{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:38:19Z","timestamp":1790336299534,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1016\/j.intimp.2008.07.009","type":"journal-article","created":{"date-parts":[[2008,8,13]],"date-time":"2008-08-13T21:42:15Z","timestamp":1218663735000},"page":"1626-1632","source":"Crossref","is-referenced-by-count":82,"title":["Ginger prevents Th2-mediated immune responses in a mouse model of airway inflammation"],"prefix":"10.1016","volume":"8","author":[{"given":"Marie Louise Berthe","family":"Ahui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Champy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulraouf","family":"Ramadan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linh","family":"Pham Van","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza","family":"Araujo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konan","family":"Brou Andr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Diem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Damotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9raphin","family":"Kati-Coulibaly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel Att\u00e9","family":"Offoumou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Dy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Thieblemont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Herbelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2008.07.009_bib1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1515\/DMDI.2001.18.3-4.159","article-title":"Ginger, an ethnomedical, chemical and pharmacological review","volume":"18","author":"Azfal","year":"2001","journal-title":"Drug Metab Drug Interact"},{"key":"10.1016\/j.intimp.2008.07.009_bib2","first-page":"309","article-title":"Ginger","volume":"125","author":"Awang","year":"1992","journal-title":"Can Pharmaceut J"},{"key":"10.1016\/j.intimp.2008.07.009_bib3","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0029-7844(00)01228-X","article-title":"Ginger for nausea and vomiting in pregnancy: randomized, double-masked, placebo-controlled trial","volume":"97","author":"Vutyavanich","year":"2001","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.intimp.2008.07.009_bib4","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1345\/aph.1G086","article-title":"Treating pregnancy-related nausea and vomiting with ginger","volume":"39","author":"Boone","year":"2005","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.intimp.2008.07.009_bib5","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1097\/01.AOG.0000154890.47642.23","article-title":"Effectiveness and safety of ginger in the treatment of pregnancy-induced nausea and vomiting","volume":"105","author":"Borrelli","year":"2005","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.intimp.2008.07.009_bib6","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.phymed.2004.07.009","article-title":"Zingiberis rhizoma: a comprehensive review on the effect and efficacy profiles","volume":"12","author":"Chrubasik","year":"2005","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2008.07.009_bib7","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/sj.bjp.0704925","article-title":"Gingerols: a novel class of vanilloid receptor (VR1) agonists","volume":"137","author":"Dedov","year":"2002","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.intimp.2008.07.009_bib8","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/newbio231232a0","article-title":"Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs","volume":"231","author":"Vane","year":"1971","journal-title":"Nature New Biol"},{"key":"10.1016\/j.intimp.2008.07.009_bib9","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1248\/cpb.30.754","article-title":"Inhibitors of prostaglandin biosynthesis from ginger","volume":"30","author":"Kuichi","year":"1982","journal-title":"Chem Pharm Bull Tokyo"},{"key":"10.1016\/j.intimp.2008.07.009_bib10","first-page":"103","article-title":"TNF-alpha expression of synoviocyte cultures is inhibited by hydroxyl-alkoxy-phenyl compounds (HAPC) from ginger","volume":"46","author":"Frondoza","year":"2000","journal-title":"Trans Orthop Res Soc"},{"key":"10.1016\/j.intimp.2008.07.009_bib11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1290\/1543-706X(2004)040<0095:AIVSAF>2.0.CO;2","article-title":"An in vitro screening assay for inhibitors of proinflammatory mediators in herbal extracts using human synoviocyte cultures","volume":"30","author":"Frondoza","year":"2004","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"10.1016\/j.intimp.2008.07.009_bib12","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1089\/acm.2005.11.149","article-title":"Ginger extract components suppress induction of chemokine expression in human synoviocytes","volume":"11","author":"Phan","year":"2005","journal-title":"J Altern Complement Med"},{"key":"10.1016\/j.intimp.2008.07.009_bib13","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1172\/JCI8204","article-title":"Th2 cells and GATA-3 in asthma: new insights into the regulation of airway inflammation","volume":"104","author":"Ray","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.intimp.2008.07.009_bib14","series-title":"Asthma, European respiratory monograph no. 23. Sheffield, UK: European Respiratory Journals Ltd.","first-page":"1","article-title":"Epidemiology of asthma","author":"Viegi","year":"2003"},{"key":"10.1016\/j.intimp.2008.07.009_bib15","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1056\/NEJM200102013440507","article-title":"Asthma","volume":"344","author":"Busse","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.intimp.2008.07.009_bib16","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1067\/mai.2003.169","article-title":"The role of T lymphocytes in the pathogenesis of asthma","volume":"111","author":"Larche","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.intimp.2008.07.009_bib17","series-title":"Asthma: basic mechanisms and clinical management","first-page":"487","article-title":"Pathophysiology of asthma","author":"Barnes","year":"1998"},{"key":"10.1016\/j.intimp.2008.07.009_bib18","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.4049\/jimmunol.136.7.2348","article-title":"Two types of murine T cell clones. I. Definition according to profiles of lymphokine activities and secreted proteins","volume":"136","author":"Mosmann","year":"1986","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2008.07.009_bib19","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0167-5699(96)80606-2","article-title":"The expanding universe of T-cell subsets: Th1, Th2 and more","volume":"17","author":"Mosmann","year":"1996","journal-title":"Immunol Today"},{"key":"10.1016\/j.intimp.2008.07.009_bib20","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.iy.07.040189.001045","article-title":"Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties","volume":"7","author":"Mosmann","year":"1989","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.intimp.2008.07.009_bib21","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1089\/jmf.2005.8.125","article-title":"Ginger\u2014an herbal medicinal product with broad anti-inflammatory actions","volume":"8","author":"Grzanna","year":"2005","journal-title":"J Med Food"},{"key":"10.1016\/j.intimp.2008.07.009_bib22","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1089\/jmf.2005.8.149","article-title":"Comparative effects of ginger root (Zingiber officinale Rosc.) on the production of inflammatory mediators in normal and osteoarthrotic sow chondrocytes","volume":"8","author":"Shen","year":"2005","journal-title":"J Med Food"},{"key":"10.1016\/j.intimp.2008.07.009_bib23","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1002\/rcm.2140","article-title":"Characterization of gingerol-related compounds in ginger rhizome (Zingiber officinale Rosc.) by high performance liquid chromatography\/electrospray ionization mass spectrometry","volume":"19","author":"Jiang","year":"2005","journal-title":"Rapid Commun Mass Spectrom"},{"key":"10.1016\/j.intimp.2008.07.009_bib24","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0021-9673(97)01013-3","article-title":"High-performance liquid chromatography\u2013electrospray mass spectrometric analysis of pungent constituents of ginger","volume":"796","author":"He","year":"1998","journal-title":"J Chromatogr B"},{"key":"10.1016\/j.intimp.2008.07.009_bib25","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1165\/ajrcmb.20.5.3446","article-title":"Mucous-cell metaplasia and inflammatory-cell recruitment are dissociated in allergic mice after antibody- and drug-dependent cell depletion in a murine model of asthma","volume":"20","author":"Haile","year":"1999","journal-title":"Am J Resp Cell Mol Biol"},{"key":"10.1016\/j.intimp.2008.07.009_bib26","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/eji.200324151","article-title":"Exacerbated Th2-mediated airway inflammation and hyperresponsiveness in autoimmune diabetes-prone NOD mice: a critical role for CD1d-dependent NKT cells","volume":"34","author":"Araujo","year":"2004","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.intimp.2008.07.009_bib27","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.4049\/jimmunol.171.4.1637","article-title":"Cutting edge: invariant V alpha 14 NKT cells are required for allergen-induced airway inflammation and hyperreactivity in an experimental asthma model","volume":"171","author":"Lisbonne","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2008.07.009_bib28","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1002\/eji.200535268","article-title":"Alpha-galactosylceramide-induced iNKT cells suppress experimental allergic asthma in sensitized mice: role of IFN gamma","volume":"35","author":"Hachem","year":"2005","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.intimp.2008.07.009_bib29","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1183\/09031936.01.00229901","article-title":"Cytokine modulators as novel therapies for airway disease","volume":"34","author":"Barnes","year":"2001","journal-title":"Eur Respir J Suppl"},{"key":"10.1016\/j.intimp.2008.07.009_bib30","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1084\/jem.184.3.1127","article-title":"IL-4-deficient Balb\/c mice resist infection with Leishmania major","volume":"184","author":"Kopf","year":"1996","journal-title":"J Exp Med."},{"key":"10.1016\/j.intimp.2008.07.009_bib31","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.cyto.2004.07.010","article-title":"Cytokine and anti-cytokine therapy for the treatment of asthma and allergic disease","volume":"28","author":"Holgate","year":"2004","journal-title":"Cytokine"},{"key":"10.1016\/j.intimp.2008.07.009_bib32","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jep.2004.09.009","article-title":"Analgesic and anti-inflammatory activities of [6]-gingerol","volume":"96","author":"Young","year":"2005","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.intimp.2008.07.009_bib33","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1172\/JCI5909","article-title":"Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production","volume":"103","author":"Zhu","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.intimp.2008.07.009_bib34","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/01.all.0000010988.60715.c8","article-title":"T-cell responses in allergy and asthma","volume":"1","author":"Romagnani","year":"2001","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.intimp.2008.07.009_bib35","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1136\/jcp.54.8.577","article-title":"New insights into the role of cytokines in asthma","volume":"54","author":"Renauld","year":"2001","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.intimp.2008.07.009_bib36","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/rr40","article-title":"Th2 cytokines and asthma. Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists","volume":"2","author":"Steinke","year":"2001","journal-title":"Respir Res"},{"key":"10.1016\/j.intimp.2008.07.009_bib37","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1067\/mai.2003.139","article-title":"Chemokines in asthma: cooperative interaction between chemokines and IL-13","volume":"111","author":"Zimmermann","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.intimp.2008.07.009_bib38","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.4049\/jimmunol.172.5.2903","article-title":"A novel anti-inflammatory role of simvastatin in a murine model of allergic asthma","volume":"172","author":"McKay","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2008.07.009_bib39","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1089\/109662003772519877","article-title":"Effects of ginger (Zingiber officinale Rosc.) on decreasing the production of inflammatory mediators in sow osteoarthrotic cartilage explants","volume":"6","author":"Shen","year":"2003","journal-title":"J Med Food"},{"key":"10.1016\/j.intimp.2008.07.009_bib40","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1002\/art.22732","article-title":"Interferon-gamma protects against the development of structural damage in experimental arthritis by regulating polymorphonuclear neutrophil influx into diseased joints","volume":"56","author":"Williams","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2008.07.009_bib41","first-page":"127","article-title":"Traditional therapeutical indication, pharmacological properties of zingiber","volume":"39","author":"Kati-Coulibaly","year":"2003","journal-title":"Med Nutr"},{"key":"10.1016\/j.intimp.2008.07.009_bib42","first-page":"139","article-title":"Oral anticoagulants and medicinal plants. An emerging interaction","volume":"15","author":"Argento","year":"2000","journal-title":"Ann Ital Med Int"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576908002270?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576908002270?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T15:59:54Z","timestamp":1684511994000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576908002270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":42,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S1567576908002270"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2008.07.009","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]}}}