib0115","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1172\/JCI118884","article-title":"The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration","volume":"98","author":"Antoniou","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.injury.2019.07.016_bib0120","doi-asserted-by":"crossref","first-page":"13106","DOI":"10.1073\/pnas.1107094108","article-title":"Tissue-engineered intervertebral discs produce new matrix, maintain disc height, and restore biomechanical function to the rodent spine","volume":"108","author":"Bowles","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.injury.2019.07.016_bib0125","doi-asserted-by":"crossref","first-page":"269","DOI":"10.22203\/eCM.v028a19","article-title":"Role and regulation of RUNX2 in osteogenesis","volume":"28","author":"Bruderer","year":"2014","journal-title":"Eur Cell Mater"},{"key":"10.1016\/j.injury.2019.07.016_bib0130","doi-asserted-by":"crossref","first-page":"320","DOI":"10.22203\/eCM.v028a22","article-title":"Enhancing inflammatory and chemotactic signals to regulate bone regeneration","volume":"28","author":"Czekanska","year":"2014","journal-title":"Eur Cell Mater"},{"key":"10.1016\/j.injury.2019.07.016_bib0135","doi-asserted-by":"crossref","first-page":"107","DOI":"10.22203\/eCM.v026a08","article-title":"Best paper NASS 2013: link-N can stimulate proteoglycan synthesis in the degenerated human intervertebral discs","volume":"26","author":"Gawri","year":"2013","journal-title":"Eur Cell Mater"},{"key":"10.1016\/j.injury.2019.07.016_bib0140","doi-asserted-by":"crossref","first-page":"e171","DOI":"10.2106\/JBJS.L.01654","article-title":"Anti-glucosaminidase IgG in sera as a biomarker of host immunity against Staphylococcus aureus in orthopaedic surgery patients","volume":"95","author":"Gedbjerg","year":"2013","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.injury.2019.07.016_bib0145","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1093\/brain\/aws268","article-title":"Autologous olfactory mucosal cell transplants in clinical spinal cord injury: a randomized double-blinded trial in a canine translational model","volume":"135","author":"Granger","year":"2012","journal-title":"Brain: J Neurol"},{"key":"10.1016\/j.injury.2019.07.016_bib0150","doi-asserted-by":"crossref","first-page":"4026","DOI":"10.1016\/j.biomaterials.2014.01.064","article-title":"3D printing of composite calcium phosphate and collagen scaffolds for bone regeneration","volume":"35","author":"Inzana","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.injury.2019.07.016_bib0155","series-title":"eCM: eCM Meeting Abstracts 2015, Collection 5","article-title":"3D printed bioceramics for dual antibiotic delivery to treat implant-associated bone infection","author":"Inzana","year":"2015"},{"key":"10.1016\/j.injury.2019.07.016_bib0160","doi-asserted-by":"crossref","first-page":"248","DOI":"10.22203\/eCM.v025a18","article-title":"Tissue engineering for articular cartilage repair--the state of the art","volume":"25","author":"Johnstone","year":"2013","journal-title":"Eur Cell Mater"},{"key":"10.1016\/j.injury.2019.07.016_bib0165","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1111\/j.1582-4934.2009.00780.x","article-title":"Mechanical load modulates chondrogenesis of human mesenchymal stem cells through the TGF-beta pathway","volume":"14","author":"Li","year":"2010","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.injury.2019.07.016_bib0170","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1089\/ten.tea.2014.0096","article-title":"In vitro osteogenic potential of human mesenchymal stem cells is predicted by Runx2\/Sox9 ratio","volume":"21","author":"Loebel","year":"2015","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.injury.2019.07.016_bib0175","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1021\/bm100046n","article-title":"Tailoring thermoreversible hyaluronan hydrogels by \"click\" chemistry and RAFT polymerization for cell and drug therapy","volume":"11","author":"Mortisen","year":"2010","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.injury.2019.07.016_bib0180","first-page":"301","article-title":"[Experimental studies on the development of reactive pseudarthroses on the canine radius]","volume":"35","author":"Muller","year":"1968","journal-title":"Helv Chir Acta"},{"key":"10.1016\/j.injury.2019.07.016_bib0185","doi-asserted-by":"crossref","first-page":"124","DOI":"10.22203\/eCM.v027a10","article-title":"CCL5\/RANTES is a key chemoattractant released by degenerative intervertebral discs in organ culture","volume":"27","author":"Pattappa","year":"2014","journal-title":"Eur Cell Mater"},{"key":"10.1016\/j.injury.2019.07.016_bib0190","first-page":"19","article-title":"The reaction of cortical bone to compression Reaktion der Kortikalis auf Kompression","author":"Perren","year":"1969","journal-title":"Acta Orthop Scand Suppl"},{"key":"10.1016\/j.injury.2019.07.016_bib0195","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.biomaterials.2014.11.049","article-title":"A combined biomaterial and cellular approach for annulus fibrosus rupture repair","volume":"42","author":"Pirvu","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.injury.2019.07.016_bib0200","doi-asserted-by":"crossref","first-page":"196","DOI":"10.22203\/eCM.v027a15","article-title":"A systematic review of animal models for Staphylococcus aureus osteomyelitis","volume":"27","author":"Reizner","year":"2014","journal-title":"Eur Cell Mater"},{"key":"10.1016\/j.injury.2019.07.016_bib0205","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/ncomms2226","article-title":"Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc","volume":"3","author":"Sakai","year":"2012","journal-title":"Nat Commun"},{"key":"10.1016\/j.injury.2019.07.016_bib0210","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1359\/jbmr.080407","article-title":"Functional adaptation to loading of a single bone is neuronally regulated and involves multiple bones","volume":"23","author":"Sample","year":"2008","journal-title":"J Bone Mineral Res"},{"key":"10.1016\/j.injury.2019.07.016_bib0215","first-page":"440","article-title":"(On the histology of primary bone healing.)","volume":"308","author":"Schenk","year":"1964","journal-title":"Langenbecks ArchKlinChir VerDtschZChir"},{"key":"10.1016\/j.injury.2019.07.016_bib0220","doi-asserted-by":"crossref","first-page":"403","DOI":"10.22203\/eCM.v020a33","article-title":"Platelet-released supernatant induces osteoblastic differentiation of human mesenchymal stem cells: potential role of BMP-2","volume":"20","author":"Verrier","year":"2010","journal-title":"Eur Cell Mater"},{"key":"10.1016\/j.injury.2019.07.016_bib0225","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.bone.2011.05.001","article-title":"Implant stability is affected by local bone microstructural quality","volume":"49","author":"Wirth","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.injury.2019.07.016_bib0230","first-page":"26","article-title":"Internal fixation of fractures: evolution of concepts","author":"Allgower","year":"1979","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.injury.2019.07.016_bib0235","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1200\/JCO.2015.61.9338","article-title":"Survival and clinical outcomes in surgically treated patients with metastatic epidural spinal cord compression: results of the prospective multicenter AO spine study","volume":"34","author":"Fehlings","year":"2016","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.injury.2019.07.016_bib0240","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1001\/archinternmed.2009.321","article-title":"Impact of a comanaged Geriatric Fracture Center on short-term hip fracture outcomes","volume":"169","author":"Friedman","year":"2009","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.injury.2019.07.016_bib0245","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s00198-007-0515-9","article-title":"Influence of osteoporosis on fracture fixation--a systematic literature review","volume":"19","author":"Goldhahn","year":"2008","journal-title":"Osteoporosis Int"},{"key":"10.1016\/j.injury.2019.07.016_bib0250","doi-asserted-by":"crossref","first-page":"S637","DOI":"10.1007\/s00198-010-1396-x","article-title":"Ortho-geriatric service--a literature review comparing different models","volume":"21","author":"Kammerlander","year":"2010","journal-title":"Osteoporosis Int"},{"issue":"Suppl 1 Pt 1","key":"10.1016\/j.injury.2019.07.016_bib0255","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2106\/JBJS.I.01462","article-title":"Open reduction and internal fixation of proximal humeral fractures with use of the locking proximal humerus plate. Surgical technique","volume":"92","author":"Konrad","year":"2010","journal-title":"J Bone Joint Surg Am"},{"issue":"Suppl 1","key":"10.1016\/j.injury.2019.07.016_bib0260","first-page":"1","article-title":"The concept of biological plating using the limited contact-dynamic compression plate (LC-DCP). Scientific background, design and application","volume":"22","author":"Perren","year":"1991","journal-title":"Injury"},{"key":"10.1016\/j.injury.2019.07.016_bib0265","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1302\/0301-620X.84B8.0841093","article-title":"Evolution of the internal fixation of long bone fractures. The scientific basis of biological internal fixation: choosing a new balance between stability and biology","volume":"84","author":"Perren","year":"2002","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.injury.2019.07.016_bib0270","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0020-1383(73)80089-0","article-title":"Fractures of the lower end of the tibia into the ankle joint: results 9 years after open reduction and internal fixation","volume":"5","author":"Ruedi","year":"1973","journal-title":"Injury"},{"key":"10.1016\/j.injury.2019.07.016_bib0275","first-page":"556","article-title":"[Intra-articular fractures of the distal tibial end]","volume":"35","author":"Ruedi","year":"1968","journal-title":"Helv Chir Acta"},{"key":"10.1016\/j.injury.2019.07.016_bib0280","first-page":"105","article-title":"The operative treatment of intra-articular fractures of the lower end of the tibia","author":"R\u00fcedi","year":"1979","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.injury.2019.07.016_bib0285","first-page":"74","article-title":"Results after internal fixation of comminuted fractures of the femoral shaft with DC plates","author":"Ruedi","year":"1979","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.injury.2019.07.016_bib0290","series-title":"Leading a Surgical Revolution The AO Foundation \u2013 Social Entrepreneurs in the Treatment of Bone Trauma","first-page":"335","article-title":"AO Institutes: Res earch, CDID, \u2018Trauma University,\u2019 and a Publishing House (Chapter 45)","author":"Jeannet","year":"2019"},{"key":"10.1016\/j.injury.2019.07.016_bib0295","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1377\/hlthaff.26.1.97","article-title":"The value of antihypertensive drugs: a perspective on medical innovation","volume":"26","author":"Cutler","year":"2007","journal-title":"Health Aff (Project Hope)"},{"key":"10.1016\/j.injury.2019.07.016_bib0300","unstructured":"Schneider R. 10 Jahre AO: AO - Dokumentationszentrale Bern, 1969."},{"key":"10.1016\/j.injury.2019.07.016_bib0305","series-title":"25 Jahre AO-Schweiz - Arbeitsgemeinschaft f\u00fcr Osteosynthesefrage 1958-1983: Arbeitsgemeinschaft fuer Osteosynthesefragen","author":"Schneider","year":"1983"},{"key":"10.1016\/j.injury.2019.07.016_bib0310","series-title":"Surgery, science and industry \u2013 A revolution in fracture care, 1950s-1990s","author":"Schlich","year":"2002"}],"container-title":["Injury"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020138319304152?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020138319304152?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T06:25:55Z","timestamp":1758090355000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020138319304152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":62,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["S0020138319304152"],"URL":"https:\/\/doi.org\/10.1016\/j.injury.2019.07.016","relation":{},"ISSN":["0020-1383"],"issn-type":[{"value":"0020-1383","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of the AO Foundation on fracture care: An evaluation of 60 years AO Foundation","name":"articletitle","label":"Article Title"},{"value":"Injury","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.injury.2019.07.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}