{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:26:32Z","timestamp":1789748792858,"version":"4.0.1"},"reference-count":21,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC 30950010"],"award-info":[{"award-number":["NSFC 30950010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC-81001325"],"award-info":[{"award-number":["NSFC-81001325"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC-81072443"],"award-info":[{"award-number":["NSFC-81072443"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People&apos;s Republic of China","doi-asserted-by":"publisher","award":["20090181110026"],"award-info":[{"award-number":["20090181110026"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.intimp.2012.03.019","type":"journal-article","created":{"date-parts":[[2012,3,31]],"date-time":"2012-03-31T01:31:53Z","timestamp":1333157513000},"page":"69-72","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Impact of tacrolimus on bone metabolism after kidney transplantation"],"prefix":"10.1016","volume":"13","author":[{"given":"Limei","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunying","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangjuan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuangao","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanlan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2012.03.019_bb0005","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1600-6143.2010.03283.x","article-title":"Long-term renal allograft survival in the United States: a critical reappraisal","volume":"11","author":"Lamb","year":"2011","journal-title":"Am J Transplant"},{"key":"10.1016\/j.intimp.2012.03.019_bb0010","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1016\/j.transproceed.2009.07.018","article-title":"Osteoporosis and related risk factors in renal transplant recipients","volume":"41","author":"Ahmadpoor","year":"2009","journal-title":"Transplant Proc"},{"key":"10.1016\/j.intimp.2012.03.019_bb0015","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.trim.2006.09.018","article-title":"Long-term problems related to immunosuppression","volume":"17","author":"Lopez","year":"2006","journal-title":"Transpl Immunol"},{"key":"10.1016\/j.intimp.2012.03.019_bb0020","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nrneph.2009.192","article-title":"Bone disease after renal transplantation","volume":"6","author":"Malluche","year":"2010","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.intimp.2012.03.019_bb0025","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1093\/ndt\/10.11.2096","article-title":"Bone loss after kidney transplantation: a longitudinal study in 115 graft recipients","volume":"10","author":"Grotz","year":"1995","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.intimp.2012.03.019_bb0030","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1097\/00007890-200208270-00011","article-title":"Bone mineral density and fracture prevalence in long-term kidney graft recipients","volume":"74","author":"Durieux","year":"2002","journal-title":"Transplantation"},{"key":"10.1016\/j.intimp.2012.03.019_bb0035","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/TP.0b013e3181afe9e7","article-title":"Pharmacogenetics of calcineurin inhibitors in renal transplantation","volume":"88","author":"Coto","year":"2009","journal-title":"Transplantation"},{"key":"10.1016\/j.intimp.2012.03.019_bb0040","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.lfs.2008.10.011","article-title":"Immunosuppressant FK506 decreases the intracellular magnesium in the human osteoblast cell by inhibiting the ERK1\/2 pathway","volume":"84","author":"Jeon","year":"2009","journal-title":"Life Sci"},{"key":"10.1016\/j.intimp.2012.03.019_bb0045","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.bone.2003.05.003","article-title":"Expression of osteoclast differentiation factor and osteoclastogenesis inhibitory factor in rat osteoporosis induced by immunosuppressant FK506","volume":"34","author":"Fukunaga","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.intimp.2012.03.019_bb0050","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.transproceed.2007.11.040","article-title":"Impact of calcineurin inhibitors on bone metabolism in primary kidney transplant patients","volume":"40","author":"Bozkaya","year":"2008","journal-title":"Transplant Proc"},{"key":"10.1016\/j.intimp.2012.03.019_bb0055","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1007\/s00774-004-0523-1","article-title":"Regulation of bone metabolism in immunosuppressant (FK506)-treated rats","volume":"22","author":"Kirino","year":"2004","journal-title":"J Bone Miner Metab"},{"key":"10.1016\/j.intimp.2012.03.019_bb0060","first-page":"207","article-title":"Effect of low-dose tacrolimus coadministered with raloxifene on the skeletal system in male rats","volume":"66","author":"Folwarczna","year":"2009","journal-title":"Acta Pol Pharm"},{"key":"10.1016\/j.intimp.2012.03.019_bb0065","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/j.intimp.2011.08.015","article-title":"CNI induced Th17\/Treg imbalance and susceptibility to renal dysfunction in renal transplantation","volume":"11","author":"Li","year":"2011","journal-title":"Int Immunopharmacol"},{"issue":"Suppl. 2","key":"10.1016\/j.intimp.2012.03.019_bb0070","first-page":"127","article-title":"Osteoporosis after renal transplantation","volume":"23","author":"Trabulus","year":"2003","journal-title":"Nefrologia"},{"key":"10.1016\/j.intimp.2012.03.019_bb0075","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1097\/01.tp.0000203557.36884.e3","article-title":"Lumbar bone mineral density in renal transplant patients on neoral and tacrolimus: a four-year prospective study","volume":"81","author":"Marcen","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.intimp.2012.03.019_bb0110","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.bone.2004.09.021","article-title":"Characterisation of cytosolic FK506 binding protein 12 and its role in modulating expression of Cbfa1 and osterix in ROS 17\/2.8 cells","volume":"36","author":"Varanasi","year":"2005","journal-title":"Bone"},{"key":"10.1016\/j.intimp.2012.03.019_bb0085","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1111\/j.1600-6143.2006.01557.x","article-title":"Late low-dose steroid withdrawal in renal transplant recipients increases bone formation and bone mineral density","volume":"6","author":"Farmer","year":"2006","journal-title":"Am J Transplant"},{"key":"10.1016\/j.intimp.2012.03.019_bb0090","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.maturitas.2009.12.021","article-title":"Optimizing bone health in chronic kidney disease","volume":"65","author":"Pelletier","year":"2010","journal-title":"Maturitas"},{"key":"10.1016\/j.intimp.2012.03.019_bb0095","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1365-2265.2008.03187.x","article-title":"Utility of serum tartrate-resistant acid phosphatase (TRACP5b) as a bone resorption marker in patients with chronic kidney disease: independence from renal dysfunction","volume":"69","author":"Yamada","year":"2008","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.intimp.2012.03.019_bb0100","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1007\/s00198-009-0901-6","article-title":"Bone fragility in male glucocorticoid-induced osteoporosis is not defined by bone mineral density","volume":"20","author":"Hayashi","year":"2009","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.intimp.2012.03.019_bb0105","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1093\/ndt\/gfr214","article-title":"Impact of sirolimus, tacrolimus and mycophenolate mofetil on osteoclastogenesis\u2014implications for post-transplantation bone disease","volume":"26","author":"Westenfeld","year":"2011","journal-title":"Nephrol Dial Transplant"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576912000926?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576912000926?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:05:36Z","timestamp":1761584736000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576912000926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S1567576912000926"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2012.03.019","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of tacrolimus on bone metabolism after kidney transplantation","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2012.03.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}