{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:13:56Z","timestamp":1787314436077,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2006,4]]},"DOI":"10.1016\/j.intimp.2005.10.008","type":"journal-article","created":{"date-parts":[[2005,11,18]],"date-time":"2005-11-18T07:15:19Z","timestamp":1132298119000},"page":"686-696","source":"Crossref","is-referenced-by-count":74,"title":["Lentinan has a stimulatory effect on innate and adaptive immunity against murine Listeria monocytogenes infection"],"prefix":"10.1016","volume":"6","author":[{"given":"C.","family":"Kupfahl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Geginat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Hof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2005.10.008_bib1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/978-1-4615-3434-1_21","article-title":"Potentiation of host resistance against microbial infections by lentinan and its related polysaccharides","volume":"319","author":"Kaneko","year":"1992","journal-title":"Adv Exp Med Biol"},{"issue":"1\u20133","key":"10.1016\/j.intimp.2005.10.008_bib2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0162-3109(99)00013-2","article-title":"Therapeutic intervention with complement and beta-glucan in cancer","volume":"42","author":"Ross","year":"1999","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.intimp.2005.10.008_bib3","first-page":"423","article-title":"Antitumor and metastasis-inhibitory activities of lentinan as an immunomodulator: an overview","volume":"1","author":"Chihara","year":"1987","journal-title":"Cancer Detect Prev, Suppl"},{"key":"10.1016\/j.intimp.2005.10.008_bib4","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/09629359791550","article-title":"Overview of (1,3)-beta-d-glucan immunobiology","volume":"6","author":"Williams","year":"1997","journal-title":"Mediat Inflamm"},{"issue":"3","key":"10.1016\/j.intimp.2005.10.008_bib5","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1084\/jem.20020470","article-title":"Dectin-1 is a major beta-glucan receptor on macrophages","volume":"196","author":"Brown","year":"2002","journal-title":"J Exp Med"},{"issue":"7","key":"10.1016\/j.intimp.2005.10.008_bib6","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.4049\/jimmunol.169.7.3876","article-title":"The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte\/macrophage and neutrophil lineages","volume":"169","author":"Taylor","year":"2002","journal-title":"J Immunol"},{"issue":"9","key":"10.1016\/j.intimp.2005.10.008_bib7","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1084\/jem.20021787","article-title":"Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2","volume":"197","author":"Gantner","year":"2003","journal-title":"J Exp Med"},{"issue":"9","key":"10.1016\/j.intimp.2005.10.008_bib8","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1084\/jem.20021890","article-title":"Dectin-1 mediates the biological effects of beta-glucans","volume":"197","author":"Brown","year":"2003","journal-title":"J Exp Med"},{"issue":"3","key":"10.1016\/j.intimp.2005.10.008_bib9","first-page":"671","article-title":"Denaturation and renaturation of a beta-1,6;1,3-glucan, lentinan, associated with expression of T-cell-mediated responses","volume":"48","author":"Maeda","year":"1988","journal-title":"Cancer Res"},{"issue":"13\u201314","key":"10.1016\/j.intimp.2005.10.008_bib10","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1016\/j.intimp.2003.09.003","article-title":"The beta-(1\u21926)-branched beta-(1\u21923) glucohexose and its analogues containing an alpha-(1\u21923)-linked bond have similar stimulatory effects on the mouse spleen as Lentinan","volume":"3","author":"Yan","year":"2003","journal-title":"Int Immunopharmacol"},{"issue":"3","key":"10.1016\/j.intimp.2005.10.008_bib11","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S1074-7613(03)00233-4","article-title":"Fungal beta-glucans and mammalian immunity","volume":"19","author":"Brown","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2005.10.008_bib12","first-page":"333","article-title":"Clinical efficacy of lentinan on patients with stomach cancer: end point results of a four-year follow-up survey","volume":"1","author":"Taguchi","year":"1987","journal-title":"Cancer Detect Prev, Suppl"},{"issue":"28","key":"10.1016\/j.intimp.2005.10.008_bib13","first-page":"2662","article-title":"A multi-institutional prospective study of lentinan in advanced gastric cancer patients with unresectable and recurrent diseases: effect on prolongation of survival and improvement of quality of life. Kanagawa Lentinan Research Group","volume":"46","author":"Nakano","year":"1999","journal-title":"Hepatogastroenterology"},{"issue":"1","key":"10.1016\/j.intimp.2005.10.008_bib14","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0162-3109(82)90037-6","article-title":"The effect of lentinan on production of interleukin-1 by human monocytes","volume":"5","author":"Fruehauf","year":"1982","journal-title":"Immunopharmacology"},{"issue":"5","key":"10.1016\/j.intimp.2005.10.008_bib15","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S1567-5769(01)00212-0","article-title":"The skewing to Th1 induced by lentinan is directed through the distinctive cytokine production by macrophages with elevated intracellular glutathione content","volume":"2","author":"Murata","year":"2002","journal-title":"Int Immunopharmacol"},{"issue":"10\u201311","key":"10.1016\/j.intimp.2005.10.008_bib16","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/S1567-5769(03)00178-4","article-title":"Protective activity of Lentinan in experimental tuberculosis","volume":"3","author":"Markova","year":"2003","journal-title":"Int Immunopharmacol"},{"issue":"5C","key":"10.1016\/j.intimp.2005.10.008_bib17","first-page":"1773","article-title":"Augmentation of lymphokine-activated killer cell activity by lentinan","volume":"13","author":"Tani","year":"1993","journal-title":"Anticancer Res"},{"issue":"1","key":"10.1016\/j.intimp.2005.10.008_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01517163","article-title":"Curative effects of combination therapy with lentinan and interleukin-2 against established murine tumors, and the role of CD8-positive T cells","volume":"38","author":"Suzuki","year":"1994","journal-title":"Cancer Immunol Immunother"},{"issue":"10","key":"10.1016\/j.intimp.2005.10.008_bib19","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/nri1461","article-title":"Immune responses to Listeria monocytogenes","volume":"4","author":"Pamer","year":"2004","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"10.1016\/j.intimp.2005.10.008_bib20","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S1074-7613(02)00365-5","article-title":"In vivo depletion of CD11c(+) dendritic cells abrogates priming of CD8(+) T cells by exogenous cell-associated antigens","volume":"17","author":"Jung","year":"2002","journal-title":"Immunity"},{"issue":"12","key":"10.1016\/j.intimp.2005.10.008_bib21","doi-asserted-by":"crossref","first-page":"5608","DOI":"10.1128\/IAI.62.12.5608-5613.1994","article-title":"Characterization of Listeria monocytogenes pathogenesis in a strain expressing perfringolysin O in place of listeriolysin O","volume":"62","author":"Jones","year":"1994","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.intimp.2005.10.008_bib22","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1084\/jem.175.6.1531","article-title":"CD8+ T cells specific for a single nonamer epitope of Listeria monocytogenes are protective in vivo","volume":"175","author":"Harty","year":"1992","journal-title":"J Exp Med"},{"issue":"2","key":"10.1016\/j.intimp.2005.10.008_bib23","doi-asserted-by":"crossref","first-page":"686","DOI":"10.4049\/jimmunol.152.2.686","article-title":"Direct sequence identification and kinetic analysis of an MHC class I-restricted Listeria monocytogenes CTL epitope","volume":"152","author":"Pamer","year":"1994","journal-title":"J Immunol"},{"issue":"4","key":"10.1016\/j.intimp.2005.10.008_bib24","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1086\/315007","article-title":"Suppression of acquired immunity against Listeria monocytogenes by amphotericin B-mediated inhibition of CD8 T cell function","volume":"180","author":"Geginat","year":"1999","journal-title":"J Infect Dis"},{"issue":"9","key":"10.1016\/j.intimp.2005.10.008_bib25","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.4049\/jimmunol.158.9.4229","article-title":"Bone marrow-derived dendritic cells can process bacteria for MHC-I and MHC-II presentation to T cells","volume":"158","author":"Svensson","year":"1997","journal-title":"J Immunol"},{"issue":"6","key":"10.1016\/j.intimp.2005.10.008_bib26","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1084\/jem.176.6.1693","article-title":"Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte\/macrophage colony-stimulating factor","volume":"176","author":"Inaba","year":"1992","journal-title":"J Exp Med"},{"issue":"3","key":"10.1016\/j.intimp.2005.10.008_bib27","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.4049\/jimmunol.169.3.1410","article-title":"Cross-presentation of Listeria monocytogenes-derived CD4 T cell epitopes","volume":"169","author":"Skoberne","year":"2002","journal-title":"J Immunol"},{"issue":"3","key":"10.1016\/j.intimp.2005.10.008_bib28","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.4049\/jimmunol.166.3.1877","article-title":"A novel approach of direct ex vivo epitope mapping identifies dominant and subdominant CD4 and CD8 T cell epitopes from Listeria monocytogenes","volume":"166","author":"Geginat","year":"2001","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.intimp.2005.10.008_bib29","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Anal Biochem"},{"issue":"1","key":"10.1016\/j.intimp.2005.10.008_bib30","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1365-2958.1995.tb02218.x","article-title":"Functional analysis of the Salmonella typhimurium invasion genes invl and invJ and identification of a target of the protein secretion apparatus encoded in the inv locus","volume":"15","author":"Collazo","year":"1995","journal-title":"Mol Microbiol"},{"issue":"8","key":"10.1016\/j.intimp.2005.10.008_bib31","doi-asserted-by":"crossref","first-page":"4781","DOI":"10.4049\/jimmunol.162.8.4781","article-title":"Enhancement of the Listeria monocytogenes p60-specific CD4 and CD8 T cell memory by nonpathogenic Listeria innocua","volume":"162","author":"Geginat","year":"1999","journal-title":"J Immunol"},{"issue":"4","key":"10.1016\/j.intimp.2005.10.008_bib32","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.4049\/jimmunol.170.4.1949","article-title":"The induction and kinetics of antigen-specific CD8 T cells are defined by the stage specificity and compartmentalization of the antigen in murine toxoplasmosis","volume":"170","author":"Kwok","year":"2003","journal-title":"J Immunol"},{"issue":"4","key":"10.1016\/j.intimp.2005.10.008_bib33","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1084\/jem.184.4.1397","article-title":"Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response","volume":"184","author":"Pasparakis","year":"1996","journal-title":"J Exp Med"},{"issue":"1","key":"10.1016\/j.intimp.2005.10.008_bib34","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1074-7613(03)00171-7","article-title":"TNF\/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection","volume":"19","author":"Serbina","year":"2003","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.intimp.2005.10.008_bib35","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1254\/jjp.87.327","article-title":"Addition of Maitake D-fraction reduces the effective dosage of vancomycin for the treatment of Listeria-infected mice","volume":"84","author":"Kodama","year":"2001","journal-title":"Jpn J Pharmacol"},{"issue":"12","key":"10.1016\/j.intimp.2005.10.008_bib36","doi-asserted-by":"crossref","first-page":"7005","DOI":"10.1128\/IAI.72.12.7005-7011.2004","article-title":"Immunostimulating properties of intragastrically administered Acetobacter-derived soluble branched (1,4)-beta-d-glucans decrease murine susceptibility to Listeria monocytogenes","volume":"72","author":"Li","year":"2004","journal-title":"Infect Immun"},{"issue":"4","key":"10.1016\/j.intimp.2005.10.008_bib37","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.4049\/jimmunol.173.4.2641","article-title":"Cytoplasmic entry of Listeria monocytogenes enhances dendritic cell maturation and T cell differentiation and function","volume":"173","author":"Brzoza","year":"2004","journal-title":"J Immunol"},{"issue":"2","key":"10.1016\/j.intimp.2005.10.008_bib38","doi-asserted-by":"crossref","first-page":"600","DOI":"10.4049\/jimmunol.174.2.600","article-title":"Cutting edge: Bcl-3 up-regulation by signal 3 cytokine (IL-12) prolongs survival of antigen-activated CD8 T cells","volume":"174","author":"Valenzuela","year":"2005","journal-title":"J Immunol"},{"issue":"6C","key":"10.1016\/j.intimp.2005.10.008_bib39","first-page":"4707","article-title":"Immunoregulatory effects of the antitumor polysaccharide lentinan on Th1\/Th2 balance in patients with digestive cancers","volume":"20","author":"Yoshino","year":"2000","journal-title":"Anticancer Res"},{"issue":"2","key":"10.1016\/j.intimp.2005.10.008_bib40","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nri1001","article-title":"Interleukin-12 and the regulation of innate resistance and adaptive immunity","volume":"3","author":"Trinchieri","year":"2003","journal-title":"Nat Rev Immunol"},{"issue":"10","key":"10.1016\/j.intimp.2005.10.008_bib41","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1002\/1521-4141(2002010)32:10<2807::AID-IMMU2807>3.0.CO;2-0","article-title":"Contribution of CD8+ T cells to innate immunity: IFN-gamma secretion induced by IL-12 and IL-18","volume":"32","author":"Berg","year":"2002","journal-title":"Eur J Immunol"},{"issue":"10","key":"10.1016\/j.intimp.2005.10.008_bib42","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1084\/jem.20031051","article-title":"Memory CD8+ T cells provide innate immune protection against Listeria monocytogenes in the absence of cognate antigen","volume":"198","author":"Berg","year":"2003","journal-title":"J Exp Med"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576905002924?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576905002924?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T17:37:39Z","timestamp":1706722659000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576905002924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["S1567576905002924"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2005.10.008","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2006,4]]}}}