{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:58:47Z","timestamp":1792547927344,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1016\/j.intimp.2007.11.008","type":"journal-article","created":{"date-parts":[[2008,1,7]],"date-time":"2008-01-07T12:55:52Z","timestamp":1199710552000},"page":"458-467","source":"Crossref","is-referenced-by-count":41,"title":["Polysaccharides from Antrodia camphorata mycelia extracts possess immunomodulatory activity and inhibits infection of Schistosoma mansoni"],"prefix":"10.1016","volume":"8","author":[{"given":"Yu-Jen","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Ching","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Nan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Fen","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Yawn","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Chu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kin-Mu","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2007.11.008_bib1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.canlet.2004.08.012","article-title":"Apoptotic effects of extract from Antrodia camphorata fruiting bodies in human hepatocellular carcinoma cell lines","volume":"221","author":"Hsu","year":"2005","journal-title":"Cancer Lett"},{"key":"10.1016\/j.intimp.2007.11.008_bib2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1207\/s15327914nc4802_9","article-title":"Induction of apoptosis by Antrodia camphorata in human premyelocytic leukemia HL-60 cells","volume":"48","author":"Hseu","year":"2004","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.intimp.2007.11.008_bib3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1574-6968.2002.tb11110.x","article-title":"Antrodia camphorata polysaccharides exhibit anti-hepatitis B virus effects","volume":"209","author":"Lee","year":"2002","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.intimp.2007.11.008_bib4","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0024-3205(02)01686-7","article-title":"Protection of oxidative damage by aqueous extract from Antrodia camphorata mycelia in normal human erythrocytes","volume":"71","author":"Hseu","year":"2002","journal-title":"Life Sci"},{"key":"10.1016\/j.intimp.2007.11.008_bib5","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0378-1097(03)00953-4","article-title":"Anti-inflammatory activity of the extracts from mycelia of Antrodia camphorata cultured with water-soluble fractions from five different Cinnamomum species","volume":"231","author":"Shen","year":"2004","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.intimp.2007.11.008_bib6","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1021\/jf0209701","article-title":"Protective effects of fermented filtrate from Antrodia camphorata in submerged culture against CCl4-induced hepatic toxicity in rats","volume":"51","author":"Song","year":"2003","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.intimp.2007.11.008_bib7","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1021\/jf021159t","article-title":"Antioxidative and hepatoprotective effects of Antrodia camphorata extract","volume":"51","author":"Hsiao","year":"2003","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.intimp.2007.11.008_bib8","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.taap.2004.05.016","article-title":"Antitumor effects of the partially purified polysaccharides from Antrodia camphorata and the mechanism of its action","volume":"201","author":"Liu","year":"2004","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.intimp.2007.11.008_bib9","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/32588","article-title":"Dendritic cells and the control of immunity","volume":"392","author":"Banchereau","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2007.11.008_bib10","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1182\/blood.V90.9.3245","article-title":"Dendritic cells: unique leukocyte populations which control the primary immune response","volume":"90","author":"Hart","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2007.11.008_bib11","doi-asserted-by":"crossref","first-page":"168","DOI":"10.4049\/jimmunol.162.1.168","article-title":"Generation of tumor immunity by bone marrow-derived dendritic cells correlates with dendritic cell maturation stage","volume":"162","author":"Labeur","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2007.11.008_bib12","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1006\/cimm.1997.1196","article-title":"Differential effects of LPS and CD40 ligand stimulations on the induction of IL-12 production by dendritic cells and macrophages","volume":"181","author":"Kato","year":"1997","journal-title":"Cell Immunol"},{"key":"10.1016\/j.intimp.2007.11.008_bib13","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1002\/eji.1830271209","article-title":"Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions","volume":"27","author":"Jonuleit","year":"1997","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.intimp.2007.11.008_bib14","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1084\/jem.184.2.747","article-title":"Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation","volume":"184","author":"Cella","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.intimp.2007.11.008_bib15","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1084\/jem.189.3.587","article-title":"CD8alpha+ and CD8alpha\u2212 subclasses of dendritic cells direct the development of distinct T helper cells in vivo","volume":"189","author":"Maldonado-Lopez","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.intimp.2007.11.008_bib16","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/89726","article-title":"Dendritic cell lineage, plasticity and cross-regulation","volume":"2","author":"Liu","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1016\/j.intimp.2007.11.008_bib17","first-page":"657","article-title":"Public health impact of schistosomiasis: disease and mortality","author":"Schistosomiasis WECotCo","year":"1993","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.intimp.2007.11.008_bib18","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri843","article-title":"The immunobiology of schistosomiasis","volume":"2","author":"Pearce","year":"2002","journal-title":"Nat Rev"},{"key":"10.1016\/j.intimp.2007.11.008_bib19","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1128\/IAI.70.2.427-433.2002","article-title":"Immunology of parasitic helminth infections","volume":"70","author":"MacDonald","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.intimp.2007.11.008_bib20","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1084\/jem.193.10.1135","article-title":"Role of the parasite-derived prostaglandin D2 in the inhibition of epidermal Langerhans cell migration during schistosomiasis infection","volume":"193","author":"Angeli","year":"2001","journal-title":"J Exp Med"},{"key":"10.1016\/j.intimp.2007.11.008_bib21","doi-asserted-by":"crossref","first-page":"4567","DOI":"10.4049\/jimmunol.165.8.4567","article-title":"A role for parasite-induced PGE2 in IL-10-mediated host immunoregulation by skin stage schistosomula of Schistosoma mansoni","volume":"165","author":"Ramaswamy","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2007.11.008_bib22","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1128\/IAI.73.1.395-402.2005","article-title":"Dendritic cells activated with products released by schistosome larvae drive Th2-type immune responses, which can be inhibited by manipulation of CD40 costimulation","volume":"73","author":"Jenkins","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.intimp.2007.11.008_bib23","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.4049\/jimmunol.173.2.1224","article-title":"CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development","volume":"173","author":"McKee","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2007.11.008_bib24","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1046\/j.1365-3024.2001.00423.x","article-title":"Defect of protective immunity to Schistosoma mansoni infection in Mongolian gerbils involves limited recruitment of dendritic cells in the vaccinated skin","volume":"23","author":"Sato","year":"2001","journal-title":"Parasite Immunol"},{"key":"10.1016\/j.intimp.2007.11.008_bib25","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.4049\/jimmunol.173.2.1240","article-title":"Schistosoma mansoni worms induce anergy of T cells via selective up-regulation of programmed death ligand 1 on macrophages","volume":"173","author":"Smith","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2007.11.008_bib26","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.vaccine.2003.07.010","article-title":"IL-12 enhances protective immunity in mice engendered by immunization with recombinant 14\u00a0kDa Schistosoma mansoni fatty acid-binding protein through an IFN-gamma and TNF-alpha dependent pathway","volume":"22","author":"Fonseca","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.intimp.2007.11.008_bib27","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1016\/S0264-410X(99)00555-1","article-title":"Protective immunity induced by the full-length cDNA encoding paramyosin of Chinese Schistosoma japonicum","volume":"18","author":"Zhou","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.intimp.2007.11.008_bib28","series-title":"Carbohydrate analysis : a practical approach","author":"Chaplin","year":"1994"},{"key":"10.1016\/j.intimp.2007.11.008_bib29","series-title":"Guideline on Validation of the Limulus Amebocyte Lysate test as an end-product endotoxin test for human and animal parenteral drugs, biological products, and medical devices","author":"U.S. Department of Health and Human Services, Public Health Service, Food and Drug Administration","year":"1987"},{"key":"10.1016\/j.intimp.2007.11.008_bib30","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/(SICI)1097-0215(19970317)70:6<699::AID-IJC12>3.0.CO;2-5","article-title":"The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes","volume":"70","author":"Wang","year":"1997","journal-title":"Int J Cancer"},{"key":"10.1016\/j.intimp.2007.11.008_bib31","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/08923970600809363","article-title":"Effects of oral administration of Phellinus linteus on the production of Th1- and Th2-type cytokines in mice","volume":"28","author":"Oh","year":"2006","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"10.1016\/j.intimp.2007.11.008_bib32","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/s00253-002-1076-7","article-title":"Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides","volume":"60","author":"Wasser","year":"2002","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.intimp.2007.11.008_bib33","first-page":"4","article-title":"The use of mushroom glucans and proteoglycans in cancer treatment","volume":"5","author":"Kidd","year":"2000","journal-title":"Altern Med Rev"},{"key":"10.1016\/j.intimp.2007.11.008_bib34","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1745-7254.2007.00500.x","article-title":"Modulation of inflammation-related genes of polysaccharides fractionated from mycelia of medicinal basidiomycete Antrodia camphorata","volume":"28","author":"Wu","year":"2007","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.intimp.2007.11.008_bib35","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1006\/expr.1996.0097","article-title":"Schistosoma mansoni: relationship of tumor necrosis factor-alpha to morbidity and collagen deposition in chronic experimental infection","volume":"84","author":"Adewusi","year":"1996","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.intimp.2007.11.008_bib36","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1084\/jem.176.1.47","article-title":"The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells","volume":"176","author":"Vremec","year":"1992","journal-title":"J Exp Med"},{"key":"10.1016\/j.intimp.2007.11.008_bib37","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/jlb.66.2.242","article-title":"Role of CD8alpha+ and CD8alpha\u2212 dendritic cells in the induction of primary immune responses in vivo","volume":"66","author":"Maldonado-Lopez","year":"1999","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.intimp.2007.11.008_bib38","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1189\/jlb.69.6.951","article-title":"CD8alpha(\u2212) and CD8alpha(+) subclasses of dendritic cells undergo phenotypic and functional maturation in vitro and in vivo","volume":"69","author":"De Smedt","year":"2001","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.intimp.2007.11.008_bib39","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.4049\/jimmunol.167.8.4345","article-title":"Cytokines regulate the capacity of CD8alpha(+) and CD8alpha(\u2212) dendritic cells to prime Th1\/Th2 cells in vivo","volume":"167","author":"Maldonado-Lopez","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2007.11.008_bib40","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/BF02986610","article-title":"Importance of CD4+ helper T-cells in antitumor immunity","volume":"77","author":"Shiku","year":"2003","journal-title":"Int J Hematol"},{"key":"10.1016\/j.intimp.2007.11.008_bib41","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1084\/jem.186.1.65","article-title":"Induction of a CD8+ cytotoxic T lymphocyte response by cross-priming requires cognate CD4+ T cell help","volume":"186","author":"Bennett","year":"1997","journal-title":"J Exp Med"},{"key":"10.1016\/j.intimp.2007.11.008_bib42","series-title":"Kuby immunology","author":"Kuby","year":"2000"},{"key":"10.1016\/j.intimp.2007.11.008_bib43","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1128\/IAI.69.1.271-280.2001","article-title":"Soluble egg antigen-stimulated T helper lymphocyte apoptosis and evidence for cell death mediated by FasL(+) T and B cells during murine Schistosoma mansoni infection","volume":"69","author":"Lundy","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.intimp.2007.11.008_bib44","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.0105-2896.2004.00187.x","article-title":"Th2 response polarization during infection with the helminth parasite Schistosoma mansoni","volume":"201","author":"Pearce","year":"2004","journal-title":"Immunol Rev"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576907003785?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576907003785?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T18:15:25Z","timestamp":1684174525000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576907003785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S1567576907003785"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2007.11.008","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}