{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T20:30:09Z","timestamp":1781123409734,"version":"3.54.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1016\/j.intimp.2009.01.007","type":"journal-article","created":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T10:10:35Z","timestamp":1233655835000},"page":"433-438","source":"Crossref","is-referenced-by-count":7,"title":["Effects of 1-bromopropane, a substitute for chlorofluorocarbons, on BDNF expression"],"prefix":"10.1016","volume":"9","author":[{"given":"Yasuhiro","family":"Yoshida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiteru","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiqin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Fueta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Ishidao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Kunugita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Yanagihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Sugiura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Hori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uki","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2009.01.007_bib1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0024-3205(02)02247-6","article-title":"Hyperexcitability and changes in activities of Ca2+\/calmodulin-dependent kinase II and mitogen-activated protein kinase in the hippocampus of rats exposed to 1-bromopropane","volume":"72","author":"Fueta","year":"2002","journal-title":"Life Sci"},{"key":"10.1016\/j.intimp.2009.01.007_bib2","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0161-813X(03)00049-4","article-title":"Inhalation of 1-bromopropane causes excitation in the central nervous system of male F344 rats","volume":"24","author":"Honma","year":"2003","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.intimp.2009.01.007_bib3","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0161-813X(02)00195-X","article-title":"Dose-dependent biochemical changes in rat central nervous system after 12-week exposure to 1-bromopropane","volume":"24","author":"Wang","year":"2003","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.intimp.2009.01.007_bib4","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/toxsci\/67.1.114","article-title":"Biochemical changes in the central nervous system of rats exposed to 1-bromopropane for seven days","volume":"67","author":"Wang","year":"2002","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.intimp.2009.01.007_bib5","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/toxsci\/55.1.116","article-title":"1-Bromopropane, an alternative to ozone layer depleting solvents, is dose-dependently neurotoxic to rats in long-term inhalation exposure","volume":"55","author":"Ichihara","year":"2000","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.intimp.2009.01.007_bib6","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/toxsci\/71.1.96","article-title":"Exposure to 1-bromopropane causes ovarian dysfunction in rats","volume":"71","author":"Yamada","year":"2003","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.intimp.2009.01.007_bib7","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/ajim.10320","article-title":"A survey on exposure level, health status, and biomarkers in workers exposed to 1-bromopropane","volume":"45","author":"Ichihara","year":"2004","journal-title":"Am J Ind Med"},{"key":"10.1016\/j.intimp.2009.01.007_bib8","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev.neuro.22.1.295","article-title":"Neurotrophins and synaptic plasticity","volume":"22","author":"McAllister","year":"1999","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.intimp.2009.01.007_bib9","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35085068","article-title":"Transcriptional regulation by the phosphorylation-dependent factor CREB","volume":"2","author":"Mayr","year":"2001","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.intimp.2009.01.007_bib10","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/glia.1107","article-title":"Immune function of astrocytes","volume":"36","author":"Dong","year":"2001","journal-title":"Glia"},{"key":"10.1016\/j.intimp.2009.01.007_bib11","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1093\/brain\/awf015","article-title":"BDNF and gp145trkB in multiple sclerosis brain lesions: neuroprotective interactions between immune and neuronal cells?","volume":"125","author":"Stadelmann","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.intimp.2009.01.007_bib12","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1046\/j.1471-4159.1994.63020509.x","article-title":"Expression of neurotrophins and their receptors in primary astroglial cultures: induction by cyclic AMP-elevating agents","volume":"63","author":"Condorelli","year":"1994","journal-title":"J Neurochem"},{"key":"10.1016\/j.intimp.2009.01.007_bib13","doi-asserted-by":"crossref","first-page":"4793","DOI":"10.1523\/JNEUROSCI.12-12-04793.1992","article-title":"Regulation of brain-derived neurotrophic factor and nerve growth factor mRNA in primary cultures of hippocampal neurons and astrocytes","volume":"12","author":"Zafra","year":"1992","journal-title":"J Neurosci"},{"key":"10.1016\/j.intimp.2009.01.007_bib14","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.ne.19.030196.001445","article-title":"Physiology of the neurotrophins","volume":"19","author":"Lewin","year":"1996","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.intimp.2009.01.007_bib15","doi-asserted-by":"crossref","first-page":"6856","DOI":"10.1523\/JNEUROSCI.15-10-06856.1995","article-title":"Changes in neurotrophic factor expression and receptor activation following exposure of hippocampal neuron\/astrocyte cocultures to kainic acid","volume":"15","author":"Rudge","year":"1995","journal-title":"J Neurosci"},{"key":"10.1016\/j.intimp.2009.01.007_bib16","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0092-8674(03)00035-7","article-title":"The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function","volume":"112","author":"Egan","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2009.01.007_bib17","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jneuroim.2004.09.013","article-title":"Effects of interferon-beta on the cytokine production of astrocytes","volume":"159","author":"Okada","year":"2005","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.intimp.2009.01.007_bib18","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1074\/jbc.M311498200","article-title":"Interleukin 1 activates STAT3\/nuclear factor-kappaB cross-talk via a unique TRAF6- and p65-dependent mechanism","volume":"279","author":"Yoshida","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.intimp.2009.01.007_bib19","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0896-6273(02)00828-0","article-title":"Function and regulation of CREB family transcription factors in the nervous system","volume":"35","author":"Lonze","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.intimp.2009.01.007_bib20","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/0092-8674(89)90013-5","article-title":"Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133","volume":"59","author":"Gonzalez","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2009.01.007_bib21","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/(SICI)1097-0274(199905)35:5<523::AID-AJIM10>3.0.CO;2-W","article-title":"Occupational health survey on workers exposed to 2-bromopropane at low concentrations","volume":"35","author":"Ichihara","year":"1999","journal-title":"Am J Ind Med"},{"key":"10.1016\/j.intimp.2009.01.007_bib22","doi-asserted-by":"crossref","first-page":"387","DOI":"10.5271\/sjweh.159","article-title":"Hematopoietic and reproductive hazards of Korean electronic workers exposed to solvents containing 2-bromopropane","volume":"22","author":"Kim","year":"1996","journal-title":"Scand J Work Environ Health"},{"key":"10.1016\/j.intimp.2009.01.007_bib23","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1006\/enrs.2000.4226","article-title":"Neurotoxicity of 2-bromopropane and 1-bromopropane, alternative solvents for chlorofluorocarbons","volume":"85","author":"Yu","year":"2001","journal-title":"Environ Res"},{"key":"10.1016\/j.intimp.2009.01.007_bib24","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.neuroscience.2003.12.025","article-title":"Electrophysiology and immunohistochemistry in the hippocampal ca1 and the dentate gyrus of rats chronically exposed to 1-bromopropane, a substitute for specific chlorofluorocarbons","volume":"124","author":"Fueta","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.intimp.2009.01.007_bib25","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1101\/gad.841400","article-title":"Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system","volume":"14","author":"Bibel","year":"2000","journal-title":"Genes Dev"},{"key":"10.1016\/j.intimp.2009.01.007_bib26","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/35049004","article-title":"Neurotrophins as synaptic modulators","volume":"2","author":"Poo","year":"2001","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.intimp.2009.01.007_bib27","doi-asserted-by":"crossref","first-page":"35920","DOI":"10.1074\/jbc.M204784200","article-title":"Involvement of an upstream stimulatory factor as well as cAMP-responsive element-binding protein in the activation of brain-derived neurotrophic factor gene promoter I","volume":"277","author":"Tabuchi","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.intimp.2009.01.007_bib28","doi-asserted-by":"crossref","first-page":"10399","DOI":"10.1523\/JNEUROSCI.22-23-10399.2002","article-title":"Cellular mechanisms regulating activity-dependent release of native brain-derived neurotrophic factor from hippocampal neurons","volume":"22","author":"Balkowiec","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.intimp.2009.01.007_bib29","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1006\/mcne.1996.0017","article-title":"Regulated release and polarized localization of brain-derived neurotrophic factor in hippocampal neurons","volume":"7","author":"Goodman","year":"1996","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.intimp.2009.01.007_bib30","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1126\/science.274.5290.1133","article-title":"Synaptic activity and the construction of cortical circuits","volume":"274","author":"Katz","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.intimp.2009.01.007_bib31","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.bbrc.2004.04.012","article-title":"BDNF is induced by wild-type alpha-synuclein but not by the two mutants, A30P or A53T, in glioma cell line","volume":"318","author":"Kohno","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.intimp.2009.01.007_bib32","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.conb.2004.08.014","article-title":"Neurotrophin action on a rapid timescale","volume":"14","author":"Kovalchuk","year":"2004","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.intimp.2009.01.007_bib33","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1046\/j.0022-3042.2001.00752.x","article-title":"Ceramide activates microglia to enhance the production\/secretion of brain-derived neurotrophic factor (BDNF) without induction of deleterious factors in vitro","volume":"80","author":"Nakajima","year":"2002","journal-title":"J Neurochem"},{"key":"10.1016\/j.intimp.2009.01.007_bib34","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0896-6273(03)00538-5","article-title":"Pro-region of neurotrophins: role in synaptic modulation","volume":"39","author":"Lu","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.intimp.2009.01.007_bib35","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1289\/ehp.6995","article-title":"Neurologic abnormalities in workers of a 1-bromopropane factory","volume":"112","author":"Ichihara","year":"2004","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.intimp.2009.01.007_bib36","first-page":"1300","article-title":"Neurologic Illness associated with occupational exposure to the solvent 1-bromopropane\u2014New Jersey and Pennsylvania, 2007\u20132008. Centers for disease control and prevention (CDC)","volume":"57","author":"Perrone","year":"2008","journal-title":"Morb Mortal Wkly Rep"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576909000228?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576909000228?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T19:21:05Z","timestamp":1558120865000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576909000228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["S1567576909000228"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2009.01.007","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2009,4]]}}}