{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:16:25Z","timestamp":1788671785283,"version":"build-2803163510"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017138","name":"Region V\u00e4stra G\u00f6taland Regional Executive Board","doi-asserted-by":"publisher","award":["ALFGBG-812881"],"award-info":[{"award-number":["ALFGBG-812881"]}],"id":[{"id":"10.13039\/100017138","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017138","name":"Region V\u00e4stra G\u00f6taland Regional Executive Board","doi-asserted-by":"publisher","award":["ALFGBG-518371"],"award-info":[{"award-number":["ALFGBG-518371"]}],"id":[{"id":"10.13039\/100017138","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","intestinalfailurejournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Intestinal Failure"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.intf.2025.100345","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:46:34Z","timestamp":1767746794000},"page":"100345","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Intestinal preservation using a tailored luminal solution and aeration: A small animal study"],"prefix":"10.1016","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3680-1267","authenticated-orcid":false,"given":"Jasmine","family":"Bagge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind Manikantan","family":"Padma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Casselbrant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edina","family":"Sehic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3323-5618","authenticated-orcid":false,"given":"Mats","family":"Hellstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3783-5207","authenticated-orcid":false,"given":"Mihai","family":"Oltean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.intf.2025.100345_bib1","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/ajt.12979","article-title":"Intestinal Transplant Association. Intestinal transplant registry report: global activity and trends","volume":"15","author":"Grant","year":"2015","journal-title":"Am J Transpl"},{"issue":"4","key":"10.1016\/j.intf.2025.100345_bib2","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1097\/SLA.0b013e3181b67725","article-title":"Five hundred intestinal and multivisceral transplantations at a single center: major advances with new challenges","volume":"250","author":"Abu-Elmagd","year":"2009","journal-title":"Ann Surg"},{"issue":"10","key":"10.1016\/j.intf.2025.100345_bib3","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1097\/00007890-200105270-00010","article-title":"Bacterial translocation in clinical intestinal transplantation","volume":"71","author":"Cicalese","year":"2001","journal-title":"Transplantation"},{"key":"10.1016\/j.intf.2025.100345_bib4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jss.2018.01.011","article-title":"Posttransplant complications in adult recipients of intestine grafts without bowel decontamination","volume":"225","author":"Clouse","year":"2018","journal-title":"J Surg Res"},{"issue":"6","key":"10.1016\/j.intf.2025.100345_bib5","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1111\/ajt.16418","article-title":"Luminal polyethylene glycol solution delays the onset of preservation injury in the human intestine","volume":"21","author":"S\u00f8fteland","year":"2021","journal-title":"Am J Transpl J Am Soc Transpl Am Soc Transpl Surg"},{"issue":"1","key":"10.1016\/j.intf.2025.100345_bib6","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jss.2014.10.001","article-title":"Luminal solutions protect mucosal barrier during extended preservation","volume":"194","author":"Oltean","year":"2015","journal-title":"J Surg Res"},{"issue":"12","key":"10.1016\/j.intf.2025.100345_bib7","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1111\/aor.14640","article-title":"End-ischemic hypothermic oxygenated machine perfusion does not improve renal outcome following liver transplantation from aged donors: a single-center retrospective report","volume":"47","author":"Nor\u00e9n","year":"2023","journal-title":"Artif Organs"},{"issue":"2","key":"10.1016\/j.intf.2025.100345_bib8","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.trre.2011.09.001","article-title":"Protective effects of hypothermic ex vivo perfusion on ischemia\/reperfusion injury and transplant outcomes","volume":"26","author":"Henry","year":"2012","journal-title":"Transpl Rev (Orlando)"},{"issue":"10263","key":"10.1016\/j.intf.2025.100345_bib9","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/S0140-6736(20)32411-9","article-title":"COMPARE Trial Collaboration and Consortium for Organ Preservation in Europe (COPE). Oxygenated versus standard cold perfusion preservation in kidney transplantation (COMPARE): a randomised, double-blind, paired, phase 3 trial","volume":"396","author":"Jochmans","year":"2020","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.intf.2025.100345_bib10","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1097\/SLA.0000000000006055","article-title":"Routine end-ischemic hypothermic oxygenated machine perfusion in liver transplantation from donors after brain death: a randomized controlled trial","volume":"278","author":"Gr\u0105t","year":"2023","journal-title":"Ann Surg"},{"issue":"5","key":"10.1016\/j.intf.2025.100345_bib11","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1097\/SLA.0000000000005110","volume":"274","author":"Czigany","year":"2021","journal-title":"Ann Surg"},{"issue":"1","key":"10.1016\/j.intf.2025.100345_bib12","doi-asserted-by":"crossref","first-page":"13732","DOI":"10.1038\/s41598-024-64660-x","article-title":"Intraluminal oxygen can keep small bowel mucosa intact in a segmental ischemia model","volume":"14","author":"Trentadue","year":"2024","journal-title":"Sci Rep"},{"issue":"11","key":"10.1016\/j.intf.2025.100345_bib13","doi-asserted-by":"crossref","DOI":"10.1097\/TXD.0000000000001390","article-title":"Orthotopic transplantation of the full-length porcine intestine after normothermic machine perfusion","volume":"8","author":"Abraham","year":"2022","journal-title":"Transpl Direct"},{"issue":"13","key":"10.1016\/j.intf.2025.100345_bib14","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.3390\/ijms20133135","article-title":"Intestinal preservation injury: a comparison between rat, porcine and human intestines","volume":"20","author":"S\u00f8fteland","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"8","key":"10.1016\/j.intf.2025.100345_bib15","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1111\/j.1600-6143.2012.04067.x","article-title":"Intraluminal polyethylene glycol stabilizes tight junctions and improves intestinal preservation in the rat","volume":"12","author":"Oltean","year":"2012","journal-title":"Am J Transpl"},{"issue":"1","key":"10.1016\/j.intf.2025.100345_bib16","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1006\/jsre.1997.5186","article-title":"Glutamine protects function and improves preservation of small bowel segments","volume":"73","author":"Sasaki","year":"1997","journal-title":"J Surg Res"},{"issue":"2","key":"10.1016\/j.intf.2025.100345_bib17","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/TP.0000000000005144","article-title":"L-Alanyl-L-glutamine alleviated ischemia-reperfusion injury and primary graft dysfunction in rat lung transplants","volume":"109","author":"Sun","year":"2025","journal-title":"Transplantation"},{"issue":"4","key":"10.1016\/j.intf.2025.100345_bib18","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1136\/gut.2003.027540","article-title":"Arginine stimulates intestinal cell migration through a focal adhesion kinase dependent mechanism","volume":"53","author":"Rhoads","year":"2004","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.intf.2025.100345_bib19","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1159\/000526274","article-title":"Mucosal recovery after intestinal transplantation in the rat: a sequential histological and molecular assessment","volume":"64","author":"Bagge","year":"2023","journal-title":"Eur Surg Res"},{"issue":"3","key":"10.1016\/j.intf.2025.100345_bib20","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/TP.0b013e3181c9905a","article-title":"Improved intestinal preservation using an intraluminal macromolecular solution: evidence from a rat model","volume":"89","author":"Oltean","year":"2010","journal-title":"Transplantation"},{"issue":"4","key":"10.1016\/j.intf.2025.100345_bib21","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/j.1600-6143.2004.00365.x","article-title":"Protective roles of polyethylene glycol and trimetazidine against cold ischemia and reperfusion injuries of pig kidney graft","volume":"4","author":"Faure","year":"2004","journal-title":"Am J Transpl"},{"issue":"3","key":"10.1016\/j.intf.2025.100345_bib22","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1124\/jpet.102.033688","article-title":"Polyethylene glycol reduces early and long-term cold ischemia-reperfusion and renal medulla injury","volume":"302","author":"Faure","year":"2002","journal-title":"J Pharm Exp Ther"},{"issue":"6","key":"10.1016\/j.intf.2025.100345_bib23","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1097\/TP.0b013e3181ebf796","article-title":"Reduced ischemia-reoxygenation injury in rat intestine after luminal preservation with a tailored solution","volume":"90","author":"Roskott","year":"2010","journal-title":"Transplantation"},{"issue":"7","key":"10.1016\/j.intf.2025.100345_bib24","article-title":"Luminal preloading with hydrogen-rich saline ameliorates ischemia-reperfusion injury following intestinal transplantation in rats","volume":"24","author":"Yamamoto","year":"2020","journal-title":"Pedia Transpl"},{"issue":"4","key":"10.1016\/j.intf.2025.100345_bib25","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.ajt.2023.10.026","article-title":"Comparison of the effects of normothermic machine perfusion and cold storage preservation on porcine intestinal allograft regenerative potential and viability","volume":"24","author":"Ludwig","year":"2024","journal-title":"Am J Transpl"},{"issue":"1","key":"10.1016\/j.intf.2025.100345_bib26","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1124\/jpet.117.247023","article-title":"Luminal polyethylene glycol alleviates intestinal preservation injury irrespective of molecular size","volume":"366","author":"Casselbrant","year":"2018","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"10.1016\/j.intf.2025.100345_bib27","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1006\/clim.2002.5257","article-title":"Glutamine protects activated human T cells from apoptosis by up-regulating glutathione and Bcl-2 levels","volume":"104","author":"Chang","year":"2002","journal-title":"Clin Immunol (Orlando, Fla.)"},{"issue":"6","key":"10.1016\/j.intf.2025.100345_bib28","doi-asserted-by":"crossref","first-page":"C1355","DOI":"10.1152\/ajpcell.00224.2002","article-title":"Glutamine delays spontaneous apoptosis in neutrophils","volume":"284","author":"Pithon-Curi","year":"2003","journal-title":"Am J Physiol Cell Physiol"},{"issue":"3","key":"10.1016\/j.intf.2025.100345_bib29","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1034\/j.1600-6143.2002.20307.x","article-title":"Defining the role of a tailored luminal solution for small bowel preservation","volume":"2","author":"Fujimoto","year":"2002","journal-title":"Am J Transpl"}],"container-title":["Intestinal Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950456225003100?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950456225003100?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:55:44Z","timestamp":1788670544000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2950456225003100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":29,"alternative-id":["S2950456225003100"],"URL":"https:\/\/doi.org\/10.1016\/j.intf.2025.100345","relation":{},"ISSN":["2950-4562"],"issn-type":[{"value":"2950-4562","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intestinal preservation using a tailored luminal solution and aeration: A small animal study","name":"articletitle","label":"Article Title"},{"value":"Intestinal Failure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intf.2025.100345","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of International Intestinal Rehabilitation & Transplant Association.","name":"copyright","label":"Copyright"}],"article-number":"100345"}}