{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:39:45Z","timestamp":1789763985255,"version":"4.0.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.intimp.2010.02.002","type":"journal-article","created":{"date-parts":[[2010,2,9]],"date-time":"2010-02-09T15:25:13Z","timestamp":1265729113000},"page":"556-561","source":"Crossref","is-referenced-by-count":40,"title":["Xanthohumol inhibits IL-12 production and reduces chronic allergic contact dermatitis"],"prefix":"10.1016","volume":"10","author":[{"given":"Young-Chang","family":"Cho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Kyun","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Jung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheong-Weon","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ik-Soo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bok Yun","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2010.02.002_bib1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0888-7543(05)80283-6","article-title":"Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5","volume":"14","author":"Sieburth","year":"1992","journal-title":"Genomics"},{"key":"10.1016\/j.intimp.2010.02.002_bib2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1084\/jem.183.1.147","article-title":"The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells","volume":"183","author":"Ma","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.intimp.2010.02.002_bib3","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3109\/08830189809043002","article-title":"Proinflammatory and immunoregulatory functions of interleukin-12","volume":"16","author":"Trinchieri","year":"1998","journal-title":"Int Rev of Immunol"},{"key":"10.1016\/j.intimp.2010.02.002_bib4","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.4049\/jimmunol.156.3.1082","article-title":"Molecular cloning and characterization of murine IL-12 genes","volume":"156","author":"Yoshimoto","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2010.02.002_bib5","doi-asserted-by":"crossref","first-page":"7307","DOI":"10.1073\/pnas.92.16.7307","article-title":"Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes","volume":"92","author":"Bacon","year":"1995","journal-title":"Proc Nat Acad Sci USA"},{"key":"10.1016\/j.intimp.2010.02.002_bib6","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1084\/jem.181.5.1755","article-title":"Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4","volume":"181","author":"Jacobson","year":"1995","journal-title":"J Exp Med"},{"key":"10.1016\/j.intimp.2010.02.002_bib7","doi-asserted-by":"crossref","first-page":"6073","DOI":"10.1074\/jbc.272.9.6073","article-title":"Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases","volume":"272","author":"Zou","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.intimp.2010.02.002_bib8","doi-asserted-by":"crossref","first-page":"510","DOI":"10.4049\/jimmunol.162.1.510","article-title":"IFN-gamma increases the severity and accelerates the onset of experimental autoimmune uveitis in transgenic rats","volume":"162","author":"Egwuagu","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2010.02.002_bib9","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/S0015-0282(00)00517-3","article-title":"Evidence of a T(H) 1 type response associated with recurrent miscarriage","volume":"73","author":"Jenkins","year":"2000","journal-title":"Fertil Steril"},{"key":"10.1016\/j.intimp.2010.02.002_bib10","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/415536a","article-title":"Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease","volume":"415","author":"Monney","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2010.02.002_bib11","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1084\/jem.182.5.1281","article-title":"Antibodies to interleukin 12 abrogate established experimental colitis in mice","volume":"182","author":"Neurath","year":"1995","journal-title":"J Exp Med"},{"key":"10.1016\/j.intimp.2010.02.002_bib12","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/jaut.2000.0469","article-title":"IL-12 plays a pathologic role at the inflammatory loci in the development of diabetes in NOD mice","volume":"16","author":"Nitta","year":"2001","journal-title":"J Autoimmun"},{"key":"10.1016\/j.intimp.2010.02.002_bib13","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.4049\/jimmunol.160.3.1132","article-title":"Alloantigen-reactive Th1 development in IL-12-deficient mice","volume":"160","author":"Piccotti","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2010.02.002_bib14","first-page":"CR607","article-title":"T-helper (1) cytokines increase during early pregnancy in women with a history of recurrent spontaneous abortion","volume":"8","author":"Rezaei","year":"2002","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.intimp.2010.02.002_bib15","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0041-1345(98)01825-9","article-title":"Involvement of Th1 subset in allogeneic keratinocyte rejection","volume":"31","author":"Rouabhia","year":"1999","journal-title":"Transplant Proc"},{"key":"10.1016\/j.intimp.2010.02.002_bib16","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1016\/S0041-1345(00)02666-X","article-title":"Role of interleukin-12 in acute graft-versus-host disease(1)","volume":"33","author":"Welniak","year":"2001","journal-title":"Transplant Proc"},{"key":"10.1016\/j.intimp.2010.02.002_bib17","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/S0031-9422(96)00744-3","article-title":"Prenylflavonoids from Humulus lupulus","volume":"44","author":"Stevens","year":"1997","journal-title":"Phytochemistry"},{"key":"10.1016\/j.intimp.2010.02.002_bib18","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.phytochem.2004.04.025","article-title":"Xanthohumol and related prenylflavonoids from hops and beer: to your good health!","volume":"65","author":"Stevens","year":"2004","journal-title":"Phytochemistry"},{"key":"10.1016\/j.intimp.2010.02.002_bib19","first-page":"959","article-title":"Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop","volume":"1","author":"Gerhauser","year":"2002","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.intimp.2010.02.002_bib20","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1021\/tx050058x","article-title":"Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase","volume":"18","author":"Dietz","year":"2005","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.intimp.2010.02.002_bib21","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1080\/004982500237631","article-title":"In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus","volume":"30","author":"Henderson","year":"2000","journal-title":"Xenobiotica"},{"key":"10.1016\/j.intimp.2010.02.002_bib22","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0304-3835(99)00328-6","article-title":"Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells","volume":"149","author":"Miranda","year":"2000","journal-title":"Cancer Lett"},{"key":"10.1016\/j.intimp.2010.02.002_bib23","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1248\/bpb.26.61","article-title":"Inhibitors of nitric oxide production from hops (Humulus lupulus L.)","volume":"26","author":"Zhao","year":"2003","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.intimp.2010.02.002_bib24","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0278-6915(99)00019-8","article-title":"Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines","volume":"37","author":"Miranda","year":"1999","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.intimp.2010.02.002_bib25","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1096\/fj.05-5128fje","article-title":"Mechanisms of the antiangiogenic activity by the hop flavonoid xanthohumol: NF-kappaB and Akt as targets","volume":"20","author":"Albini","year":"2006","journal-title":"Faseb J"},{"key":"10.1016\/j.intimp.2010.02.002_bib26","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0031-9422(97)00157-X","article-title":"Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus","volume":"46","author":"Tabata","year":"1997","journal-title":"Phytochemistry"},{"key":"10.1016\/j.intimp.2010.02.002_bib27","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1271\/bbb.61.158","article-title":"Bone resorption inhibitors from hop extract","volume":"61","author":"Tobe","year":"1997","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.intimp.2010.02.002_bib28","first-page":"189","article-title":"Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus","volume":"64","author":"Wang","year":"2004","journal-title":"Antiviral Res"},{"key":"10.1016\/j.intimp.2010.02.002_bib29","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.intimp.2007.12.017","article-title":"Differential anti-inflammatory pathway by xanthohumol in IFN-gamma and LPS-activated macrophages","volume":"8","author":"Cho","year":"2008","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.intimp.2010.02.002_bib30","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1021\/np060310g","article-title":"Microbial metabolism of the prenylated chalcone xanthohumol","volume":"69","author":"Kim","year":"2006","journal-title":"Journal of natural products"},{"key":"10.1016\/j.intimp.2010.02.002_bib31","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1016\/0040-4020(78)88432-4","article-title":"Synthesis of (\u00b1) lupinifoun, di-O-methyl xanthohumol and isoxanthohumol and related compounds","volume":"34","author":"Jain","year":"1978","journal-title":"Tetrahedron"},{"key":"10.1016\/j.intimp.2010.02.002_bib32","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0014-2999(02)02554-2","article-title":"Effects of FK506 (tacrolimus hydrate) on chronic oxazolone-induced dermatitis in rats","volume":"456","author":"Fujii","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.intimp.2010.02.002_bib33","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0190-9622(08)81147-4","article-title":"Persistent allergic contact dermatitis from squaric acid dibutyl ester","volume":"28","author":"Fowler","year":"1993","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.intimp.2010.02.002_bib34","first-page":"221","article-title":"Contact allergies due to drugs","volume":"116","author":"Perrenoud","year":"1996","journal-title":"Revue medicale de la Suisse romande"},{"key":"10.1016\/j.intimp.2010.02.002_bib35","first-page":"467","article-title":"Contact dermatitis due to cosmetics","volume":"130","author":"Vigan","year":"2003","journal-title":"Ann Dermatol de Venereol"},{"key":"10.1016\/j.intimp.2010.02.002_bib36","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1600-0536.1983.tb04432.x","article-title":"Dermatitis from a chromium dental plate","volume":"9","author":"Hubler","year":"1983","journal-title":"Contact dermatitis"},{"key":"10.1016\/j.intimp.2010.02.002_bib37","doi-asserted-by":"crossref","first-page":"307","DOI":"10.4103\/0378-6323.35733","article-title":"Relationship between nickel allergy and diet","volume":"73","author":"Sharma","year":"2007","journal-title":"Indian J Dermatol, Venereol Leprol"},{"key":"10.1016\/j.intimp.2010.02.002_bib38","first-page":"530","article-title":"Psoriasis as a T cell-mediated autoimmune disease","volume":"59","author":"Barker","year":"1998","journal-title":"Hosp Med"},{"key":"10.1016\/j.intimp.2010.02.002_bib39","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1046\/j.1523-1747.1999.00749.x","volume":"113","author":"Austin","year":"1999","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.intimp.2010.02.002_bib40","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/1523-1747.ep12371752","article-title":"T cells involved in psoriasis vulgaris belong to the Th1 subset","volume":"102","author":"Schlaak","year":"1994","journal-title":"The Journal of investigative dermatology"},{"key":"10.1016\/j.intimp.2010.02.002_bib41","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/1523-1747.ep12371679","article-title":"The cytokine network in lesional and lesion-free psoriatic skin is characterized by a T-helper type 1 cell-mediated response","volume":"101","author":"Uyemura","year":"1993","journal-title":"The Journal of investigative dermatology"},{"key":"10.1016\/j.intimp.2010.02.002_bib42","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1056\/NEJMoa062382","article-title":"A human interleukin-12\/23 monoclonal antibody for the treatment of psoriasis","volume":"356","author":"Krueger","year":"2007","journal-title":"The New England journal of medicine"},{"key":"10.1016\/j.intimp.2010.02.002_bib43","first-page":"123","article-title":"The IL-12 family member p40 chain as a master switch and novel therapeutic target in psoriasis","author":"Nestle","year":"2004","journal-title":"The Journal of investigative dermatology"},{"key":"10.1016\/j.intimp.2010.02.002_bib44","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.4049\/jimmunol.177.7.4917","article-title":"An anti-IL-12p40 antibody down-regulates type 1 cytokines, chemokines, and IL-12\/IL-23 in psoriasis","volume":"177","author":"Toichi","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2010.02.002_bib45","doi-asserted-by":"crossref","first-page":"18951","DOI":"10.1073\/pnas.0605794103","article-title":"Regions of IkappaBalpha that are critical for its inhibition of NF-kappaB.DNA interaction fold upon binding to NF-kappaB","volume":"103","author":"Truhlar","year":"2006","journal-title":"Proc Nat Acad Sci USA"},{"key":"10.1016\/j.intimp.2010.02.002_bib46","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1101\/gad.6.10.1899","article-title":"I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention","volume":"6","author":"Beg","year":"1992","journal-title":"Genes Dev"},{"key":"10.1016\/j.intimp.2010.02.002_bib47","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0092-8674(00)81699-2","article-title":"The crystal structure of the IkappaBalpha\/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation","volume":"95","author":"Huxford","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2010.02.002_bib48","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/med.2610050203","article-title":"The use of microorganisms for the study of drug metabolism","volume":"5","author":"Clark","year":"1985","journal-title":"Med Res Rev"},{"key":"10.1016\/j.intimp.2010.02.002_bib49","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2174\/1389201033489847","article-title":"Application of microbial biotransformation for the new drug discovery using natural drugs as substrates","volume":"4","author":"Venisetty","year":"2003","journal-title":"Curr Pharm Biotechnol"},{"key":"10.1016\/j.intimp.2010.02.002_bib50","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1600-0536.2006.00918.x","article-title":"Intrinsic characteristics of contact and respiratory allergens influence production of polarizing cytokines by dendritic cells","volume":"55","author":"Toebak","year":"2006","journal-title":"Contact Dermatitis"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576910000615?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576910000615?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T04:39:00Z","timestamp":1685421540000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576910000615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S1567576910000615"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2010.02.002","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}