{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:21:05Z","timestamp":1790374865635,"version":"4.1.0"},"reference-count":111,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","intpsychogeriatrics.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Psychogeriatrics"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.inpsyc.2026.100226","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T11:36:41Z","timestamp":1780918601000},"page":"100226","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["From depression symptom management to dementia prevention: Considering next decade research, treatment, and advocacy priorities to reduce the impact of depression in neurocognitive disorders"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5171-5028","authenticated-orcid":false,"given":"Jordan","family":"Karp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meryl","family":"Butters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0083-9389","authenticated-orcid":false,"given":"Lucia","family":"Crivelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Hermida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Paula","family":"Gastiazoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Gatchel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1711-3306","authenticated-orcid":false,"given":"Marie Anne","family":"Gebara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9484-3206","authenticated-orcid":false,"given":"Melanie","family":"Gentry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Mimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1501-4774","authenticated-orcid":false,"given":"Richard Oude","family":"Voshaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Van Den Bossche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3862-3441","authenticated-orcid":false,"given":"Kristina","family":"Zdanys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1163-5584","authenticated-orcid":false,"given":"Maria","family":"Lapid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10452","key":"10.1016\/j.inpsyc.2026.100226_bib1","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0140-6736(24)01296-0","article-title":"Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission","volume":"404","author":"Livingston","year":"2024","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.inpsyc.2026.100226_bib2","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.jagp.2018.05.002","article-title":"Depression and risk of alzheimer dementia: a longitudinal analysis to determine predictors of increased risk among older adults with depression","volume":"26","author":"Gallagher","year":"2018","journal-title":"Am J Geriatr Psychiatry"},{"issue":"3","key":"10.1016\/j.inpsyc.2026.100226_bib3","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/s41380-024-02792-2","article-title":"Comorbid health outcomes in patients with schizophrenia: an umbrella review of systematic reviews and meta-analyses","volume":"30","author":"Lee","year":"2025","journal-title":"Mol Psychiatry"},{"issue":"4","key":"10.1016\/j.inpsyc.2026.100226_bib4","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s11065-018-9396-2","article-title":"Prevalence of depression, anxiety and PTSD in people with dementia: a systematic review and meta-analysis","volume":"28","author":"Kuring","year":"2018","journal-title":"Neuropsychol Rev"},{"issue":"7","key":"10.1016\/j.inpsyc.2026.100226_bib5","doi-asserted-by":"crossref","first-page":"4841","DOI":"10.1002\/alz.14049","article-title":"The risk of Alzheimer\u2019s disease and cognitive impairment characteristics in eight mental disorders: a UK biobank observational study and mendelian randomization analysis","volume":"20","author":"Liu","year":"2024","journal-title":"Alzheimers Dement J Alzheimers Assoc"},{"key":"10.1016\/j.inpsyc.2026.100226_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2020.00009","article-title":"Depression, anxiety, and apathy in mild cognitive impairment: current perspectives","volume":"12","author":"Ma","year":"2020","journal-title":"Front Aging Neurosci"},{"issue":"3","key":"10.1016\/j.inpsyc.2026.100226_bib7","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1017\/S0033291721002099","article-title":"Association between risk of dementia and very late-onset schizophrenia-like psychosis: a Swedish population-based cohort study","volume":"53","author":"Stafford","year":"2023","journal-title":"Psychol Med"},{"issue":"1","key":"10.1016\/j.inpsyc.2026.100226_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41398-021-01269-y","article-title":"Late-life depression and increased risk of dementia: a longitudinal cohort study","volume":"11","author":"Ly","year":"2021","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.inpsyc.2026.100226_bib9","unstructured":"American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM-5-TR). Arlington (VA): American Psychiatric Association; Accesed 2025 Aug. \u3008https:\/\/psychiatryonline.org\/doi\/book\/10.1176\/appi.books.9780890425787\u3009."},{"key":"10.1016\/j.inpsyc.2026.100226_bib10","unstructured":"World Health Organization. International Classification of Diseases 11th Revision (ICD-11). Geneva: World Health Organization; Accesed 2025 Aug. \u3008https:\/\/icd.who.int\/en\/\u3009."},{"issue":"_1","key":"10.1016\/j.inpsyc.2026.100226_bib11","article-title":"Characteristics associated with depression in long-term care residents with dementia","volume":"45","author":"Gruber-Baldini","year":"2005","journal-title":"Gerontologist"},{"issue":"5","key":"10.1016\/j.inpsyc.2026.100226_bib12","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jalz.2011.05.2410","article-title":"Neuropsychiatric symptoms in Alzheimer\u2019s disease","volume":"7","author":"Lyketsos","year":"2011","journal-title":"Alzheimers Dement"},{"issue":"2","key":"10.1016\/j.inpsyc.2026.100226_bib13","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.eurpsy.2008.09.001","article-title":"Proposed diagnostic criteria for apathy in Alzheimer\u2019s disease and other neuropsychiatric disorders","volume":"24","author":"Robert","year":"2009","journal-title":"Eur Psychiatry"},{"issue":"6","key":"10.1016\/j.inpsyc.2026.100226_bib14","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/JGP.0b013e318165dbae","article-title":"Diagnosing depression in alzheimer disease with the national institute of mental health provisional criteria","volume":"16","author":"Teng","year":"2008","journal-title":"Am J Geriatr Psychiatry J Am Assoc Geriatr Psychiatry"},{"issue":"2","key":"10.1016\/j.inpsyc.2026.100226_bib15","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1017\/S1041610217001880","article-title":"Affective and emotional dysregulation as pre-dementia risk markers: exploring the mild behavioral impairment symptoms of depression, anxiety, irritability, and euphoria","volume":"30","author":"Ismail","year":"2018","journal-title":"Int Psychogeriatr"},{"issue":"3","key":"10.1016\/j.inpsyc.2026.100226_bib16","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3390\/geriatrics9030064","article-title":"Treating depression in dementia patients: a risk or remedy\u2014a narrative review","volume":"9","author":"Sultan","year":"2024","journal-title":"Geriatrics"},{"issue":"8","key":"10.1016\/j.inpsyc.2026.100226_bib17","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/s44220-025-00460-0","article-title":"Proteogenomic signature of Alzheimer\u2019s disease and related dementia risk in individuals with major depressive disorder","volume":"3","author":"Diniz","year":"2025","journal-title":"Nat Ment Health"},{"issue":"4","key":"10.1016\/j.inpsyc.2026.100226_bib18","doi-asserted-by":"crossref","first-page":"904","DOI":"10.3390\/psychiatryint5040061","article-title":"Current Diagnostic Challenges in late-life depression and neurocognitive disorders","volume":"5","author":"Adriani","year":"2024","journal-title":"Psychiatry Int"},{"key":"10.1016\/j.inpsyc.2026.100226_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2020.110010","article-title":"Neural substrates for late-life depression: a selective review of structural neuroimaging studies","volume":"104","author":"Kim","year":"2021","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.inpsyc.2026.100226_bib20","unstructured":"Lichter D.G. Frontal-subcorticalcircuits. In: Anderson CA, Filley CM, Arciniegas DB, editors. Behavioral Neurology & Neuropsychiatry [Internet]. Cambridge: Cambridge University Press; 2013 [cited 2025 Aug 12]. p. 59\u201387. Available from: https:\/\/www.cambridge.org\/core\/books\/behavioral-neurology-neuropsychiatry\/frontalsubcorticalcircuits\/3F6273AC057151D48A9BCBC05FFE5585 doi:\u300810.1017\/CBO9781139016919.007\u3009."},{"key":"10.1016\/j.inpsyc.2026.100226_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.00253","article-title":"Evidence for structural and functional alterations of frontal-executive and corticolimbic circuits in late-life depression and relationship to mild cognitive impairment and dementia: a systematic review","volume":"14","author":"Rashidi-Ranjbar","year":"2020","journal-title":"Front Neurosci"},{"key":"10.1016\/j.inpsyc.2026.100226_bib22","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.2147\/NDT.S170989","article-title":"Neuronal connectivity in major depressive disorder: a systematic review","volume":"14","author":"Helm","year":"2018","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.1016\/j.inpsyc.2026.100226_bib23","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41398-024-02734-0","article-title":"Major depressive disorder associated alterations in the effective connectivity of the face processing network: a systematic review","volume":"14","author":"Jamieson","year":"2024","journal-title":"Transl Psychiatry"},{"issue":"11","key":"10.1016\/j.inpsyc.2026.100226_bib24","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1002\/hbm.25001","article-title":"The role of the subgenual anterior cingulate cortex in dorsomedial prefrontal-amygdala neural circuitry during positive-social emotion regulation","volume":"41","author":"Scharnowski","year":"2020","journal-title":"Hum Brain Mapp"},{"issue":"6","key":"10.1016\/j.inpsyc.2026.100226_bib25","doi-asserted-by":"crossref","DOI":"10.1002\/alz.70195","article-title":"Diverse tau pathologies in late-life mood disorders revealed by PET and autopsy assays","volume":"21","author":"Kurose","year":"2025","journal-title":"Alzheimers Dement"},{"issue":"1","key":"10.1016\/j.inpsyc.2026.100226_bib26","doi-asserted-by":"crossref","first-page":"578","DOI":"10.3390\/ijms24010578","article-title":"Selected biomarkers of depression: what are the effects of cytokines and inflammation?","volume":"24","author":"Harsanyi","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.inpsyc.2026.100226_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2025.1584607","article-title":"Neurobiological and therapeutic landmarks of depression associated with Alzheimer\u2019s disease dementia","volume":"17","author":"Untu","year":"2025","journal-title":"Front Aging Neurosci"},{"issue":"3","key":"10.1016\/j.inpsyc.2026.100226_bib28","doi-asserted-by":"crossref","first-page":"523","DOI":"10.14283\/jpad.2022.42","article-title":"Aging, senescence, and dementia","volume":"9","author":"Behfar","year":"2022","journal-title":"J Prev Alzheimers Dis"},{"issue":"1","key":"10.1016\/j.inpsyc.2026.100226_bib29","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41392-024-01738-y","article-title":"Major depressive disorder: hypothesis, mechanism, prevention and treatment","volume":"9","author":"Cui","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.inpsyc.2026.100226_bib30","article-title":"PET imaging of the serotonin 1A receptor in major depressive disorder: hierarchical multivariate analysis of [11C]WAY100635 overcomes outcome measure discrepancies","author":"Matheson","year":"2024","journal-title":"bioRxiv"},{"issue":"1","key":"10.1016\/j.inpsyc.2026.100226_bib31","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s11357-024-01359-x","article-title":"Monoamine alterations in Alzheimer\u2019s disease and their implications in comorbid neuropsychiatric symptoms","volume":"47","author":"Saggu","year":"2025","journal-title":"GeroScience"},{"issue":"3","key":"10.1016\/j.inpsyc.2026.100226_bib32","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.3233\/JAD-180564","article-title":"Depression and Alzheimer\u2019s disease biomarkers predict driving decline","volume":"66","author":"Babulal","year":"2018","journal-title":"J Alzheimers Dis JAD"},{"issue":"1","key":"10.1016\/j.inpsyc.2026.100226_bib33","doi-asserted-by":"crossref","DOI":"10.18103\/mra.v11i1.3466","article-title":"Depression and plasma biomarkers of Alzheimer\u2019s disease in a diverse community cohort: the impact of ethnicity and level of depression","volume":"11","author":"Hall","year":"2023","journal-title":"Med Res Arch"},{"issue":"2","key":"10.1016\/j.inpsyc.2026.100226_bib34","doi-asserted-by":"crossref","first-page":"E11","DOI":"10.1097\/NNR.0000000000000709","article-title":"Salivary cortisol and melatonin, sleep, and behavioral patterns in older adults living with dementia","volume":"73","author":"Cho","year":"2024","journal-title":"Nurs Res"},{"issue":"8","key":"10.1016\/j.inpsyc.2026.100226_bib35","first-page":"1847","article-title":"Complementing the genome with an \"exposome\": the outstanding challenge of environmental exposure measurement in molecular epidemiology","volume":"14","author":"Wild","year":"2005","journal-title":"Cancer epidemiology biomarkers & prevention a publication American Association Cancer Research cosponsored American Society Preventive Oncology"},{"issue":"4","key":"10.1016\/j.inpsyc.2026.100226_bib36","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0749-3797(98)00017-8","article-title":"Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults","volume":"14","author":"Felitti","year":"1998","journal-title":"Advers Child Exp (ACE) Study Am J Prev Med"},{"issue":"10","key":"10.1016\/j.inpsyc.2026.100226_bib37","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S1474-4422(14)70172-3","article-title":"Connections between sleep and cognition in older adults","volume":"13","author":"Yaffe","year":"2014","journal-title":"Lancet Neurol"},{"issue":"9","key":"10.1016\/j.inpsyc.2026.100226_bib38","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1038\/nn.3786","article-title":"Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci","volume":"17","author":"De Jager","year":"2014","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.inpsyc.2026.100226_bib39","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev-publhealth-031811-124544","article-title":"Early intervention to reduce the global health and economic burden of major depression in older adults","volume":"33","author":"Reynolds","year":"2012","journal-title":"Annu Rev Public Health"},{"key":"10.1016\/j.inpsyc.2026.100226_bib40","doi-asserted-by":"crossref","first-page":"j2353","DOI":"10.1136\/bmj.j2353","article-title":"Moderate alcohol consumption as risk factor for adverse brain outcomes and cognitive decline: longitudinal cohort study","volume":"357","author":"Topiwala","year":"2017","journal-title":"BMJ (Clin Res Ed )"},{"issue":"2","key":"10.1016\/j.inpsyc.2026.100226_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055821","article-title":"Structural and functional imaging studies in chronic cannabis users: a systematic review of adolescent and adult findings","volume":"8","author":"Batalla","year":"2013","journal-title":"PloS One"},{"issue":"6","key":"10.1016\/j.inpsyc.2026.100226_bib42","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1001\/jamapsychiatry.2018.0335","article-title":"Association of cannabis with cognitive functioning in adolescents and young adults: a systematic review and meta-analysis","volume":"75","author":"Scott","year":"2018","journal-title":"JAMA Psychiatry"},{"issue":"2","key":"10.1016\/j.inpsyc.2026.100226_bib43","first-page":"78","article-title":"Successful cognitive and emotional aging","volume":"9","author":"Jeste","year":"2010","journal-title":"World Psychiatry J World Psychiatr Assoc (WPA)"},{"issue":"3","key":"10.1016\/j.inpsyc.2026.100226_bib44","doi-asserted-by":"crossref","first-page":"345","DOI":"10.31887\/DCNS.2008.10.3\/mabutters","article-title":"Pathways linking late-life depression to persistent cognitive impairment and dementia","volume":"10","author":"Butters","year":"2008","journal-title":"Dialog- Clin Neurosci"},{"issue":"3","key":"10.1016\/j.inpsyc.2026.100226_bib45","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/mp.2016.55","article-title":"Intrinsic functional connectivity in late-life depression: trajectories over the course of pharmacotherapy in remitters and non-remitters","volume":"22","author":"Karim","year":"2017","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.inpsyc.2026.100226_bib46","first-page":"602","article-title":"Neuroplasticity and treatment response in late-life depression","volume":"27","author":"Gunning","year":"2019","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1016\/j.inpsyc.2026.100226_bib47","first-page":"371","article-title":"Neuroticism is associated with structural brain changes in late-life depression","volume":"204","author":"Andreescu","year":"2014","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.inpsyc.2026.100226_bib48","first-page":"329","article-title":"Late-life depression and risk of vascular dementia and Alzheimer\u2019s disease: systematic review and meta-analysis of community-based cohort studies","volume":"21","author":"Diniz","year":"2013","journal-title":"Am J Geriatr Psychiatry"},{"issue":"3","key":"10.1016\/j.inpsyc.2026.100226_bib49","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/gerona\/58.3.M249","article-title":"Depression in late life: review and commentary","volume":"58","author":"Blazer","year":"2003","journal-title":"J Gerontol Ser A Biol Sci Med Sci"},{"key":"10.1016\/j.inpsyc.2026.100226_bib50","unstructured":"Gordon R.S., Jr (1983). An operational classification of disease prevention. Public health reports (Washington, D.C.: 1974), 98(2), 107\u2013109."},{"key":"10.1016\/j.inpsyc.2026.100226_bib51","series-title":"Preventing mental, emotional, and behavioral disorders among young people: progress and possibilities","author":"Institute of Medicine (US)","year":"2009"},{"issue":"5","key":"10.1016\/j.inpsyc.2026.100226_bib52","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1161\/CIR.0000000000001078","article-title":"Life's essential 8: updating and enhancing the american heart association's construct of cardiovascular health: a presidential advisory from the american heart association","volume":"146","author":"Lloyd-Jones","year":"2022","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.inpsyc.2026.100226_bib53","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/01.JGP.0000300629.35408.94","article-title":"Tailored activities to manage neuropsychiatric behaviors in persons with dementia and reduce caregiver burden: a randomized pilot study","volume":"16","author":"Gitlin","year":"2008","journal-title":"Am J Geriatr Psychiatry J Am Assoc Geriatr Psychiatry"},{"issue":"1","key":"10.1016\/j.inpsyc.2026.100226_bib54","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1016\/S1389-9457(08)70014-5","article-title":"Cognitive consequences of sleep and sleep loss","volume":"9","author":"Walker","year":"2008","journal-title":"Sleep Med"},{"issue":"1-3","key":"10.1016\/j.inpsyc.2026.100226_bib55","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jad.2011.01.011","article-title":"Insomnia as a predictor of depression: a meta-analytic evaluation of longitudinal epidemiological studies","volume":"135","author":"Baglioni","year":"2011","journal-title":"J Affect Disord"},{"issue":"2","key":"10.1016\/j.inpsyc.2026.100226_bib56","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nrneurol.2013.269","article-title":"Sleep and Alzheimer disease pathology--a bidirectional relationship","volume":"10","author":"Ju","year":"2014","journal-title":"Nat Rev Neurol"},{"issue":"6","key":"10.1016\/j.inpsyc.2026.100226_bib57","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1001\/jama.2011.1115","article-title":"Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women","volume":"306","author":"Yaffe","year":"2011","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.inpsyc.2026.100226_bib58","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1001\/jamapsychiatry.2024.3241","article-title":"Slowing cognitive decline in major depressive disorder and mild cognitive impairment: a randomized clinical trial","volume":"82","author":"Rajji","year":"2025","journal-title":"JAMA Psychiatry"},{"issue":"147","key":"10.1016\/j.inpsyc.2026.100226_bib59","doi-asserted-by":"crossref","first-page":"147ra111","DOI":"10.1126\/scitranslmed.3003748","article-title":"A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid \u03b2","volume":"4","author":"Iliff","year":"2012","journal-title":"Sci Transl Med"},{"issue":"6156","key":"10.1016\/j.inpsyc.2026.100226_bib60","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.1241224","article-title":"Sleep drives metabolite clearance from the adult brain","volume":"342","author":"Xie","year":"2013","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.inpsyc.2026.100226_bib61","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1001\/archpsyc.60.7.737","article-title":"Treating depression in Alzheimer disease: efficacy and safety of sertraline therapy, and the benefits of depression reduction: the DIADS","volume":"60","author":"Lyketsos","year":"2003","journal-title":"Arch General Psychiatry"},{"issue":"1","key":"10.1016\/j.inpsyc.2026.100226_bib62","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1001\/jamapsychiatry.2014.1305","article-title":"Problem adaptation therapy for older adults with major depression and cognitive impairment: a randomized clinical trial","volume":"72","author":"Kiosses","year":"2015","journal-title":"JAMA Psychiatry"},{"issue":"1","key":"10.1016\/j.inpsyc.2026.100226_bib63","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1001\/archgenpsychiatry.2010.177","article-title":"Problem-solving therapy and supportive therapy in older adults with major depression and executive dysfunction: effect on disability","volume":"68","author":"Alexopoulos","year":"2011","journal-title":"Arch General Psychiatry"},{"key":"10.1016\/j.inpsyc.2026.100226_bib64","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0140-6736(11)60830-1","article-title":"Sertraline or mirtazapine for depression in dementia (HTA\u2011SADD): a randomised, multicentre, double\u2011blind, placebo\u2011controlled trial","volume":"378","author":"Banerjee","year":"2011","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.inpsyc.2026.100226_bib65","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/JGP.0b013e3181c796eb","article-title":"Sertraline for the treatment of depression in Alzheimer disease","volume":"18","author":"Rosenberg","year":"2010","journal-title":"Am J Geriatr Psychiatry J Am Assoc Geriatr Psychiatry"},{"key":"10.1016\/j.inpsyc.2026.100226_bib66","first-page":"1","article-title":"Management of depression in dementia: renewed evidence and evolving clinical implications","volume":"35","author":"Banerjee","year":"2023","journal-title":"Int Psychogeriatr"},{"key":"10.1016\/j.inpsyc.2026.100226_bib67","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2024.1354025","article-title":"Mitigating cellular aging and enhancing cognitive functionality: visual arts-mediated cognitive activation therapy in neurocognitive disorders","volume":"16","author":"Campisi","year":"2024","journal-title":"Front Aging Neurosci"},{"issue":"3","key":"10.1016\/j.inpsyc.2026.100226_bib68","first-page":"34","article-title":"\u0399nnovative health promotion strategies: A 6-month longitudinal study on computerized cognitive training for older adults with minor neurocognitive disorders","volume":"15","author":"Tsiakiri","year":"2025","journal-title":"Eur J Investig Health Psychol Educ"},{"issue":"5","key":"10.1016\/j.inpsyc.2026.100226_bib69","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3390\/life14050597","article-title":"The role of physical activity in adjunctive nursing management of neuro-degenerative diseases among older adults: a systematic review of interventional studies","volume":"14","author":"Alanazi","year":"2024","journal-title":"Life"},{"issue":"7\u20138","key":"10.1016\/j.inpsyc.2026.100226_bib70","first-page":"e1360","article-title":"Nonpharmacological approaches for behavioural and psychological symptoms of dementia in older adults: a systematic review of reviews","volume":"27","author":"Legere","year":"2018","journal-title":"J Clin Nurs"},{"issue":"7","key":"10.1016\/j.inpsyc.2026.100226_bib71","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1002\/gps.5095","article-title":"Problem-solving therapy reduces subjective burden levels in caregivers of family members with mild cognitive impairment or early-stage dementia: secondary analysis of a randomized clinical trial","volume":"34","author":"Garand","year":"2019","journal-title":"Int J Geriatr Psychiatry"},{"issue":"10","key":"10.1016\/j.inpsyc.2026.100226_bib72","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2024-084130","article-title":"Efficacy of problem-solving therapy in treating late-life depression with potential cognitive impairment: a systematic review and meta-analysis","volume":"14","author":"Huang","year":"2024","journal-title":"BMJ Open"},{"issue":"3","key":"10.1016\/j.inpsyc.2026.100226_bib73","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1080\/07317110902895226","article-title":"Applications of preference assessment procedures in depression and agitation management in elders with dementia","volume":"32","author":"Feliciano","year":"2009","journal-title":"Clin Gerontol"},{"issue":"12","key":"10.1016\/j.inpsyc.2026.100226_bib74","doi-asserted-by":"crossref","first-page":"543","DOI":"10.4140\/TCP.n.2020.543","article-title":"Depression and its treatment in late life","volume":"35","author":"Hutchinson","year":"2020","journal-title":"Sr Care Pharm"},{"issue":"1","key":"10.1016\/j.inpsyc.2026.100226_bib75","article-title":"Technology-enabled recreation and leisure programs and activities for older adults with cognitive impairment: rapid scoping review","volume":"3","author":"Kokorelias","year":"2024","journal-title":"JMIR Neurotechnology"},{"key":"10.1016\/j.inpsyc.2026.100226_bib76","article-title":"Virtual reality-based reminiscence therapy for older adults to improve psychological well-being and cognition: a systematic review","author":"Ng","year":"2024","journal-title":"J Clin Nurs"},{"issue":"1","key":"10.1016\/j.inpsyc.2026.100226_bib77","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s12877-018-0897-x","article-title":"Interventions to address social connectedness and loneliness for older adults: a scoping review","volume":"18","author":"O\u2019Rourke","year":"2018","journal-title":"BMC Geriatr"},{"issue":"5","key":"10.1016\/j.inpsyc.2026.100226_bib78","doi-asserted-by":"crossref","DOI":"10.1093\/ageing\/afaf136","article-title":"Effects of reminiscence therapy for loneliness in older adults: a systematic review and meta-analysis","volume":"54","author":"Yang","year":"2025","journal-title":"Age Ageing"},{"issue":"11","key":"10.1016\/j.inpsyc.2026.100226_bib79","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1017\/S1041610218002168","article-title":"A systematic review and meta-analysis on the effect of reminiscence therapy for people with dementia","volume":"31","author":"Park","year":"2019","journal-title":"Int Psychogeriatr"},{"issue":"3","key":"10.1016\/j.inpsyc.2026.100226_bib80","article-title":"Reminiscence therapy for dementia","volume":"3","author":"Woods","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"10.1016\/j.inpsyc.2026.100226_bib81","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1001\/jamapsychiatry.2014.1305","article-title":"Problem adaptation therapy for older adults with major depression and cognitive impairment: a randomized clinical trial","volume":"72","author":"Kiosses","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.inpsyc.2026.100226_bib82","series-title":"Study of the use of antidepressants for depression in dementia: the HTA-SADD trial \u2013 a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine [Internet","article-title":"Study of the use of antidepressants for depression in dementia: the HTA-SADD trial \u2013 a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine","author":"Banerjee","year":"2013"},{"issue":"8","key":"10.1016\/j.inpsyc.2026.100226_bib83","article-title":"Antidepressants for treating depression in dementia","volume":"8","author":"Dudas","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.inpsyc.2026.100226_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2024.116114","article-title":"Antidepressants for treating depression among older adults with dementia: a systematic review and meta-analysis","volume":"340","author":"Lenouvel","year":"2024","journal-title":"Psychiatry Res"},{"issue":"1","key":"10.1016\/j.inpsyc.2026.100226_bib85","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s12883-023-03191-w","article-title":"A systematic review and meta-analysis on the efficacy outcomes of selective serotonin reuptake inhibitors in depression in Alzheimer\u2019s disease","volume":"23","author":"Zhang","year":"2023","journal-title":"BMC Neurol"},{"key":"10.1016\/j.inpsyc.2026.100226_bib86","series-title":"Antidepressants: From Biogenic Amines to New Mechanisms of Action [Internet]","first-page":"37","article-title":"Tricyclic Antidepressants and Monoamine Oxidase Inhibitors: Are They Too Old for a New Look?","author":"Chockalingam","year":"2019"},{"issue":"2","key":"10.1016\/j.inpsyc.2026.100226_bib87","first-page":"29","article-title":"Treatments for depression in older persons with dementia","volume":"17","author":"Gellis","year":"2009","journal-title":"Ann Long-Term Care J Am Med Dir Assoc"},{"key":"10.1016\/j.inpsyc.2026.100226_bib88","unstructured":"Edinoff A.N., Raveendran K., Colon M.A., Thomas B.H., Trettin K.A., Hunt G.W., et al. Selective Serotonin Reuptake Inhibitors and Associated Bleeding Risks: A Narrative and Clinical Review. Health Psychol Res. 10(4):39580. doi:\u300810.52965\/001c.39580\u3009 PubMed PMID: 36425234; PubMed Central PMCID: PMC9680839."},{"key":"10.1016\/j.inpsyc.2026.100226_bib89","doi-asserted-by":"crossref","DOI":"10.1002\/phar.70004","article-title":"Evaluation of hyponatremia among older adults exposed to selective serotonin reuptake inhibitors and thiazide diuretics - Matsuura - 2025 - Pharmacotherapy","author":"Matsuura","year":"2025","journal-title":"J Human Pharmacol Drug Ther - Wiley Online Libr [Internet]"},{"issue":"5","key":"10.1016\/j.inpsyc.2026.100226_bib90","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1111\/jgs.17686","article-title":"A comparative analysis of selective serotonin reuptake inhibitors and fall risk in older adults","volume":"70","author":"Haddad","year":"2022","journal-title":"J Am Geriatr Soc"},{"issue":"6","key":"10.1016\/j.inpsyc.2026.100226_bib91","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1177\/2042098618772979","article-title":"Evaluating the risk of QTc prolongation associated with antidepressant use in older adults: a review of the evidence","volume":"9","author":"Rochester","year":"2018","journal-title":"Ther Adv Drug Saf"},{"issue":"9","key":"10.1016\/j.inpsyc.2026.100226_bib92","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.jagp.2019.03.021","article-title":"HTA-SADD Investigator Group. Sertraline and Mirtazapine Versus Placebo in Subgroups of Depression in Dementia: Findings From the HTA-SADD Randomized Controlled Trial","volume":"27","author":"Zuidersma","year":"2019","journal-title":"Am J Geriatr Psychiatry J Am Assoc Geriatr Psychiatry"},{"key":"10.1016\/j.inpsyc.2026.100226_bib93","doi-asserted-by":"crossref","unstructured":"Costello H., Roiser J.P., Howard R. Antidepressant medications in dementia: evidence and potential mechanisms of treatment-resistance. Psychol Med. 53(3):654\u2013667. doi:\u300810.1017\/S003329172200397X\u3009 PubMed PMID: 36621964; PubMed Central PMCID: PMC9976038.","DOI":"10.1017\/S003329172200397X"},{"key":"10.1016\/j.inpsyc.2026.100226_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.jad.2025.119551","article-title":"Consistent differential effects of bupropion and mirtazapine in major depression","volume":"388","author":"Strobl","year":"2025","journal-title":"J Affect Disord"},{"issue":"7","key":"10.1016\/j.inpsyc.2026.100226_bib95","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2025.24119","article-title":"Control group outcomes in trials of psilocybin, SSRIs, or esketamine for depression: a meta-analysis","volume":"8","author":"Hieronymus","year":"2025","journal-title":"JAMA Netw Open"},{"issue":"1","key":"10.1016\/j.inpsyc.2026.100226_bib96","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/s41597-024-03538-z","article-title":"Molecular signatures of premature aging in Major depression and substance use disorders","volume":"11","author":"Onisiforou","year":"2024","journal-title":"Sci Data"},{"issue":"5","key":"10.1016\/j.inpsyc.2026.100226_bib97","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1192\/bjp.186.5.410","article-title":"Distinctive neurocognitive effects of repetitive transcranial magnetic stimulation and electroconvulsive therapy in major depression","volume":"186","author":"Schulze-Rauschenbach","year":"2005","journal-title":"Br J Psychiatry"},{"issue":"11","key":"10.1016\/j.inpsyc.2026.100226_bib98","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1136\/jnnp-2023-332680","article-title":"A phase I trial of accelerated intermittent theta burst rTMS for amnestic MCI","volume":"95","author":"Aghamoosa","year":"2024","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.inpsyc.2026.100226_bib99","doi-asserted-by":"crossref","DOI":"10.3389\/fnhum.2021.723715","article-title":"Effects of repetitive transcranial magnetic stimulation in patients with mild cognitive impairment: a meta-analysis of randomized controlled trials","volume":"15","author":"Zhang","year":"2021","journal-title":"Front Hum Neurosci"},{"issue":"1","key":"10.1016\/j.inpsyc.2026.100226_bib100","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12984-024-01313-0","article-title":"Can transcranial direct current stimulation combined with interactive computerized cognitive training boost cognition and gait performance in older adults with mild cognitive impairment? a randomized controlled trial","volume":"21","author":"Lau","year":"2024","journal-title":"J Neuroeng Rehabil"},{"issue":"1","key":"10.1016\/j.inpsyc.2026.100226_bib101","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1186\/s13063-019-3360-1","article-title":"Effect of home-based transcranial direct current stimulation (tDCS) on cognitive function in patients with mild cognitive impairment: a study protocol for a randomized, double-blind, cross-over study","volume":"20","author":"Park","year":"2019","journal-title":"Trials"},{"issue":"2","key":"10.1016\/j.inpsyc.2026.100226_bib102","doi-asserted-by":"crossref","first-page":"194","DOI":"10.25259\/JNRP_629_2023","article-title":"Transcranial direct current stimulation-efficacy in mild cognitive impairment: a meta-analysis","volume":"15","author":"Sandhya","year":"2024","journal-title":"J Neurosci Rural Pract"},{"key":"10.1016\/j.inpsyc.2026.100226_bib103","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2024.1460853","article-title":"Decreased prefrontal activation during verbal fluency task after repetitive transcranial magnetic stimulation treatment for depression in Alzheimer\u2019s disease: a functional near-infrared spectroscopy study","volume":"16","author":"Zhao","year":"2025","journal-title":"Front Aging Neurosci"},{"issue":"6","key":"10.1016\/j.inpsyc.2026.100226_bib104","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1177\/03000605241258473","article-title":"Is there evidence for using ketamine among individuals with dementia?","volume":"52","author":"Kapoor","year":"2024","journal-title":"J Int Med Res"},{"issue":"2","key":"10.1016\/j.inpsyc.2026.100226_bib105","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3390\/neurolint14020025","article-title":"The possible application of ketamine in the treatment of depression in Alzheimer\u2019s disease","volume":"14","author":"Mohammad Shehata","year":"2022","journal-title":"Neurol Int"},{"issue":"3","key":"10.1016\/j.inpsyc.2026.100226_bib106","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jagp.2022.11.013","article-title":"Intravenous ketamine for late-life treatment-resistant depression: a pilot study of tolerability, safety, clinical benefits, and effect on cognition","volume":"31","author":"Oughli","year":"2023","journal-title":"Am J Geriatr Psychiatry J Am Assoc Geriatr Psychiatry"},{"issue":"3","key":"10.1016\/j.inpsyc.2026.100226_bib107","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0006-3223(02)01347-1","article-title":"Risk factors for suicide in later life","volume":"52","author":"Conwell","year":"2002","journal-title":"Biol Psychiatry"},{"issue":"3","key":"10.1016\/j.inpsyc.2026.100226_bib108","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/01.JGP.0000302930.75387.7e","article-title":"Hospital-diagnosed dementia and suicide: a longitudinal study using prospective, nationwide register data","volume":"16","author":"Erlangsen","year":"2008","journal-title":"Am J Geriatr Psychiatry J Am Assoc Geriatr Psychiatry"},{"issue":"7","key":"10.1016\/j.inpsyc.2026.100226_bib109","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.jpsychires.2013.02.009","article-title":"Suicides in older adults: a case-control psychological autopsy study in Australia","volume":"47","author":"De Leo","year":"2013","journal-title":"J Psychiatr Res"},{"issue":"10","key":"10.1016\/j.inpsyc.2026.100226_bib110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1001\/jamapsychiatry.2013.75","article-title":"Reward signals, attempted suicide, and impulsivity in late-life depression","volume":"70","author":"Dombrovski","year":"2013","journal-title":"JAMA Psychiatry"},{"issue":"1","key":"10.1016\/j.inpsyc.2026.100226_bib111","first-page":"1","article-title":"Suicide prevention in older adults: the role of social connectedness","volume":"21","author":"Van Orden","year":"2013","journal-title":"Am J Geriatr Psychiatry"}],"container-title":["International Psychogeriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104161022600044X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104161022600044X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T11:37:01Z","timestamp":1780918621000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S104161022600044X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":111,"alternative-id":["S104161022600044X"],"URL":"https:\/\/doi.org\/10.1016\/j.inpsyc.2026.100226","relation":{},"ISSN":["1041-6102"],"issn-type":[{"value":"1041-6102","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"From depression symptom management to dementia prevention: Considering next decade research, treatment, and advocacy priorities to reduce the impact of depression in neurocognitive disorders","name":"articletitle","label":"Article Title"},{"value":"International Psychogeriatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.inpsyc.2026.100226","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of International Psychogeriatric Association.","name":"copyright","label":"Copyright"}],"article-number":"100226"}}