{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:33:17Z","timestamp":1790926397918,"version":"4.1.0"},"reference-count":122,"publisher":"Elsevier BV","issue":"14","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1016\/j.intimp.2007.07.013","type":"journal-article","created":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T12:57:45Z","timestamp":1185973065000},"page":"1934-1947","source":"Crossref","is-referenced-by-count":25,"title":["Molecular genetics and mechanisms of apoptosis in carcinomas of the lung and pleura: Therapeutic targets"],"prefix":"10.1016","volume":"7","author":[{"given":"L.R.","family":"Motadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.L.","family":"Misso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Dlamini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.D.","family":"Bhoola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2007.07.013_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lungcan.2004.10.009","article-title":"Lung cancer in women","volume":"48","author":"Pauk","year":"2005","journal-title":"Lung Cancer"},{"key":"10.1016\/j.intimp.2007.07.013_bib2","first-page":"3","article-title":"Environmental tobacco smoke \u2014 a major preventable cause of impaired health at work","volume":"28","author":"Zitting","year":"2002","journal-title":"Scand J Work Environ Health"},{"key":"10.1016\/j.intimp.2007.07.013_bib3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/humu.10177","article-title":"The TP53 gene, tobacco exposure, and lung cancer","volume":"21","author":"Toyooka","year":"2003","journal-title":"Hum Mutat"},{"key":"10.1016\/j.intimp.2007.07.013_bib4","doi-asserted-by":"crossref","first-page":"6898","DOI":"10.1038\/sj.onc.1205563","article-title":"The p53 network in lung carcinogenesis","volume":"21","author":"Robles","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.intimp.2007.07.013_bib5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S1535-6108(02)00102-2","article-title":"The RB and p53 pathways in cancer","volume":"2","author":"Sherr","year":"2002","journal-title":"Cancer Cell"},{"key":"10.1016\/j.intimp.2007.07.013_bib6","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1093\/carcin\/20.8.1403","article-title":"How many tumor suppressor genes are involved in human lung carcinogenesis?","volume":"20","author":"Kohno","year":"1999","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.intimp.2007.07.013_bib7","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.semcancer.2004.04.002","article-title":"The inhibitor of apoptosis protein family (IAPs): an emerging therapeutic target in cancer","volume":"14","author":"Nachmias","year":"2004","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.intimp.2007.07.013_bib8","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00262-003-0474-8","article-title":"Apoptosis pathway in cancer and cancer therapy","volume":"55","author":"Debatin","year":"2004","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.intimp.2007.07.013_bib9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0009-8981(02)00297-8","article-title":"Apoptosis: biochemical aspects and clinical implications","volume":"326","author":"Kiechle","year":"2002","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.intimp.2007.07.013_bib10","first-page":"27","article-title":"Exploiting death receptor signaling pathways for tumor therapy","volume":"1705","author":"Fulda","year":"2004","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.intimp.2007.07.013_bib11","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1136\/bmj.328.7455.1529","article-title":"The mortality of doctors in relation to their smoking habits: a preliminary report","volume":"328","author":"Doll","year":"1954","journal-title":"Br Med J"},{"key":"10.1016\/j.intimp.2007.07.013_bib12","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1136\/bmj.309.6959.901","article-title":"Mortality in relation to smoking: 40\u00a0years' observations on male British doctors","volume":"309","author":"Doll","year":"1994","journal-title":"BMJ"},{"key":"10.1016\/j.intimp.2007.07.013_bib13","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/sj.bjc.6602359","article-title":"Mortality from cancer in relation to smoking: 50\u00a0years observations on British doctors","volume":"92","author":"Doll","year":"2005","journal-title":"Br J Cancer"},{"key":"10.1016\/j.intimp.2007.07.013_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lungcan.2004.10.009","article-title":"Lung cancer in women","volume":"48","author":"Pauk","year":"2005","journal-title":"Lung Cancer"},{"key":"10.1016\/j.intimp.2007.07.013_bib15","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1378\/chest.120.5.1577","article-title":"Effect of smoking cessation on major histologic types of lung cancer","volume":"120","author":"Khuder","year":"2001","journal-title":"Chest"},{"key":"10.1016\/j.intimp.2007.07.013_bib16","first-page":"3","article-title":"Environmental tobacco smoke \u2014 a major preventable cause of impaired health at work","volume":"28","author":"Zitting","year":"2002","journal-title":"Scand J Work Environ Health"},{"key":"10.1016\/j.intimp.2007.07.013_bib17","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/annhyg\/44.8.565","article-title":"The quantitative risks of mesothelioma and lung cancer in relation to asbestos exposure","volume":"44","author":"Hodgson","year":"2000","journal-title":"Ann Occup Hyg"},{"key":"10.1016\/j.intimp.2007.07.013_bib18","first-page":"6392","article-title":"Epidemiology of environmental and occupational cancer","volume":"23","author":"Boffetta","year":"2004","journal-title":"Oncology"},{"key":"10.1016\/j.intimp.2007.07.013_bib19","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1183\/09031936.01.00275301","article-title":"The new World Health Organization classification of lung tumours","volume":"18","author":"Brambilla","year":"2001","journal-title":"Eur Respir J"},{"key":"10.1016\/j.intimp.2007.07.013_bib20","series-title":"World Health Organization Classification of Tumours","first-page":"9","article-title":"Pathology and genetics of tumours of the lung, pleura, thymus and heart","author":"Travis","year":"2004"},{"key":"10.1016\/j.intimp.2007.07.013_bib21","doi-asserted-by":"crossref","first-page":"80S","DOI":"10.1378\/chest.117.4_suppl_1.80S","article-title":"Diagnosis of lung cancer: pathology of invasive and preinvasive neoplasia","volume":"117","author":"Franklin","year":"2000","journal-title":"Chest"},{"key":"10.1016\/j.intimp.2007.07.013_bib22","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1097\/00000478-200307000-00009","article-title":"Lung adenocarcinoma with mixed bronchioloalveolar and invasive components: clinicopathological features, subclassification by extent of invasive foci, and immunohistochemical characterization","volume":"27","author":"Terasaki","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.intimp.2007.07.013_bib23","first-page":"199","article-title":"Immunohistochemical study of p53 in human lung carcinomas","volume":"143","author":"Brambilla","year":"1993","journal-title":"Am J Pathol"},{"key":"10.1016\/j.intimp.2007.07.013_bib24","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/1097-0142(20000625)90:3<148::AID-CNCR3>3.0.CO;2-9","article-title":"A review of cytologic findings in neuroendocrine carcinomas including carcinoid tumors with histologic correlation","volume":"90","author":"Nicholson","year":"2000","journal-title":"Cancer"},{"key":"10.1016\/j.intimp.2007.07.013_bib25","first-page":"S5","article-title":"The neuroendocrine system and its tumors: an overview","volume":"115","author":"DeLellis","year":"2001","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.intimp.2007.07.013_bib26","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1080\/019021401317138487","article-title":"Differential regulation of calcitonin secretion in normal and neoplastic pulmonary neuroendocrine cells in vitro","volume":"27","author":"Pu","year":"2001","journal-title":"Exp Lung Res"},{"key":"10.1016\/j.intimp.2007.07.013_bib27","first-page":"138","article-title":"Divergent differentiation in neuroendocrine lung tumors","volume":"17","author":"Brambilla","year":"2000","journal-title":"Semin Diagn Pathol"},{"key":"10.1016\/j.intimp.2007.07.013_bib28","first-page":"211","article-title":"Bronchopulmonary carcinoids: an analysis of 1875 reported cases with special reference to a comparison between typical carcinoids and atypical varieties","volume":"5","author":"Soga","year":"1999","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"10.1016\/j.intimp.2007.07.013_bib29","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1093\/ajcp\/92.5.566","article-title":"Immunohistochemical differentiation of sarcomatoid mesotheliomas from other spindle cell neoplasms","volume":"92","author":"Cagle","year":"1989","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.intimp.2007.07.013_bib30","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1136\/thorax.58.10.892","article-title":"Lung cancer. 9: molecular biology of lung cancer: clinical implications","volume":"58","author":"Fong","year":"2003","journal-title":"Thorax"},{"key":"10.1016\/j.intimp.2007.07.013_bib31","first-page":"1949","article-title":"High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic\/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints","volume":"60","author":"Wistuba","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.intimp.2007.07.013_bib32","first-page":"4894","article-title":"Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering","volume":"60","author":"Girard","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.intimp.2007.07.013_bib33","doi-asserted-by":"crossref","first-page":"6915","DOI":"10.1038\/sj.onc.1205835","article-title":"Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers","volume":"21","author":"Zabarovsky","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.intimp.2007.07.013_bib34","first-page":"450","article-title":"Comparative genomic hybridization and loss of heterozygosity analyses identify a common region of deletion at 15q11.1-15 in human malignant mesothelioma","volume":"59","author":"Balsara","year":"1999","journal-title":"Cancer Res"},{"key":"10.1016\/j.intimp.2007.07.013_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2003.08.005","article-title":"Genealogy, expression, and molecular mechanisms in apoptosis","volume":"101","author":"Dlamini","year":"2004","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.intimp.2007.07.013_bib36","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1101\/gad.12.19.2973","article-title":"The complexity of p53 modulation: emerging patterns from divergent signals","volume":"12","author":"Giaccia","year":"1998","journal-title":"Genes Dev"},{"key":"10.1016\/j.intimp.2007.07.013_bib37","first-page":"993","article-title":"MDM2, an introduction","volume":"1","author":"Iwakuma","year":"2003","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.intimp.2007.07.013_bib38","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1158\/1541-7786.20.2.1","article-title":"Inhibition of the p53-MDM2 interaction: targeting a protein\u2013protein interface","volume":"2","author":"Ch\u00e8ne","year":"2004","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.intimp.2007.07.013_bib39","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1021\/jm990966p","article-title":"Discovery of potent antagonists of the interaction between human double minute 2 and tumor suppressor p53","volume":"43","author":"Garcia-Echeverria","year":"2000","journal-title":"Med Chem"},{"key":"10.1016\/j.intimp.2007.07.013_bib40","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1016\/j.ejca.2005.08.009","article-title":"Tumour suppressor retinoblastoma protein Rb: a transcriptional regulator","volume":"41","author":"Zhu","year":"2005","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.intimp.2007.07.013_bib41","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/ijc.2910580612","article-title":"Loss of heterozygosity at the RB locus correlates with loss of RB protein in primary malignant neuro-endocrine lung carcinomas","volume":"58","author":"Gouyer","year":"1994","journal-title":"Int J Cancer"},{"key":"10.1016\/j.intimp.2007.07.013_bib42","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.semcancer.2004.08.005","article-title":"Origins and selection of p53 mutations in lung carcinogenesis","volume":"15","author":"Rodin","year":"2005","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.intimp.2007.07.013_bib43","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.bbrc.2005.03.192","article-title":"The role of p53 in treatment responses of lung cancer","volume":"331","author":"Viktorsson","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.intimp.2007.07.013_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0027-5107(02)00106-9","article-title":"On the origin of p53 G:C\u2192T:A transversions in lung cancers","volume":"508","author":"Rodin","year":"2000","journal-title":"Mutat Res"},{"key":"10.1016\/j.intimp.2007.07.013_bib45","doi-asserted-by":"crossref","first-page":"7435","DOI":"10.1038\/sj.onc.1205803","article-title":"Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers","volume":"21","author":"Pfeifer","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.intimp.2007.07.013_bib46","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.bbrc.2005.03.189","article-title":"The transcriptional targets of p53 in apoptosis control","volume":"331","author":"Yu","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.intimp.2007.07.013_bib47","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1586\/14737140.6.4.515","article-title":"Regulation of the G1\/S phase of the cell cycle and alterations in the RB pathway in human lung cancer","volume":"6","author":"Wikman","year":"2006","journal-title":"Expert Rev Anticancer Ther"},{"key":"10.1016\/j.intimp.2007.07.013_bib48","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/(SICI)1096-9896(199908)188:4<351::AID-PATH385>3.0.CO;2-W","article-title":"Alterations of expression of Rb, p16(INK4A) and cyclin D1 in non-small cell lung carcinoma and their clinical significance","volume":"188","author":"Brambilla","year":"1999","journal-title":"J Pathol"},{"key":"10.1016\/j.intimp.2007.07.013_bib49","first-page":"2197","article-title":"Transcriptional activation plays a role in the induction of apoptosis by transiently transfected wild-type p53","volume":"11","author":"Yonish-Rouach","year":"1995","journal-title":"Oncogene"},{"key":"10.1016\/j.intimp.2007.07.013_bib50","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/mc.2940110202","article-title":"Evidence for a p53-independent pathway for upregulation of SDI1\/CIP1\/WAF1\/p21 RNA in human cells","volume":"11","author":"Johnson","year":"1994","journal-title":"Mol Carcinog"},{"key":"10.1016\/j.intimp.2007.07.013_bib51","doi-asserted-by":"crossref","first-page":"16000","DOI":"10.1074\/jbc.M312264200","article-title":"MDM2 is a negative regulator of p21 WAFI\/CIPI, independent of p53","volume":"276","author":"Zhang","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.intimp.2007.07.013_bib52","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S1535-6108(03)00244-7","article-title":"Puma is an essential mediator of p53-dependent and-independent apoptotic pathways","volume":"4","author":"Jeffers","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.intimp.2007.07.013_bib53","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1073\/pnas.2627984100","article-title":"PUMA mediates the apoptotic response to p53 in colorectal cancer cells","volume":"100","author":"Yu","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.intimp.2007.07.013_bib54","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.bbrc.2005.03.189","article-title":"The transcriptional targets of p53 in apoptosis control","volume":"331","author":"Yu","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.intimp.2007.07.013_bib55","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nrc883","article-title":"The Bcl2 family: regulators of the cellular life- or-death switch","volume":"2","author":"Cory","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.intimp.2007.07.013_bib56","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/416560a","article-title":"p63 and p73 are required for p53-dependent apoptosis in response to DNA damage","volume":"416","author":"Flores","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2007.07.013_bib57","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.canlet.2005.10.001","article-title":"Triptolide induces Bcl-2 cleavage and mitochondria dependent apoptosis in p53-deficient HL-60 cells","volume":"241","author":"Wan","year":"2006","journal-title":"Cancer Lett"},{"key":"10.1016\/j.intimp.2007.07.013_bib58","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0006-2952(03)00254-5","article-title":"Investigation of anticancer mechanism of thiadiazole-based compound in human non-small cell lung cancer A549 cells","volume":"66","author":"Chou","year":"2003","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.intimp.2007.07.013_bib59","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/mthe.2002.0648","article-title":"Adenovirus-mediated transfer of BAX driven by the vascular endothelial growth factor promoter induces apoptosis in lung cancer cells","volume":"6","author":"Kaliberov","year":"2002","journal-title":"Mol Ther"},{"key":"10.1016\/j.intimp.2007.07.013_bib60","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.abb.2004.02.038","article-title":"Modulation of apoptotic signalling by carotenoids in cancer cells","volume":"430","author":"Palozza","year":"2004","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.intimp.2007.07.013_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3260001","article-title":"Caspases: the executioners of apoptosis","volume":"326","author":"Cohen","year":"1997","journal-title":"Biochem J"},{"key":"10.1016\/j.intimp.2007.07.013_bib62","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/35037710","article-title":"The biochemistry of apoptosis","volume":"407","author":"Hengartner","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2007.07.013_bib63","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.ceb.2003.10.009","article-title":"Mechanisms of caspase activation","volume":"15","author":"Boatright","year":"2003","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.intimp.2007.07.013_bib64","doi-asserted-by":"crossref","first-page":"6914","DOI":"10.1093\/emboj\/16.23.6914","article-title":"The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases","volume":"16","author":"Roy","year":"1997","journal-title":"EMBO J"},{"key":"10.1016\/j.intimp.2007.07.013_bib65","doi-asserted-by":"crossref","first-page":"48168","DOI":"10.1074\/jbc.M405022200","article-title":"Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors","volume":"279","author":"Wang","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.intimp.2007.07.013_bib66","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1042\/bj20030583","article-title":"Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein","volume":"373","author":"Shin","year":"2003","journal-title":"Biochem J"},{"key":"10.1016\/j.intimp.2007.07.013_bib67","doi-asserted-by":"crossref","first-page":"14401","DOI":"10.1074\/jbc.M210133200","article-title":"Peptides targeting caspase inhibitors","volume":"278","author":"Tamm","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.intimp.2007.07.013_bib68","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1042\/BJ20041108","article-title":"Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP","volume":"385","author":"Vucic","year":"2005","journal-title":"Biochem J"},{"key":"10.1016\/j.intimp.2007.07.013_bib69","first-page":"831","article-title":"Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptide","volume":"63","author":"Yang","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.intimp.2007.07.013_bib70","doi-asserted-by":"crossref","first-page":"8223","DOI":"10.1021\/bi034227t","article-title":"Structure and function analysis of peptide antagonists of melanoma inhibitor of apoptosis (ML-IAP)","volume":"42","author":"Franklin","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.intimp.2007.07.013_bib71","first-page":"117","article-title":"Apoptosis regulators","volume":"7","author":"Harada","year":"2003","journal-title":"Rev Clin Exp Hematol"},{"key":"10.1016\/j.intimp.2007.07.013_bib72","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/jcp.10327","article-title":"Survivin study: what is the next wave?","volume":"197","author":"Li","year":"2003","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.intimp.2007.07.013_bib73","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nm0897-917","article-title":"A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma","volume":"3","author":"Ambrosini","year":"1997","journal-title":"Nat Med"},{"key":"10.1016\/j.intimp.2007.07.013_bib74","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.lungcan.2004.05.002","article-title":"Expression of survivin mRNA and living mRNA in non-small-cell lung cancer","volume":"46","author":"Tanabe","year":"2004","journal-title":"Lung Cancer"},{"key":"10.1016\/j.intimp.2007.07.013_bib75","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.lungcan.2005.03.037","article-title":"Differential expression of survivin-2B and survivin-DeltaEx3 is inversely associated with disease relapse and patient survival in non-small-cell lung cancer (NSCLC)","volume":"49","author":"Ling","year":"2005","journal-title":"Lung Cancer"},{"key":"10.1016\/j.intimp.2007.07.013_bib76","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.lungcan.2004.10.017","article-title":"Tumor specific expression of survivin-2B in lung cancer as a novel target of immunotherapy","volume":"48","author":"Ichiki","year":"2005","journal-title":"Lung Cancer"},{"key":"10.1016\/j.intimp.2007.07.013_bib77","doi-asserted-by":"crossref","first-page":"6702","DOI":"10.1038\/sj.onc.1207630","article-title":"Sensitization for anticancer drug-induced apoptosis by the chemopreventive agent resveratrol","volume":"23","author":"Fulda","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.intimp.2007.07.013_bib78","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/35037728","article-title":"CD95's deadly mission in the immune system","volume":"407","author":"Krammer","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2007.07.013_bib79","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cellsig.2003.08.007","article-title":"Death receptor-induced cell killing","volume":"16","author":"Thorburn","year":"2004","journal-title":"Cell Signal"},{"key":"10.1016\/j.intimp.2007.07.013_bib80","doi-asserted-by":"crossref","first-page":"22522","DOI":"10.1074\/jbc.M010505200","article-title":"The cytokines tumor necrosis factor-alpha (TNF-alpha) and TNF-related apoptosis-inducing ligand differentially modulate proliferation and apoptotic pathways in human keratinocytes expressing the human papillomavirus-16 E7 oncoprotein","volume":"276","author":"Basile","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.intimp.2007.07.013_bib81","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.1074\/jbc.271.9.4961","article-title":"FADD\/MORT1 is a common mediator of CD95 (Fas\/Apo-1) and tumor necrosis factor receptor-induced apoptosis","volume":"271","author":"Chinnaiyan","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.intimp.2007.07.013_bib82","doi-asserted-by":"crossref","first-page":"550","DOI":"10.4161\/cc.2.6.566","article-title":"Death receptor activation complexes: it takes two to activate TNF receptor 1","volume":"2","author":"Sheikh","year":"2003","journal-title":"Cell Cycle"},{"key":"10.1016\/j.intimp.2007.07.013_bib83","doi-asserted-by":"crossref","first-page":"6910","DOI":"10.1038\/sj.onc.1203238","article-title":"Control of apoptosis by Rel\/NF-kappaB transcription factors","volume":"18","author":"Barkett","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.intimp.2007.07.013_bib84","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1172\/JCI26322","article-title":"IKK\/NF-kappaB signaling: balancing life and death \u2014 a new approach to cancer therapy","volume":"115","author":"Luo","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.intimp.2007.07.013_bib85","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/S0003-4975(00)01635-0","article-title":"Inhibition of NF-kappaB sensitizes non-small cell lung cancer cells to chemotherapy-induced apoptosis","volume":"70","author":"Jones","year":"2000","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.intimp.2007.07.013_bib86","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.lungcan.2003.11.017","article-title":"Fundamental principals of tumor necrosis factor-alpha gene therapy approach and implications for patients with lung carcinoma","volume":"44","author":"Sanglioglu","year":"2004","journal-title":"Lung Cancer"},{"key":"10.1016\/j.intimp.2007.07.013_bib87","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0304-3835(00)00529-2","article-title":"Human tumor necrosis factor-alpha mutant RGD-V29 (F4614) shows potent antitumor activity and reduced toxicity against human tumor xenografted nude mice","volume":"159","author":"Kuroda","year":"2000","journal-title":"Cancer Lett"},{"key":"10.1016\/j.intimp.2007.07.013_bib88","first-page":"1741","article-title":"Human pancreatic adenocarcinomas express Fas and Fas ligand yet are resistant to Fas-mediated apoptosis","volume":"58","author":"Ungefroren","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/j.intimp.2007.07.013_bib89","first-page":"3449","article-title":"Cellular predictive factors for the drug response of lung cancer","volume":"20","author":"Volm","year":"2000","journal-title":"Anticancer Res"},{"key":"10.1016\/j.intimp.2007.07.013_bib90","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.cdp.2004.09.001","article-title":"Soluble Fas and Fas ligand provide new information on metastasis and response to chemotherapy in SCLC patients","volume":"29","author":"Shimizu","year":"2005","journal-title":"Cancer Detect Prev"},{"key":"10.1016\/j.intimp.2007.07.013_bib91","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/S0022-5223(02)73227-3","article-title":"Fas-associating death domain protein overexpression induces apoptosis in lung cancer cells","volume":"125","author":"Kim","year":"2003","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.intimp.2007.07.013_bib92","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1006\/bbrc.2000.4218","article-title":"Overexpression of Bcl-2 blocks TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human lung cancer cells","volume":"280","author":"Sun","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.intimp.2007.07.013_bib93","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/sj.neo.7900203","article-title":"TRAIL\/Apo-2L: mechanisms and clinical applications in cancer","volume":"3","author":"Srivastava","year":"2001","journal-title":"Neoplasia"},{"key":"10.1016\/j.intimp.2007.07.013_bib94","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1158\/0008-5472.CAN-03-1656","article-title":"Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chomopreventive agent resveratrol","volume":"64","author":"Fulda","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.intimp.2007.07.013_bib95","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1074\/jbc.M009713200","article-title":"Triptolide and chemotherapy cooperate in tumor cell apoptosis. A role for the p53 pathway","volume":"276","author":"Chang","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.intimp.2007.07.013_bib96","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/emm.2002.64","article-title":"Triptolide sensitizes lung cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by inhibition of NF-\u03baB activation","volume":"34","author":"Lee","year":"2002","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.intimp.2007.07.013_bib97","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.canlet.2005.10.001","article-title":"Triptolide induces Bcl-2 cleavage and mitochondria dependent apoptosis in p53-deficient HL-60 cells","volume":"241","author":"Wan","year":"2006","journal-title":"Cancer Lett"},{"key":"10.1016\/j.intimp.2007.07.013_bib98","doi-asserted-by":"crossref","first-page":"E41","DOI":"10.1038\/35004069","article-title":"Cytochrome c release from mitochondria: all or nothing","volume":"2","author":"Martinou","year":"2000","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.intimp.2007.07.013_bib99","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1042\/0264-6021:3410233","article-title":"The mitochondrial permeability transition pore and its role in cell death","volume":"34","author":"Crompton","year":"1999","journal-title":"Biochem J"},{"key":"10.1016\/j.intimp.2007.07.013_bib100","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1126\/science.1092734","article-title":"Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis","volume":"303","author":"Chipuk","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.intimp.2007.07.013_bib101","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.lungcan.2004.01.021","article-title":"Expression of p53 protein and the apoptotic regulatory molecules Bcl-2, Bcl-XL, and Bax in locally advanced squamous cell carcinoma of the lung","volume":"45","author":"Shabnam","year":"2004","journal-title":"Lung Cancer"},{"key":"10.1016\/j.intimp.2007.07.013_bib102","doi-asserted-by":"crossref","first-page":"7611","DOI":"10.1038\/sj.onc.1207970","article-title":"Cooperation of betulinic acid and TRAIL to induce apoptosis in tumor cells","volume":"23","author":"Fulda","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.intimp.2007.07.013_bib103","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1593\/neo.04442","article-title":"Sensitization for anticancer drug-induced apoptosis by betulinic acid","volume":"7","author":"Fulda","year":"2005","journal-title":"Neoplasia"},{"key":"10.1016\/j.intimp.2007.07.013_bib104","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1517\/14796694.1.3.339","article-title":"Can targeting apoptosis resolve the cancer saga","volume":"1","author":"Dlamini","year":"2005","journal-title":"Future Oncol"},{"key":"10.1016\/j.intimp.2007.07.013_bib105","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s00280-002-0522-7","article-title":"Current status of the molecular mechanisms of anticancer drug-induced apoptosis. The contribution of molecular-level analysis to cancer chemotherapy","volume":"50","author":"Kim","year":"2002","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.intimp.2007.07.013_bib106","first-page":"11","article-title":"Apoptosis mechanisms: implications for cancer drug discovery","volume":"18","author":"Reed","year":"2004","journal-title":"Oncology"},{"key":"10.1016\/j.intimp.2007.07.013_bib107","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1067\/mtc.2003.180","article-title":"Enhancement of depsipeptide-mediated apoptosis of lung or esophageal cancer cells by flavopiridol: activation of the mitochondria-dependent death-signaling pathway","volume":"125","author":"Nguyen","year":"2003","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.intimp.2007.07.013_bib108","first-page":"3920","article-title":"A phase I dose-finding study of combined treatment with an antisense Bcl-2 oligonucleotide (Genasense) and mitoxantrone in patients with metastatic hormone-refractory prostate cancer","volume":"7","author":"Chi","year":"2001","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.intimp.2007.07.013_bib109","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nature03579","article-title":"An inhibitor of Bcl-2 family proteins induces regression of solid tumours","volume":"435","author":"Oltersdorf","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2007.07.013_bib110","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/S0169-5002(05)81549-1","article-title":"A ten-year review of progress in the treatment of non-small-cell lung cancer with gemcitabine","volume":"1","author":"Natale","year":"2005","journal-title":"Lung Cancer"},{"key":"10.1016\/j.intimp.2007.07.013_bib111","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/ijc.1628","article-title":"Expression of a non-functional p53 affects the sensitivity of cancer cells to gemcitabine","volume":"97","author":"Galmarini","year":"2002","journal-title":"Int J Cancer"},{"key":"10.1016\/j.intimp.2007.07.013_bib112","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ejphar.2004.09.006","article-title":"Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway","volume":"502","author":"Chang","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.intimp.2007.07.013_bib113","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1038\/sj.onc.1206390","article-title":"Role of NF-kappaB and Akt\/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death","volume":"22","author":"Arlt","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.intimp.2007.07.013_bib114","first-page":"407","article-title":"Polymorphism of the p53 gene within the codon 72 in lung cancer patients","volume":"48","author":"Biro\u0161","year":"2001","journal-title":"Neoplasma"},{"key":"10.1016\/j.intimp.2007.07.013_bib115","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0169-5002(00)00188-4","article-title":"Germ line polymorphisms of the tumor suppressor gene p53 and lung cancer","volume":"31","author":"Biro\u0161","year":"2001","journal-title":"Lung Cancer"},{"key":"10.1016\/j.intimp.2007.07.013_bib116","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/sj.onc.1207239","article-title":"Induction of p53-regulated genes in lung cancer cells: implications of the mechanism for adenoviral p53-mediated apoptosis","volume":"23","author":"Gu","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.intimp.2007.07.013_bib117","doi-asserted-by":"crossref","first-page":"5359","DOI":"10.1038\/sj.onc.1203935","article-title":"Adenovirus-mediated p16INK4a gene expression radiosensitizes non-small cell lung cancer cells in a p53-dependent manner","volume":"19","author":"Kawabe","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.intimp.2007.07.013_bib118","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.cell.2005.06.004","article-title":"Stem cells for lung cancer?","volume":"121","author":"Berns","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2007.07.013_bib119","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cell.2005.03.032","article-title":"Identification of bronchioalveolar stem cells in normal lung and lung cancer","volume":"121","author":"Kim","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2007.07.013_bib120","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/nm1379","article-title":"Roots and stems: stem cells in cancer","volume":"12","author":"Polyak","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.intimp.2007.07.013_bib121","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.gde.2005.12.008","article-title":"Stem cells in the etiology and treatment of cancer","volume":"16","author":"Zhang","year":"2006","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.intimp.2007.07.013_bib122","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.tibtech.2004.12.004","article-title":"In situ stem cell therapy: novel targets, familiar challenges","volume":"23","author":"Agrawal","year":"2005","journal-title":"Trends Biotech"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576907002007?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576907002007?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T16:57:15Z","timestamp":1683997035000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576907002007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":122,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["S1567576907002007"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2007.07.013","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}