{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T02:21:44Z","timestamp":1715998904384},"reference-count":46,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1016\/j.intimp.2009.08.026","type":"journal-article","created":{"date-parts":[[2009,9,10]],"date-time":"2009-09-10T10:15:01Z","timestamp":1252577701000},"page":"1452-1459","source":"Crossref","is-referenced-by-count":7,"title":["Enhanced immunogenicity and cross-reactivity of HIV-1 V3-peptide and multiple antigen peptides conjugated to distinct carrier proteins"],"prefix":"10.1016","volume":"9","author":[{"given":"Luis J.","family":"Cruz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ania","family":"Cabrales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Iglesias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio C.","family":"Aguilar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis J.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osvaldo","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2009.08.026_bib1","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0140-6736(96)09339-7","article-title":"HIV vaccines: where we and where we are going","volume":"348","author":"Haynes","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2009.08.026_bib2","doi-asserted-by":"crossref","first-page":"3612","DOI":"10.4049\/jimmunol.142.10.3612","article-title":"Polyvalent human immunodeficiency virus synthetic immunogen comprised of envelope gp120 T helper cell sites and B cell neutralization epitopes","volume":"142","author":"Palker","year":"1989","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2009.08.026_bib3","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.virol.2007.09.024","article-title":"Focusing the immune response on the V3 loop, a neutralizing epitope of the HIV-1 gp120 envelope","volume":"372","author":"Zolla-Pazner","year":"2008","journal-title":"Virology"},{"key":"10.1016\/j.intimp.2009.08.026_bib4","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1128\/JVI.02143-07","article-title":"The first hypervariable region of the gp120 Env glycoprotein defines the neutralizing susceptibility of heterologous human immunodeficiency virus type 1 isolates to neutralizing antibodies elicited by the SF162gp140 immunogen","volume":"82","author":"Ching","year":"2008","journal-title":"J Virol"},{"key":"10.1016\/j.intimp.2009.08.026_bib5","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1097\/00002030-199101001-00004","article-title":"The role of the V3 loop in HIV infection","volume":"5","author":"Moore","year":"1991","journal-title":"AIDS"},{"key":"10.1016\/j.intimp.2009.08.026_bib6","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1096\/fasebj.5.10.1712328","article-title":"Neutralization of HIV-1: a paradox of humoral properties","volume":"5","author":"Nara","year":"1991","journal-title":"FASEB J"},{"key":"10.1016\/j.intimp.2009.08.026_bib7","doi-asserted-by":"crossref","first-page":"4995","DOI":"10.1016\/j.vaccine.2006.03.083","article-title":"Cross-clade recognition and neutralization by the V3 region from clade C human immunodeficiency virus-1 envelope","volume":"24","author":"Wu","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.intimp.2009.08.026_bib8","doi-asserted-by":"crossref","first-page":"7136","DOI":"10.1128\/JVI.71.9.7136-7139.1997","article-title":"Selective employment of chemokine receptors as human immunodeficiency virus type 1 co-receptors determined by individual amino acids within the envelope V3 loop","volume":"71","author":"Speck","year":"1997","journal-title":"J Virol"},{"key":"10.1016\/j.intimp.2009.08.026_bib9","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1089\/aid.2006.0130","article-title":"Structural basis for coreceptor selectivity by the HIV type 1 V3 loop","volume":"23","author":"Cardozo","year":"2007","journal-title":"AIDS Res Hum Retrovir"},{"key":"10.1016\/j.intimp.2009.08.026_bib10","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.vaccine.2007.11.022","article-title":"V3 CTL epitope density in a single recombinant molecule antigen differentially affects the number and activity of primary and memory CD8+ T cells","volume":"26","author":"Lu","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.intimp.2009.08.026_bib11","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1096\/fasebj.5.10.1712327","article-title":"Development of artificial vaccines against HIV using defined epitopes","volume":"5","author":"Berzofsky","year":"1991","journal-title":"FASEB J"},{"key":"10.1016\/j.intimp.2009.08.026_bib12","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1099\/0022-1317-77-10-2403","article-title":"Loss of antibody reactivity directed against the V3 domain of certain human immunodeficiency virus type 1 variants during disease progression","volume":"77","author":"Schreiber","year":"1996","journal-title":"J Gen Virol"},{"key":"10.1016\/j.intimp.2009.08.026_bib13","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/00002030-199509030-00005","article-title":"Safety and immunogenicity of a V3 loop synthetic peptide conjugated to purified protein derivative in HIV-seronegative volunteers","volume":"9","author":"Rubinstein","year":"1995","journal-title":"AIDS"},{"key":"10.1016\/j.intimp.2009.08.026_bib14","doi-asserted-by":"crossref","first-page":"4165","DOI":"10.1128\/JVI.75.9.4165-4175.2001","article-title":"Vaccine-elicited V3 loop-specific antibodies in rhesus monkeys and control of a simian-human immunodeficiency virus expressing a primary patient human immunodeficiency virus type 1 isolate envelope","volume":"75","author":"Letvin","year":"2001","journal-title":"J Virol"},{"key":"10.1016\/j.intimp.2009.08.026_bib15","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1089\/aid.1997.13.317","article-title":"Correlation of titer of antibody to principal neutralizing domain of HIVMN strain with disease progression in Japanese hemophiliacs seropositive for HIV type 1","volume":"4","author":"Yamanaka","year":"1997","journal-title":"AIDS Res Hum Retrovir"},{"key":"10.1016\/j.intimp.2009.08.026_bib16","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.virol.2008.08.032","article-title":"Neutralizing activity of antibodies to the V3 loop region of HIV-1 gp120 relative to their epitope fine specificity","volume":"381","author":"Pantophlet","year":"2008","journal-title":"Virology"},{"key":"10.1016\/j.intimp.2009.08.026_bib17","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1128\/JVI.79.3.1452-1462.2005","article-title":"Vaccination of rhesus macaques with recombinant Mycobacterium bovis bacillus Calmette\u2013Gu\u00e9rin Env V3 elicits neutralizing antibody-mediated protection against simian\u2013human immunodeficiency virus with a homologous but not a heterologous V3 motif","volume":"79","author":"Someya","year":"2005","journal-title":"J Virol"},{"key":"10.1016\/j.intimp.2009.08.026_bib18","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.vaccine.2008.10.051","article-title":"Safety and immunogenicity of a CTL multiepitope peptide vaccine for HIV with or without GM-CSF in a phase I trial","volume":"27","author":"Spearman","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.intimp.2009.08.026_bib19","first-page":"109","article-title":"Chimeric protein containing HIV-1 T cell epitopes: expression in E. coli, purification and induction of antibodies in mice","volume":"5","author":"Iglesias","year":"2001","journal-title":"J Biochem Mol Biol Biophys"},{"key":"10.1016\/j.intimp.2009.08.026_bib20","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.vaccine.2008.10.041","article-title":"Combining DNA technologies and different modes of immunization for induction of humoral and cellular anti-HIV-1 immune responses","volume":"27","author":"Br\u00e5ve","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.intimp.2009.08.026_bib21","doi-asserted-by":"crossref","first-page":"4648","DOI":"10.1016\/j.vaccine.2005.08.050","article-title":"A multivalent HIV-vaccine: development of a plasmid DNA for the expression of HIV envelope glycoproteins with hypervariable V3-loop domains","volume":"24","author":"Schilling","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.intimp.2009.08.026_bib22","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1089\/vim.2008.0046","article-title":"Co-immunization of mice with a retroviral DNA vaccine and GITRL-encoding plasmid augments vaccine-induced protection against retrovirus infection","volume":"21","author":"Dittmer","year":"2008","journal-title":"Viral Immunol"},{"key":"10.1016\/j.intimp.2009.08.026_bib23","doi-asserted-by":"crossref","first-page":"5752","DOI":"10.1016\/j.vaccine.2008.08.025","article-title":"HIV blocking antibodies following immunisation with chimaeric peptides coding a short N-terminal sequence of the CCR5 receptor","volume":"26","author":"Chain","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.intimp.2009.08.026_bib24","doi-asserted-by":"crossref","first-page":"4328","DOI":"10.1016\/S0264-410X(01)00111-6","article-title":"A phase I clinical trial of a multi-epitope polypeptide TAB9 combined with Montanide ISA 720 adjuvant in non-HIV-1 infected human volunteers","volume":"19","author":"Toledo","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.intimp.2009.08.026_bib25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/(SICI)1099-1387(200005)6:5<217::AID-PSC242>3.0.CO;2-U","article-title":"Immunogenicity comparison of a multi-antigenic peptide bearing V3 sequences of the human immunodeficiency virus type 1 with TAB9 protein in mice","volume":"6","author":"Cruz","year":"2000","journal-title":"J Pept Sci"},{"key":"10.1016\/j.intimp.2009.08.026_bib26","first-page":"85","article-title":"Cytokine-induced augmentation of DNA vaccine-elicited SIV-specific immunity in rhesus monkeys","volume":"104","author":"Barouch","year":"2000","journal-title":"Dev Biol"},{"key":"10.1016\/j.intimp.2009.08.026_bib27","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1126\/science.1118398","article-title":"Structure of a V3-containing HIV-1 gp120 core","volume":"310","author":"Huang","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.intimp.2009.08.026_bib28","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1021\/bc034119j","article-title":"Andreu DA comparative study of different presentation strategies for an HIV peptide immunogen","volume":"15","author":"Cruz","year":"2004","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.intimp.2009.08.026_bib29","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0168-1656(99)00201-1","article-title":"Large-scale production of recombinant hepatitis B surface antigen from Pichia pastoris","volume":"77","author":"Ard\u00ed","year":"2000","journal-title":"J Biotechnol"},{"issue":"Pt 1","key":"10.1016\/j.intimp.2009.08.026_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BA19990115","article-title":"B-cell epitope mapping of the Neisseria meningitidis P64k protein using overlapping peptides","volume":"32","author":"Gonz\u00e1lez","year":"2000","journal-title":"Biotechnol Appl Biochem"},{"key":"10.1016\/j.intimp.2009.08.026_bib31","first-page":"522","article-title":"Simultaneous multiple peptide synthesis: the rapid preparation of large numbers of discrete peptides for biological, immunological and methodological studies","volume":"4","author":"Houghten","year":"1986","journal-title":"BioTechniques"},{"key":"10.1016\/j.intimp.2009.08.026_bib32","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0003-2697(70)90146-6","article-title":"Color test for detection of free terminal amino groups in solid-phase synthesis of peptides","volume":"34","author":"Kaiser","year":"1970","journal-title":"Anal Biochem"},{"key":"10.1016\/j.intimp.2009.08.026_bib33","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.intimp.2009.08.026_bib34","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/psc.336","article-title":"Study of different coupling agents in the conjugation of a V3-based synthetic MAP to carrier proteins","volume":"7","author":"Cruz","year":"2001","journal-title":"J Pept Sci"},{"key":"10.1016\/j.intimp.2009.08.026_bib35","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0022-1759(90)90428-X","article-title":"A novel carbodiimide coupling method for synthetic peptides: enhanced antipeptide antibody responses","volume":"129","author":"Deen","year":"1990","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.intimp.2009.08.026_bib36","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of proteins utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1016\/j.intimp.2009.08.026_bib37","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0168-1656(97)00103-X","article-title":"Antigen recognition characteristics and comparative performance in immunoaffinity purification of two monoclonal antibodies specific for the hepatitis B virus surface antigen","volume":"56","author":"M.E.","year":"1997","journal-title":"J Biotechnol"},{"key":"10.1016\/j.intimp.2009.08.026_bib38","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0166-0934(97)00196-1","article-title":"An immunoassay with bovine serum albumin coupled peptides for the improved detection of anti V3 antibodies in HIV-1 + human sera","volume":"71","author":"G\u00f3mez","year":"1998","journal-title":"J Virol Methods"},{"key":"10.1016\/j.intimp.2009.08.026_bib39","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.molimm.2004.06.038","article-title":"Broader cross-reactivity after conjugation of V3 based multiple antigen peptides to HBsAg","volume":"42","author":"Iglesias","year":"2005","journal-title":"Mol Immunol"},{"key":"10.1016\/j.intimp.2009.08.026_bib40","first-page":"35","article-title":"Linear polymerization of a synthetic peptide of the V3 region from HIV-1 JY1 isolate using acetamidomethyl-protected thiol groups of cysteine residues","volume":"17","author":"Cruz","year":"2000","journal-title":"Biotecnol Aplic"},{"key":"10.1016\/j.intimp.2009.08.026_bib41","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/BF02447862","article-title":"Peptide synthesis containing a B-cell and a T-cell epitope on dextran beads and evaluation of humoral response against bead-peptide construct","volume":"7","author":"Cruz","year":"2001","journal-title":"Lett Pept Sci"},{"key":"10.1016\/j.intimp.2009.08.026_bib42","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1021\/bc049944u","article-title":"Different immune response of mice immunized with conjugates containing multiple copies of either consensus or mixotope versions of the V3 loop peptide from human immunodeficiency virus type 1","volume":"15","author":"Cruz","year":"2004","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.intimp.2009.08.026_bib43","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1002\/eji.1830200733","article-title":"A multiple antigen peptide from the repetitive sequence of the Plasmodium malariae circumsporozoite protein induces a specific antibody response in mice of various H-2 haplotypes","volume":"20","author":"Del Giudice","year":"1990","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.intimp.2009.08.026_bib44","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0968-4328(99)00145-6","article-title":"Haliotis tuberculata hemocyanin (HtH): analysis of oligomeric stability of HtH1 and HtH2, and comparison with keyhole limpet hemocyanin KLH1 and KLH2","volume":"31","author":"Harris","year":"2000","journal-title":"Micron"},{"key":"10.1016\/j.intimp.2009.08.026_bib45","doi-asserted-by":"crossref","first-page":"733","DOI":"10.2337\/diabetes.47.5.733","article-title":"Definition of multiple ICA512\/phogrin autoantibody epitopes and detection of intramolecular epitope spreading in relatives of patients with type 1 diabetes","volume":"47","author":"Kawasaki","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/j.intimp.2009.08.026_bib46","doi-asserted-by":"crossref","first-page":"4424","DOI":"10.1128\/IAI.64.11.4424-4432.1996","article-title":"Control by H-2 genes of the Th1 response induced against a foreign antigen expressed by attenuated Salmonella typhimurium","volume":"64","author":"Lo-Man","year":"1996","journal-title":"Infect Immun"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576909002653?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576909002653?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T17:30:37Z","timestamp":1685122237000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576909002653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":46,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S1567576909002653"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2009.08.026","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2009,11]]}}}