{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T07:00:58Z","timestamp":1790492458587,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007312","name":"National Center for Geriatrics and Gerontology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","intpsychogeriatrics.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Psychogeriatrics"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.inpsyc.2026.100199","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T20:43:43Z","timestamp":1771361023000},"page":"100199","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Frontostriatal volumes and anterior thalamic mediation of late-life depressive symptoms across the cognitive spectrum from normal aging to Alzheimer\u2019s disease: A structural equation modelling study"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5981-5795","authenticated-orcid":false,"given":"Fumihiko","family":"Yasuno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7927-9483","authenticated-orcid":false,"given":"Yasuyuki","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5544-7649","authenticated-orcid":false,"given":"Takashi","family":"Nihashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Minami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikaru","family":"Minami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinori","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4293-4333","authenticated-orcid":false,"given":"Takashi","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.inpsyc.2026.100199_bib1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3389\/fnsys.2016.00104","article-title":"Cortico-striatal-thalamic loop circuits of the salience network: a central pathway in psychiatric disease and treatment","volume":"10","author":"Peters","year":"2016","journal-title":"Front Syst Neurosci"},{"key":"10.1016\/j.inpsyc.2026.100199_bib2","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1111\/cns.12835","article-title":"Brain structure alterations in depression: psychoradiological evidence","volume":"24","author":"Zhang","year":"2018","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.inpsyc.2026.100199_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2021.102830","article-title":"Cognitive impairment and depression: meta-analysis of structural magnetic resonance imaging studies","volume":"32","author":"Zackov\u00e1","year":"2021","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.inpsyc.2026.100199_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2022.103295","article-title":"The thalamus is the causal hub of intervention in patients with major depressive disorder: evidence from the Granger causality analysis","volume":"37","author":"Yang","year":"2023","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.inpsyc.2026.100199_bib5","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1177\/0004867415585857","article-title":"The thalamus as a putative biomarker in neurodegenerative disorders","volume":"49","author":"Power","year":"2015","journal-title":"Aust N Z J Psychiatry"},{"key":"10.1016\/j.inpsyc.2026.100199_bib6","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.conb.2007.07.003","article-title":"The thalamus is more than just a relay","volume":"17","author":"Sherman","year":"2007","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.inpsyc.2026.100199_bib7","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.neubiorev.2021.06.042","article-title":"Disentangling the influences of multiple thalamic nuclei on prefrontal cortex and cognitive control","volume":"128","author":"Phillips","year":"2021","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.inpsyc.2026.100199_bib8","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/s41593-021-00996-1","article-title":"Thalamic subnetworks as units of function","volume":"25","author":"Roy","year":"2022","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.inpsyc.2026.100199_bib9","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.neuroimage.2018.08.012","article-title":"A probabilistic atlas of the human thalamic nuclei combining ex vivo MRI and histology","volume":"183","author":"Iglesias","year":"2018","journal-title":"Neuroimage"},{"key":"10.1016\/j.inpsyc.2026.100199_bib10","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.inpsyc.2026.100199_bib11","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1176\/ajp.141.11.1356","article-title":"A new rating scale for Alzheimer's disease","volume":"141","author":"Rosen","year":"1984","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.inpsyc.2026.100199_bib12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0022-3956(82)90033-4","article-title":"Development and validation of a geriatric depression screening scale: a preliminary report","volume":"17","author":"Yesavage","year":"1982","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.inpsyc.2026.100199_bib13","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/1097-4679(199403)50:2<256::AID-JCLP2270500218>3.0.CO;2-E","article-title":"Validation of the Geriatric Depression Scale--Short Form among inpatients","volume":"50","author":"Lesher","year":"1994","journal-title":"J Clin Psychol"},{"key":"10.1016\/j.inpsyc.2026.100199_bib14","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/cercor\/bhg087","article-title":"Automatically parcellating the human cerebral cortex","volume":"14","author":"Fischl","year":"2004","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.inpsyc.2026.100199_bib15","first-page":"179","article-title":"Cortical surface-based analysis","volume":"9","author":"Dale","year":"1999","journal-title":"I Segm Surf Reconstr Neuroimage"},{"key":"10.1016\/j.inpsyc.2026.100199_bib16","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.neuroimage.2012.01.021","article-title":"FreeSurfer","volume":"62","author":"Fischl","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.inpsyc.2026.100199_bib17","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest","volume":"31","author":"Desikan","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.inpsyc.2026.100199_bib18","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1093\/schbul\/sbae037","article-title":"Distinct volume alterations of thalamic nuclei across the schizophrenia spectrum","volume":"50","author":"Thalhammer","year":"2024","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.inpsyc.2026.100199_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-40507-9","article-title":"Structural equation modelling of work related musculoskeletal disorders among dumper operators","volume":"13","author":"Kar","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.inpsyc.2026.100199_bib20","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1017\/S1041610224000541","article-title":"Depressive symptoms and cognitive decline in older adults","volume":"36","author":"Forbes","year":"2024","journal-title":"Int Psychogeriatr"},{"key":"10.1016\/j.inpsyc.2026.100199_bib21","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1017\/S1041610220003622","article-title":"Depressive symptoms with cognitive dysfunction increase the risk of cognitive impairment: analysis of the Korean Longitudinal Study of Aging (KLoSA), 2006-2018","volume":"33","author":"Shin","year":"2021","journal-title":"Int Psychogeriatr"},{"key":"10.1016\/j.inpsyc.2026.100199_bib22","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1017\/S1041610222000515","article-title":"Cognitive phenotypes in late-life depression","volume":"35","author":"Szymkowicz","year":"2023","journal-title":"Int Psychogeriatr"},{"key":"10.1016\/j.inpsyc.2026.100199_bib23","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/ana.410300410","article-title":"Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment","volume":"30","author":"Terry","year":"1991","journal-title":"Ann Neurol"},{"key":"10.1016\/j.inpsyc.2026.100199_bib24","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1002\/jnr.22392","article-title":"Synapse loss in dementias","volume":"88","author":"Clare","year":"2010","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.inpsyc.2026.100199_bib25","doi-asserted-by":"crossref","first-page":"785","DOI":"10.3233\/JAD-230199","article-title":"Microglia-astrocyte communication in Alzheimer's disease","volume":"95","author":"Wu","year":"2023","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.inpsyc.2026.100199_bib26","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40478-018-0515-3","article-title":"White matter changes in Alzheimer's disease: a focus on myelin and oligodendrocytes","volume":"6","author":"Nasrabady","year":"2018","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.inpsyc.2026.100199_bib27","doi-asserted-by":"crossref","first-page":"7","DOI":"10.31887\/DCNS.2016.18.1\/shaber","article-title":"Corticostriatal circuitry","volume":"18","author":"Haber","year":"2016","journal-title":"Dialog Clin Neurosci"},{"key":"10.1016\/j.inpsyc.2026.100199_bib28","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/mp.2016.60","article-title":"Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group","volume":"22","author":"Schmaal","year":"2017","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.inpsyc.2026.100199_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.euroneuro.2011.05.003","article-title":"Magnetic resonance imaging studies in unipolar depression: systematic review and meta-regression analyses","volume":"22","author":"Arnone","year":"2012","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.inpsyc.2026.100199_bib30","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1002\/hbm.20233","article-title":"Testing effective connectivity changes with structural equation modeling: what does a bad model tell us?","volume":"27","author":"Protzner","year":"2006","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.inpsyc.2026.100199_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neubiorev.2021.02.047","article-title":"The anterior thalamic nuclei and cognition: a role beyond space?","volume":"126","author":"Nelson","year":"2021","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.inpsyc.2026.100199_bib32","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1093\/brain\/aww083","article-title":"Thalamic pathology and memory loss in early Alzheimer's disease: moving the focus from the medial temporal lobe to Papez circuit","volume":"139","author":"Aggleton","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.inpsyc.2026.100199_bib33","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1080\/13803395.2014.913554","article-title":"Immediate effects of deep brain stimulation of anterior thalamic nuclei on executive functions and emotion-attention interaction in humans","volume":"36","author":"Hartikainen","year":"2014","journal-title":"J Clin Exp Neuropsychol"},{"key":"10.1016\/j.inpsyc.2026.100199_bib34","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.neuron.2019.06.005","article-title":"Thalamocortical circuit motifs: a general framework","volume":"103","author":"Halassa","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.inpsyc.2026.100199_bib35","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1152\/jn.00038.2025","article-title":"Neuroscience of human ventral lateral thalamic nucleus related to movement and movement disorders","volume":"134","author":"Lenz","year":"2025","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.inpsyc.2026.100199_bib36","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.neuron.2015.11.034","article-title":"Pulvinar-cortex interactions in vision and attention","volume":"89","author":"Zhou","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.inpsyc.2026.100199_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneumeth.2020.108951","article-title":"The sensitivity of diffusion MRI to microstructural properties and experimental factors","volume":"347","author":"Afzali","year":"2021","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.inpsyc.2026.100199_bib38","first-page":"197","article-title":"Imaging connectivity: MRI and the structural networks of the brain","volume":"28","author":"Clayden","year":"2013","journal-title":"Funct Neurol"},{"key":"10.1016\/j.inpsyc.2026.100199_bib39","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/2045-5380-1-11","article-title":"Frontostriatal functional connectivity in major depressive disorder","volume":"1","author":"Furman","year":"2011","journal-title":"Biol Mood Anxiety Disord"},{"key":"10.1016\/j.inpsyc.2026.100199_bib40","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/s41398-019-0514-6","article-title":"Mechanisms and treatment of late-life depression","volume":"9","author":"Alexopoulos","year":"2019","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.inpsyc.2026.100199_bib41","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s41380-021-01265-0","article-title":"Influences of dopaminergic system dysfunction on late-life depression","volume":"27","author":"Taylor","year":"2022","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.inpsyc.2026.100199_bib42","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1001\/jamapsychiatry.2015.0071","article-title":"Large-scale network dysfunction in major depressive disorder: a meta-analysis of resting-state functional connectivity","volume":"72","author":"Kaiser","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.inpsyc.2026.100199_bib43","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41386-021-01132-0","article-title":"The role of prefrontal cortex in cognitive control and executive function","volume":"47","author":"Friedman","year":"2022","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.inpsyc.2026.100199_bib44","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1192\/bjp.bp.117.205021","article-title":"Behavioural activation for depression in older people: systematic review and meta-analysis","volume":"211","author":"Orgeta","year":"2017","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.inpsyc.2026.100199_bib45","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1001\/jamaneurol.2021.3356","article-title":"Effect of methylphenidate on apathy in patients with Alzheimer disease: the ADMET 2 randomized clinical trial","volume":"78","author":"Mintzer","year":"2021","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.inpsyc.2026.100199_bib46","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.psc.2011.02.005","article-title":"3rd. Late-life depression: evidence-based treatment and promising new directions for research and clinical practice","volume":"34","author":"Andreescu","year":"2011","journal-title":"Psychiatr Clin North Am"},{"key":"10.1016\/j.inpsyc.2026.100199_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12144748","article-title":"Effectiveness of repetitive transcranial magnetic stimulation in the treatment of depression in the elderly: a retrospective natural analysis","volume":"12","author":"Almheiri","year":"2023","journal-title":"J Clin Med"}],"container-title":["International Psychogeriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1041610226000177?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1041610226000177?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T18:03:44Z","timestamp":1776189824000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1041610226000177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":47,"alternative-id":["S1041610226000177"],"URL":"https:\/\/doi.org\/10.1016\/j.inpsyc.2026.100199","relation":{},"ISSN":["1041-6102"],"issn-type":[{"value":"1041-6102","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Frontostriatal volumes and anterior thalamic mediation of late-life depressive symptoms across the cognitive spectrum from normal aging to Alzheimer\u2019s disease: A structural equation modelling study","name":"articletitle","label":"Article Title"},{"value":"International Psychogeriatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.inpsyc.2026.100199","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of International Psychogeriatric Association.","name":"copyright","label":"Copyright"}],"article-number":"100199"}}