{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T04:44:52Z","timestamp":1785386692499,"version":"3.55.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1016\/j.intimp.2007.08.019","type":"journal-article","created":{"date-parts":[[2007,9,17]],"date-time":"2007-09-17T12:21:45Z","timestamp":1190031705000},"page":"1651-1658","source":"Crossref","is-referenced-by-count":31,"title":["Topical application of silymarin reduces chemical-induced irritant contact dermatitis in BALB\/c mice"],"prefix":"10.1016","volume":"7","author":[{"given":"Mi Hwa","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Kee","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunju","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Bae","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song-Kyu","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu-Hwan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwan Mook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Soon","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2007.08.019_bib1","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.jaad.2005.04.075","article-title":"A systematic review of contact dermatitis treatment and prevention","volume":"53","author":"Saary","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.intimp.2007.08.019_bib2","first-page":"327","article-title":"Occupational dermatoses","volume":"34","author":"Nixon","year":"2005","journal-title":"Aust Fam Physician"},{"key":"10.1016\/j.intimp.2007.08.019_bib3","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/PL00012416","article-title":"Vitamin E ointment at high dose levels suppresses contact dermatitis in rats by stabilizing keratinocytes","volume":"51","author":"Kuriyama","year":"2002","journal-title":"Inflamm Res"},{"key":"10.1016\/j.intimp.2007.08.019_bib4","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1055\/s-2005-864137","article-title":"Topical application of luteolin inhibits scratching behavior associated with allergic cutaneous reaction in mice","volume":"71","author":"Baolin","year":"2005","journal-title":"Planta Med"},{"key":"10.1016\/j.intimp.2007.08.019_bib5","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1006\/taap.1995.1232","article-title":"Neuropeptide modulation of chemically induced skin irritation","volume":"135","author":"Veronesi","year":"1995","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.intimp.2007.08.019_bib6","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1600-0536.1994.tb00598.x","article-title":"Topical application of artesunate on guinea pig allergic contact dermatitis","volume":"30","author":"Chen","year":"1994","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.intimp.2007.08.019_bib7","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.0022-202X.2005.23831.x","article-title":"Topical application of a novel immunomodulatory peptide, RDP58, reduces skin inflammation in the phorbol ester-induced dermatitis model","volume":"125","author":"De Vry","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.intimp.2007.08.019_bib8","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1172\/JCI114907","article-title":"Immune and inflammatory processes in cutaneous tissues. Mechanisms and speculations","volume":"86","author":"Kupper","year":"1990","journal-title":"J Clin Invest"},{"key":"10.1016\/j.intimp.2007.08.019_bib9","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1023\/A:1015868809990","article-title":"Protection against microcystin-LR-induced hepatotoxicity by Silymarin: biochemistry, histopathology, and lethality","volume":"8","author":"Mereish","year":"1991","journal-title":"Pharm Res"},{"key":"10.1016\/j.intimp.2007.08.019_bib10","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/0006-2952(92)90168-I","article-title":"Lipid peroxidation and irreversible damage in the rat hepatocyte model. Protection by the silybin-phospholipid complex IdB 1016","volume":"43","author":"Carini","year":"1992","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.intimp.2007.08.019_bib11","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/s000180050111","article-title":"Silibinin, a plant extract with antioxidant and membrane stabilizing properties, protects exocrine pancreas from cyclosporin A toxicity","volume":"53","author":"von Schonfeld","year":"1997","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.intimp.2007.08.019_bib12","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1002\/hep.510230415","article-title":"Inhibition of Kupffer cell functions as an explanation for the hepatoprotective properties of silibinin","volume":"23","author":"Dehmlow","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2007.08.019_bib13","first-page":"4457","article-title":"Anticancer potential of silymarin: from bench to bed side","volume":"26","author":"Agarwal","year":"2006","journal-title":"Anticancer Res"},{"key":"10.1016\/j.intimp.2007.08.019_bib14","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1124\/jpet.302.1.138","article-title":"Inhibition of inducible nitric-oxide synthase expression by silymarin in lipopolysaccharide-stimulated macrophages","volume":"302","author":"Kang","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.intimp.2007.08.019_bib15","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1093\/carcin\/bgi096","article-title":"Silibinin inhibits ultraviolet B radiation-induced mitogenic and survival signaling, and associated biological responses in SKH-1 mouse skin","volume":"26","author":"Gu","year":"2005","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.intimp.2007.08.019_bib16","doi-asserted-by":"crossref","first-page":"6349","DOI":"10.1158\/0008-5472.CAN-04-1632","article-title":"Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling","volume":"64","author":"Mallikarjuna","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.intimp.2007.08.019_bib17","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.bcp.2005.10.009","article-title":"Estrogen receptor-independent inhibition of tumor necrosis factor-\u03b1 gene expression by phytoestrogen equol is mediated by blocking nuclear factor-\u03baB activation in mouse macrophages","volume":"71","author":"Kang","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.intimp.2007.08.019_bib18","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1006\/abio.1995.1126","article-title":"Substitution of chloroform by bromo-chloropropane in the single-step method of RNA isolation","volume":"225","author":"Chomczynski","year":"1995","journal-title":"Anal Biochem"},{"key":"10.1016\/j.intimp.2007.08.019_bib19","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1080\/10715760600868552","article-title":"Inhibitory effect of peroxiredoxin II (Prx II) on Ras-ERK-NF-\u03baB pathway in mouse embryonic fibroblast (MEF) senescence","volume":"40","author":"Han","year":"2006","journal-title":"Free Radic Res"},{"key":"10.1016\/j.intimp.2007.08.019_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-9255-2-1","article-title":"Suppression of neutrophil accumulation in mice by cutaneous application of geranium essential oil","volume":"2","author":"Maruyama","year":"2005","journal-title":"J Inflam (Lond)"},{"key":"10.1016\/j.intimp.2007.08.019_bib21","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1615\/CritRevImmunol.v26.i4.20","article-title":"Neutrophil infiltration and chemokines","volume":"26","author":"Kobayashi","year":"2006","journal-title":"Crit Rev Immunol"},{"key":"10.1016\/j.intimp.2007.08.019_bib22","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0014-5793(03)00827-5","article-title":"Silymarin inhibits TNF-\u03b1-induced expression of adhesion molecules in human umbilical vein endothelial cells","volume":"550","author":"Kang","year":"2003","journal-title":"FEBS Lett"},{"key":"10.1016\/j.intimp.2007.08.019_bib23","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/346274a0","article-title":"Mast cells as a source of both preformed and immunologically inducible TNF-\u03b1\/cachectin","volume":"346","author":"Gordon","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2007.08.019_bib24","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1084\/jem.172.6.1609","article-title":"Human keratinocytes are a source for tumor necrosis factor \u03b1: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light","volume":"172","author":"Kock","year":"1990","journal-title":"J Exp Med"},{"key":"10.1016\/j.intimp.2007.08.019_bib25","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/jlb.45.5.429","article-title":"Activated Langerhans cells release tumor necrosis factor","volume":"45","author":"Larrick","year":"1989","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.intimp.2007.08.019_bib26","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/0190-9622(91)70102-8","article-title":"Tumor necrosis factor","volume":"24","author":"Wakefield","year":"1991","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.intimp.2007.08.019_bib27","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1365-2133.1995.tb08666.x","article-title":"Tumour necrosis factor \u03b1 is pro-inflammatory in normal human skin and modulates cutaneous adhesion molecule expression","volume":"132","author":"Groves","year":"1995","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.intimp.2007.08.019_bib28","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1084\/jem.173.3.673","article-title":"Tumor necrosis factor is a critical mediator in hapten induced irritant and contact hypersensitivity reactions","volume":"173","author":"Piguet","year":"1991","journal-title":"J Exp Med"},{"key":"10.1016\/j.intimp.2007.08.019_bib29","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bcp.2003.08.032","article-title":"Protection against lipopolysaccharide-induced sepsis and inhibition of interleukin-1\u03b2 and prostaglandin E2 synthesis by silymarin","volume":"67","author":"Kang","year":"2004","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.intimp.2007.08.019_bib30","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1023\/A:1016453009818","article-title":"In vivo and in vitro percutaneous absorption of cancer preventive flavonoid apigenin in different vehicles in mouse skin","volume":"13","author":"Li","year":"1996","journal-title":"Pharm Res"},{"key":"10.1016\/j.intimp.2007.08.019_bib31","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.bbrc.2003.11.109","article-title":"Costunolide inhibits interleukin-1\u03b2 expression by down-regulation of AP-1 and MAPK activity in LPS-stimulated RAW 264.7 cells","volume":"313","author":"Kang","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.intimp.2007.08.019_bib32","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1016\/S1567-5769(01)00113-8","article-title":"Suppression of IL-8 gene expression by radicicol is mediated through the inhibition of ERK1\/2 and p38 signaling and negative regulation of NF-\u03baB and AP-1","volume":"1","author":"Na","year":"2001","journal-title":"Int Immunopharmacol"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576907002627?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576907002627?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T02:34:30Z","timestamp":1556850870000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576907002627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":32,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["S1567576907002627"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2007.08.019","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}