{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:54:11Z","timestamp":1776387251005,"version":"3.51.2"},"reference-count":25,"publisher":"Elsevier BV","issue":"7-8","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1016\/j.intimp.2009.04.002","type":"journal-article","created":{"date-parts":[[2009,4,9]],"date-time":"2009-04-09T08:42:01Z","timestamp":1239266521000},"page":"968-970","source":"Crossref","is-referenced-by-count":61,"title":["Comparison of morphine and tramadol effects on phagocytic activity of mice peritoneal phagocytes in vivo"],"prefix":"10.1016","volume":"9","author":[{"given":"Hedayatollah","family":"Shirzad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrdad","family":"Shahrani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Rafieian-Kopaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2009.04.002_bib1","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/sj.bjp.0701138","article-title":"Antinociceptive and immunosuppressive effects of opiate drugs: a structure-related activity study","volume":"121","author":"Sacerdote","year":"1997","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.intimp.2009.04.002_bib2","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1016\/S0024-3205(02)02087-8","article-title":"Immunosuppression induced by central action of morphine is not blocked by mifepristone (RU 486)","volume":"71","author":"Liang-Suo","year":"2002","journal-title":"Life Sci"},{"issue":"5","key":"10.1016\/j.intimp.2009.04.002_bib3","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/01.mjt.0000132250.95650.85","article-title":"Opioid therapy and immunosuppression: review","volume":"11","author":"Vallejo","year":"2004","journal-title":"Am J Ther"},{"issue":"5","key":"10.1016\/j.intimp.2009.04.002_bib4","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1398-9995.2007.01345.x","article-title":"Codeine induces human mast cell chemokine and cytokine production: involvement of G-protein activation","volume":"62","author":"Sheen","year":"2007","journal-title":"Allergy"},{"issue":"1\u20132","key":"10.1016\/j.intimp.2009.04.002_bib5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jneuroim.2006.07.012","article-title":"Interferon-gamma down-regulates transcription of the Mu-opioid receptor gene in neuronal and immune cells","volume":"181","author":"Kraus","year":"2006","journal-title":"J Neuroimmunol"},{"issue":"1\u20133","key":"10.1016\/j.intimp.2009.04.002_bib6","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ejphar.2006.08.012","article-title":"Beta-endorphin differentially affects inflammation in two inbred rat strains","volume":"549","author":"Stanojevi\u0107","year":"2006","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.intimp.2009.04.002_bib7","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/S0165-5728(97)00216-6","article-title":"Opiates and infections","volume":"83","author":"Risdahl","year":"1998","journal-title":"J Neuroimmunol"},{"issue":"7","key":"10.1016\/j.intimp.2009.04.002_bib8","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1348-0421.2006.tb03824.x","article-title":"Enhancement of mice susceptibility to infection with Listeria monocytogenes by the treatment of morphine","volume":"50","author":"Asakura","year":"2006","journal-title":"Microbiol Immunol"},{"issue":"12","key":"10.1016\/j.intimp.2009.04.002_bib9","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1086\/518039","article-title":"Morphine priming rescues high-dose morphine-induced biological perturbations","volume":"195","author":"Bhaskaran","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1016\/j.intimp.2009.04.002_bib10","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1001\/archsurg.1991.01410280056007","article-title":"Effect of morphine on growth of metastatic colon cancer in vivo","volume":"126","author":"Yeager","year":"1991","journal-title":"Arch Surg"},{"issue":"6","key":"10.1016\/j.intimp.2009.04.002_bib11","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.bbi.2007.01.001","article-title":"Buprenorphine ameliorates the effect of surgery on hypothalamus-pituitary-adrenal axis, natural killer cell activity and metastatic colonization in rats in comparison with morphine or fentanyl treatment","volume":"21","author":"Franchi","year":"2007","journal-title":"Brain Behav Immun"},{"issue":"90","key":"10.1016\/j.intimp.2009.04.002_bib12","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1097\/00000539-200006000-00028","article-title":"The effects of tramadol and morphine on immune responses and pain after surgery in cancer patients","author":"Sacerdote","year":"2000","journal-title":"Anesth Analg"},{"issue":"105","key":"10.1016\/j.intimp.2009.04.002_bib13","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1476-5381.1992.tb14226.x","article-title":"Interaction of the central analgesic tramadol, with the uptake and release of 5-hydroxytryptamine in the rat brain in vitro","author":"Driessen","year":"1992","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.intimp.2009.04.002_bib14","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1111\/j.1476-5381.1993.tb12882.x","article-title":"Effects of the central analgesic tramadol on the uptake and release of noradrenaline and dopamine in vitro","volume":"108","author":"Driessen","year":"1993","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.intimp.2009.04.002_bib15","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1089\/089277902320913314","article-title":"Morphine-induced macrophage apoptosis modulates migration of macrophages: use of in vitro model of urinary tract infection","volume":"16","author":"Malik","year":"2002","journal-title":"J Endourol"},{"key":"10.1016\/j.intimp.2009.04.002_bib16","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1086\/324667","article-title":"Morphine-induced degradation of the host defense barrier: role of macrophage injury","volume":"184","author":"Bhaskaran","year":"2001","journal-title":"J Infect Dis"},{"key":"10.1016\/j.intimp.2009.04.002_bib17","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0304-3959(97)00055-9","article-title":"Effects of tramadol on immune responses and nociceptive thresholds in mice","volume":"72","author":"Sacerdote","year":"1997","journal-title":"Pain"},{"key":"10.1016\/j.intimp.2009.04.002_bib18","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1006\/cimm.1996.0304","article-title":"An IL-3 induced splenic NC-1.1+ mast cell line mediate natural cytotoxicity independent of TNF-a","volume":"174","author":"Shirzadeh","year":"1996","journal-title":"Cell Immunol"},{"issue":"10","key":"10.1016\/j.intimp.2009.04.002_bib19","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/BF03021601","article-title":"Tramadol does not impair the phagocytic capacity of human peripheral blood cells","volume":"52","author":"Beilin","year":"2005","journal-title":"Can J Anaesth"},{"issue":"1\u20132","key":"10.1016\/j.intimp.2009.04.002_bib20","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0376-8716(99)00079-4","article-title":"Reversibility of morphine effects on phagocytosis by murine macrophages","volume":"58","author":"L\u00e1zaro","year":"2000","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.intimp.2009.04.002_bib21","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0192-0561(99)00048-X","article-title":"Effects of tramadol and its enantiomers on concanavalin-A induced proliferation and NK activity of mouse splenocytes: involvement of serotonin","volume":"21","author":"Sacerdote","year":"1999","journal-title":"Int J Immunopharmacol"},{"key":"10.1016\/j.intimp.2009.04.002_bib22","series-title":"Clinical Pharmacology","first-page":"343","author":"Laurence","year":"1987"},{"key":"10.1016\/j.intimp.2009.04.002_bib23","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0165-5728(85)90031-1","article-title":"Involvement of peripheral and central catecholamine systems in neural\u2013immune interactions","volume":"10","author":"Livnat","year":"1985","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.intimp.2009.04.002_bib24","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1006\/brbi.1998.0532","article-title":"Role of serotonin in the immune system and in neuroimmune interaction","volume":"12","author":"Mossner","year":"1998","journal-title":"Brain Behav Immun"},{"issue":"7","key":"10.1016\/j.intimp.2009.04.002_bib25","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.biopha.2006.06.015","article-title":"Pain management: is opioid immunosuppression a clinical problem?","volume":"60","author":"Budd","year":"2006","journal-title":"Biomed Pharmacother"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576909001325?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576909001325?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T14:57:53Z","timestamp":1545317873000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576909001325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":25,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S1567576909001325"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2009.04.002","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}