{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:29:35Z","timestamp":1791163775707,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"10-11","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2004,10]]},"DOI":"10.1016\/j.intimp.2004.05.006","type":"journal-article","created":{"date-parts":[[2004,6,2]],"date-time":"2004-06-02T17:19:18Z","timestamp":1086196758000},"page":"1307-1318","source":"Crossref","is-referenced-by-count":101,"title":["Dexamethasone protects against dopaminergic neurons damage in a mouse model of Parkinson's disease"],"prefix":"10.1016","volume":"4","author":[{"given":"Iwona","family":"Kurkowska-Jastrz\u0119bska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Litwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona","family":"Joniec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Ciesielska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Przyby\u0142kowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Cz\u0142onkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Cz\u0142onkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2004.05.006_BIB1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0197-4580(00)00124-X","article-title":"Inflammation and Alzheimer disease","volume":"21","author":"Akiyama","year":"2000","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.intimp.2004.05.006_BIB2","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1001\/archneur.60.8.1059","article-title":"Non-steroidal anti-inflammatory drugs and the risk of Parkinson's disease","volume":"60","author":"Chen","year":"2003","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.intimp.2004.05.006_BIB3","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1212\/WNL.54.3.732","article-title":"Anti-inflammatory drugs and Alzheimer type pathology in aging","volume":"54","author":"Mackenzie","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.intimp.2004.05.006_BIB4","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1212\/WNL.47.2.425","article-title":"Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiological studies","volume":"47","author":"McGeer","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.intimp.2004.05.006_BIB5","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1212\/WNL.43.8.1609","article-title":"Clinical trial of indomethacin in Alzheimer's disease","volume":"43","author":"Rogers","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.intimp.2004.05.006_BIB6","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1056\/NEJMoa010178","article-title":"Nonsteroidal antiinflammatory drugs and the risk of Alzheimer disease","volume":"21","author":"Veld","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.intimp.2004.05.006_BIB7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0169-328X(94)00202-P","article-title":"Diurnal variation in kainate induced AP-1 activation in rat brain: influence of glucocorticoids","volume":"28","author":"Unlap","year":"1995","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.intimp.2004.05.006_BIB8","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0304-3940(95)11963-W","article-title":"Inhibition of NFkB DNA binding activity by glucocorticoids in rat brain","volume":"198","author":"Unlap","year":"1995","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.intimp.2004.05.006_BIB9","first-page":"85","article-title":"Down-regulation of microglial cyclooxygenase-2 and inducible nitric synthase expression by lipocortin","volume":"10","author":"Minghetti","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.intimp.2004.05.006_BIB10","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/(SICI)1098-1136(199705)20:1<23::AID-GLIA3>3.0.CO;2-6","article-title":"Glucocorticoid and mineralocorticoid receptors in microglial cells: the two receptors mediate differential effects of corticosteroids","volume":"20","author":"Tanaka","year":"1997","journal-title":"Glia"},{"key":"10.1016\/j.intimp.2004.05.006_BIB11","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1212\/WNL.54.3.588","article-title":"A randomized controlled trial of prednisone in Alzheimer disease","volume":"54","author":"Aisen","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.intimp.2004.05.006_BIB12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0165-5728(93)90209-H","article-title":"Immunological changes in the MPTP-induced Parkinson's disease mouse model","volume":"42","author":"Bieganowska","year":"1993","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.intimp.2004.05.006_BIB13","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1006\/neur.1996.0020","article-title":"Microglial reaction in MPTP induced Parkinson's disease mice model","volume":"5","author":"Cz\u0142onkowska","year":"1996","journal-title":"Neurodegeneration"},{"key":"10.1016\/j.intimp.2004.05.006_BIB14","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0162-3109(98)00022-8","article-title":"The microglial and astrocytic involvement in Parkinson's disease mice model induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)","volume":"39","author":"Kohutnicka","year":"1998","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.intimp.2004.05.006_BIB15","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1006\/exnr.1998.6993","article-title":"The inflammatory reaction following 1-methyl-4-phenyl-12,3,6-tetrahydropyridine intoxication in mouse","volume":"156","author":"Kurkowska-Jastrz\u0119bska","year":"1999","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.intimp.2004.05.006_BIB16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.55782\/ane-2003-1461","article-title":"Dynamics of expression of the mRNA for cytokines and inducible nitric synthase in a murine model of Parkinson's disease","volume":"63","author":"Ciesielska","year":"2003","journal-title":"Acta Neurobiol. Exp."},{"key":"10.1016\/j.intimp.2004.05.006_BIB17","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1046\/j.1471-4159.1998.71041635.x","article-title":"Aspirin and salicylate protect against MPTP-induced dopamine depletion in mice","volume":"71","author":"Aubin","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/j.intimp.2004.05.006_BIB18","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1023\/A:1027312901477","article-title":"Metallothionein inducers protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in mice","volume":"22","author":"Rojas","year":"1997","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.intimp.2004.05.006_BIB19","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1002\/(SICI)1097-4547(19990915)57:6<916::AID-JNR17>3.0.CO;2-J","article-title":"Effect of dexamethasone on elevated cytokine mRNA levels in chemical-induced hippokampal injury","volume":"57","author":"Bruccoleri","year":"1999","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.intimp.2004.05.006_BIB20","first-page":"63","article-title":"Neurosteroids: expression of steroidogenic enzymes and regulation of steroids biosynthesis in the CNS","volume":"51","author":"Mensah-Nyagan","year":"1999","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.intimp.2004.05.006_BIB21","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0304-3940(00)01603-7","article-title":"Dexamethasone enhanced sensitivity of mouse hippocampal HT22 cells for oxidative stress is associated with the suppression of nuclear factor-kappa B","volume":"295","author":"Braun","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.intimp.2004.05.006_BIB22","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/S0306-4522(98)00311-X","article-title":"Ligand and subfield specificity of corticoid-induced neuronal loss in the rat hippocampal formation","volume":"89","author":"Sousa","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.intimp.2004.05.006_BIB23","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/S0306-4522(98)00685-X","article-title":"Dexamethasone selectively suppresses microglial trophic responses to hippocampal deafferentation","volume":"91","author":"Woods","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.intimp.2004.05.006_BIB24","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0306-4522(97)00534-4","article-title":"Phencyclidine and corticosteroids induce apoptosis of a subpopulation of striatal neurons: a neural substrate for psychosis?","volume":"84","author":"Mitchell","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/j.intimp.2004.05.006_BIB25","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0306-4522(01)00070-7","article-title":"Dexamethasone induces limited apoptosis and extensive sublethal damage to specific subregions of the striatum and hippocampus: implication for mood disorders","volume":"104","author":"Haynes","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.intimp.2004.05.006_BIB26","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S0531-5565(00)00148-0","article-title":"Heme oxygenase-1: role in brain aging and neurodegeneration","volume":"35","author":"Schipper","year":"2000","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.intimp.2004.05.006_BIB27","first-page":"395","article-title":"Systemic dexamethasone administration increases septal Trk autophosphorylation in adult rats via an induction of nerve growth factor","volume":"45","author":"Saporito","year":"1994","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.intimp.2004.05.006_BIB28","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1159\/000139171","article-title":"The effects of anti-TNF-alpha antibody and dexamethasone on TCDD-induced oxidative stress in mice","volume":"48","author":"Alsharif","year":"1994","journal-title":"Pharmacology"},{"key":"10.1016\/j.intimp.2004.05.006_BIB29","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0165-5728(91)90119-R","article-title":"Effects of dexamethasone on microglial activation in vivo: selective downregulation of major histocompability complex class II expression in regenerating facial nucleus","volume":"34","author":"Kiefer","year":"1991","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.intimp.2004.05.006_BIB30","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.4049\/jimmunol.163.6.3484","article-title":"Glucocorticoids induce apoptosis in human monocytes: potenil role of IL-1beta","volume":"163","author":"Schmidt","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2004.05.006_BIB31","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/(SICI)1097-4547(20000501)60:3<401::AID-JNR15>3.0.CO;2-L","article-title":"Expression of alpha2-macroglobulin receptor\/low density lipoprotein receptor-related protein (LRP) in rat microglial cells","volume":"60","author":"Marzolo","year":"2000","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.intimp.2004.05.006_BIB32","doi-asserted-by":"crossref","first-page":"634","DOI":"10.3171\/jns.2000.93.4.0634","article-title":"Dexamethasone induced abolition of the inflammatory response in an experimental glioma model: a flow cytometry study","volume":"93","author":"Badie","year":"2000","journal-title":"J. Neurosurg."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576904001535?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576904001535?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T10:20:51Z","timestamp":1705141251000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576904001535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":32,"journal-issue":{"issue":"10-11","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["S1567576904001535"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2004.05.006","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2004,10]]}}}