{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:56:36Z","timestamp":1762458996741},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National High Technology \u201c863\u201d Programs of China","award":["2002 AA217031-2"],"award-info":[{"award-number":["2002 AA217031-2"]}]},{"name":"China National Natural Science Fund Committee","award":["30270298"],"award-info":[{"award-number":["30270298"]}]},{"name":"Jiangsu Natural Science Fund Committee","award":["BK 95092309","BG2001011"],"award-info":[{"award-number":["BK 95092309","BG2001011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.intimp.2012.03.008","type":"journal-article","created":{"date-parts":[[2012,3,28]],"date-time":"2012-03-28T07:32:12Z","timestamp":1332919932000},"page":"82-87","source":"Crossref","is-referenced-by-count":23,"title":["Nasal immunization with different forms of heat shock protein-65 reduced high-cholesterol-diet-driven rabbit atherosclerosis"],"prefix":"10.1016","volume":"13","author":[{"given":"Jun","family":"Long","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongping","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiming","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongyue","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2012.03.008_bb0005","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis\u2014an inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.intimp.2012.03.008_bb0010","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1038\/nm1102-1218","article-title":"Innate and acquired immunity in atherogenesis","volume":"8","author":"Binder","year":"2002","journal-title":"Nat Med"},{"key":"10.1016\/j.intimp.2012.03.008_bb0015","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1161\/01.RES.0000029784.15893.10","article-title":"Innate and adaptive immunity in the pathogenesis of atherosclerosis","volume":"91","author":"Hansson","year":"2002","journal-title":"Circ Res"},{"key":"10.1016\/j.intimp.2012.03.008_bb0020","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature01323","article-title":"Inflammation in atherosclerosis","volume":"420","author":"Libby","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2012.03.008_bb0025","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2217\/14796678.4.2.125","article-title":"A vaccine against atherosclerosis: myth or reality?","volume":"4","author":"Van Puijvelde","year":"2008","journal-title":"Future Cardiol"},{"key":"10.1016\/j.intimp.2012.03.008_bb0030","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1096\/fasebj.11.13.9367355","article-title":"Atherosclerosis, autoimmunity, and vascular-associated lymphoid tissue","volume":"11","author":"Wick","year":"1997","journal-title":"FASEB J"},{"key":"10.1016\/j.intimp.2012.03.008_bb0035","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1161\/hc0802.103729","article-title":"Heat shock proteins, inflammation, and cardiovascular disease","volume":"105","author":"Pockley","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.intimp.2012.03.008_bb0040","first-page":"161","article-title":"Stress proteins, autoimmunity, and autoimmune disease","volume":"167","author":"Winfield","year":"1991","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.intimp.2012.03.008_bb0045","first-page":"71","article-title":"Immunohistochemical localization of heat shock protein-70 in normal-appearing and atherosclerotic specimens of human arteries","volume":"136","author":"Berberian","year":"1990","journal-title":"Am J Pathol"},{"key":"10.1016\/j.intimp.2012.03.008_bb0050","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0140-6736(93)92613-X","article-title":"Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis","volume":"341","author":"Xu","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2012.03.008_bb0055","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1161\/01.ATV.12.7.789","article-title":"Induction of arteriosclerosis in normocholesterolemic rabbits by immunization with heat shock protein 65","volume":"12","author":"Xu","year":"1992","journal-title":"Arterioscler Thromb"},{"key":"10.1016\/j.intimp.2012.03.008_bb0060","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1161\/01.ATV.19.3.505","article-title":"Enhanced fatty streak formation in C57BL\/6J mice by immunization with heat shock protein-65","volume":"19","author":"George","year":"1999","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.intimp.2012.03.008_bb0065","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1161\/01.CIR.100.11.1169","article-title":"Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis: clinical significance determined in a follow-up study","volume":"100","author":"Xu","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.intimp.2012.03.008_bb0070","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1097\/01.fjc.0000161402.91456.70","article-title":"Vaccinating rabbits with a cholesteryl ester transfer protein (CETP) B-Cell epitope carried by heat shock protein-65 (Hsp65) for inducing anti-CETP antibodies and reducing aortic lesions in vivo","volume":"45","author":"Gaofu","year":"2005","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.intimp.2012.03.008_bb0075","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1016\/j.lfs.2005.05.037","article-title":"Antibody against cholesteryl ester transfer protein (CETP) elicited by a recombinant chimeric enzyme vaccine attenuated atherosclerosis in a rabbit model","volume":"77","author":"Gaofu","year":"2005","journal-title":"Life Sci"},{"key":"10.1016\/j.intimp.2012.03.008_bb0080","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1006\/jaut.1999.0351","article-title":"Immunization of low-density lipoprotein receptor deficient (LDL-RD) mice with heat shock protein 65 (HSP-65) promotes early atherosclerosis","volume":"14","author":"Afek","year":"2000","journal-title":"J Autoimmun"},{"key":"10.1016\/j.intimp.2012.03.008_bb0085","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/S0735-1097(02)02135-6","article-title":"Oral tolerance with heat shock protein 65 attenuates Mycobacterium tuberculosis-induced and high-fat-diet-driven atherosclerotic lesions","volume":"40","author":"Harats","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.intimp.2012.03.008_bb0090","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1161\/01.CIR.0000029750.99462.30","article-title":"Mucosal administration of heat shock protein-65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient mice","volume":"106","author":"Maron","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.intimp.2012.03.008_bb0095","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1161\/ATVBAHA.107.151274","article-title":"Induction of oral tolerance to HSP60 or an HSP60-peptide activates T cell regulation and reduces atherosclerosis","volume":"27","author":"Van Puijvelde","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.intimp.2012.03.008_bb0100","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1097\/01.mol.0000182532.11512.90","article-title":"Regulatory T cell responses: potential role in the control of atherosclerosis","volume":"16","author":"Mallat","year":"2005","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.intimp.2012.03.008_bb0105","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nm1343","article-title":"Natural regulatory T cells control the development of atherosclerosis in mice","volume":"12","author":"Ait-Oufella","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.intimp.2012.03.008_bb0110","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1016\/j.vaccine.2005.12.030","article-title":"Improved efficacy of DNA vaccination against breast cancer by boosting with the repeat beta-hCG C-terminal peptide carried by mycobacterial heat-shock protein HSP65","volume":"24","author":"Yi","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.intimp.2012.03.008_bb0115","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1016\/j.vaccine.2004.01.060","article-title":"Long-lasting specific antibodies against CETP induced by subcutaneous and mucosal administration of a 26-amino acid CETP epitope carried by heat shock protein 65 kDa in the absence of adjuvants","volume":"22","author":"Gaofu","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.intimp.2012.03.008_bb0120","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0022-1759(86)90268-1","article-title":"Antibody avidity determination by ELISA using thiocyanate elution","volume":"86","author":"Pullen","year":"1986","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.intimp.2012.03.008_bb0125","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1128\/IAI.67.4.1688-1693.1999","article-title":"Immunization of mice with DNA-based Pfs25 elicits potent malaria transmission-blocking antibodies","volume":"67","author":"Lobo","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.intimp.2012.03.008_bb0130","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S1357-4310(96)10034-4","article-title":"The role of heat shock proteins in protection and pathophysiology of the arterial wall","volume":"2","author":"Xu","year":"1996","journal-title":"Mol Med Today"},{"key":"10.1016\/j.intimp.2012.03.008_bb0135","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.imlet.2009.05.007","article-title":"Nasal immunization with heat shock protein 65 attenuates atherosclerosis and reduces serum lipids in cholesterol-fed wild-type rabbits probably through different mechanisms","volume":"125","author":"Xiong","year":"2009","journal-title":"Immunol Lett"},{"key":"10.1016\/j.intimp.2012.03.008_bb0140","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1600-065X.1991.tb00824.x","article-title":"Role of hsp60 during autoimmune and bacterial inflammation","volume":"121","author":"Kiessling","year":"1991","journal-title":"Immunol Rev"},{"key":"10.1016\/j.intimp.2012.03.008_bb0145","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/0140-6736(92)90926-T","article-title":"Autoantibody against oxidised LDL and progression of carotid atherosclerosis","volume":"339","author":"Salonen","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2012.03.008_bb0150","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0167-5699(95)80067-0","article-title":"Is atherosclerosis an immunologically mediated disease?","volume":"16","author":"Wick","year":"1995","journal-title":"Immunol Today"},{"key":"10.1016\/j.intimp.2012.03.008_bb0155","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0021-9150(95)05706-4","article-title":"Induction of heat shock protein in monocytic cells by oxidized low density lipoprotein","volume":"121","author":"Frosteg\u00e5rd","year":"1996","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.intimp.2012.03.008_bb0160","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1161\/01.CIR.98.11.1108","article-title":"Induction of early atherosclerosis in LDL-receptor-deficient mice immunized with beta2-glycoprotein I","volume":"98","author":"George","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.intimp.2012.03.008_bb0165","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1146\/annurev.med.48.1.341","article-title":"Oral tolerance for the treatment of autoimmune diseases","volume":"48","author":"Weiner","year":"1997","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.intimp.2012.03.008_bb0170","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0065-2776(08)60787-7","article-title":"Oral tolerance: mechanisms and therapeutic applications","volume":"73","author":"Faria","year":"1999","journal-title":"Adv Immunol"},{"key":"10.1016\/j.intimp.2012.03.008_bb0175","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1016\/S0264-410X(99)00526-5","article-title":"CpG DNA induces stronger immune responses with less toxicity than other adjuvants","volume":"18","author":"Weeratna","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.intimp.2012.03.008_bb0180","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1016\/S0264-410X(00)00496-5","article-title":"The potential of oligodeoxynucleotides as mucosal and parenteral adjuvants","volume":"19","author":"McCluskie","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.intimp.2012.03.008_bb0185","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0264-410X(00)00208-5","article-title":"Oral, intrarectal and intranasal immunization using CpG and non-CpG oligodeoxynucleotides as adjuvants","volume":"19","author":"McCluskie","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.intimp.2012.03.008_bb0190","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1172\/JCI113046","article-title":"Tumor necrosis factor-alpha stimulates hepatic lipogenesis in the rat in vivo","volume":"80","author":"Feingold","year":"1987","journal-title":"J Clin Invest"},{"key":"10.1016\/j.intimp.2012.03.008_bb0195","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1161\/01.ATV.11.3.495","article-title":"Effect of interleukin-1 on lipid metabolism in the rat: similarities to and differences from tumor necrosis factor","volume":"11","author":"Feingold","year":"1991","journal-title":"Arterioscler Thromb"},{"key":"10.1016\/j.intimp.2012.03.008_bb0200","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1210\/endo.136.5.7720663","article-title":"Interleukin-6 stimulates hepatic triglyceride secretion in rats","volume":"136","author":"Nonogaki","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.intimp.2012.03.008_bb0205","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1084\/jem.164.4.1093","article-title":"Recombinant gamma interferon induces hypertriglyceridemia and inhibits post-heparin lipase activity in cancer patients","volume":"164","author":"Kurzrock","year":"1986","journal-title":"J Exp Med"},{"key":"10.1016\/j.intimp.2012.03.008_bb0210","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S0190-9622(88)70173-5","article-title":"Changes in serum lipids in patients with condylomata acuminata treated with interferon alfa-n1 (Wellferon)","volume":"19","author":"Olsen","year":"1988","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.intimp.2012.03.008_bb0215","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1096\/fj.01-0483fje","article-title":"Attenuation of atherogenesis by systemic and local adenovirus-mediated gene transfer of interleukin-10 in LDLr\u2212\/\u2212 mice","volume":"15","author":"Von Der Th\u00fcsen","year":"2001","journal-title":"FASEB J"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576912000811?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576912000811?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T19:51:39Z","timestamp":1593892299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576912000811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S1567576912000811"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2012.03.008","relation":{},"ISSN":["1567-5769"],"issn-type":[{"type":"print","value":"1567-5769"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}