{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:56:22Z","timestamp":1786114582600,"version":"build-2736575974"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007184","name":"Yale University School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007184","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Interventional Pain Medicine"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.inpm.2026.100799","type":"journal-article","created":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T09:21:57Z","timestamp":1780824117000},"page":"100799","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early pain-response trajectories after basivertebral nerve ablation and their relationship to 12-month clinical outcomes"],"prefix":"10.1016","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8280-4015","authenticated-orcid":false,"given":"Charles A.","family":"Odonkor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7682-5297","authenticated-orcid":false,"given":"Muhammad Uzair","family":"Siddique","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6468-8009","authenticated-orcid":false,"given":"Mustafa Reha","family":"Dodurgali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8285-8785","authenticated-orcid":false,"given":"Sarvesh","family":"Palaniappan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8872-295X","authenticated-orcid":false,"given":"Cameron","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selaiman","family":"Noori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Diep","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhir K.","family":"Kadian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mannat","family":"Kadian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6691-2764","authenticated-orcid":false,"given":"David W.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Durkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6319-5908","authenticated-orcid":false,"given":"Peter G.","family":"Whang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.inpm.2026.100799_bib1","article-title":"Patient selection, clinical outcomes, associated healthcare utilization, and cost-effectiveness of basivertebral nerve ablation for the treatment of vertebrogenic low back pain: a narrative review","volume":"24","author":"Ehsanian","year":"2025","journal-title":"N Am Spine Soc J"},{"key":"10.1016\/j.inpm.2026.100799_bib2","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.2147\/JPR.S378544","article-title":"Best practice guidelines on the diagnosis and treatment of vertebrogenic pain with basivertebral nerve ablation from the American society of pain and neuroscience","volume":"15","author":"Sayed","year":"2022","journal-title":"J Pain Res"},{"key":"10.1016\/j.inpm.2026.100799_bib3","article-title":"Modic changes and their role in vertebrogenic back pain: a literature review","author":"Wen","year":"2025","journal-title":"Skelet Radiol"},{"key":"10.1016\/j.inpm.2026.100799_bib4","doi-asserted-by":"crossref","DOI":"10.1097\/CORR.0000000000003565","article-title":"Modic changes are associated with increased pain intensity, greater disability, and reduced quality of life in low back pain","author":"Yang","year":"2025","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.inpm.2026.100799_bib5","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1016\/j.spinee.2019.05.598","article-title":"A prospective, randomized, multicenter study of intraosseous basivertebral nerve ablation for the treatment of chronic low back pain","volume":"19","author":"Khalil","year":"2019","journal-title":"Spine J"},{"key":"10.1016\/j.inpm.2026.100799_bib6","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1136\/rapm-2020-102259","article-title":"Prospective, randomized, multicenter study of intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: 12-month results","volume":"46","author":"Smuck","year":"2021","journal-title":"Reg Anesth Pain Med"},{"key":"10.1016\/j.inpm.2026.100799_bib7","article-title":"Prospective, randomized, multicenter study of intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: 24-month treatment arm results","volume":"8","author":"Koreckij","year":"2021","journal-title":"N Am Spine Soc J"},{"key":"10.1016\/j.inpm.2026.100799_bib8","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1007\/s00586-020-06448-x","article-title":"Long-term outcomes following intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: 5-year treatment arm results from a prospective randomized double-blind sham-controlled multi-center study","volume":"29","author":"Fischgrund","year":"2020","journal-title":"Eur Spine J"},{"issue":"Suppl 2","key":"10.1016\/j.inpm.2026.100799_bib9","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1093\/pm\/pnac070","article-title":"The effectiveness of intraosseous basivertebral nerve radiofrequency ablation for the treatment of vertebrogenic low back pain: an updated systematic review with single-arm meta-analysis","volume":"23","author":"Conger","year":"2022","journal-title":"Pain Med"},{"key":"10.1016\/j.inpm.2026.100799_bib10","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1093\/pm\/pnaf122","article-title":"The effectiveness of basivertebral nerve radiofrequency ablation for the treatment of vertebrogenic low back pain: 1-year results of a prospective real-world cohort study","volume":"27","author":"McCormick","year":"2026","journal-title":"Pain Med"},{"key":"10.1016\/j.inpm.2026.100799_bib11","article-title":"Timing and trajectory of pain and functional outcomes after basivertebral nerve ablation: a prospective cohort study","volume":"4","author":"Odonkor","year":"2025","journal-title":"Interv Pain Med"},{"issue":"Suppl 2","key":"10.1016\/j.inpm.2026.100799_bib12","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1093\/pm\/pnac050","article-title":"The relationship between patient demographic and clinical characteristics and successful treatment outcomes after basivertebral nerve radiofrequency ablation: a pooled cohort study of three prospective clinical trials","volume":"23","author":"Boody","year":"2022","journal-title":"Pain Med"},{"issue":"Suppl 2","key":"10.1016\/j.inpm.2026.100799_bib13","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1093\/pm\/pnac069","article-title":"Pain location and exacerbating activities associated with treatment success following basivertebral nerve ablation: an aggregated cohort study of multicenter prospective clinical trial data","volume":"23","author":"McCormick","year":"2022","journal-title":"Pain Med"},{"issue":"2","key":"10.1016\/j.inpm.2026.100799_bib14","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.spinee.2016.08.032","article-title":"Ablation of the basivertebral nerve for treatment of back pain: a clinical study","volume":"17","author":"Becker","year":"2017","journal-title":"Spine J"},{"key":"10.1016\/j.inpm.2026.100799_bib15","article-title":"Basi-vertebral nerve ablation (BVNA): part 1","author":"Khan","year":"2026","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.inpm.2026.100799_bib16","article-title":"Basi-vertebral nerve ablation (BVNA): part 2","author":"Khan","year":"2026","journal-title":"AJNR Am J Neuroradiol"},{"issue":"5","key":"10.1016\/j.inpm.2026.100799_bib17","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s00234-020-02577-8","article-title":"Intra-osseous basivertebral nerve radiofrequency ablation (BVA) for the treatment of vertebrogenic chronic low back pain","volume":"63","author":"De Vivo","year":"2021","journal-title":"Neuroradiology"},{"issue":"2","key":"10.1016\/j.inpm.2026.100799_bib18","first-page":"E269","article-title":"Rapid and delayed effects of pulsed radiofrequency on neuropathic pain: electrophysiological, molecular, and behavioral evidence supporting long-term depression","volume":"20","author":"Huang","year":"2017","journal-title":"Pain Physician"},{"issue":"2","key":"10.1016\/j.inpm.2026.100799_bib19","first-page":"279","article-title":"Pulsed radiofrequency to the dorsal root ganglion or the sciatic nerve reduces neuropathic pain behavior, decreases peripheral pro-inflammatory cytokines and spinal \u03b2-catenin in chronic constriction injury rats","volume":"44","author":"Jiang","year":"2019","journal-title":"Reg Anesth Pain Med"},{"issue":"6","key":"10.1016\/j.inpm.2026.100799_bib20","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1093\/bja\/aex089","article-title":"Characterization of peripheral and central sensitization after dorsal root ganglion intervention in patients with unilateral lumbosacral radicular pain: a prospective pilot study","volume":"118","author":"Mehta","year":"2017","journal-title":"Br J Anaesth"},{"issue":"7","key":"10.1016\/j.inpm.2026.100799_bib21","first-page":"525","article-title":"Pulsed radiofrequency in interventional pain management: cellular and molecular mechanisms of action - an update and review","volume":"24","author":"Sam","year":"2021","journal-title":"Pain Physician"},{"key":"10.1016\/j.inpm.2026.100799_bib22","article-title":"Characterization of the effects of pulsed radio frequency treatment of the dorsal root ganglion on cerebrospinal fluid cellular and peptide constituents in patients with chronic radicular pain: a randomised, triple-blinded, controlled trial","volume":"347","author":"Moore","year":"2020","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.inpm.2026.100799_bib23","first-page":"1","article-title":"Pulsed radiofrequency and epigenetic modulation of pain pathways: a systematic review based on preclinical evidence","volume":"18","author":"Occhigrossi","year":"2025","journal-title":"J Pain Res"},{"issue":"10","key":"10.1016\/j.inpm.2026.100799_bib24","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1007\/s00256-022-04051-3","article-title":"Predictive value of immediate pain relief after lumbar transforaminal epidural injection with local anesthetics and steroids for single level radiculopathy","volume":"51","author":"Germann","year":"2022","journal-title":"Skelet Radiol"},{"issue":"8","key":"10.1016\/j.inpm.2026.100799_bib25","doi-asserted-by":"crossref","first-page":"E851","DOI":"10.36076\/ppj.2024.7.E851","article-title":"Predicting responses to interventional pain management techniques for chronic low back pain: a single-center observational study (PReTi-Back Study)","volume":"27","author":"Garcia-Hernandez","year":"2024","journal-title":"Pain Physician"},{"issue":"1\u20132","key":"10.1016\/j.inpm.2026.100799_bib26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.pain.2004.09.012","article-title":"Core outcome measures for chronic pain clinical trials: IMMPACT recommendations","volume":"113","author":"Dworkin","year":"2005","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.inpm.2026.100799_bib28","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1136\/rapm-2021-103247","article-title":"Multicenter study evaluating factors associated with treatment outcome for low back pain injections","volume":"47","author":"Cohen","year":"2022","journal-title":"Reg Anesth Pain Med"},{"key":"10.1016\/j.inpm.2026.100799_bib29","article-title":"Mixed-duration basivertebral nerve ablation for vertebrogenic low back pain: lesion strategies and clinical outcomes in a multicenter retrospective cohort study","volume":"21","author":"Odonkor","year":"2026","journal-title":"Pain Med"},{"issue":"5","key":"10.1016\/j.inpm.2026.100799_bib30","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1007\/s00586-018-5496-1","article-title":"Intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: a prospective randomized double-blind sham-controlled multicenter study","volume":"27","author":"Fischgrund","year":"2018","journal-title":"Eur Spine J"},{"key":"10.1016\/j.inpm.2026.100799_bib31","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.2147\/JPR.S317697","article-title":"Placebo effect of sham spine procedures in chronic low back pain: a systematic review","volume":"14","author":"Jamjoom","year":"2021","journal-title":"J Pain Res"},{"issue":"12","key":"10.1016\/j.inpm.2026.100799_bib32","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-009655","article-title":"To what extent are surgery and invasive procedures effective beyond a placebo response? A systematic review with meta-analysis of randomized, sham-controlled trials","volume":"5","author":"Jonas","year":"2015","journal-title":"BMJ Open"},{"issue":"1","key":"10.1016\/j.inpm.2026.100799_bib27","doi-asserted-by":"crossref","first-page":"E19","DOI":"10.36076\/ppj.2020\/23\/E19","article-title":"Fantastic four: age, spinal cord stimulator waveform, pain localization and history of spine surgery influence the odds of successful spinal cord stimulator trial","volume":"23","author":"Odonkor","year":"2020","journal-title":"Pain Physician"}],"container-title":["Interventional Pain Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772594426000646?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772594426000646?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T21:13:46Z","timestamp":1785964426000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772594426000646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2772594426000646"],"URL":"https:\/\/doi.org\/10.1016\/j.inpm.2026.100799","relation":{},"ISSN":["2772-5944"],"issn-type":[{"value":"2772-5944","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early pain-response trajectories after basivertebral nerve ablation and their relationship to 12-month clinical outcomes","name":"articletitle","label":"Article Title"},{"value":"Interventional Pain Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.inpm.2026.100799","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of International Pain & Spine Intervention Society.","name":"copyright","label":"Copyright"}],"article-number":"100799"}}