{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T21:47:13Z","timestamp":1782337633663,"version":"3.54.5"},"reference-count":38,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2006,4]]},"DOI":"10.1016\/j.intimp.2005.10.007","type":"journal-article","created":{"date-parts":[[2005,11,12]],"date-time":"2005-11-12T12:11:11Z","timestamp":1131797471000},"page":"703-713","source":"Crossref","is-referenced-by-count":30,"title":["Inhibitory effects of Actinidia polygama extract and cyclosporine A on OVA-induced eosinophilia and bronchial hyperresponsiveness in a murine model of asthma"],"prefix":"10.1016","volume":"6","author":[{"given":"Young-Cheol","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Hyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Bae","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong-Soo","family":"Roh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang-Cheon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2005.10.007_bib1","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1164\/ajrccm\/142.2.434","article-title":"Mucosal inflammation in asthma","volume":"142","author":"Djukanovic","year":"1990","journal-title":"Am Rev Respir Dis"},{"issue":"2","key":"10.1016\/j.intimp.2005.10.007_bib2","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S1525-0016(03)00003-0","article-title":"Gene therapy for asthma","volume":"7","author":"Factor","year":"2003","journal-title":"Mol Ther"},{"key":"10.1016\/j.intimp.2005.10.007_bib3","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1056\/NEJM199805283382206","article-title":"Eosinophilia","volume":"28","author":"Rothenberg","year":"1998","journal-title":"N Engl J Med"},{"issue":"12","key":"10.1016\/j.intimp.2005.10.007_bib4","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/BF02994759","article-title":"Anti-inflammation activity of Actinidia polygama","volume":"26","author":"Kim","year":"2003","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.intimp.2005.10.007_bib5","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/0140-6736(92)91646-P","article-title":"Cyclosporine A in corticosteroid-dependent chronic severe asthma","volume":"339","author":"Alexander","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2005.10.007_bib6","first-page":"65","article-title":"Cyclosporine A reduces T lymphocyte activity and improve airway hyperresponsiveness in corticosteroid-dependent choronic severe asthma","volume":"75","author":"Fukuda","year":"1995","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.intimp.2005.10.007_bib7","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1164\/ajrccm.162.4.9911117","article-title":"Attenuation of the allergen-induced late asthmatic reaction by cyclosporine A is associated with inhibition of bronchial eosinophils, interleukin-5, granulocyte macrophage colony-stimulating factor, and eotaxin","volume":"162","author":"Khan","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.intimp.2005.10.007_bib8","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1007\/PL00000243","article-title":"The effect of allergen-induced airway inflammation on airway remodeling in a murine model of allergic asthma","volume":"50","author":"Tanaka","year":"2001","journal-title":"Inflamm Res"},{"key":"10.1016\/j.intimp.2005.10.007_bib9","first-page":"218","article-title":"Allergen-induced airway inflammation and bronchial responsiveness in interleukin-5 receptor \u03b1 chain-deficient mice","volume":"27","author":"Tanaka","year":"1997","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.intimp.2005.10.007_bib10","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1172\/JCI7010","article-title":"The late, but not early, asthmatic response is dependent on IL-5 and correlates with eosinophil infiltration","volume":"104","author":"Cieslewicz","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.intimp.2005.10.007_bib11","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.jaci.2003.07.005","article-title":"Diesel exhaust particles exert acute effects on airway inflammation and function in murine allergen provocation models","volume":"112","author":"Hao","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.intimp.2005.10.007_bib12","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1084\/jem.185.12.2143","article-title":"Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma","volume":"185","author":"Lee","year":"1997","journal-title":"J Exp Med"},{"key":"10.1016\/j.intimp.2005.10.007_bib13","doi-asserted-by":"crossref","first-page":"L813","DOI":"10.1152\/ajplung.2001.280.4.L813","article-title":"Blockade of CD49d inhibits allergic airway pathologies independent of effects on leukocyte recruitment","volume":"280","author":"Borchers","year":"2001","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.intimp.2005.10.007_bib14","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/0091-6749(91)90408-G","article-title":"Asthma and inflammation","volume":"87","author":"Kay","year":"1991","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.intimp.2005.10.007_bib15","first-page":"373","article-title":"Bronchoalveolar eosinophilia during allergen-induced late asthmatic reactions","volume":"131","author":"de Monchy","year":"1985","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.intimp.2005.10.007_bib16","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1164\/ajrccm\/139.3.806","article-title":"Cellular events in the bronchi in mild asthma and after bronchial provocation","volume":"139","author":"Beasley","year":"1989","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.intimp.2005.10.007_bib17","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/0091-6749(94)90252-6","article-title":"Blood and bronchoalveolar eosinophils in allergic subjects after segmental antigen challenge: surface phenotype, density heterogeneity, and prostanoid production","volume":"93","author":"Kroegel","year":"1994","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.intimp.2005.10.007_bib18","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1165\/ajrcmb.16.5.9160833","article-title":"Cytokine and eosinophil responses in the lung, peripheral blood, and bone marrow compartments in a murine model of allergen-induced airways inflammation","volume":"16","author":"Ohkawara","year":"1997","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.intimp.2005.10.007_bib19","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1164\/ajrccm\/137.1.62","article-title":"Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma: relationship to bronchial hyperreactivity","volume":"137","author":"Wardlaw","year":"1988","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.intimp.2005.10.007_bib20","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1056\/NEJM199010113231505","article-title":"Eosinophilic inflammation in asthma","volume":"323","author":"Bousquet","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1016\/j.intimp.2005.10.007_bib21","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/0091-6749(90)90151-S","article-title":"The eosinophil and bronchial asthma: current understanding","volume":"85","author":"Gleich","year":"1990","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.intimp.2005.10.007_bib22","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1136\/thx.53.5.419","article-title":"Measurement of airway hyperresponsiveness: new considerations","volume":"53","author":"Lotvall","year":"1998","journal-title":"Thorax"},{"key":"10.1016\/j.intimp.2005.10.007_bib23","first-page":"716","article-title":"Preferential generation of leukotriene C4 by human eosinophils","volume":"56","author":"Shaw","year":"1984","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.intimp.2005.10.007_bib24","doi-asserted-by":"crossref","first-page":"532","DOI":"10.4049\/jimmunol.138.2.532","article-title":"Synthesis and release of leukotriene C4 by human eosinophils","volume":"138","author":"Owen","year":"1987","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2005.10.007_bib25","first-page":"609","article-title":"Endotoxin responsiveness and grain dust-induced inflammation in the lower respiratory tract","volume":"267","author":"Schwartz","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1016\/j.intimp.2005.10.007_bib26","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/01.all.0000010988.60715.c8","article-title":"T-cell responses in allergy and asthma","volume":"1","author":"Romagnani","year":"2001","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.intimp.2005.10.007_bib27","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/0091-6749(94)90195-3","article-title":"The role of adhesion molecules in human eosinophils and basophils recruitment","volume":"94","author":"Bochner","year":"1994","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.intimp.2005.10.007_bib28","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1084\/jem.183.1.195","article-title":"Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model","volume":"183","author":"Foster","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.intimp.2005.10.007_bib29","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1172\/JCI2686","article-title":"Circulating, but not local lung, IL-5 is required for the development of antigen-induced airways eosinophilia","volume":"102","author":"Wang","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.intimp.2005.10.007_bib30","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/0091-6749(94)90335-2","article-title":"Mechanisms of allergic pulmonary eosinophilia in the mouse","volume":"94","author":"Kung","year":"1994","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.intimp.2005.10.007_bib31","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1172\/JCI5909","article-title":"Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production","volume":"103","author":"Zhu","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.intimp.2005.10.007_bib32","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.4049\/jimmunol.148.11.3618","article-title":"Structure of the mouse interleukin-10 gene and chromosomal localization of the mouse and human genes","volume":"148","author":"Kim","year":"1992","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2005.10.007_bib33","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1182\/blood.V91.7.2240","article-title":"Eotaxin induces a rapid release of eosinophils and their progenitors from the bone marrow","volume":"91","author":"Palframan","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2005.10.007_bib34","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/intimm\/10.4.395","article-title":"Molecular characterization of the low-affinity IgE receptor Fc\u03b5RII\/CD23 expressed by human eosinophils","volume":"10","author":"Soussi Gounni","year":"1998","journal-title":"Int Immunol"},{"key":"10.1016\/j.intimp.2005.10.007_bib35","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1378\/chest.123.3_suppl.439S-a","article-title":"New and exploratory therapies for asthma","volume":"123","author":"Homer","year":"2003","journal-title":"CHEST"},{"key":"10.1016\/j.intimp.2005.10.007_bib36","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1172\/JCI119145","article-title":"Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody","volume":"99","author":"Heath","year":"1997","journal-title":"J Clin Invest"},{"issue":"11","key":"10.1016\/j.intimp.2005.10.007_bib37","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/j.1365-2222.1993.tb00277.x","article-title":"Expression of CD35 (CR1) and CD11b (CR3) on circulating neutrophils and eosinophils from allergic asthmatic children","volume":"23","author":"Berends","year":"1993","journal-title":"Clin Exp Allergy"},{"issue":"3","key":"10.1016\/j.intimp.2005.10.007_bib38","first-page":"593","article-title":"Expression of surface CD11b antigen and eosinophil activation","volume":"51","author":"Yachie","year":"1993","journal-title":"Nippon Rinsho"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576905002900?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576905002900?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T10:48:45Z","timestamp":1683283725000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576905002900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["S1567576905002900"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2005.10.007","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2006,4]]}}}