{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:02:43Z","timestamp":1788447763455,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["2009-0068626"],"award-info":[{"award-number":["2009-0068626"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.intimp.2010.02.011","type":"journal-article","created":{"date-parts":[[2010,2,24]],"date-time":"2010-02-24T04:36:50Z","timestamp":1266986210000},"page":"605-610","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":121,"title":["Curcumin attenuates inflammatory response in IL-1\u03b2-induced human synovial fibroblasts and collagen-induced arthritis in mouse model"],"prefix":"10.1016","volume":"10","author":[{"given":"Dong-Oh","family":"Moon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mun-Ok","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung Hyun","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Min","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi-Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2010.02.011_bib1","doi-asserted-by":"crossref","DOI":"10.1146\/annurev.immunol.14.1.397","article-title":"Role of cytokines in rheumatoid arthritis","volume":"14","author":"Feldmann","year":"1996","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.intimp.2010.02.011_bib2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S1359-6101(02)00018-7","article-title":"Cytokines and anti-cytokine biologicals in autoimmunity: present and future","volume":"13","author":"Andreakos","year":"2002","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.intimp.2010.02.011_bib3","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/S0149-2918(00)80005-3","article-title":"Celecoxib, a selective cyclooxygenase-2 inhibitor for the treatment of rheumatoid arthritis and osteoarthritis","volume":"21","author":"Goldenberg","year":"1999","journal-title":"Clin Ther"},{"key":"10.1016\/j.intimp.2010.02.011_bib4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/rheumatology\/keg038","article-title":"The active metabolite of leflunomide, A77 1726, inhibits the production of prostaglandin E(2), matrix metalloproteinase 1 and interleukin 6 in human fibroblast-like synoviocytes","volume":"42","author":"Burger","year":"2003","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.intimp.2010.02.011_bib5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000108645","article-title":"TNF-\u03b1 and IL-1\u03b2-mediated regulation of MMP-9 and TIMP-1 in human glomerular mesangial cells","volume":"107","author":"Nee","year":"2007","journal-title":"Nephron Exp Nephrol"},{"key":"10.1016\/j.intimp.2010.02.011_bib6","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3109\/10408369009105897","article-title":"Interleukins and tumor necrosis factor in inflammation","volume":"28","author":"Warren","year":"1990","journal-title":"Crit Rev Clin Lab Sci"},{"key":"10.1016\/j.intimp.2010.02.011_bib7","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/art.1780280804","article-title":"Release of interleukin-1 from human synovial tissue in vitro","volume":"28","author":"Wood","year":"1985","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.intimp.2010.02.011_bib8","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1186\/ar112","article-title":"Fibroblast biology. Effector signals released by the synovial fibroblast in arthritis","volume":"2","author":"Ritchlin","year":"2000","journal-title":"Arthritis Res"},{"key":"10.1016\/j.intimp.2010.02.011_bib9","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.bcp.2006.08.007","article-title":"The alternative NF-\u03baB pathway from biochemistry to biology: pitfalls and promises for future drug development","volume":"72","author":"Dejardin","year":"2006","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.intimp.2010.02.011_bib10","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/ar2457","article-title":"The roles of the classical and alternative nuclear factor-kappaB pathways: potential implications for autoimmunity and rheumatoid arthritis","volume":"10","author":"Brown","year":"2008","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.intimp.2010.02.011_bib11","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.joca.2006.04.008","article-title":"NF-\u03baB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis","volume":"14","author":"Roman-Blas","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.intimp.2010.02.011_bib12","doi-asserted-by":"crossref","first-page":"R42","DOI":"10.1186\/ar2650","article-title":"Analysis of TNFAIP3, a feedback inhibitor of nuclear factor-kappaB and the neighbor intergenic 6q23 region in rheumatoid arthritis susceptibility","volume":"11","author":"Dieguez-Gonzalez","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.intimp.2010.02.011_bib13","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1002\/art.23986","article-title":"Antiinflammatory effect of Rho kinase blockade via inhibition of NF-\u03baB activation in rheumatoid arthritis","volume":"58","author":"He","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.intimp.2010.02.011_bib14","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bbrc.2008.11.002","article-title":"Inhibition of IL-1\u03b2-mediated inflammatory responses by the I\u03baB alpha super-repressor in human fibroblast-like synoviocytes","volume":"378","author":"Lee","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.intimp.2010.02.011_bib15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.tips.2008.11.002","article-title":"Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets","volume":"30","author":"Aggarwal","year":"2009","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.intimp.2010.02.011_bib16","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.biocel.2008.06.010","article-title":"Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases","volume":"41","author":"Aggarwal","year":"2009","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.intimp.2010.02.011_bib17","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/978-0-387-46401-5_19","article-title":"Curcumin and autoimmune disease","volume":"595","author":"Bright","year":"2007","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.intimp.2010.02.011_bib18","first-page":"365","article-title":"Curcumin induces apoptosis and inhibits prostaglandin E(2) production in synovial fibroblasts of patients with rheumatoid arthritis","volume":"20","author":"Park","year":"2007","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.intimp.2010.02.011_bib19","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.bcp.2007.01.005","article-title":"Suppression of NF-\u03baB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: implications for the treatment of osteoarthritis","volume":"73","author":"Shakibaei","year":"2007","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.intimp.2010.02.011_bib20","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1172\/JCI114908","volume":"86","author":"Alvaro-Gracia","year":"1990","journal-title":"J Clin Invest"},{"key":"10.1016\/j.intimp.2010.02.011_bib21","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/283666a0","article-title":"Immunisation against heterologous type II collagen induces arthritis in mice","volume":"283","author":"Courtenay","year":"1980","journal-title":"Nature"},{"issue":"Suppl 3","key":"10.1016\/j.intimp.2010.02.011_bib22","doi-asserted-by":"crossref","first-page":"iii45","DOI":"10.1136\/ard.2007.079830","article-title":"Amplifying elements of arthritis and joint destruction","volume":"66","author":"van den Berg","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.intimp.2010.02.011_bib23","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1196\/annals.1422.033","article-title":"The immunology of rheumatoid arthritis","volume":"1108","author":"Scrivo","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.intimp.2010.02.011_bib24","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1146\/annurev.cb.10.110194.002201","article-title":"Structure, regulation and function of NF-\u03baB","volume":"10","author":"Siebenlist","year":"1994","journal-title":"Annu Rev Cell Biol"},{"key":"10.1016\/j.intimp.2010.02.011_bib25","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrm2083","article-title":"Integrating cell-signalling pathways with NF-\u03baB and IKK function","volume":"8","author":"Perkins","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.intimp.2010.02.011_bib26","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1146\/annurev.iy.02.040184.001215","article-title":"Collagen autoimmune arthritis","volume":"2","author":"Stuart","year":"1984","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.intimp.2010.02.011_bib27","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1600-065X.1995.tb00063.x","article-title":"Therapeutic regulation of T cells in rheumatoid arthritis","volume":"144","author":"Breedveld","year":"1995","journal-title":"Immunol Rev"},{"key":"10.1016\/j.intimp.2010.02.011_bib28","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.autrev.2007.02.017","article-title":"B cells in rheumatoid arthritis","volume":"7","author":"Bugatti","year":"2007","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.intimp.2010.02.011_bib29","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1084\/jem.154.3.688","article-title":"collagen induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates","volume":"154","author":"Wooley","year":"1981","journal-title":"J Exp Med"},{"key":"10.1016\/j.intimp.2010.02.011_bib30","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1093\/intimm\/11.7.1065","article-title":"Collagen-induced arthritis development requires alpha beta T cells but not gamma delta T cells: studies with T cell-deficient (TCR mutant) mice","volume":"11","author":"Corthay","year":"1999","journal-title":"Int Immunol"},{"key":"10.1016\/j.intimp.2010.02.011_bib31","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s00011-004-1271-3","article-title":"The differential effects of IL-1 and TNF-\u03b1 on proinflammatory cytokine and matrix metalloproteinase expression in human chondrosarcoma cells","volume":"53","author":"Shi","year":"2004","journal-title":"Inflamm Res"},{"key":"10.1016\/j.intimp.2010.02.011_bib32","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/rheumatology\/40.3.247","article-title":"Expression of proteinases and inflammatory cytokines in subchondral bone regions in the destructive joint of rheumatoid arthritis","volume":"40","author":"Kaneko","year":"2001","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.intimp.2010.02.011_bib33","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0945-053X(99)00030-X","article-title":"Collagenase-3 (MMP-13) and its activators in rheumatoid arthritis: localization in the pannus-hard tissue junction and inhibition by alendronate","volume":"18","author":"Konttinen","year":"1999","journal-title":"Matrix Biol"},{"key":"10.1016\/j.intimp.2010.02.011_bib34","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.joca.2004.02.005","article-title":"Differential induction and regulation of matrix metalloproteinases in osteoarthritic tissue and fluid synovial fibroblasts","volume":"12","author":"Fuchs","year":"2004","journal-title":"Osteoarthritis Cartilage"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576910000706?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576910000706?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:04:45Z","timestamp":1761584685000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576910000706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S1567576910000706"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2010.02.011","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Curcumin attenuates inflammatory response in IL-1\u03b2-induced human synovial fibroblasts and collagen-induced arthritis in mouse model","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2010.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}