{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T06:32:45Z","timestamp":1791009165830,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"vor","delay-in-days":303,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1016\/j.intimp.2010.06.014","type":"journal-article","created":{"date-parts":[[2010,7,2]],"date-time":"2010-07-02T04:38:26Z","timestamp":1278045506000},"page":"1113-1118","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"title":["Antinociceptive and anti-inflammatory activities of lectin from the marine green alga Caulerpa cupressoides"],"prefix":"10.1016","volume":"10","author":[{"given":"Edfranck Sousa Oliveira","family":"Vanderlei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kharla Kharolyni Nobre Rabelo","family":"Patoilo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neiberg Alc\u00e2ntara","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Patr\u00edcia Souza","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Ari\u00e9vilo Gurgel","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana Maria Castelo Melo","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Edna Pereira","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilma","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma Maria Barros","family":"Benevides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2010.06.014_bib1","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0091-3057(03)00014-5","article-title":"Acetic acid conditioning stimulus induces long lasting antinociception of somatic inflammatory pain","volume":"74","author":"Kurihara","year":"2003","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.intimp.2010.06.014_bib2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.cbpc.2006.05.007","article-title":"Review: metabolites from algae with economical impact","volume":"146","author":"Cardozo","year":"2007","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"10.1016\/j.intimp.2010.06.014_bib3","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/BF00398968","article-title":"The role of lectins in plant defense","volume":"27","author":"Peumans","year":"1995","journal-title":"Histochem J"},{"key":"10.1016\/j.intimp.2010.06.014_bib4","series-title":"The lectins: properties, functions, and applications in biology and medicine","first-page":"33","author":"Liener","year":"1986"},{"key":"10.1016\/j.intimp.2010.06.014_bib5","doi-asserted-by":"crossref","first-page":"827","DOI":"10.2307\/1223710","article-title":"Typification of Caulerpa cupressoides (Vahl) C. Agardh and C. taxifolia (Vahl) C. Agardh (Chlorophyta, Caulerpaceae)","volume":"50","author":"Nielsen","year":"2001","journal-title":"Taxon"},{"key":"10.1016\/j.intimp.2010.06.014_bib6","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1515\/botm.1991.34.3.211","article-title":"Screening of brazilian marine algae for hemagglutinins","volume":"34","author":"Ainouz","year":"1991","journal-title":"Bot Mar"},{"key":"10.1016\/j.intimp.2010.06.014_bib7","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1515\/BOT.2001.003","article-title":"Purification and partial characterization of the lectin from the marine green alga Caulerpa cupressoides (Vahl) C. Agardh","volume":"44","author":"Benevides","year":"2001","journal-title":"Bot Mar"},{"key":"10.1016\/j.intimp.2010.06.014_bib8","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1590\/S0100-879X2002000600012","article-title":"Antinociceptive activity of sulfated carbohydrates from the red algae Bryothamnion seaforthii (Turner) K\u00fctz. and B. triquetrum (S.G.Gmel.) M.Howe","volume":"35","author":"Viana","year":"2002","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.intimp.2010.06.014_bib9","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1590\/S0100-879X2007000100016","article-title":"Antinociceptive properties in mice of a lectin isolated from the marine alga Amansia multifida Lamouroux","volume":"40","author":"Neves","year":"2007","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.intimp.2010.06.014_bib10","first-page":"412","article-title":"Acetic acid for analgesic screening","volume":"18","author":"Koster","year":"1959","journal-title":"Fed Proc"},{"key":"10.1016\/j.intimp.2010.06.014_bib11","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0304-3959(87)90088-1","article-title":"The formalin test in mice: dissociation between inflammatory and non-inflammatory pain","volume":"30","author":"Hunskaar","year":"1987","journal-title":"Pain"},{"key":"10.1016\/j.intimp.2010.06.014_bib12","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0022-3565(25)05180-8","article-title":"Synthetic analgesics. II. Dithienylbutenyl and dithienylbutylamines","volume":"107","author":"Eddy","year":"1953","journal-title":"J Pharmacol Exper Ther"},{"key":"10.1016\/j.intimp.2010.06.014_bib13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF01966691","article-title":"Blockade by antimacrophage serum of the migration of PMN neutrophils in to the inflamed peritoneal cavity","volume":"17","author":"Souza","year":"1985","journal-title":"Agents Actions"},{"key":"10.1016\/j.intimp.2010.06.014_bib14","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3181\/00379727-111-27849","article-title":"Carrageenin induced oedema in hind paw of rats as an assay for anti-inflammatory drugs","volume":"111","author":"Winter","year":"1962","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.intimp.2010.06.014_bib15","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0378-8741(98)00043-9","article-title":"Antinociceptive and anti-inflammatory effects of Sambucus ebulus rhizome extract in rats","volume":"61","author":"Ahmadiani","year":"1998","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.intimp.2010.06.014_bib16","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.phymed.2008.09.010","article-title":"Antinociceptive activity of swertiamarin isolated from Enicostemma axillare","volume":"16","author":"Jaishree","year":"2009","journal-title":"Phytomed"},{"key":"10.1016\/j.intimp.2010.06.014_bib17","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0165-2427(96)05718-2","article-title":"Lectin-carbohydrate interaction in the immune system","volume":"55","author":"Ni","year":"1996","journal-title":"Vet Immunol Immunopathol"},{"key":"10.1016\/j.intimp.2010.06.014_bib18","first-page":"148","article-title":"Preliminary studies on anti-inflammatory and analgesic activities of Spilanthes acmella in experimental animal models","volume":"36","author":"Chakraborty","year":"2004","journal-title":"Ind J Pharmacol"},{"key":"10.1016\/j.intimp.2010.06.014_bib19","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.1476-5381.1996.tb15226.x","article-title":"Antinociceptive profile of the pseudopepitide B2 bradykin in and receptor antagonist NPC18688 in mice","volume":"117","author":"Correa","year":"1996","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.intimp.2010.06.014_bib20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0014-2999(99)00790-6","article-title":"Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice","volume":"387","author":"Ribeiro","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.intimp.2010.06.014_bib21","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1016\/S0024-3205(01)01374-1","article-title":"Involvement of vanilloid receptor VR1 and prostanoids in the acid-induced writhing responses of mice","volume":"69","author":"Ikeda","year":"2001","journal-title":"Life Sci"},{"key":"10.1016\/j.intimp.2010.06.014_bib22","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0304-3959(92)90003-T","article-title":"The formalin test: an evaluation of the method","volume":"51","author":"Tj\u00f8lsen","year":"1992","journal-title":"Pain"},{"key":"10.1016\/j.intimp.2010.06.014_bib23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0014-2999(01)01038-X","article-title":"B vitamins induce an antinociceptive effect in the acetic acid and formaldehyde models of nociception in mice","volume":"421","author":"Fran\u00e7a","year":"2001","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.intimp.2010.06.014_bib24","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1248\/bpb.31.588","article-title":"Antinociceptive effect of hydroxydihydrocarvone","volume":"31","author":"Oliveira","year":"2008","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.intimp.2010.06.014_bib25","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.phymed.2008.10.007","article-title":"Antinociceptive activity of 1-nitro-2-phenylethane, the main component of Anibacanelilla essential oil","volume":"16","author":"Lima","year":"2009","journal-title":"Phytomed"},{"key":"10.1016\/j.intimp.2010.06.014_bib26","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/00000539-200107000-00039","article-title":"The antinociceptive effect of the combination of spinal morphine with systemic morphine or buprenorphine","volume":"93","author":"Nemirovsky","year":"2001","journal-title":"Anesthesiol Analgesic"},{"key":"10.1016\/j.intimp.2010.06.014_bib27","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00210-008-0262-2","article-title":"Antinociceptive and anti-inflammatory effects of a mucin-binding agglutinin isolated from the red marine alga Hypnea cervicornis","volume":"377","author":"Bitencourt","year":"2008","journal-title":"Naunyn\u2013Schmiedeberg's Arch Pharmacol"},{"key":"10.1016\/j.intimp.2010.06.014_bib28","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/BF02028296","article-title":"Neutrophil migration induced by inflammatory stimuli is reduced by macrophage depletion","volume":"24","author":"Souza","year":"1988","journal-title":"Agents Actions"},{"key":"10.1016\/j.intimp.2010.06.014_bib29","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0022-3565(25)33046-6","article-title":"Dextran and carrageenin evoke different inflammatory response in rat with respect to composition of infiltrates and effect of indomethacin","volume":"221","author":"Lo","year":"1982","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.intimp.2010.06.014_bib30","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1211\/0022357056352","article-title":"Anti-inflammatory and anti-microbial effect of lectin from Lonchocarpus sericeus seeds in an experimental model of infectious peritonitis","volume":"57","author":"Alencar","year":"2005","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.intimp.2010.06.014_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00210-006-0097-7","article-title":"Modulation of acute inflammation by a chitin-binding lectin from Araucaria angustifolia seeds via mast cells","volume":"374","author":"Mota","year":"2006","journal-title":"Naunyn\u2013Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.intimp.2010.06.014_bib32","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.bbrc.2006.09.149","article-title":"Purification and biological effects of Araucaria angustifolia (Araucariaceae) seed lectin","volume":"50","author":"Santi-Gadelha","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.intimp.2010.06.014_bib33","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.intimp.2007.02.001","article-title":"Lonchocarpus sericeus lectin decreases leukocyte migration and mechanical hypernociception by inhibiting cytokine and chemokines production","volume":"7","author":"Napimoga","year":"2007","journal-title":"Int Immunopharmacol"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576910002018?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576910002018?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:04:58Z","timestamp":1761584698000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576910002018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S1567576910002018"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2010.06.014","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antinociceptive and anti-inflammatory activities of lectin from the marine green alga Caulerpa cupressoides","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2010.06.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}