{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:35:59Z","timestamp":1777426559693,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.intimp.2010.05.004","type":"journal-article","created":{"date-parts":[[2010,5,18]],"date-time":"2010-05-18T01:32:46Z","timestamp":1274146366000},"page":"929-932","source":"Crossref","is-referenced-by-count":6,"title":["Methylene chloride protects against cecal ligation and puncture-induced acute lung injury by modulating inflammatory mediators"],"prefix":"10.1016","volume":"10","author":[{"given":"Qingfeng","family":"Pang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidong","family":"Dou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuhua","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenli","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinming","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2010.05.004_bib1","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/MAJ.0b013e318195493e","article-title":"Update on ARDS: beyond the low tidal volume","volume":"337","author":"Dernaika","year":"2009","journal-title":"Am J Med Sci"},{"issue":"8","key":"10.1016\/j.intimp.2010.05.004_bib2","doi-asserted-by":"crossref","first-page":"870","DOI":"10.2310\/JIM.0b013e3181c04681","article-title":"Pharmacologic therapies on the horizon for acute lung injury\/acute respiratory distress syndrome","volume":"57","author":"Jacobson","year":"2009","journal-title":"J Investig Med"},{"key":"10.1016\/j.intimp.2010.05.004_bib3","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1164\/rccm.200805-722OC","article-title":"Has mortality from acute respiratory distress syndrome decreased over time? A systematic review","volume":"179","author":"Phua","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.intimp.2010.05.004_bib4","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1165\/rcmb.2009-0170TR","article-title":"Heme oxygenase-1\/carbon monoxide: from metabolism to molecular therapy","volume":"41","author":"Ryter","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.intimp.2010.05.004_bib5","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1124\/pr.57.4.3","article-title":"Carbon monoxide: endogenous production, physiological functions, and pharmacological applications","volume":"57","author":"Wu","year":"2005","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.intimp.2010.05.004_bib6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2174\/187221308786241929","article-title":"Heme oxygenase-1 and carbon monoxide: emerging therapeutic targets in inflammation and allergy","volume":"2","author":"Pae","year":"2008","journal-title":"Recent Pat Inflamm Allergy Drug Discov"},{"key":"10.1016\/j.intimp.2010.05.004_bib7","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1089\/ars.2008.2043","article-title":"Heme oxygenase-1 and the vascular bed: from molecular mechanisms to therapeutic opportunities","volume":"10","author":"Loboda","year":"2008","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.intimp.2010.05.004_bib8","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1165\/rcmb.2006-0333TR","article-title":"Carbon monoxide and bilirubin: potential therapies for pulmonary\/vascular injury and disease","volume":"36","author":"Ryter","year":"2007","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.intimp.2010.05.004_bib9","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.coph.2006.03.002","article-title":"Therapeutic applications of carbon monoxide in lung disease","volume":"6","author":"Ryter","year":"2006","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.intimp.2010.05.004_bib10","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1517\/13543784.14.11.1305","article-title":"Therapeutic applications of carbon monoxide-releasing molecules","volume":"14","author":"Motterlini","year":"2005","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.intimp.2010.05.004_bib11","doi-asserted-by":"crossref","first-page":"465","DOI":"10.2174\/138161208783597362","article-title":"Carbon monoxide-releasing molecules: a pharmacological expedient to counteract inflammation","volume":"14","author":"Alcaraz","year":"2008","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.intimp.2010.05.004_bib12","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1097\/01.tp.0000232716.91887.c5","article-title":"Induction of carbon monoxide in donor animals prior to organ procurement reduces graft immunogenicity and inhibits chronic allograft dysfunction","volume":"82","author":"Martins","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.intimp.2010.05.004_bib13","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/(SICI)1099-1263(199609)16:5<437::AID-JAT371>3.0.CO;2-2","article-title":"Effect of a single administration of benzene, toluene or m-xylene on carboxyhaemoglobin elevation and metabolism of dichloromethane in rats","volume":"16","author":"Kim","year":"1996","journal-title":"J Appl Toxicol"},{"key":"10.1016\/j.intimp.2010.05.004_bib14","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1159\/000073387","article-title":"Distance of cecum ligated influences mortality, tumor necrosis factor-alpha and Interleukin-6 expression following cecal ligation and puncture in the rat","volume":"35","author":"Singleton","year":"2003","journal-title":"Eur Surg Res"},{"key":"10.1016\/j.intimp.2010.05.004_bib15","doi-asserted-by":"crossref","first-page":"F563","DOI":"10.1152\/ajprenal.00220.2005","article-title":"Products of heme oxygenase and their potential therapeutic applications","volume":"290","author":"Kirkby","year":"2006","journal-title":"Am J physiol Renal Physiol"},{"key":"10.1016\/j.intimp.2010.05.004_bib16","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s00134-009-1575-4","article-title":"Beneficial effects of the heme oxygenase-1\/carbon monoxide system in patients with severe sepsis\/septic shock","volume":"36","author":"Takaki","year":"2010","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.intimp.2010.05.004_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2009.04.007","article-title":"Ryter SW.Heme oxygenase-1, a critical arbitrator of cell death pathways in lung injury and disease","volume":"47","author":"Morse","year":"2009","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.intimp.2010.05.004_bib18","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.freeradbiomed.2004.07.008","article-title":"The role of heme oxygenase-1 promoter polymorphisms in human disease","volume":"37","author":"Exner","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.intimp.2010.05.004_bib19","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.atherosclerosis.2003.11.021","article-title":"A promoter variant of the heme oxygenase-1 gene may reduce the incidence of ischemic heart","volume":"173","author":"Ono","year":"2004","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.intimp.2010.05.004_bib20","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1007\/s00134-009-1504-6","article-title":"Heme oxygenase-1 microsatellite polymorphism and haplotypes are associated with the development of acuterespiratory distress syndrome","volume":"35","author":"Sheu","year":"2009","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.intimp.2010.05.004_bib21","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.tox.2006.09.008","article-title":"Chronic inhalation of carbon monoxide: effects on the respiratory and cardiovascular system at doses corresponding totobacco smoking","volume":"228","author":"Sorhaug","year":"2006","journal-title":"Toxicology"},{"key":"10.1016\/j.intimp.2010.05.004_bib22","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s00134-008-1011-1","article-title":"Use of carbon monoxide as a therapeutic agent: promises and challenges","volume":"34","author":"Foresti","year":"2008","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.intimp.2010.05.004_bib23","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/jat.2550150417","article-title":"Methylene chloride","volume":"15","author":"Dhillon","year":"1995","journal-title":"J Appl Toxicol"},{"key":"10.1016\/j.intimp.2010.05.004_bib24","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/0278-6915(86)90322-4","article-title":"Review of investigations of dichloromethane metabolism and subchronic oral toxicity as the basis for the design of chronic oral studies in rats and mice","volume":"24","author":"Kirschman","year":"1986","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.intimp.2010.05.004_bib25","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1177\/0310057X9101900403","article-title":"Carbon monoxide poisoning","volume":"19","author":"Gorman","year":"1991","journal-title":"Anaesth Intensive Care"},{"key":"10.1016\/j.intimp.2010.05.004_bib26","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0736-4679(84)90078-7","article-title":"Carbon monoxide poisoning: mechanisms, presentation, and controversies in management","volume":"1","author":"Olson","year":"1984","journal-title":"J Emerg Med"},{"key":"10.1016\/j.intimp.2010.05.004_bib27","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev.pharmtox.46.120604.141053","article-title":"CO as a cellular signaling molecule","volume":"46","author":"Kim","year":"2006","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.intimp.2010.05.004_bib28","doi-asserted-by":"crossref","first-page":"4744","DOI":"10.4049\/jimmunol.172.8.4744","article-title":"Carbon monoxide produced by heme oxygenase-1 suppresses T cell proliferation via inhibition of IL-2 production","volume":"172","author":"Pae","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2010.05.004_bib29","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/74680","article-title":"Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway","volume":"6","author":"Otterbein","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.intimp.2010.05.004_bib30","doi-asserted-by":"crossref","first-page":"36993","DOI":"10.1074\/jbc.M302942200","article-title":"Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1","volume":"278","author":"Morse","year":"2003","journal-title":"J Biol Chem"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576910001633?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576910001633?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T03:49:48Z","timestamp":1559101788000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576910001633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S1567576910001633"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2010.05.004","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}