{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:06:26Z","timestamp":1790229986275,"version":"4.1.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1016\/j.intimp.2008.06.004","type":"journal-article","created":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T06:43:40Z","timestamp":1214894620000},"page":"1475-1480","source":"Crossref","is-referenced-by-count":40,"title":["Inhibition of atopic dermatitis by topical application of silymarin in NC\/Nga mice"],"prefix":"10.1016","volume":"8","author":[{"given":"Jong Soon","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Kee","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Hwa","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunju","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Woo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Hoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Bae","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu-Hwan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song-Kyu","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwan Mook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2008.06.004_bib1","doi-asserted-by":"crossref","first-page":"S86","DOI":"10.1016\/j.jaad.2005.04.034","article-title":"Atopic dermatitis","volume":"53","author":"Abramovits","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.intimp.2008.06.004_bib2","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1046\/j.1365-2222.2003.01749.x","article-title":"Family history and risk of atopic dermatitis in children up to 4\u00a0years","volume":"33","author":"Bohme","year":"2003","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.intimp.2008.06.004_bib3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0091-6749(00)90171-4","article-title":"The environmental predictors of allergic disease","volume":"105","author":"von Mutius","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.intimp.2008.06.004_bib4","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1046\/j.1365-2133.2001.04135.x","article-title":"Environmental associations with eczema in early life","volume":"144","author":"Harris","year":"2001","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.intimp.2008.06.004_bib5","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1034\/j.1398-9995.2003.23790.x","article-title":"A mouse model of the atopic eczema\/dermatitis syndrome by repeated application of a crude extract of house-dust mite Dermatophagoides farinae","volume":"58","author":"Matsuoka","year":"2003","journal-title":"Allergy"},{"key":"10.1016\/j.intimp.2008.06.004_bib6","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jaci.2006.03.047","article-title":"Cytokines and chemokines orchestrate atopic skin inflammation","volume":"118","author":"Homey","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.intimp.2008.06.004_bib7","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/ni1158","article-title":"Mast cells in the development of adaptive immune responses","volume":"6","author":"Galli","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1016\/j.intimp.2008.06.004_bib8","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1023\/A:1015868809990","article-title":"Protection against microcystin-LR-induced hepatotoxicity by Silymarin: biochemistry, histopathology, and lethality","volume":"8","author":"Mereish","year":"1991","journal-title":"Pharm Res"},{"key":"10.1016\/j.intimp.2008.06.004_bib9","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/0006-2952(92)90168-I","article-title":"Lipid peroxidation and irreversible damage in the rat hepatocyte model. Protection by the silybin-phospholipid complex IdB 1016","volume":"43","author":"Carini","year":"1992","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.intimp.2008.06.004_bib10","first-page":"4457","article-title":"Anticancer potential of silymarin: from bench to bed side","volume":"26","author":"Agarwal","year":"2006","journal-title":"Anticancer Res"},{"key":"10.1016\/j.intimp.2008.06.004_bib11","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1124\/jpet.302.1.138","article-title":"Inhibition of inducible nitric-oxide synthase expression by silymarin in lipopolysaccharide-stimulated macrophages","volume":"302","author":"Kang","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.intimp.2008.06.004_bib12","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1093\/carcin\/bgi096","article-title":"Silibinin inhibits ultraviolet B radiation-induced mitogenic and survival signaling, and associated biological responses in SKH-1 mouse skin","volume":"26","author":"Gu","year":"2005","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.intimp.2008.06.004_bib13","doi-asserted-by":"crossref","first-page":"6349","DOI":"10.1158\/0008-5472.CAN-04-1632","article-title":"Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling","volume":"64","author":"Mallikarjuna","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.intimp.2008.06.004_bib14","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/j.intimp.2007.08.019","article-title":"Topical application of silymarin reduces chemical-induced irritant contact dermatitis in BALB\/c mice","volume":"7","author":"Han","year":"2007","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.intimp.2008.06.004_bib15","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bcp.2003.08.032","article-title":"Protection against lipopolysaccharide-induced sepsis and inhibition of interleukin-1\u03b2 and prostaglandin E2 synthesis by silymarin","volume":"67","author":"Kang","year":"2004","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.intimp.2008.06.004_bib16","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1016\/j.intimp.2006.06.011","article-title":"Induction of atopic eczema\/dermatitis syndrome-like skin lesions by repeated topical application of a crude extract of Dermatophagoides pteronyssinus in NC\/Nga mice","volume":"6","author":"Kang","year":"2006","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.intimp.2008.06.004_bib17","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1006\/abio.1995.1126","article-title":"Substitution of chloroform by bromo-chloropropane in the single-step method of RNA isolation","volume":"225","author":"Chomczynski","year":"1995","journal-title":"Anal Biochem"},{"key":"10.1016\/j.intimp.2008.06.004_bib18","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1159\/000049520","article-title":"Atopic dermatitis-like skin lesions induced by topical application of mite antigens in NC\/Nga mice","volume":"126","author":"Sasakawa","year":"2001","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.intimp.2008.06.004_bib19","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1248\/bpb.27.1376","article-title":"Establishment of allergic dermatitis in NC\/Nga mice as a model for severe atopic dermatitis","volume":"27","author":"Gao","year":"2004","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.intimp.2008.06.004_bib20","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1254\/jjp.76.175","article-title":"Effect of tacrolimus hydrate (FK506) ointment on spontaneous dermatitis in NC\/Nga mice","volume":"76","author":"Hiroi","year":"1998","journal-title":"Jpn J Pharmacol"},{"key":"10.1016\/j.intimp.2008.06.004_bib21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000076128","article-title":"Topical application of FK506 (tacrolimus) ointment inhibits mite antigen-induced dermatitis by local action in NC\/Nga mice","volume":"133","author":"Sasakawa","year":"2004","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.intimp.2008.06.004_bib22","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1006\/bbrc.1997.7375","article-title":"Novel cancer chemopreventive effects of a flavonoid antioxidant silymarin: inhibition of mRNA expression of an endogenous tumor promoter TNF \u03b1","volume":"239","author":"Zi","year":"1997","journal-title":"Biochem Biophys Res Commun"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576908001793?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576908001793?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T08:32:58Z","timestamp":1545899578000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576908001793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["S1567576908001793"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2008.06.004","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}