{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T10:51:39Z","timestamp":1773658299062,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.intimp.2010.05.010","type":"journal-article","created":{"date-parts":[[2010,5,26]],"date-time":"2010-05-26T09:11:55Z","timestamp":1274865115000},"page":"967-977","source":"Crossref","is-referenced-by-count":12,"title":["Protective effect of chloral hydrate against lipopolysaccharide\/D-galactosamine-induced acute lethal liver injury and zymosan-induced peritonitis in mice"],"prefix":"10.1016","volume":"10","author":[{"given":"Qingjun","family":"Pan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sha","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2010.05.010_bib1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1128\/CVI.13.2.281-288.2006","article-title":"General anesthesia delays the inflammatory response and increases survival for mice with endotoxic shock","volume":"13","author":"Fuentes","year":"2006","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.intimp.2010.05.010_bib2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/00000542-200301000-00017","article-title":"Isoflurane pretreatment inhibits lipopolysaccharide-induced inflammation in rats","volume":"98","author":"Plachinta","year":"2003","journal-title":"Anesthesiology"},{"key":"10.1016\/j.intimp.2010.05.010_bib3","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1097\/00000542-200410000-00015","article-title":"Local anesthetics reduce mortality and protect against renal and hepatic dysfunction in murine septic peritonitis","volume":"101","author":"Gallos","year":"2004","journal-title":"Anesthesiology"},{"key":"10.1016\/j.intimp.2010.05.010_bib4","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/00000542-200207000-00005","article-title":"Isoflurane pretreatment inhibits cytokine-induced cell death in cultured rat smooth muscle cells and human endothelial cells","volume":"97","author":"de Klaver","year":"2002","journal-title":"Anesthesiology"},{"key":"10.1016\/j.intimp.2010.05.010_bib5","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1213\/01.ane.0000255729.96438.b0","article-title":"Use of anesthetic agents in neonates and young children","volume":"104","author":"Mellon","year":"2007","journal-title":"Anesth Analg"},{"key":"10.1016\/j.intimp.2010.05.010_bib6","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1093\/bja\/ael144","article-title":"The effect of melatonin on sedation of children undergoing magnetic resonance imaging","volume":"97","author":"Sury","year":"2006","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.intimp.2010.05.010_bib7","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.ijnurstu.2008.11.001","article-title":"Utilization of analgesics, sedatives, and pain scores in infants with a prolonged hospitalization: a prospective descriptive cohort study","volume":"46","author":"Harrison","year":"2009","journal-title":"Int J Nurs Stud"},{"issue":"Suppl 3","key":"10.1016\/j.intimp.2010.05.010_bib8","first-page":"S45","article-title":"A comparison of oral chloral hydrate and sublingual midazolam sedation for echocardiogram in children","volume":"91","author":"Layangool","year":"2008","journal-title":"J Med Assoc Thai"},{"key":"10.1016\/j.intimp.2010.05.010_bib9","first-page":"1901","article-title":"Effect of slight sedation with chloral hydrate on the BOLD response of children s visual cortex: a self-control fMRI study","volume":"24","author":"Liu","year":"2008","journal-title":"Chin J Med Imaging Technol"},{"key":"10.1016\/j.intimp.2010.05.010_bib10","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1472-8206.2008.00580.x","article-title":"Evaluation of antioxidant and neuroprotective effect of ethanolic extract of Embelia ribes Burm in focal cerebral ischemia\/reperfusion-induced oxidative stress in rats","volume":"22","author":"Nazam","year":"2008","journal-title":"Fundam Clin Pharmacol"},{"key":"10.1016\/j.intimp.2010.05.010_bib11","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s00360-009-0352-6","article-title":"Body and brain temperature coupling: the critical role of cerebral blood flow","volume":"179","author":"Zhu","year":"2009","journal-title":"J Comp Physiol B"},{"key":"10.1016\/j.intimp.2010.05.010_bib12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/WNR.0b013e328302ee46","article-title":"Uncoupling of flow and metabolism by chloral hydrate: a rat in-vivo autoradiographic study","volume":"20","author":"Uematsu","year":"2009","journal-title":"NeuroReport"},{"key":"10.1016\/j.intimp.2010.05.010_bib13","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1159\/000225984","article-title":"Effect of tempol, a membrane-permeable radical scavenger, on mesenteric blood flow and organ injury in a murine cecal ligation and puncture model of septic shock","volume":"43","author":"Yuksel","year":"2009","journal-title":"Eur Surg Res"},{"key":"10.1016\/j.intimp.2010.05.010_bib14","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1289\/ehp.9047","article-title":"Application of cryopreserved human hepatocytes in trichloroethylene risk assessment: relative disposition of chloral hydrate to trichloroacetate and trichloroethanol","volume":"114","author":"Bronley-DeLancey","year":"2006","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.intimp.2010.05.010_bib15","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.tox.2007.12.018","article-title":"Kinetics of chloral hydrate and its metabolites in male human volunteers","volume":"245","author":"Merdink","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.intimp.2010.05.010_bib16","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1007\/s00228-009-0694-8","article-title":"Evidence of safety of chloral hydrate for prolonged sedation in PICU in a tertiary teaching hospital in southern Brazil","volume":"65","author":"Kohut","year":"2009","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.intimp.2010.05.010_bib17","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.bcp.2004.10.003","article-title":"Protective effect of dextromethorphan against endotoxic shock in mice","volume":"69","author":"Li","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.intimp.2010.05.010_bib18","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1248\/bpb.27.2024","article-title":"Protective effect of protocatechuic acid isopropyl ester against murine models of sepsis: inhibition of TNF-alpha and nitric oxide production and augmentation of IL-10","volume":"27","author":"Yan","year":"2004","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.intimp.2010.05.010_bib19","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/S0024-3205(99)00375-6","article-title":"Gallium nitrate suppresses the production of nitric oxide and liver damage in a murine model of LPS-induced septic shock","volume":"65","author":"Krecic-Shepard","year":"1999","journal-title":"Life Sci"},{"key":"10.1016\/j.intimp.2010.05.010_bib20","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1189\/jlb.69.1.33","article-title":"Role of mast cells in zymosan-induced peritoneal inflammation in Balb\/c and mast cell-deficient WBB6F1 mice","volume":"69","author":"Kolaczkowska","year":"2001","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.intimp.2010.05.010_bib21","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1399-6576.1992.tb03452.x","article-title":"Effects of anaesthesia and surgery on the immune response","volume":"36","author":"Salo","year":"1992","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.intimp.2010.05.010_bib22","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1172\/JCI200319523","article-title":"The enigma of sepsis","volume":"112","author":"Riedemann","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.intimp.2010.05.010_bib23","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S1089-3261(03)00026-6","article-title":"Fulminant liver disease","volume":"7","author":"Schiodt","year":"2003","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.intimp.2010.05.010_bib24","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.surg.2004.08.001","article-title":"New insight into the pathogenesis of sepsis and the sepsis syndrome","volume":"137","author":"Johnson","year":"2005","journal-title":"Surgery"},{"key":"10.1016\/j.intimp.2010.05.010_bib25","doi-asserted-by":"crossref","first-page":"R49","DOI":"10.1186\/cc5783","article-title":"Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis","volume":"11","author":"Bozza","year":"2007","journal-title":"Crit Care"},{"key":"10.1016\/j.intimp.2010.05.010_bib26","first-page":"147","article-title":"D-galactosamine lethality model: scope and limitations","volume":"10","author":"Silverstein","year":"2004","journal-title":"J Endotoxin Res"},{"key":"10.1016\/j.intimp.2010.05.010_bib27","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/01.shk.0000228801.56223.92","article-title":"Increased susceptibility to septic and endotoxic shock in monocyte chemoattractant protein 1\/cc chemokine ligand 2-deficient mice correlates with reduced interleukin 10 and enhanced macrophage migration inhibitory factor production","volume":"26","author":"Gomes","year":"2006","journal-title":"Shock"},{"key":"10.1016\/j.intimp.2010.05.010_bib28","first-page":"3","article-title":"Isolation of mouse neutrophils","volume":"Chapter 3","author":"Luo","year":"2001","journal-title":"Curr Protoc Immunol"},{"key":"10.1016\/j.intimp.2010.05.010_bib29","first-page":"203","article-title":"Separation, cultivation and identification of mouse peritoneal macrophages","volume":"27","author":"Meizhen","year":"2006","journal-title":"Med J Wuhan Univ"},{"key":"10.1016\/j.intimp.2010.05.010_bib30","doi-asserted-by":"crossref","first-page":"4346","DOI":"10.1158\/0008-5472.CAN-06-4067","article-title":"Listeria monocytogenes promotes tumor growth via tumor cell toll-like receptor 2 signaling","volume":"67","author":"Huang","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.intimp.2010.05.010_bib31","doi-asserted-by":"crossref","first-page":"15107","DOI":"10.1074\/jbc.M111204200","article-title":"HSP70 as endogenous stimulus of the Toll\/interleukin-1 receptor signal pathway","volume":"277","author":"Vabulas","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.intimp.2010.05.010_bib32","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1097\/00003246-199707000-00001","article-title":"Anti-inflammatory therapies to treat sepsis and septic shock: a reassessment","volume":"25","author":"Zeni","year":"1997","journal-title":"Crit Care Med"},{"key":"10.1016\/j.intimp.2010.05.010_bib33","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.2174\/138161209788453130","article-title":"Anti-cytokine therapeutics: history and update","volume":"15","author":"Ratsimandresy","year":"2009","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.intimp.2010.05.010_bib34","first-page":"127","article-title":"Immune modulation in sepsis","volume":"4","author":"Hall","year":"2009","journal-title":"J Pediatr Infect Dis"},{"key":"10.1016\/j.intimp.2010.05.010_bib35","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/SPC.0b013e32832f4149","article-title":"New results from the use of bisphosphonates in cancer patients","volume":"3","author":"Coleman","year":"2009","journal-title":"Curr Opin Support Palliat Care"},{"key":"10.1016\/j.intimp.2010.05.010_bib36","doi-asserted-by":"crossref","first-page":"5001","DOI":"10.1200\/JCO.2009.22.7389","article-title":"Short-term thalidomide incorporated into double autologous stem-cell transplantation improves outcomes in comparison with double autotransplantation for multiple myeloma","volume":"27","author":"Cavo","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.intimp.2010.05.010_bib37","first-page":"200","article-title":"Advances in research of ketamine addiction mechanism","volume":"25","author":"Liu","year":"2009","journal-title":"Fa Yi Xue Za Zhi"},{"issue":"711\u20136","key":"10.1016\/j.intimp.2010.05.010_bib38","first-page":"716","article-title":"Differential effects of anesthetics on endotoxin-induced liver injury","volume":"58","author":"Suliburk","year":"2005","journal-title":"J Trauma"},{"key":"10.1016\/j.intimp.2010.05.010_bib39","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.4049\/jimmunol.168.3.1441","article-title":"In vivo imaging of NF-kappa B activity","volume":"168","author":"Carlsen","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2010.05.010_bib40","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.jnutbio.2008.07.002","article-title":"Retinoic acid dampens LPS-induced NF-kappaB activity: results from human monoblasts and in vivo imaging of NF-kappaB reporter mice","volume":"20","author":"Austenaa","year":"2009","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.intimp.2010.05.010_bib41","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1365-2826.2007.01560.x","article-title":"Attenuated stress response to acute lipopolysaccharide challenge and ethanol administration in vasopressin V1b receptor knockout mice","volume":"19","author":"Lolait","year":"2007","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.intimp.2010.05.010_bib42","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jneuroim.2008.03.015","article-title":"Lipopolysaccharide and a social stressor influence behaviour, corticosterone and cytokine levels: divergent actions in cyclooxygenase-2 deficient mice and wild type controls","volume":"197","author":"Hayley","year":"2008","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.intimp.2010.05.010_bib43","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.imbio.2007.07.005","article-title":"Gelatinase B\/MMP-9 as an inflammatory marker enzyme in mouse zymosan peritonitis: comparison of phase-specific and cell-specific production by mast cells, macrophages and neutrophils","volume":"213","author":"Kolaczkowska","year":"2008","journal-title":"Immunobiology"},{"key":"10.1016\/j.intimp.2010.05.010_bib44","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.4049\/jimmunol.172.3.1483","article-title":"Zwitterionic polysaccharides stimulate T cells with no preferential V beta usage and promote anergy, resulting in protection against experimental abscess formation","volume":"172","author":"Stingele","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2010.05.010_bib45","doi-asserted-by":"crossref","first-page":"7528","DOI":"10.1073\/pnas.0800152105","article-title":"Hyper innate responses in neonates lead to increased morbidity and mortality after infection","volume":"105","author":"Zhao","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.intimp.2010.05.010_bib46","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.intimp.2009.12.010","article-title":"Tetrandrine attenuates lipopolysaccharide-induced fulminant hepatic failure in D-galactosamine-sensitized mice","volume":"10","author":"Gong","year":"2010","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.intimp.2010.05.010_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2010.01.008","article-title":"Protective effects of Asiaticoside on acute liver injury induced by lipopolysaccharide\/D-galactosamine in mice","author":"Zhang","year":"2010","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2010.05.010_bib48","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/j.1472-8206.2009.00759.x","article-title":"Protective effect of p-methoxyl-diphenyl diselenide in lethal acute liver failure induced by lipopolysaccharide and D-galactosamine in mice","volume":"23","author":"Wilhelm","year":"2009","journal-title":"Fundam Clin Pharmacol"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576910001839?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576910001839?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T08:48:20Z","timestamp":1685609300000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576910001839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":48,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S1567576910001839"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2010.05.010","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}