{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:36:49Z","timestamp":1789137409725,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":537,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["CNPq 481459\/2009-0"],"award-info":[{"award-number":["CNPq 481459\/2009-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["303369\/2009-4"],"award-info":[{"award-number":["303369\/2009-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"crossref","award":["FAPEMIG 01110\/08"],"award-info":[{"award-number":["FAPEMIG 01110\/08"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"crossref","award":["PPM 0216\/10"],"award-info":[{"award-number":["PPM 0216\/10"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.intimp.2011.12.025","type":"journal-article","created":{"date-parts":[[2012,1,13]],"date-time":"2012-01-13T22:01:15Z","timestamp":1326492075000},"page":"465-470","source":"Crossref","is-referenced-by-count":30,"title":["Immunomodulatory effects and improved prognosis of experimental autoimmune encephalomyelitis after O-tetradecanoyl-genistein treatment"],"prefix":"10.1016","volume":"12","author":[{"given":"Sandra B.R.","family":"Castro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso O.R.","family":"Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio C.S.","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyria T.","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edvia L.","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Mazzoccoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe P.","family":"Mesquita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nath\u00e1lia S.V.","family":"Figueiredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Juliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Christina M.N.","family":"Casta\u00f1on","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacy","family":"Gameiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro V.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique C.","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2011.12.025_bb0005","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1093\/brain\/awh453","article-title":"Intrathecal activation of the IL-17\/IL-8 axis in opticospinal multiple sclerosis","volume":"128","author":"Ishizu","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.intimp.2011.12.025_bb0010","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/ni0901-762","article-title":"Multiple sclerosis: a two stage disease","volume":"2","author":"Steinman","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1016\/j.intimp.2011.12.025_bb0015","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1365-2567.2008.02837.x","article-title":"T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis","volume":"125","author":"Hedegaard","year":"2008","journal-title":"Immunology"},{"key":"10.1016\/j.intimp.2011.12.025_bb0020","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.immunol.23.021704.115707","article-title":"Immunology of multiple sclerosis","volume":"23","author":"Sospedra","year":"2005","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.intimp.2011.12.025_bb0025","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jneuroim.2007.11.006","article-title":"Production and functions of IL-17 in microglia","volume":"194","author":"Kawanokuchi","year":"2008","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.intimp.2011.12.025_bb0030","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cellimm.2005.11.002","article-title":"Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis","volume":"237","author":"Hofstetter","year":"2005","journal-title":"Cell Immunol"},{"key":"10.1016\/j.intimp.2011.12.025_bb0035","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.bbi.2010.09.012","article-title":"Docosahexaenoic acid prevents dendritic cell maturation, inhibits antigen-specific Th1\/Th17 differentiation and suppresses experimental autoimmune encephalomyelitis","volume":"25","author":"Kong","year":"2011","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.intimp.2011.12.025_bb0040","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1096\/fj.09-141978","article-title":"Cellular mechanisms of IL-17-induced blood\u2013brain barrier disruption","volume":"24","author":"Huppert","year":"2010","journal-title":"FASEB J"},{"key":"10.1016\/j.intimp.2011.12.025_bb0045","doi-asserted-by":"crossref","first-page":"6030","DOI":"10.4049\/jimmunol.177.9.6030","article-title":"IL-10 signaling is essential for 1,25-dihydroxyvitamin D3-mediated inhibition of experimental autoimmune encephalomyelitis","volume":"177","author":"Spach","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2011.12.025_bb0050","doi-asserted-by":"crossref","first-page":"602","DOI":"10.4049\/jimmunol.166.1.602","article-title":"Central nervous system expression of IL-10 Inhibits autoimmune encephalomyelitis","volume":"166","author":"Cua","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2011.12.025_bb0055","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1002\/cncr.24250","article-title":"Genistein enhances the effect of epidermal growth factor receptor tyrosine kinase inhibitors and inhibits nuclear factor kappa B in nonsmall cell lung cancer cell lines","volume":"115","author":"Gadgeel","year":"2009","journal-title":"Cancer"},{"key":"10.1016\/j.intimp.2011.12.025_bb0060","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.4049\/jimmunol.178.8.5048","article-title":"A critical role for p53 in the control of NF-kappa B-dependent gene expression in TLR-4-stimulated dendritic cells exposed to genistein","volume":"178","author":"Dijsselbloem","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2011.12.025_bb0065","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1158\/0008-5472.CAN-04-2807","article-title":"Genistein inhibits p38 map kinase activation, matrix metalloproteinase type 2, and cell invasion in human prostate epithelial cells","volume":"65","author":"Huang","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.intimp.2011.12.025_bb0070","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.intimp.2008.05.002","article-title":"Genistein down-modulates pro-inflammatory cytokines and reverses clinical signs of experimental autoimmune encephalomyelitis","volume":"8","author":"De Paula","year":"2008","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.intimp.2011.12.025_bb0075","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ijpharm.2006.12.046","article-title":"Comparison of oral bioavailability of genistein and genistin in rats","volume":"337","author":"Kwon","year":"2007","journal-title":"Int J Pharm"},{"key":"10.1016\/j.intimp.2011.12.025_bb0080","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/toxsci\/kfj077","article-title":"Kinetics of genistein and its conjugated metabolites in pregnant Sprague\u2013Dawley rats following single and repeated genistein administration","volume":"90","author":"Soucy","year":"2006","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.intimp.2011.12.025_bb0085","doi-asserted-by":"crossref","first-page":"7805","DOI":"10.1016\/S0040-4020(00)00698-0","article-title":"Synthesis of antioxidant isoflavone fatty acid esters","volume":"56","author":"Lewis","year":"2000","journal-title":"Tetrahedron"},{"key":"10.1016\/j.intimp.2011.12.025_bb0090","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1747-0285.2010.01026.x","article-title":"Preparation of amino alcohols condensed with carbohydrates: evaluation of cytotoxicity and inhibitory effect on NO production","volume":"76","author":"Corr\u00eaa","year":"2010","journal-title":"Chem Biol Drug Des"},{"key":"10.1016\/j.intimp.2011.12.025_bb0095","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.canlet.2003.08.023","article-title":"Cytostatic and cytotoxic activity of synthetic genistein glycosides against human cancer cell lines","volume":"203","author":"Polkowski","year":"2004","journal-title":"Cancer Lett"},{"key":"10.1016\/j.intimp.2011.12.025_bb0100","doi-asserted-by":"crossref","first-page":"e3126","DOI":"10.1371\/journal.pone.0003126","article-title":"Hyperbaric oxygen prevents early death caused by experimental cerebral malaria","volume":"3","author":"Blacon","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2011.12.025_bb0105","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/ni1488","article-title":"IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways","volume":"8","author":"Zhou","year":"2007","journal-title":"Nat Immunol"},{"key":"10.1016\/j.intimp.2011.12.025_bb0110","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/intimm\/dxp095","article-title":"Regulatory T cells: how do they suppress immune responses?","volume":"21","author":"Sakaguchi","year":"2009","journal-title":"Int Immunol"},{"key":"10.1016\/j.intimp.2011.12.025_bb0115","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1084\/jem.20030152","article-title":"Conversion of peripheral CD4+CD25\u2212 na\u00efve T cells to CD4+CD25+ regulatory T cells by TGF-\u03b2 induction of transcription factor Foxp3","volume":"198","author":"Chen","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.intimp.2011.12.025_bb0120","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature04753","article-title":"Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells","volume":"441","author":"Betelli","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2011.12.025_bb0125","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1126\/science.1160062","article-title":"CTLA-4 control over Foxp3+regulatory T cell function","volume":"322","author":"Wing","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.intimp.2011.12.025_bb0130","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1084\/jem.192.2.303","article-title":"Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4","volume":"192","author":"Takahashi","year":"2000","journal-title":"J Exp Med"},{"key":"10.1016\/j.intimp.2011.12.025_bb0135","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1093\/brain\/awh068","article-title":"Blood\u2013brain barrier permeability and monocyte infiltration in experimental allergic encephalomyelitis: a quantitative MRI study","volume":"127","author":"Floris","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.intimp.2011.12.025_bb0140","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1002\/eji.200636662","article-title":"Development of an anti-IL-17A auto-vaccine that prevents experimental auto-immune encephalomyelitis","volume":"36","author":"Uyttenhove","year":"2006","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.intimp.2011.12.025_bb0145","doi-asserted-by":"crossref","first-page":"566","DOI":"10.4049\/jimmunol.177.1.566","article-title":"IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis","volume":"177","author":"Komiyama","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2011.12.025_bb0150","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature04754","article-title":"Transforming growth factor-\u03b2 induces development of the Th17 lineage","volume":"441","author":"Mangan","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2011.12.025_bb0155","doi-asserted-by":"crossref","first-page":"9041","DOI":"10.1073\/pnas.0802218105","article-title":"IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis","volume":"105","author":"Serada","year":"2008","journal-title":"PNAS"},{"key":"10.1016\/j.intimp.2011.12.025_bb0160","doi-asserted-by":"crossref","first-page":"944","DOI":"10.4049\/jimmunol.154.2.944","article-title":"TNF-\u03b1 expression by resident microglia and infiltrating leukocytes in the central nervous system of mice with experimental allergic encephalomyelitis: regulation by Th1 cytokines","volume":"154","author":"Renno","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2011.12.025_bb0165","doi-asserted-by":"crossref","first-page":"419","DOI":"10.4049\/jimmunol.164.1.419","article-title":"Kinetics and cellular origin of cytokines in the central nervous system: insight into mechanisms of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis","volume":"164","author":"Juedes","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2011.12.025_bb0170","doi-asserted-by":"crossref","first-page":"4712","DOI":"10.4049\/jimmunol.169.9.4712","article-title":"Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune response and central nervous system inflammation during active experimental autoimmune encephalomyelitis","volume":"169","author":"Kohm","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2011.12.025_bb0175","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.intimp.2010.07.011","article-title":"Regulatory role of resveratrol on Th17 in autoimmune disease","volume":"11","author":"Petro","year":"2011","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.intimp.2011.12.025_bb0180","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s12031-010-9483-1","article-title":"Amelioration of experimental autoimmune encephalomyelitis by \u03b2-elemene treatment is associated with Th17 and Treg cell balance","volume":"44","author":"Zhang","year":"2011","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.intimp.2011.12.025_bb0185","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.4049\/jimmunol.177.3.1552","article-title":"Pertussis toxin reduces the number of splenic Foxp3+ regulatory T cells","volume":"177","author":"Cassan","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2011.12.025_bb0190","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/eji.200535353","article-title":"Pertussis toxin as an adjuvant suppresses the number and function of CD4+CD25+ regulatory cells","volume":"36","author":"Chen","year":"2006","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.intimp.2011.12.025_bb0195","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/intimm\/dxh029","article-title":"IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells","volume":"16","author":"Zhang","year":"2004","journal-title":"Int Immunol"},{"key":"10.1016\/j.intimp.2011.12.025_bb0200","doi-asserted-by":"crossref","first-page":"5191","DOI":"10.4049\/jimmunol.179.8.5191","article-title":"Enhanced engagement of CTLA-4 induces antigen-specific CD4+CD25+Foxp3+ and CD4+CD25\u2212TGF-\u03b21+ adaptive regulatory T cells","volume":"179","author":"Li","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2011.12.025_bb0205","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1073\/pnas.042684699","article-title":"Cytotoxic T lymphocyte antigen-4 (CTLA-4) limits the expansion of encephalitogenic T cells in experimental autoimmune encephalomyelitis (EAE)-resistant BALB\/c mice","volume":"99","author":"Hurwitz","year":"2002","journal-title":"PNAS"},{"key":"10.1016\/j.intimp.2011.12.025_bb0210","doi-asserted-by":"crossref","first-page":"7415","DOI":"10.4049\/jimmunol.179.11.7415","article-title":"Therapeutic effect of anthracene-based anticancer agent ethonafide in an animal model of multiple sclerosis","volume":"179","author":"Piao","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2011.12.025_bb0215","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1084\/jem.20080159","article-title":"IL-12 and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition","volume":"205","author":"Kroenke","year":"2008","journal-title":"J Exp Med"},{"key":"10.1016\/j.intimp.2011.12.025_bb0220","first-page":"3420","article-title":"Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression","volume":"118","author":"Matsushita","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.intimp.2011.12.025_bb0225","doi-asserted-by":"crossref","first-page":"8389","DOI":"10.1073\/pnas.1433000100","article-title":"Human cerebrospinal fluid central memory CD4+ T cells: evidence for trafficking through choroid plexus and meninges via P-selectin","volume":"100","author":"Kivisakk","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.intimp.2011.12.025_bb0230","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1172\/JCI41911","article-title":"Trafficking of immune cells in the central nervous system","volume":"120","author":"Wilson","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.intimp.2011.12.025_bb0235","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.it.2005.07.004","article-title":"The ins and outs of T lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms","volume":"26","author":"Engelhardt","year":"2005","journal-title":"Trends Immunol"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576912000070?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576912000070?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T14:59:44Z","timestamp":1686668384000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576912000070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S1567576912000070"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2011.12.025","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}