{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:41:36Z","timestamp":1783690896621,"version":"3.55.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1016\/j.intimp.2009.08.011","type":"journal-article","created":{"date-parts":[[2009,8,29]],"date-time":"2009-08-29T10:01:29Z","timestamp":1251540089000},"page":"1394-1400","source":"Crossref","is-referenced-by-count":17,"title":["Evidence of anti-inflammatory effects of Pioglitazone in the murine pleurisy model induced by carrageenan"],"prefix":"10.1016","volume":"9","author":[{"given":"T\u00e2nia Silvia","family":"Fr\u00f6de","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziliani","family":"da Silva Buss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Oliveira","family":"dos Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yara","family":"Santos Medeiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2009.08.011_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1096\/fj.02-1075fje","article-title":"PPAR\u03b3 ligands induce prostaglandin production in vascular smooth muscle cells: indomethacin acts as a peroxisome proliferator-activated receptor-\u03b3 antagonist","volume":"1","author":"Bishop-Bailey","year":"2003","journal-title":"FASEB J"},{"key":"10.1016\/j.intimp.2009.08.011_bib2","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1038\/sj.ijo.0802499","article-title":"Peroxisome proliferators activated receptors and inflammation: from basic science to clinical applications","volume":"27","author":"Chinetti","year":"2003","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.intimp.2009.08.011_bib3","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.hepres.2005.09.027","article-title":"Thiazolidinediones: pleiotropic drugs with potent anti-inflammatory properties for tissue protection","volume":"33","author":"Buckingham","year":"2005","journal-title":"Hepatol Res"},{"key":"10.1016\/j.intimp.2009.08.011_bib4","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1194\/jlr.R400010-JLR200","article-title":"PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis","volume":"45","author":"Li","year":"2004","journal-title":"J Lipid Res"},{"key":"10.1016\/j.intimp.2009.08.011_bib5","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.cell.2005.11.026","article-title":"The many faces of PPAR","volume":"123","author":"Lehrke","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2009.08.011_bib6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ejphar.2005.12.048","article-title":"Peroxisome proliferator-activated receptor gamma agonists as therapy for chronic airway inflammation","volume":"533","author":"Belvisi","year":"2006","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.intimp.2009.08.011_bib7","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.bbalip.2007.02.005","article-title":"PPAR\u03b3 in immunity and inflammation: cell types and diseases","volume":"1771","author":"Sz\u00e9les","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.intimp.2009.08.011_bib8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/01.shk.0000167108.88376.f2","article-title":"15-deoxy-D12, 14-prostaglandin J2 (15D-PGJ2), a peroxisome proliferator activated receptor gamma ligand, reduces tissue leukosequestration and mortality in endotoxic shock","volume":"24","author":"Kaplan","year":"2005","journal-title":"Shock"},{"key":"10.1016\/j.intimp.2009.08.011_bib9","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.pharmthera.2005.08.007","article-title":"Peroxisome proliferator-activated receptors and inflammation","volume":"110","author":"Moraes","year":"2006","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.intimp.2009.08.011_bib10","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/01.shk.0000160521.91363.88","article-title":"Peroxisome proliferators-activated receptor-\u03b3 is a new therapeutic target in sepsis and inflammation","volume":"23","author":"Zingarrelli","year":"2005","journal-title":"Shock"},{"key":"10.1016\/j.intimp.2009.08.011_bib11","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1155\/S1110724304308065","article-title":"Role of peroxisome proliferators-activated receptors in inflammation control","volume":"3","author":"Youssef","year":"2004","journal-title":"J Biomed Biotechnol"},{"key":"10.1016\/j.intimp.2009.08.011_bib12","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.phrs.2009.02.005","article-title":"Peroxisome proliferator activated receptor-\u03b3 (PPAR-\u03b3) ligands as potential therapeutic agents treat arthritis","volume":"60","author":"Giaginis","year":"2009","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.intimp.2009.08.011_bib13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.18433\/J3T886","article-title":"Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyond","volume":"11","author":"Rao","year":"2008","journal-title":"J Pharm Pharm Sci"},{"key":"10.1016\/j.intimp.2009.08.011_bib14","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1016\/S0140-6736(09)60326-3","article-title":"Glucocorticoid resistance in inflammatory diseases","volume":"373","author":"Barnes","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2009.08.011_bib15","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1128\/MCB.24.1.36-45.2004","article-title":"Trasncription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-\u220612, 14-Prostaglandin J2","volume":"24","author":"IToh","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.intimp.2009.08.011_bib16","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/j.1476-5381.1996.tb15472.x","article-title":"Anti-inflammatory effects of theophylline, cromolyn and salbutamol in a murine model of pleurisy","volume":"118","author":"Saleh","year":"1996","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.intimp.2009.08.011_bib17","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0196-9781(99)00086-8","article-title":"Effects of anti-inflammatory drugs upon nitrate and myeloperoxidase levels in the mouse pleurisy induced by carrageenan","volume":"20","author":"Saleh","year":"1999","journal-title":"Peptides"},{"key":"10.1016\/j.intimp.2009.08.011_bib18","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1080\/09629350123332","article-title":"Myeloperoxidase and adenosine-deaminase levels in the pleural fluid leakage induced by carrageenan in the mouse model of pleurisy","volume":"10","author":"Fr\u00f6de","year":"2001","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.intimp.2009.08.011_bib19","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/cyto.2000.0816","article-title":"The modulatory role played by TNF-\u03b1 and IL1-\u03b2 in the inflammatory responses induced by carrageenan in the mouse model of pleurisy","volume":"13","author":"Fr\u00f6de","year":"2001","journal-title":"Cytokine"},{"key":"10.1016\/j.intimp.2009.08.011_bib20","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/BF00920477","article-title":"Comparative evaluation of arachidonic acid (AA)- and tetradecanoylphorbol acetate (TPA)-induced dermal inflammation","volume":"17","author":"Rao","year":"1994","journal-title":"Inflammation"},{"key":"10.1016\/j.intimp.2009.08.011_bib21","first-page":"315","article-title":"Adenosine-deaminase: colorimetric method","volume":"vol. 4","author":"Giusti","year":"1984"},{"key":"10.1016\/j.intimp.2009.08.011_bib22","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/sj.bjp.0706902","article-title":"Inhibition of glycogen synthase kinase-3\u03b2 attenuates the development of carrageenan-induced lung injury in mice","volume":"149","author":"Cuzzocrea","year":"2006","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.intimp.2009.08.011_bib23","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/S0006-2952(01)00822-X","article-title":"Activation of peroxisome proliferators-activated receptor isoforms and inhibition of prostaglandin H(2) synthases by ibuprofen, naproxen, and indomethacin","volume":"62","author":"Jaradat","year":"2001","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.intimp.2009.08.011_bib24","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1161\/01.HYP.0000085332.69777.D1","article-title":"PPAR\u03b3 inhibition of cyclooxigenase-2, PGE2 synthase, and inducible nitric oxide synthase in cardiac myocytes","volume":"42","author":"Mendes","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.intimp.2009.08.011_bib25","doi-asserted-by":"crossref","first-page":"12440","DOI":"10.1074\/jbc.M007237200","article-title":"Peroxisome proliferator-activated receptor gamma ligands suppress the transcriptional activation of cyclooxygenase-2. Evidence for involvement of activator protein-1 and CREB-binding protein\/p300","volume":"276","author":"Subbaramaiah","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.intimp.2009.08.011_bib26","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/35154","article-title":"PPAR-gamma agonists inhibits production of monocyte inflammatory cytokines","volume":"391","author":"Jiang","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2009.08.011_bib27","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/34178","article-title":"The peroxisome proliferator activated receptor-gamma is a negative regulator of macrophage activation","volume":"391","author":"Ricote","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2009.08.011_bib28","doi-asserted-by":"crossref","first-page":"609","DOI":"10.4049\/jimmunol.180.1.609","article-title":"Peroxisome proliferator-activated receptor-gamma ligand, 15-deoxy-Delta12, 14-prostaglandin J2, reduces neutrophil migration via a nitric oxide pathway","volume":"180","author":"Napimoga","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2009.08.011_bib29","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.coph.2006.01.008","article-title":"Peroxisome proliferator-activated receptors and acute lung injury","volume":"6","author":"Cuzzocrea","year":"2006","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.intimp.2009.08.011_bib30","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1194\/jlr.M600235-JLR200","article-title":"Pioglitazone induces apoptosis of macrophages in human adipose tissue","volume":"47","author":"Bodles","year":"2006","journal-title":"J Lipid Res"},{"key":"10.1016\/j.intimp.2009.08.011_bib31","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/jcp.21179","article-title":"Enhance VDUP-1 gene expression by PPARgamma agonist induces apoptosis in human macrophage","volume":"214","author":"Billiet","year":"2008","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.intimp.2009.08.011_bib32","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.trim.2003.09.001","article-title":"Additional evidence of acute anti-inflammatory effects of cyclosporine A in a murine model of pleurisy","volume":"12","author":"Dalmarco","year":"2004","journal-title":"Transplant Immunol"},{"key":"10.1016\/j.intimp.2009.08.011_bib33","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/09629350210000015700","article-title":"Effects of methotrexate upon inflammatory parameters induced by carrageenan in the mouse model of pleurisy","volume":"11","author":"Dalmarco","year":"2002","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.intimp.2009.08.011_bib34","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.jhep.2007.07.030","article-title":"Importance of peroxisome proliferator-activated receptor-\u03b3 in hepatic ischemia\/reperfusion injury in mice","volume":"47","author":"Akahori","year":"2007","journal-title":"J Hepatol"},{"key":"10.1016\/j.intimp.2009.08.011_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/ar2354","article-title":"Anti-inflammatory effect of antidiabetic thiazolidinediones prevents bone resorption rather than cartilage changes in experimental polyarthritis","volume":"10","author":"Koufany","year":"2008","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.intimp.2009.08.011_bib36","doi-asserted-by":"crossref","first-page":"12953","DOI":"10.1074\/jbc.270.22.12953","article-title":"An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)","volume":"270","author":"Lehmann","year":"1995","journal-title":"Biol Chem"},{"key":"10.1016\/j.intimp.2009.08.011_bib37","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ejphar.2003.10.056","article-title":"Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-\u03b3, reduces acute inflammation","volume":"483","author":"Cuzzocrea","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.intimp.2009.08.011_bib38","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ejphar.2006.12.026","article-title":"Antinociceptive and antiedematogenic activities of fenofibrate, an agonist of PPAR alpha, and pioglitazone, an agonist of PPAR gamma","volume":"561","author":"Oliveira","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.intimp.2009.08.011_bib39","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/01.MIB.0000160805.46235.eb","article-title":"The peroxisome proliferator-activated receptor g ligand Rosiglitazone delays the onset of inflammatory bowel disease in mice with interleukin 10 deficiency","volume":"11","author":"Lytle","year":"2005","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.intimp.2009.08.011_bib40","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1136\/hrt.2004.046292","article-title":"Cardioprotective effects of peroxisome proliferator activated receptor g activators on acute myocarditis: anti-inflammatory actions associated with nuclear factor-\u043aB blockade","volume":"91","author":"Yuan","year":"2005","journal-title":"Heart"},{"key":"10.1016\/j.intimp.2009.08.011_bib41","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jneuroim.2003.11.010","article-title":"Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis","volume":"148","author":"Diab","year":"2004","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.intimp.2009.08.011_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-2840-7-3","article-title":"Rosiglitazone but not losartan prevents Nrf-2 dependent CD36 gene expression up-regulation in an in vivo atherosclerosis model","volume":"7","author":"Hernandez-Trujillo","year":"2008","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.intimp.2009.08.011_bib43","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.jacc.2008.04.055","article-title":"The peroxisome proliferator-activated receptor-\u03b3 agonist pioglitazone represses inflammation in a peroxisome proliferator-activated receptor-\u03b3 dependent manner in vitro and in vivo in mice","volume":"52","author":"Orasanu","year":"2008","journal-title":"JACC"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576909002525?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576909002525?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T21:57:21Z","timestamp":1590098241000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576909002525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":43,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S1567576909002525"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2009.08.011","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2009,11]]}}}