{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:31:00Z","timestamp":1781843460187,"version":"3.54.5"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","injuryjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Injury"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.injury.2022.01.033","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T10:55:44Z","timestamp":1642676144000},"page":"1517-1522","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Ampicillin\/sulbactam versus cefazolin plus aminoglycosides for antimicrobial prophylaxis in management of Gustilo type IIIA open fractures: A retrospective cohort study"],"prefix":"10.1016","volume":"53","author":[{"given":"Shunsuke","family":"Takahara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Tokura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuo","family":"Uefuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhito","family":"Ichimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Nishihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Takayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuko","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.injury.2022.01.033_bib0001","doi-asserted-by":"crossref","first-page":"e1025","DOI":"10.3928\/01477447-20151020-12","article-title":"Acute management of open fractures: an evidence-based review","volume":"38","author":"Halawi","year":"2015","journal-title":"Orthopedics"},{"key":"10.1016\/j.injury.2022.01.033_bib0002","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2106\/00004623-197658040-00004","article-title":"Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses","volume":"58","author":"Gustilo","year":"1976","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.injury.2022.01.033_bib0003","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1097\/TA.0000000000000398","article-title":"Evidence-based protocol for prophylactic antibiotics in open fractures: improved antibiotic stewardship with no increase in infection rates","volume":"77","author":"Rodriguez","year":"2014","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.injury.2022.01.033_bib0004","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1097\/BOT.0b013e31828d92ee","article-title":"Prophylactic antibiotics in open fractures: a pilot randomized clinical safety study","volume":"27","author":"Saveli","year":"2013","journal-title":"J Orthop Trauma"},{"key":"10.1016\/j.injury.2022.01.033_bib0005","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1302\/0301-620X.100B11.BJJ-2018-0308.R1","article-title":"Economic outcomes associated with deep surgical site infection in patients with an open fracture of the lower limb","volume":"100-b","author":"Parker","year":"2018","journal-title":"Bone Joint J"},{"key":"10.1016\/j.injury.2022.01.033_bib0006","first-page":"751","article-title":"East practice management guidelines work group: update to practice management guidelines for prophylactic antibiotic use in open fractures","volume":"70","author":"Hoff","year":"2011","journal-title":"J Trauma"},{"key":"10.1016\/j.injury.2022.01.033_bib0007","first-page":"S210","article-title":"Guidelines for the prevention of infections associated with combat-related injuries: 2011 update: endorsed by the infectious diseases society of America and the surgical infection society","volume":"71","author":"Hospenthal","year":"2011","journal-title":"J Trauma"},{"key":"10.1016\/j.injury.2022.01.033_bib0008","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1089\/sur.2006.7.379","article-title":"Surgical Infection Society guideline: prophylactic antibiotic use in open fractures: an evidence-based guideline","volume":"7","author":"Hauser","year":"2006","journal-title":"Surg Infect (Larchmt)"},{"key":"10.1016\/j.injury.2022.01.033_bib0009","doi-asserted-by":"crossref","first-page":"511","DOI":"10.2174\/1874325001206010511","article-title":"Current concepts of prophylactic antibiotics in trauma: a review","volume":"6","author":"Lane","year":"2012","journal-title":"Open Orthop J"},{"key":"10.1016\/j.injury.2022.01.033_bib0010","doi-asserted-by":"crossref","first-page":"178","DOI":"10.2174\/1874325001408010178","article-title":"Controversies in the management of open fractures","volume":"8","author":"C","year":"2014","journal-title":"Open Orthop J"},{"key":"10.1016\/j.injury.2022.01.033_bib0011","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003764.pub2","article-title":"Antibiotics for preventing infection in open limb fractures","author":"Gosselin","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.injury.2022.01.033_bib0012","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.2106\/JBJS.RVW.17.00197","article-title":"Antibiotic prophylaxis in the management of open fractures: a systematic survey of current practice and recommendations","volume":"7","author":"Chang","year":"2019","journal-title":"JBJS Rev"},{"key":"10.1016\/j.injury.2022.01.033_bib0013","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2106\/00004623-199072020-00023","article-title":"The management of open fractures","volume":"72","author":"Gustilo","year":"1990","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.injury.2022.01.033_bib0014","doi-asserted-by":"crossref","first-page":"532","DOI":"10.2106\/00004623-197456030-00010","article-title":"The role of antibiotics in the management of open fractures","volume":"56","author":"Patzakis","year":"1974","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.injury.2022.01.033_bib0015","doi-asserted-by":"crossref","first-page":"609","DOI":"10.2106\/JBJS.20.01229","article-title":"Low adherence to recommended guidelines for open fracture antibiotic prophylaxis","volume":"103","author":"Lin","year":"2021","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.injury.2022.01.033_bib0016","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1128\/AAC.01430-08","article-title":"Prevalence and risk factors for aminoglycoside nephrotoxicity in intensive care units","volume":"53","author":"Oliveira","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.injury.2022.01.033_bib0017","first-page":"239","article-title":"Comparison the efficacy of cefazolin plus gentamicin with cefazolin plus ciprofloxacin in management of Type -IIIA open fractures","volume":"13","author":"Janmohammadi","year":"2011","journal-title":"Iran Red Crescent Med J"},{"key":"10.1016\/j.injury.2022.01.033_bib0018","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/BOT.0000000000000554","article-title":"Surgical site infections in patients with Type 3 open fractures: comparing antibiotic prophylaxis with cefazolin plus gentamicin versus piperacillin\/tazobactam","volume":"30","author":"Redfern","year":"2016","journal-title":"J Orthop Trauma"},{"key":"10.1016\/j.injury.2022.01.033_bib0019","doi-asserted-by":"crossref","first-page":"e284","DOI":"10.1097\/MJT.0000000000001121","article-title":"Cefazolin monotherapy versus cefazolin plus aminoglycosides for antimicrobial prophylaxis of Type III open fractures","volume":"28","author":"Patanwala","year":"2019","journal-title":"Am J Ther"},{"key":"10.1016\/j.injury.2022.01.033_bib0020","doi-asserted-by":"crossref","first-page":"127","DOI":"10.4103\/IJCIIS.IJCIIS_7_19","article-title":"Cefazolin and an aminoglycoside compared with cefazolin alone for the antimicrobial prophylaxis of type III open orthopedic fractures","volume":"9","author":"Depcinski","year":"2019","journal-title":"Int J Crit Illn Inj Sci"},{"key":"10.1016\/j.injury.2022.01.033_bib0021","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/00005131-199308000-00012","article-title":"Interobserver reliability in the Gustilo and Anderson classification of open fractures","volume":"7","author":"Horn","year":"1993","journal-title":"J Orthop Trauma"},{"key":"10.1016\/j.injury.2022.01.033_bib0022","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.injury.2017.08.040","article-title":"Fracture-related infection: a consensus on definition from an international expert group","volume":"49","author":"Metsemakers","year":"2018","journal-title":"Injury"},{"key":"10.1016\/j.injury.2022.01.033_bib0023","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1302\/2058-5241.5.190072","article-title":"Definition and diagnosis of fracture-related infection","volume":"5","author":"McNally","year":"2020","journal-title":"EFORT Open Rev"},{"key":"10.1016\/j.injury.2022.01.033_bib0024","doi-asserted-by":"crossref","first-page":"3250","DOI":"10.1093\/jac\/dkw296","article-title":"Aminoglycoside-associated acute kidney injury in elderly patients with and without shock","volume":"71","author":"Ong","year":"2016","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.injury.2022.01.033_bib0025","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1007\/s11999-013-3394-8","article-title":"Higher Charlson comorbidity index scores are associated with readmission after orthopaedic surgery","volume":"472","author":"Voskuijl","year":"2014","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.injury.2022.01.033_bib0026","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.injury.2019.04.013","article-title":"Clinical practice in prevention of fracture-related infection: an international survey among 1197 orthopaedic trauma surgeons","volume":"50","author":"Puetzler","year":"2019","journal-title":"Injury"},{"key":"10.1016\/j.injury.2022.01.033_bib0027","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00068-017-0847-x","article-title":"Antibiotics and open fractures of the lower extremity: less is more","volume":"45","author":"Bankhead-Kendall","year":"2019","journal-title":"Eur J Trauma Emerg Surg"},{"key":"10.1016\/j.injury.2022.01.033_bib0028","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1097\/00005373-198408000-00009","article-title":"Problems in the management of type III (severe) open fractures: a new classification of type III open fractures","volume":"24","author":"Gustilo","year":"1984","journal-title":"J Trauma"},{"key":"10.1016\/j.injury.2022.01.033_bib0029","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.rbo.2016.09.004","article-title":"Infection rate in adult patients with open fractures treated at the emergency hospital and at the ULBRA university hospital in Canoas, Rio Grande do Sul, Brazil","volume":"52","author":"Guerra","year":"2017","journal-title":"Rev Bras Ortop"},{"key":"10.1016\/j.injury.2022.01.033_bib0030","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s10195-020-00549-5","article-title":"Retrospective analysis of risk factors for deep infection in lower limb Gustilo-Anderson type III fractures","volume":"21","author":"Ukai","year":"2020","journal-title":"J Orthop Traumatol"},{"key":"10.1016\/j.injury.2022.01.033_bib0031","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/BOT.0000000000000751","article-title":"Primary wound closure after open fracture: a prospective cohort study examining nonunion and deep infection","volume":"31","author":"Scharfenberger","year":"2017","journal-title":"J Orthop Trauma"},{"key":"10.1016\/j.injury.2022.01.033_bib0032","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/BOT.0000000000001282","article-title":"Risk factors for kidney dysfunction with the use of gentamicin in open fracture antibiotic treatment","volume":"32","author":"Folse","year":"2018","journal-title":"J Orthop Trauma"},{"key":"10.1016\/j.injury.2022.01.033_bib0033","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2174\/138161207779313731","article-title":"Aminoglycoside-induced ototoxicity","volume":"13","author":"Selimoglu","year":"2007","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.injury.2022.01.033_bib0034","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1056\/NEJMc053428","article-title":"Aspirin to prevent gentamicin-induced hearing loss","volume":"354","author":"Sha","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.injury.2022.01.033_bib0035","doi-asserted-by":"crossref","first-page":"701","DOI":"10.5694\/mja11.10850","article-title":"Gentamicin ototoxicity: a 23-year selected case series of 103 patients","volume":"196","author":"Ahmed","year":"2012","journal-title":"Med J Aust"}],"container-title":["Injury"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020138322000572?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020138322000572?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T06:43:14Z","timestamp":1758091394000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020138322000572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S0020138322000572"],"URL":"https:\/\/doi.org\/10.1016\/j.injury.2022.01.033","relation":{},"ISSN":["0020-1383"],"issn-type":[{"value":"0020-1383","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ampicillin\/sulbactam versus cefazolin plus aminoglycosides for antimicrobial prophylaxis in management of Gustilo type IIIA open fractures: A retrospective cohort study","name":"articletitle","label":"Article Title"},{"value":"Injury","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.injury.2022.01.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}